{"title":"Short Note on Clinical Research","authors":"Santra Andreya","doi":"10.37421/2795-6172.2021.5.124","DOIUrl":"https://doi.org/10.37421/2795-6172.2021.5.124","url":null,"abstract":"Clinical exploration is a sort of investigation of clinical or biomedical inquiries using human subjects. Clinical exploration examines don't really all include clinical medicines or trial treatments. Clinical examination can incorporate observational investigations, in which individuals are followed throughout some undefined time frame to decide wellbeing results. Clinical exploration may likewise be utilized to decide the handiness or wellbeing of another symptomatic methodology or medication treatment. Clinical examination considers are arranged ahead of time and follow a characterized convention. Epidemiologic examinations look at explicit populaces to explain how regularly a sickness happens or is found in a given gathering (the frequency and commonness), the individual factors that can cause or deteriorate infection movement, and the kinds of wellbeing and way of life choices that individuals make. Clinical preliminaries are one significant kind of clinical exploration.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"105 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84734101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discussion about Viral Disease Measles","authors":"Azeem Helani","doi":"10.37421/2795-6172.2021.5.E123","DOIUrl":"https://doi.org/10.37421/2795-6172.2021.5.E123","url":null,"abstract":"Measles is an intense foundational viral disease with fever, respiratory contribution and side effects, and a rash. Measles can cause genuine inconveniences and even fatalities. Contamination presents deep rooted invulnerability. Measles is profoundly infectious and immunization preventable. Measles causes a red, smudged rash that generally shows up first on the face what's more, behind the ears, at that point spreads descending to the chest and back lastly to the feet. When very normal, measles can now quite often be forestalled with an antibody. Measles is caused by contamination with an infection from the paramyxovirus family. Infections are minuscule parasitic microorganisms. Whenever you've been tainted, the infection attacks have cells and utilizations cell segments to finish its life cycle. The measles infection contaminates the respiratory plot first. Be that as it may, it at last spreads to different pieces of the body through the circulation system. Measles is simply known to happen in people and not in different creatures.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"8 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89356246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Going Digital Transformation of Oncology Clinical Research","authors":"R. Arai","doi":"10.37421/2795-6172.2021.5.122","DOIUrl":"https://doi.org/10.37421/2795-6172.2021.5.122","url":null,"abstract":"The COVID 19 pandemic pushed the oncology clinical research to an in-depth reengineering process. The article published at Contemporary Clinical Trials Communications [1], being part of the global literature of the World Health Organization (WHO) [2], Recommends several strategies to reduce and mitigate the risks in conducting oncology clinical research during the pandemic. Several actions led to decreased patient enrollment, and operational adjustments to comply with patient safety significantly affected the already lengthy study timelines. As a result, stakeholders are adopting technology-based approaches to reduce in-person patient visits to minimize COVID-19 dissemination and remote data monitoring.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"121 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73544993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Planning a Healthy Baby: The 21st Century Way!","authors":"Sunita Bijarnia Mahay","doi":"10.37421/2795-6172.2021.5.130","DOIUrl":"https://doi.org/10.37421/2795-6172.2021.5.130","url":null,"abstract":"Genetic carrier screening finds a new place in clinical practice today. Consequent to advanced technology coupled with increased awareness among population in the reproductive age group, this seems to be gaining popularity. Indian population is a heterogeneous mix of several sub-populations and the gene pool is quite different from the western or oriental populations. Thus, a need to detect carrier frequency was felt and a pilot study was performed at a tertiary care hospital in North India, on 200 healthy individuals. The study brought out some unexpected results, such as the high frequency of cystic fibrosis in Indian population. This mini-review provides a glimpse into the study and puts together the carrier frequencies of common autosomal recessive disorders as detected from other studies as well.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"3 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75405119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brief Discussion on Hepatitis","authors":"Joseph Lee","doi":"10.37421/2795-6172.21.5.119","DOIUrl":"https://doi.org/10.37421/2795-6172.21.5.119","url":null,"abstract":"Hepatitis implies aggravation of the liver. The liver is an vital organ that measures supplements, channels the blood, and battles contaminations. At the point when the liver is aroused or harmed, its capacity can be influenced. Weighty liquor use, poisons, a few drugs, and certain ailments can cause hepatitis(or)Hepatitis alludes to an incendiary state of the liver. It's generally brought about by a viral contamination, yet there are other potential reasons for hepatitis. Numerous diseases and conditions can cause irritation of the liver (hepatitis), yet certain infections cause about portion of all hepatitis in individuals. Infections that fundamentally assault the liver are called hepatitis infections. There are a few kinds of hepatitis infections including types A, B, C, D, E, and potentially G. Types A, B, and C are the most common. All hepatitis infections can cause intense hepatitis. Viral hepatitis types B and C can cause on going hepatitis.