Journal of Clinical Research最新文献

{"title":"Evaluating access to Malaria Rapid Diagnostic Test kit and Artemisinin-based Combination Therapy and the Quality of Treatment Practice among Over-the-Counter Medicine Sellers at the District Level in the Brong Ahafo Region - Ghana","authors":"Stephen Mensah","doi":"10.21522/TIJCR.2014.05.01.ART001","DOIUrl":"https://doi.org/10.21522/TIJCR.2014.05.01.ART001","url":null,"abstract":"","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"44 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83003002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principles, Assumptions, and Processes Established to Designate Biologics Assets as a Fast to FIH (First-in-Human) Program and the Associated Core Concepts for the Utilization of low and High-Risk Activities, Timelines and Functional Level Expectations","authors":"O. Karagiozova","doi":"10.21522/tijcr.2014.05.01.art002","DOIUrl":"https://doi.org/10.21522/tijcr.2014.05.01.art002","url":null,"abstract":"Biologics development represents a substantial advancement in the pharmaceutical industry because of their promise and huge success in the oncology, immunoscience, and cardiovascular disease areas. Prior to entering the marketed product development phase, each biopharmaceutical needs to go through series of stages that will allow or disallow the biologics asset to become a commercialized product. Each of those phases includes development planning and designing of studies to test relevant hypotheses to support the drug label if approved. The current thesis will focus on the principles, assumptions, and processes that are established to designate an asset (biologics) as a targeted first-in-human program. First-in-human studies are included under phase 1 trials, where initial human exposure is initiated to the investigational new drug (IND). Phase 1 is critical since it affirms if a compound’s mechanisms of action in humans and its development can result in a potentially new drug entity. Subsequently, step by step initiatives and processes from the perspective of different functional groups within the pharma will be revised to outline the staged procedures, methods, critical, and noncritical paths taken when a molecule is nominated as a clinical candidate. Overall alignment of deliverables will be presented between the different functional areas that partake in the first-in-human development. Strategic changes to the biologics development process, cell line development with multiple candidate sequences, initial platform fit assessment for a process, analytical and formulation will be acknowledged. Platform strategy for drug substance production, as well as, drug product composition will be outlined along with boilerplates for analytical method development to fit or not fit the platform approach. The functional groups that will be reviewed will be; Discovery, Cell line development, Drug Substance process development, Formulation development, Toxicology, Quality, Drug Substance manufacturing, Drug Product manufacturing, Stability and regulatory.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"185 1","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73179752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content-Analysis of text and video news of traffic accidents in Iran during the years 2001-2017","authors":"S. Azami-aghdash, Mohammad Amin Najafzadeh, M. Heydari, Ramin Rezapour, J. S. Khasraghi, Naser Derakhshani","doi":"10.13183/JCRG.V6I2.206","DOIUrl":"https://doi.org/10.13183/JCRG.V6I2.206","url":null,"abstract":"Purpose: The mass media is an effective tool for improving traffic culture by education. The aim of this study was to analyses the content of the text and video news on traffic accidents of Iran during the years 2001 to 2017. Methods: This qualitative study with Content-Analysis approach was conducted in 2018. The needed data was gathered by searching the keywords of “road traffic injuries, traffic accident, road traffic accident, accident, incident, and crash” in web archives of news agencies and news broadcasting channels. The data entered into an extraction table designed by the study team. To analyze the data, the Content-Analysis method was applied. The Microsoft Excel software was used to draw the figures. Results: Crossing the lane to left (wrong-way driving), distracted driving, speed limit violation, reckless driving, drowsiness and fatigue were the main causes of collisions in the news. Majority (34.5%) of the accidents occurred in early hours of day (0 to 6 mornings). Fall was the season with highest incidence of the crashes (38.15%). In the text news the light vehicle such as cars were the most involved in the crashes (54.13%). In the video news also the light vehicles were involved in majority of the crashes (90.4%). Only in 10% of the text news and 20% of the video news educational and preventive materials were included. Conclusion: Findings of this study showed that the prevention and education did not get sufficient attention in the published news on traffic accidents. It is suggested that when pressing the news on traffic accidents, besides the news of the accident, educational and preventive materials be communicated with people. ©2017 Swedish Science Pioneers, All rights reserved. Co r r e s pondence Naser Derakhshani: Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Email: derakhshani.mhc@gmail.com Tell: +989141078750","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75254538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital unilateral lamellar cataract","authors":"M. Yassine","doi":"10.17352/2455-1414.000048","DOIUrl":"https://doi.org/10.17352/2455-1414.000048","url":null,"abstract":"Lamellar or zonular cataract is a hereditary cataract that is transmitted in an autosomal dominant mode. The crystalline opacities are located at the level of the primary fibers in the embryonic nucleus. This cataract is usually bilateral and asymmetrical.