Journal of diabetes & metabolism最新文献

{"title":"He lost 18 kilograms and his diabetes","authors":"pArchana Arorap","doi":"10.4172/2155-6156-C1-102","DOIUrl":"https://doi.org/10.4172/2155-6156-C1-102","url":null,"abstract":"","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85621759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Waist Hip Ratio and Body Mass Index (BMI) in Diabetic and Non Diabetic Individuals of Chitwan, Nepal","authors":"B. Joshi, L. Shrestha","doi":"10.35248/2155-6156.19.10.817","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.817","url":null,"abstract":"Background and objectives: Diabetes mellitus (DM) comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. The incidence of type 2 DM is rapidly increasing worldwide and constitutes a major global health problem. The various risk factors for the development of type 2 DM are obesity, ethnicity, sedentary life style, sex, family history, hypertension and smoking. However, there is now overwhelming evidence from experimental, epidemiological and interventional studies that obesity is a major risk factor for Type 2 DM among all risk factors. Plethora of studies has shown a strong association between excess weight and risk of incident diabetes. Therefore, this study is designed to see the relationship of central and generalized obesities with type 2 diabetes mellitus in Chitwan district of Nepal. Materials and methods: This is a comparative study of 200 participants. The study includes 100 participants with confirmed diagnosis of type 2 DM and 100 participants without any history of type 2 DM. Subjects with age group >35 years visiting OPD and IPD with confirmed diagnosis of Type-2 Diabetes Mellitus were selected for the study and their laboratory reports were obtained for confirmation. After that detailed history of study participant’s four anthropometric measurements: weight in kg, height in cm, waist circumference in cm, hip circumference in cm were taken. Body mass index and waist hip ratio were calculated from the above data. Result: In our study mean body mass index of male and female diabetic participants was higher than of nondiabetic male and female participants. Similarly in male participants waist circumference of diabetics was higher than non-diabetics and the difference was statistically significant and in female participants WC of diabetics was also higher than non-diabetics and the difference was statistically significant. Likewise in our study the range of WHR in both male and female diabetic participants was higher than non-diabetic participants and the result was statistically significant in both the cases. Conclusion: In light of the above findings, further longitudinal study should be designed in high risk groups that would aid in better understanding of the relationship of anthropometric parameters with type-2 diabetes mellitus.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82326709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as a Diagnostic Marker for Diabetic Nephropathy in Type 1 Egyptian Diabetic Patients","authors":"A. M. Soliman, E. Awad, Abdelrahman B Abdelghffar, I. Emara, E. Azeem","doi":"10.35248/2155-6156.19.10.826","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.826","url":null,"abstract":"Aim of the work: To identify the relationship between serum concentration of 7,8-dihydro-2-deoxyguanosine (8-OHdG) and different stages of Albumin Excretion Rate (AER), as marker of nephropathy in Egyptian patients with Type 1 Diabetes(T1D).Subjects and methodology: Total 65 volunteers were distributed in 4 groups: group 1: included 20 healthy subjects as control, group 2: 15 T1D patients with AER 30 mg/g creatinine) and group 4: 15 T1D patients with (AER>30 mg/g creatinine). The blood chemistry parameters were analyzed, glycated hemoglobin (HbA1c) and serum urea and creatinine, Malodialdhyde (MDA), 8- oxodG levels were measured by ELISA.Results: Significant increase in urea and creatinine in G3 and G4 with control with a p value<0.005. Also increase in 8-OHdG and MDA with a p value<0.005 in G2, G3 and G4 compared with control.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80586549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Nurses in Diabetes Care in Kuwait: A Review","authors":"Muna Alshammari, G. Adams, R. Windle, D. Bowskill","doi":"10.35248/2155-6156.19.10.821","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.821","url":null,"abstract":"The role of nurses in diabetes care in Kuwait has changed remarkably as a result of the increase of the care burden caused by the incidence of long-term diabetic patients. Nurses working in diabetes care play significant roles that are comparable to other health care providers working in diabetes clinics and centres in Kuwait. While nurses’ roles in diabetes have been clearly established in other parts of the world, nurses’ role in Kuwait are neither fully recognised nor professionally acknowledged. The nurses caring for such patients do not have a special identifying title, or a clear job description that specifies their critical role in diabetes care. This review investigated the Kuwait nurses’ roles in diabetes care and how the performance of their duties affects the perceived quality of the nursing care provided to their diabetic patients. The significance of this review is that it provides an insight into the possibility of developing a new system of diabetes patient care that could result in patients accessing good quality care. By investigating patients' and nurses' perspectives, this study seeks to provide an in-depth understanding of the influence of the quality of nursing care in managing diabetic patients in Kuwait.