Natalja E Leeuwis-Fedorovich, M. Starink, A. C. van der Wal
{"title":"Multifocal squamous cell carcinoma arising in a Favre-Racouchot lesion - report of two cases and review of the literature.","authors":"Natalja E Leeuwis-Fedorovich, M. Starink, A. C. van der Wal","doi":"10.3315/jdcr.2015.1215","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1215","url":null,"abstract":"BACKGROUND\u0000Favre-Racouchot syndrome (nodular cutaneous elastosis with cysts and comedones) is a cutaneous disease characterized by coexistence of cysts, comedones and elastotic nodules in actinically damaged skin, typically on the face. Ultraviolet radiation plays a significant role in the development of the disease. Unilateral lesions have been described.\u0000\u0000\u0000MAIN OBSERVATION\u0000In this report we present two cases of squamous cell carcinoma arising in a unilateral Favre-Racouchot plaque. Both patients, fair-skinned, elderly, with impaired immune function developed large, deep invasive tumors with perineural extension.\u0000\u0000\u0000CONCLUSIONS\u0000Squamous cell carcinomas of large size and prominent invasive growth developing in immunocompromised individuals carry poor prognosis with regard to recurrence rate and metastasis. Manifestations of malignancy as described in this report, indicate the importance of close follow-up of patients with Favre-Racouchot syndrome.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"53 1","pages":"103-6"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84588972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delayed hypersensitivity reaction to intralesional triamcinolone acetonide following treatment for alopecia areata. Intradermal testing.","authors":"F. C. Kreeshan, P. Hampton","doi":"10.3315/jdcr.2015.1216","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1216","url":null,"abstract":"BACKGROUND\u0000Hypersensitivity reactions to intralesional corticosteroids are very rare and have been infrequently reported. Patch testing is considered the gold standard for diagnosing contact allergic dermatitis. However, intradermal testing is thought to be more accurate and sensitive in selected cases.\u0000\u0000\u0000MAIN OBSERVATION\u0000We describe a case of a delayed hypersensitivity reaction to intralesional triamcinolone acetonide following the treatment of alopecia areata. Patch testing to triamcinolone was negative but intradermal testing with a small volume of the same reagent elicited a strong reaction.\u0000\u0000\u0000CONCLUSIONS\u0000Patch testingmay be unsuccessful in detecting delayed reactions to intralesional corticosteroids. In such cases intradermal testing at a non-cosmetically sensitive sitemay be a useful diagnostic tool.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"46 1","pages":"107-9"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75708026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photoletter to the editor: Subcutaneous ciliated Mullerian cyst.","authors":"Matthew Keisling, A. Marinovich, B. Burkey","doi":"10.3315/jdcr.2015.1218","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1218","url":null,"abstract":"Cutaneous ciliated cysts are benign lesions occurring primarily on the lower extremity of girls and young women. We present a case of a cutaneous ciliated Mullerian cyst arising in the lower leg of a 14-year-old girl, with brief discussion of etiology and diagnosis. This is a rare entity with approximately 50 cases in the literature.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"27 1","pages":"116-7"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82507002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ndiaye, A. S. Sow, Abbaspour Valiollah, M. Diallo, A. Diop, R. Alaoui, B. Diatta, F. Ly, S. Niang, M. Dieng, A. Kane
{"title":"Behçet's disease in black skin. A retrospective study of 50 cases in Dakar.","authors":"M. Ndiaye, A. S. Sow, Abbaspour Valiollah, M. Diallo, A. Diop, R. Alaoui, B. Diatta, F. Ly, S. Niang, M. Dieng, A. Kane","doi":"10.3315/jdcr.2015.1213","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1213","url":null,"abstract":"INTRODUCTION\u0000Although Behçet's disease is well-documented in Eastern populations, epidemiologic data in Sub-Saharan African population is scarce. The aim of this study was to define the epidemiologic and therapeutic aspects as well as clinical course of Behçet's disease in African black population.\u0000\u0000\u0000RESULTS\u0000The study included 50 patients with Behçet's disease. The average age was 32 (18-67) years. A total of 31 patients were men and 19 were women. Two patients had a positive family history of Behçet's disease. The oral and genital aphthous lesions were present in 100% of patients. The pathergy test was positive in 16 patients (32%). Following skin conditions were observed: pseudofolliculitis in 15 patients (30%), acneiform papules in 6 patients (12%), erythema nodosum in 4 patients (8%) and leg ulcers in one patient. Ocular involvement was reported in 22 patients (44%) and joint involvement in 20 patients (40%). Neurological abnormalities were noted in 12 patients (24%). Gastrointestinal involvement with wide and deep ulcerations in the ileocecal region was observed in a patient. As treatment, a combination of oral corticosteroids and colchicine was used in 97% of our patients. Thalidomide was introduced in 3 patients and anticoagulation treatment in 19 patients. Clinical improvement was noted in 25 patients (50%), recurrence in 14 patients (28%) and 3 patients were lost to follow (6%).