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"58 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76082069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brief Note on Tuberculosis.","authors":"M. Yan","doi":"10.37421/2795-6172.21.5.117","DOIUrl":"https://doi.org/10.37421/2795-6172.21.5.117","url":null,"abstract":"Tuberculosis (TB) is an irresistible sickness typically brought about by Mycobacterium tuberculosis (MTB) microscopic organisms. Tuberculosis by and large influences the lungs, In some cases TB effected different parts of the body. Most diseases show no manifestations, wherein case it is known as dormant tuberculosis. The exemplary side effects of dynamic TB are a persistent hack with blood-containing bodily fluid, fever, night sweats, and weight reduction. Tuberculosis is spread starting with one person to another person through the air when individuals who have dynamic TB in their lungs hack, spit, talk, or sniffle. Analysis of dynamic TB depends on chest X-beams, just as minuscule assessment and culture of body liquids. Finding of inert TB depends on the tuberculin skin test (TST) or blood tests.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"47 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76496594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Commentary on Neuropathology of Pituitary Adenomas and Sellar Lesions","authors":"Peter J. Kobalka","doi":"10.37421/2795-6172.2021.5.126","DOIUrl":"https://doi.org/10.37421/2795-6172.2021.5.126","url":null,"abstract":"The pituitary gland can give rise to varied pathological processes, both neoplastic and inflammatory. Among these, the vast majority of tumors are pituitary neuroendocrine neoplasms (PitNETs), originating from the anterior pituitary lobe2. Proper classification and evaluation of these neoplasms is essential to provide proper patient management. Historically, classification relied on rather arbitrary stratification based on differences in staining with H&E3. Immunohistochemistry assay staining for pituitary hormones is now fundamental in elucidating the nature of these neoplasms, as well as newer transcription factor markers. Transcription factors illuminate cell lineage into acidophilic lineage (somatotrophs, lactotrophs, thyrotrophs), corticotroph lineage, and gonadotroph lineage.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"23 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83951427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient Segmentation in ALS Studies","authors":"Michael F. Murphy","doi":"10.37421/2795-6172.2021.5.129","DOIUrl":"https://doi.org/10.37421/2795-6172.2021.5.129","url":null,"abstract":"Does genotypic vs. phenotypic segmentation make sense in the context of an amyotrophic lateral sclerosis (ALS) study? It’s a provocative question, but one that warrants consideration. Research into the nature of ALS points to genetic mutations, often taking the form of miss aggregated or misfolded proteins. More than 20 genes have been causally linked to ALS. Four genetic mutations are common; the others are relatively rare . Certain genetic mutations appear to run in families but the same mutations can also be found in sporadic (i.e., non-familial) cases. These mutations have formed the basis for past patient segmentation efforts but there is reason to question whether such segmentation efforts have any relevance to the presentation of ALS itself. Do these genetic mutations actually express different phenotypes? Do they play any role in the sign, symptoms, or trajectories of the disease? Conversely, do therapies targeting the identified genes- even if they could effectively correct the physiological consequences of a specific mutation-actually have an effect on ALS in the patient? The recent history of drug development offers mixed answers to these questions. In the world of oncology, targeted, personalized genetic therapies are producing compelling outcomes . Conversely, targeted therapeutic development for ALS has largely been ultimately unsuccessful, despite promising early phase clinical results . It may be that targeted therapies in oncology have been successful because the underlying biology of different cancers is more fully understood. In contrast, much remains unknown about the underlying biology of ALS . Further, treatment of a systemic disease such as ALS may inherently be more difficult than treatment of a disease with a specific target such as a solid tumor with a discreet set of genetic mutations as may be the case in oncology. While many genetic mutations in ALS have been identified and studied, and while the phenotypic presentations of ALS are identifiable and agreed upon, the connections between genotype and phenotype remain incomplete. As efforts to find therapies targeting ALS continue down both paths, it becomes increasingly important for members of the clinical and research communities to develop a better understanding of where and how genotype and phenotype are linked, particularly because the links between phenotype and genotype can affect the design and conduct of ALS clinical trials in critical ways.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"43 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74710745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brief Note on Lipoma","authors":"Roy E. Lee","doi":"10.37421/2795-6172.21.5.118","DOIUrl":"https://doi.org/10.37421/2795-6172.21.5.118","url":null,"abstract":"A lipoma is a kind tumor made of fat tissue. They are for the most part delicate to the touch, portable, and effortless. They typically happen simply under the skin, however sporadically might be more profound. Most are under 5 cm in size. Normal areas incorporate upper back, shoulders, and midsection. A couple of individuals have various lipomas. The reason is by and large muddled .Risk factors incorporate family ancestry, stoutness, and absence of activity. Determination is commonly founded on an actual test. At times clinical imaging or tissue biopsy is utilized to affirm the analysis. Treatment is regularly by perception or careful evacuation. Once in a while, the condition may repeat following expulsion, yet this can by and large be made do with rehash a medical procedure. They are not for the most part connected with a future danger of malignancy. Lipomas regularly happen in grown-ups somewhere in the range of 40 and 60 years of age. Males are more frequently influenced than females. They are the most widely recognized noncancerous delicate tissue tumor. The primary utilization of the expression \"lipoma\" to depict these tumors was in 1709.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"68 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86040153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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