Journal of dermatological case reports最新文献_第5页

Pityriasis rosea-like cutaneous eruption as the presenting symptom of Hodgkin lymphoma. Case report and review of the literature. 玫瑰样皮疹是霍奇金淋巴瘤的主要症状。病例报告及文献复习。

Journal of dermatological case reports Pub Date : 2015-09-30 DOI: 10.3315/jdcr.2015.1212

Elena Vrotsos, Jacquelyn Dosal, Martin Zaiac, John Alexis

{"title":"Pityriasis rosea-like cutaneous eruption as the presenting symptom of Hodgkin lymphoma. Case report and review of the literature.","authors":"Elena Vrotsos, Jacquelyn Dosal, Martin Zaiac, John Alexis","doi":"10.3315/jdcr.2015.1212","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1212","url":null,"abstract":"Background: Cutaneous involvement by Hodgkin lymphoma is extremely rare and usually follows extensive involvement of the lymph nodes. Cutaneous manifestations of Hodgkin lymphoma may be divided into specific and non-specific. Generalized pruritus is one of the most common non-specific presentations of Hodgkin lymphoma as is cutaneous granulomas. Such signs and symptoms should prompt thorough physical exam, including evaluation of lymph nodes, especially in a young patient.Main observation: We report a case of a 22-year-old man who presented with night sweats, weight loss, dry cough, and generalized maculopapular eruption that started with a large patch in the center of the chest and spread to the extremities. Biopsy of the rash revealed pityriasis rosea-like findings. A computerized tomography scan of the chest revealed a mediastinal mass. Biopsy of the mediastinal mass revealed Reed-Sternberg cells in a fibrotic background, diagnostic of Hodgkin lymphoma, nodular sclerosis type.Conclusion: In conclusion, the presentation of Hodgkin lymphoma as a pityriasis rosea-like cutaneous eruption is rare and clinicians should be aware of this presentation. In this paper we review the non-specific cutaneous manifestations of Hodgkin lymphoma in an effort to raise awareness of the diversity of early cutaneous signs of Hodgkin lymphoma.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 3","pages":"81-4"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619165/pdf/jdcr-09-081.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Large eccrine angiomatous hamartoma: a novel clinical presentation of disease. 大胰腺血管瘤错构瘤:一种新的临床表现。

Journal of dermatological case reports Pub Date : 2015-09-30 DOI: 10.3315/jdcr.2015.1211

Uffe Nygaard, Søren Dalager, Eva Spaun, Lene Hedelund

引用次数: 5

Brooke-Spiegler Syndrome - an underrecognized cause of multiple familial scalp tumors: report of a new germline mutation. 布鲁克-斯皮格勒综合征-多种家族性头皮肿瘤的未被认识的原因:一个新的种系突变的报告。

Journal of dermatological case reports Pub Date : 2015-09-30 DOI: 10.3315/jdcr.2015.1208

André Castro Pinho, Miguel José Pinto Gouveia, Ana Rita Portelinha Gameiro, José Carlos Pereira Silva Cardoso, Maria Margaria Martins Gonçalo

{"title":"Brooke-Spiegler Syndrome - an underrecognized cause of multiple familial scalp tumors: report of a new germline mutation.","authors":"André Castro Pinho, Miguel José Pinto Gouveia, Ana Rita Portelinha Gameiro, José Carlos Pereira Silva Cardoso, Maria Margaria Martins Gonçalo","doi":"10.3315/jdcr.2015.1208","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1208","url":null,"abstract":"Background: Brooke-Spiegler syndrome (BSS) is probably an underdiagnosed genodermatosis that predisposes for the development of cylindromas, spiradenomas and trichoepitheliomas mainly of the head and neck. Wide phenotypic variability regarding the number and type of lesions can be observed within a family. Mutations of the CYLD gene are identified in the vast majority of cases and play a key role in BSS pathogenesis.Main observations: Two first degree relatives with numerous erythematous telangiectatic nodules of the scalp present for decades, with recurring tendency regardless the multiple previous excisions. Histopathological review of the lesions revealed predominantly \"spiradenocylindromas\" in the proband and cylindromas in her sister. The suspicion of BSS was confirmed after detection of a new nonsense germline mutation of CYLD (c.1783C>T pGln 595*) in the proband.Conclusions: BSS diagnosis can be challenging and is based on clinical-pathological correlation, positive familial association and identification of CYLD mutations. CYLD exerts antineoplastic effects by downregulating intracellular NF-κB signalling pathways. The reported mutation affecting the ubiquitin-specific protease domain leads to a truncated and catalytically inactive enzyme. Despite the expanding list of CYLD mutations no firm genotype-phenotype correlation is known so far. Early recognition and treatment of BSS avoid disfiguring changes like \"turban tumor\".","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 3","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619162/pdf/jdcr-09-067.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

How to treat actinic keratosis? An update. 如何治疗光化性角化病?一个更新。

Journal of dermatological case reports Pub Date : 2015-06-30 DOI: 10.3315/jdcr.2015.1199

Claudia Costa, Massimiliano Scalvenzi, Fabio Ayala, Gabriella Fabbrocini, Giuseppe Monfrecola