\u0000\u0000\u0000CONCLUSION\u0000The Behçet's disease is not uncommon in black skin and generally affects young adults. Severe aphthous ulcers of the oral cavity and genital area are the most consistent finding.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"137 1","pages":"98-102"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80260355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Garrido-Colmenero, R. Ruiz-Villaverde, E. Martínez-García, J. Aneiros-Fernández, J. Tercedor-Sánchez
{"title":"Photoletter to the editor: Response of linear porokeratosis to photodynamic therapy in an 11-year-old girl.","authors":"C. Garrido-Colmenero, R. Ruiz-Villaverde, E. Martínez-García, J. Aneiros-Fernández, J. Tercedor-Sánchez","doi":"10.3315/jdcr.2015.1220","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1220","url":null,"abstract":"Porokeratoses are a group of different entities that belong to the skin keratinization disorders. From the histological point of view the main and common characteristic of these disorders is the presence of compact parakeratotic columns known as cornoid lamellae. All varieties should be carefully treated and followed-up because of the risk of developing malignant epithelial tumors. We report the successful response to photodynamic therapy (PDT) in a pediatric patient diagnosed with linear porokeratosis.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"43 1","pages":"118-9"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73351604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sunil K Kothiwala, Mahesh Prajapat, Chhitar Mal Kuldeep, Arpita Jindal
{"title":"Cryptococcal panniculitis in a renal transplant recipient: case report and review of literature.","authors":"Sunil K Kothiwala, Mahesh Prajapat, Chhitar Mal Kuldeep, Arpita Jindal","doi":"10.3315/jdcr.2015.1205","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1205","url":null,"abstract":"<p><strong>Background: </strong>Cryptococcosis is a deep fungal infection caused by Cryptococcus neoformans. The infection usually involves the lungs, the central nervous system as well as the skin, the bones and the urinary tract. Immunocompromised individuals, including solid organ transplant recipients, are at higher risk for cryptococcal infections.</p><p><strong>Main observations: </strong>We present a 40-year-old renal transplant recipient who developed a slightly painful, erythematous, indurated plaque on his thigh several years after a kidney transplant. Histopathology revealed cryptococcal panniculitis and cryptococcus neoformans subsequently grew from the tissue culture. There was no other systemic involvement.</p><p><strong>Conclusion: </strong>The primary cutaneous form of cryptococcosis is extremely rare and early diagnosis and treatment is essential in view of possible dissemination and variable nonspecific clinical manifestations.</p>","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 3","pages":"76-80"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619164/pdf/jdcr-09-076.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tainá Scalfoni Fracaroli, Ludmilla Queirós Miranda, Juan Piñeiro Maceira, Carlos Baptista Barcaui
{"title":"Photoletter to the editor: Exogenous pigmentation after Diplopoda exposure leading to a dermatoscopic parallel ridge pattern on the plantar region.","authors":"Tainá Scalfoni Fracaroli, Ludmilla Queirós Miranda, Juan Piñeiro Maceira, Carlos Baptista Barcaui","doi":"10.3315/jdcr.2015.1209","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1209","url":null,"abstract":"<p><p>The millipedes (also known as \"gongolos\") are arthropods characterized by a cylindrical body consisting of rings. When threatened, they release chemicals that can cause erythema and hyperpigmentation. We report the case of a patient who developed a darkened macule on the plantar region after stepping on a millipede. Dermatoscopic examination showed a parallel-ridge pattern, which is considered typical for acral melanoma. A detailed history was essential for the diagnosis, as the clinical and dermatoscopic features suggested a malignant melanocytic lesion. </p>","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 3","pages":"85-6"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3315/jdcr.2015.1209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Markus Reinholz, Markus Heppt, Julia K Tietze, Thomas Ruzicka, Gerd G Gauglitz, Jürgen Schauber