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"98 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81288798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Combined Curcuma xanthorrhiza Rhizome and Averrhoa blimbi Fruit Extract on Decreasing Blood Glucose Levels, Insulitis Degree and Liver Structure Repair of Diabetic Male Wistar Rats Streptozotocin Induced","authors":"K. Alipin, Nurani Istiqamah, Annisa Maryani, Madihah","doi":"10.35248/2155-6156.19.10.835","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.835","url":null,"abstract":"Curcuma xanthorrhiza Roxb. rhizomes and Averrhoa bilimbi L. fruits have been potential as anti-diabetic herbs. Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels or hyperglycemia due to deficiency or ineffectiveness of insulin. The combined use of natural herb (polyherb) is expected to produce a holistic effect in maintaining health and treating disease. This study aims to determine the effectiveness and optimum dosage combination C. xanthorrhiza rhizomes and A. blimbi fruit extract as anti-diabetic herbs in decreasing blood glucose levels, improve pancreas histopathology and the liver structure repair of diabetic male Wistar rats induced by streptozotocin. Twenty-one rats were divided into eighteen diabetic and three nondiabetic rats. The diabetic rats were divided equally into six groups; treated with CMC 0.5% (diabetic control), glibenclamide dosage 0.45 mg/kg bw (reference), extract of C. xanthorrhiza dosage 17.5 mg/kg bw, extract of A. blimbi dosage 750 mg/kg bw, combined extract dosages 767.5 and 383.75 mg/kg bw for 21 constitutive days. The results showed that a higher dosage of combination extract (767.5 mg/kg bw) that significantly lowered blood glucose levels (54.86 ± 34.61%) and improved the pancreas histopathology characterized by increasing number (9.33 ± 0.58) and diameter (53.34 ± 8.82) of Langerhans islet as well as decreasing insulitis degree compared to diabetic rats (p<0.05) and from treatment dosage 383.75 mg/kg bw could decrease the diameter of central vein and percentage necrotized cells of hepatocytes which significantly different with reference and diabetic control (p<0.05), and comparable with nondiabetic rats. In conclusion, the combined extracts were more effective than single extract to treat diabetic rats induced by streptozotocin.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80095557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Diabetes in Relatives of Diabetic Patients Using Insulinoma Antigen-2 Antibody-A Biomarker for Type 1 Diabetes in Jos, Nigeria","authors":"Bot Dy, Ahmed Km, J Shindang, A Ekwempu, Olaniru Ob, D. Chundusu, Bot Sy, Mwantok Ea, Pwajok Pg, Ojofeitimi Eo, O. Igwe, M. Aa, Afolabi Ta, A. Haladu, K. Ezra","doi":"10.35248/2155-6156.19.10.831","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.831","url":null,"abstract":"Background: Type 1 diabetes is a chronic autoimmune disease caused by the destruction of insulin-secreting islet cells of the pancreas by several islet cell-specific autoantibodies that can be detected many months or years before the onset of diabetes. The presence of these antibodies can be attributed largely to environmental agents and also genetic factors. Knowing the frequency of these autoantibodies in a population is an important step for a better understanding, diagnosis and management of Type 1 diabetes. The aim of the research was to screen and identify those at greatest risk of diabetes (relatives of diabetic patients) early in life, as a precautionary step with the hope to deliver care in order to avoid the disease and its complications later in life. Method: The study was conducted on eighty-eight apparently healthy young and adolescent first-degree relatives of diabetic patients in Jos metropolis. Blood samples were collected, centrifuged and serum was aseptically separated within two hours. A commercial ELISA test kit - Medizym® anti-IA2 was used to determine the presence of anti-IA-2 autoantibodies in serum obtained from participants enrolled in the study. Results: The results obtained showed twelve participants of both sexes (13.64%) having positive titers of the IA-2 antibodies which were statistically significant. Conclusion: From the results, we conclude that with significant titers of the IA-2 antibodies among young adolescents, there is the likelihood of them developing diabetes later in life depending on the period of exposure to the factors responsible for triggering the autoimmune process. The results are hereby discussed and recommendations made.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77416530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Presence and Characteristics of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals","authors":"S. Du, Hongmei Zhang, Hui Wu, Shu Ye, Wen Li, Q. Su","doi":"10.35248/2155-6156.19.10.818","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.818","url":null,"abstract":"The article entitled “Presence and Characteristics of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals” has been accepted for publication in the Journal of Diabetes and Metabolism considering the statements provided in the article as personal opinion of the author which was found not having any conflict or biasness towards anything. As the article was a perspective one, information provided by the author was considered as an opinion to be expressed through publication. Publisher took decision to make the article online solely based on the reviewers suggestion which considered the article not but a personal opinion of the author. However, it is found that the author have some personal concerns and issues, therefore, being retracted from the journal.