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"34 1","pages":"013-013"},"PeriodicalIF":0.0,"publicationDate":"2018-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81968765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Expression and Significance of TIPE1 in Lichen Planus","authors":"Yang Peiwen, Zheng Yan, Li Changji, Cheng Caifeng","doi":"10.15226/2378-1726/5/1/00177","DOIUrl":"https://doi.org/10.15226/2378-1726/5/1/00177","url":null,"abstract":"","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"127 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76327227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral iris, lens and Chorioretinal Coloboma: A Case Report","authors":"M. Hamed, Abdoulsalam Youssoufou Soulay, K. Reda, A. Oubaaz","doi":"10.17352/2455-1414.000047","DOIUrl":"https://doi.org/10.17352/2455-1414.000047","url":null,"abstract":"Colobomas are genetic malformations due to lack of closure of the embryonic fissure. These are rare malformations that can sit at any level of the eye. Colobomas can be uni or bilateral, sporadic or hereditary. It may be associated with other ocular manifestations and extra-ocular malformations involving a general, clinical and radiological examination.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"5 1","pages":"012-012"},"PeriodicalIF":0.0,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82938376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological Pathways in Hidradenitis Suppurativa: Current Concepts and Innovative Therapies","authors":"José Antonio Guzmán Cubilla, B. Abdalla, P. Criado, L. Oyafuso","doi":"10.15226/2378-1726/5/1/00176","DOIUrl":"https://doi.org/10.15226/2378-1726/5/1/00176","url":null,"abstract":"Hidradenitis Suppurativa is a chronic and disabling disease characterized by pustules, nodules, abscesses, and scaring. It affects natural body folds (inguinal, axillary, inframammary), perianal region and genitalia. Several comorbidities are related to this disease, such as: obesity, smoking, acne, folliculitis, and hyperandrogenism. Disorders in keratinization, systemic upregulation of complement (C5a) activation and changes in cutaneous microbiome stimulate the development of autoinflammatory state, promoting the increase of CD4+ Thelper lymphocytes (Th-17 and Th-1). These changes stimulate the expression of toll-like receptors type 2, enabling the NLRP3 inflammasome and triggering of the caspase-dependent inflammatory cascade. Intralesional increase of dendritic cells, macrophage and neutrophil influx stimulate the production of pus, promoting necrosis and apoptosis of inflammatory cells undergoing a special type of cell death program, releasing proinflammatory cytokines (pyroptosis). In addition, patients affected with this condition presents an imbalance of IL-36 proinflammatory cytokines and decreased levels of its antagonist receptor IL-36Ra. Treatment is frustrating and includes the use of broad-spectrum antibiotics, surgical procedures, and oral retinoids. The first and only one biologic therapy approved is a TNF-α inhibitor (Adalimumab); other alternatives are under development, inhibiting IL-17 (Secukinumab, Bimekizumab and CJM112) IL-12 and IL-23 (Ustekinumab); and IL-1 (Anakinra, Canakinumab). Recent articles showed that liraglutide, a glucagon-like-1 pep-tide (GLP-1) agonist, could be used to treat one of the comorbidities associated with HS (insulin resistance). Finally, inhibition of IL-36 and C5a could be an option to treat this recalcitrant and exhausting disease. Highlights: Pathogenesis of HS involves genetic and environmental factors that trigger the innate immune response. Several cytokines participate in the inflammatory response of the skin. HS is chronic and relapsing causing a negative impact on patient ́s quality of life, expensive medical approaches, and huge number of comorbidities. New biological drugs, former medical treatments and cutaneous surgical interventions can be combined to better assist of patients suffering of HS.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"37 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84531091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifi ed prosthetic rehabilitation of an enucleated pediatric patient with exposed intraocular implant","authors":"Rani Ranabhatt, H. Aggarwal, S. Singh, V. Shah","doi":"10.17352/2455-1414.000046","DOIUrl":"https://doi.org/10.17352/2455-1414.000046","url":null,"abstract":"Introduction: Retinoblastoma is one of the leading cancers in children below 5 years, leaving an \u0000ocular defect after enucleation. The loss of an eye requires early replacement so that socket contraction \u0000is minimal, growth of surrounding tissues is less retarted and the patient may return to a normal social \u0000life. Primary placement (at the time of enucleation) of hydroxyapatite intraocular implants is done in order \u0000to prevent volume defi cit and increase motility of the prosthesis.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"33 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"2018-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80118098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucoma: May new technologies help in early diagnosis?","authors":"Lorenzo Casillo, Stefano Tricarico, E. Vingolo","doi":"10.17352/2455-1414.000045","DOIUrl":"https://doi.org/10.17352/2455-1414.000045","url":null,"abstract":"Purpose: to identify new functional parameters that may help in the early primary open angle glaucoma (POAG) diagnosis.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"16 1","pages":"005-008"},"PeriodicalIF":0.0,"publicationDate":"2018-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84769056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Effectiveness of Pulsed Dye Laser 585 nm in Treating Multiple Keloids in Young Female with Body Dysmorphic Disorder (BDD) had Multiple Plastic Surgeries, Jeddah, 2017","authors":"T. Magliah, S. Hindi, E. Alturkistani, E. Alharbi","doi":"10.15226/2378-1726/5/1/00175","DOIUrl":"https://doi.org/10.15226/2378-1726/5/1/00175","url":null,"abstract":"Flash Lamp Pulsed Dye Laser (FPDL) is a non-ablative technology that has an excellent reputation in vascular lesion treatment. It is always the first line treatment for scars; these can be successfully treated using different methods, such as ablative lasers or plastic surgery. 43 year old Saudi female known to have body dysmorphic disorder, had long history of repetitive plastic surgeries in different body sites came complaining of her inappropriate body shape and her weight planning for more plastic surgeries. Patients presented 9 months back complaining of multiple keloids at the sites of previous plastic surgeries. PDL 585 nm was started (fluence 4.0 j/cm, pulse width 20 ms, pulse rate 1.5 Hz). PDL showed subjective and clinically improvement in treating keloids, decreasing the size and thickness. Further trials are recommended to confirm our results.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"44 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75747287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}