{"title":"How to treat actinic keratosis? An update.","authors":"Claudia Costa, Massimiliano Scalvenzi, Fabio Ayala, Gabriella Fabbrocini, Giuseppe Monfrecola","doi":"10.3315/jdcr.2015.1199","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1199","url":null,"abstract":"Actinic keratosis (AKs) is one of the most common skin lesions leading to an increased risk of developing squamous cell carcinoma and other skin malignancies. The lesions principally arise as a result of excessive ultraviolet (UV) exposure. AKs may regress spontaneously, remain stable or evolve to invasive squamous cell carcinoma. The risk of squamous cell carcinoma is significantly increased patients with more than 5 AKs. The main mechanisms involved in the formation of AK are inflammation, mutagenesis, oxidative stress, impaired apoptosis, immunosuppression, disregulation of cell growth and proliferation, and tissue remodeling. Human papilloma virus has also been correlated with the formation of some AKs. As an individual ages, his skin is exposed to increasing cumulative amounts of UV light and other environmental insults. This is especially true for the head, neck and forearms. These insults do not target only the skin where individual lesions develop, but also the surrounding area. In this area undetectable preclinical AK lesions or dysplastic cells may be present. The whole affected area is known as the 'field'. Therefore, management is divided into lesion-directed and field-directed therapies. Currently, the therapies in use are lesion-directed cryotherapy and/or excision, and field-directed topical agents: 5-fluorouracil, diclofenac, photodynamic therapy, imiquimod, and ingenol mebutate. Combining lesion- and field-directed therapies showed good results and several novel therapies are under investigation. Treatment is variable and personalized, what makes a gold standard management algorithm difficult to design. This review aims to describe the rationale behind the available treatment options for AKs based on current understanding of pathophysiology and epidemiology. ","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 2","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517799/pdf/jdcr-09-029.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33891001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Pigmented colloid milium associated with exogenous ochronosis in a farmer with long-term exposure to fertilizers. 长期接触化肥的农民外源性衰老与色素胶体含量的关系。

Journal of dermatological case reports Pub Date : 2015-06-30 DOI: 10.3315/jdcr.2015.1197

Maryam Akhyani, Parvaneh Hatami, Zahra Yadegarfar, Alireza Ghanadan

{"title":"Pigmented colloid milium associated with exogenous ochronosis in a farmer with long-term exposure to fertilizers.","authors":"Maryam Akhyani, Parvaneh Hatami, Zahra Yadegarfar, Alireza Ghanadan","doi":"10.3315/jdcr.2015.1197","DOIUrl":"https://doi.org/10.3315/jdcr.2015.1197","url":null,"abstract":"Background: Colloid milium is a rare cutaneous deposition disorder characterized by translucent papules developing on sun-exposed regions such as the face, neck and dorsal aspects of the hands and back. Exogenous ochronosis is caused by the accumulation of homogentisic acid resulting from long-term application of certain topical agents. Histology is characterized by yellow-brown pigment deposits in the papillary dermis. Prolonged use of hydroquinone may result in the development of the pigmented form of colloid milium, sometimes in association with ochronosis.Case report: A 53-year-old man presented with a 3-year history of multiple slow spreading pigmented papules on the dorsa of his hands, nose and ears. The patient had a long history of exposure to sun and fertilizers with no history of using hydroquinone bleaching creams. A later biopsy revealed the diagnosis of pigmented colloid milium associated with exogenous ochronosis.Conclusion: UV light damage and long contact with fertilizers may have a role in the development of pigmented colloid milium associated with exogenous ochronosis.","PeriodicalId":15601,"journal":{"name":"Journal of dermatological case reports","volume":"9 2","pages":"42-5"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3315/jdcr.2015.1197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33891004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Erlotinib induced ectropion following papulopustular rash. 厄洛替尼引起丘疹疹后外翻。

Journal of dermatological case reports Pub Date : 2015-06-30 DOI: 10.3315/jdcr.2015.1203

Andac Salman, Eren Cerman, Dilek Seckin, Metin Kanitez

引用次数: 5

Hemosiderotic dermatofibroma: clinical and dermoscopic presentation mimicking melanoma. 含铁血黄素性皮肤纤维瘤:临床和皮肤镜表现酷似黑色素瘤。

Journal of dermatological case reports Pub Date : 2015-06-30 DOI: 10.3315/jdcr.2015.1198

André Laureano, Cândida Fernandes, Jorge Cardoso

引用次数: 9

Photoletter to the editor: Pigmented dermatofibrosarcoma protuberans in a 4-year-old girl and ultrasonographic findings. 致编辑:1例4岁女童的色素性皮肤纤维肉瘤和超声检查结果。

Journal of dermatological case reports Pub Date : 2015-06-30 DOI: 10.3315/jdcr.2015.1201

Ryo Tanaka, Kiichi Inagawa, Naoki Kanomata, Jiro Hata, Wataru Fujimoto

引用次数: 2

Photoletter to the editor: Lamellar ichthyosis and arthrogryposis in a premature neonate. 给编辑的信:板层状鱼鳞病和关节挛缩在一个早产儿。

Journal of dermatological case reports Pub Date : 2015-06-30 DOI: 10.3315/jdcr.2015.1202

Chiara De Leonibus, Claudio Lembo, Alfredo Santantonio, Tiziana Fioretti, Silvana Rojo, Francesco Salvatore, Massimiliano De Vivo, Gabriella Esposito, Paolo Giliberti

引用次数: 4

Photoletter to the editor: An eczema-like, pruritic, nonbullous form of bullous pemphigoid. 致编辑:一种湿疹样，瘙痒性，非大疱性类天疱疮。

Journal of dermatological case reports Pub Date : 2015-06-30 DOI: 10.3315/jdcr.2015.1200

Kui Young Park, Moo Yeol Hyun, In Kwon Yeo, Seong Jun Seo, Chang Kwun Hong

引用次数: 3