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"210 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86845856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Glycated Albumin and GA/HbA1c Ratio as a New Markers of Glycemic Control in Children with Type 1 Diabetes Mellitus","authors":"Ashraf Mohamed Abdelfadil, L. Aboul-Fotoh, A. Higazi","doi":"10.35248/2155-6156.19.10.830","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.830","url":null,"abstract":"Introduction: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and accompanied by long term damage, dysfunction and failure of various organs. Several studies have shown that Glycated Albumin (GA) is more reliable DM monitor and a better marker of glycemic control in patients with fluctuating and poorly controlled type 2 DM. Moreover, serum GA is not affected by factors that affect hemoglobin metabolism. The aim of the study: To study the value of serum glycated albumin as a new marker for glycemic control in diabetic children. Methods: 30 diabetic children were included in the study in addition to 20, sex and age matched apparently healthy children as a control group. The associations among HbA1c, GA, and GA/HbA1c ratio were examined, referred and managed in Children’s Hospital, Minia University. The results: Plasma glucose, GA and HbA1c measurements were done at baseline, after the 1st and after the 3rd months for all the subjects. GA levels strongly correlated with HbA1c% in the diabetic group. The mean GA and HbA1c values were significantly lower in control group than in diabetic group (p<0.001). GA, HbA1c and the ratio decreased significantly within 4 weeks, but GA showed a significantly larger decrease than HbA1c. Conclusion: GA seems to be more accurately reflect short term glycemic control than HbA1c.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86099118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Visual Evoked Response is Linked to Vascular Endothelial Growth Factor and Autonomic Dysfunction in Type 2 Diabetes Mellitus","authors":"A. Sirisha, Yerrabelli Dhanalakshmi, G. Pal, M. Wyawahare, S. Ahuja","doi":"10.35248/2155-6156.19.10.833","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.833","url":null,"abstract":"Aims: In this study, we aimed to assess the link between visual evoked potentials (VEP), angiogenic marker (VEGF) and autonomic function tests in type-2 diabetes mellitus (T2DM). Methods: Age-matched 86 male subjects (44 type-2 diabetics on treatment and 42 normal healthy volunteers) were recruited for this study. Body mass index (BMI), basal cardiovascular parameters, spectral analysis of heart rate variability (HRV), were assessed. Fasting blood glucose, insulin, HOMA-IR and VEGF were estimated. The independent association of the P100 latency of VEP with VEGF was determined by multiple regression analysis. Results: LF-HF ratio a marker of sympathovagal balance, increased significantly (p=0.0287) in diabetic group compared to the control group. Comparison of visual evoked potentials between controls and diabetic groups showed significant increase in latency of P100 of both the eyes (right eye p<0.0001, left eye p=0.0003) among the cases. There was significant increase (p=0.0091) in VEGF in diabetic subjects when compared to control. Also positive and significant correlation of P100 latency of VEP with VEGF is seen in diabetics. Conclusions: There is delayed latency of VEP and increased VEGF in type 2 diabetic people. The correlation between VEP and VEGF could indicate the probable role of angiogenesis leading to reduced integrity of the neural pathways in T2DM.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87951036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part III. Type I or II Diabetogenic Effects of Streptozocin","authors":"Yongqiang Liu, Jiajun Gao, Xiaoliang Wang, Y. Wang, Y. Xiao","doi":"10.35248/2155-6156.19.10.823","DOIUrl":"https://doi.org/10.35248/2155-6156.19.10.823","url":null,"abstract":"Streptozocin (STZ), a naturally occurring glucosamine-nitrosourea compound, has been used for diabetogenic induction in animals for diabetic research due to its high toxicity to pancreatic beta cells. This study was to evaluate the diabetogenic effects of STZ by multiple low doses or by single high dose in normoglycemic Non-Human Primates (NHPs). Each monkey in the 1st group (n=6) was intravenously administered with 7.5 to 15 mg/kg STZ once every 2 to 4 weeks until successful induction of hyperglycemia or until the end of this 28-week study. In the 2nd group (n=7) each monkey was intravenously injected with 35 mg/kg STZ once only. Plasm glucose, insulin and lipid levels were monitored weekly during the study. The hyperglycemic responses to STZ were more severe in the NHPs treated with the single high dose. Among them one animal died on the 2nd day after STZ dosing. Compared with STZ multiple low doses, single high dose caused much severe insulin depletion, similar to Type I diabetes. In addition, beta-cell sensitivity to STZ toxicity varied obviously among individual monkeys, some highly sensitive and some almost no response at all. STZ also resulted in abnormal response to the intravenous glucose tolerance test (ivGTT). These results demonstrate that hyperglycemic levels among STZ-treated animals varied and differed significantly after either single high dose or multiple low doses. Our data may help researchers to understand the diabetogenic process and variability of STZ induction in NHPs and to choose a severe or moderate model for their research.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90037222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}