{"title":"Photoletter to the editor: Topical 0.5% brimonidine gel to camouflage redness of immature scars.","authors":"Markus Reinholz, Markus Heppt, Julia K Tietze, Thomas Ruzicka, Gerd G Gauglitz, Jürgen Schauber","doi":"10.3315/jdcr.2015.1210","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1210","url":null,"abstract":"<p><p>Cutaneous scars develop as a result of a defective wound healing process. Scars are commonly visible as erythematous, sometimes disfiguring lesions which might be stigmatizing for the affected patient. Only a few therapies to improve the appearance of scars are available. Recently, brimonidine - a selective α2-receptor-agonist which causes vasoconstriction of small cutaneous vessels - was approved for the treatment of erythemato-telangiectatic rosacea. Topical brimonidine might also be helpful to improve redness of immature scars. Here we report on the effect of brimonidine 0.5% gel on a flat, erythematous scar in a 25-year-old female patient. Whitening of the scar could be observed immediately after application of brimonidine 0.5% gel and a good clinical result was observed within one hour. This effect lasted for up to three hours. We conclude that brimonidine 0.5% gel is a suitable topical therapy to reduce erythema in visible cutaneous scars. </p>","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 3","pages":"87-8"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619167/pdf/jdcr-09-087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Sole Chimenti, Marina Talamonti, Lucia Novelli, Miriam Teoli, Marco Galluzzo, Paola Triggianese, Roberto Perricone
{"title":"Long-term ustekinumab therapy of psoriasis in patients with coexisting rheumatoid arthritis and Sjögren syndrome. Report of two cases and review of literature.","authors":"Maria Sole Chimenti, Marina Talamonti, Lucia Novelli, Miriam Teoli, Marco Galluzzo, Paola Triggianese, Roberto Perricone","doi":"10.3315/jdcr.2015.1207","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1207","url":null,"abstract":"<p><strong>Background: </strong>Inteleukin (IL)12 and IL23 are two main cytokines involved in the pathogenesis of immune-mediated disease. IL12 is produced by macrophages and B lymphocytes and mediates differentiation of Th1 lymphocytes, while IL23 is a pro-inflammatory cytokine essential for the differentiation of Th17 cells. Ustekinumab is a human monoclonal antibody directed against the p40 protein subunit shared by IL12 and IL23, therefore it blocks the signal transmission of both cytokines.</p><p><strong>Main observations: </strong>We present two cases and discuss the long-term efficacy of ustekinumab as a treatment of psoriasis in patients affected by autoimmune diseases, rheumatoid arthritis and Sjögren's syndrome, who presented with severe psoriasis after anti-TNF treatment.</p><p><strong>Conclusions: </strong>To the best of our knowledge, these are the first cases reported in the literature describing the long-term good efficacy of ustekinumab not only on paradoxical forms of psoriasis induced by anti-TNF-α drugs, but also on the articular involvement in a patient affected by RA and in a patient affected by Sjögren syndrome.</p>","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 3","pages":"71-5"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3315/jdcr.2015.1207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vasiliki A Zampeli, Undine Lippert, Georgios Nikolakis, Evgenia Makrantonaki, Thrasivoulos G Tzellos, Ulf Krause, Christos C Zouboulis
{"title":"Disseminated refractory pyoderma gangraenosum during an ulcerative colitis flare. Treatment with infliximab.","authors":"Vasiliki A Zampeli, Undine Lippert, Georgios Nikolakis, Evgenia Makrantonaki, Thrasivoulos G Tzellos, Ulf Krause, Christos C Zouboulis","doi":"10.3315/jdcr.2015.1206","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1206","url":null,"abstract":"<p><strong>Background: </strong>Pyoderma gangraenosum is an immune-mediated, inflammatory, neutrophilic dermatosis of unknown etiology, which represents one of the extraintestinal manifestations of inflammatory bowel disease. It is a rare disease that occurs in less than 1% of patients with inflammatory bowel disease and with the same ratio in patients with Crohn's disease and ulcerative colitis.</p><p><strong>Main observations: </strong>A 36-year-old woman was diagnosed with ulcerative colitis 6 years before admission to our dermatology department with an acute disseminated pyoderma gangraenosum with mucosal involvement, during a flare of ulcerative colitis. Disease progression was interrupted by intravenous administration of the tumor necrosis factor-α inhibitor infliximab at 5 mg/kg at weeks 0, 2, and 6 (1st cycle) and every 8 weeks thereafter. Improvement of intestinal, skin and oral manifestations was evident already after the 1st cycle of treatment and has been maintained since (at least 16 months).</p><p><strong>Conclusions: </strong>This case report is one of very few on disseminated pyoderma gangraenosum with oral involvement complicating ulcerative colitis, where infliximab was shown to have a rapid efficacy on skin, mucosal and bowel symptoms.</p>","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 3","pages":"62-6"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619161/pdf/jdcr-09-062.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}