Journal of drug delivery最新文献_第9页

Critical assessment of implantable drug delivery devices in glaucoma management. 青光眼治疗中植入式给药装置的关键评价。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-08-26 DOI: 10.1155/2013/895013

Dharani Manickavasagam, Moses O Oyewumi

{"title":"Critical assessment of implantable drug delivery devices in glaucoma management.","authors":"Dharani Manickavasagam, Moses O Oyewumi","doi":"10.1155/2013/895013","DOIUrl":"https://doi.org/10.1155/2013/895013","url":null,"abstract":"Glaucoma is a group of heterogeneous disorders involving progressive optic neuropathy that can culminate into visual impairment and irreversible blindness. Effective therapeutic interventions must address underlying vulnerability of retinal ganglion cells (RGCs) to degeneration in conjunction with correcting other associated risk factors (such as elevated intraocular pressure). However, realization of therapeutic outcomes is heavily dependent on suitable delivery system that can overcome myriads of anatomical and physiological barriers to intraocular drug delivery. Development of clinically viable sustained release systems in glaucoma is a widely recognized unmet need. In this regard, implantable delivery systems may relieve the burden of chronic drug administration while potentially ensuring high intraocular drug bioavailability. Presently there are no FDA-approved implantable drug delivery devices for glaucoma even though there are several ongoing clinical studies. The paper critically assessed the prospects of polymeric implantable delivery systems in glaucoma while identifying factors that can dictate (a) patient tolerability and acceptance, (b) drug stability and drug release profiles, (c) therapeutic efficacy, and (d) toxicity and biocompatibility. The information gathered could be useful in future research and development efforts on implantable delivery systems in glaucoma. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/895013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31758976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Intravital microscopic research of microembolization with degradable starch microspheres. 可降解淀粉微球微栓塞的显微活体研究。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-11-13 DOI: 10.1155/2013/242060

Micaela Ebert, Juergen Ebert, Gerd Berger

{"title":"Intravital microscopic research of microembolization with degradable starch microspheres.","authors":"Micaela Ebert, Juergen Ebert, Gerd Berger","doi":"10.1155/2013/242060","DOIUrl":"https://doi.org/10.1155/2013/242060","url":null,"abstract":"Treatment efficacy in cancer patients using systemically applied cytostatic drugs is decreased by cytotoxic side effects, which limits the use of efficient dosages. Degradable starch microspheres (DSM) are used to apply drugs into blood vessels which supply the target organ leading to drug accumulation in the target organ by reduction of the blood flow. The present investigations show that DSM is a very effective embolization material leading to effective and enhanced accumulation of 5-FU within the liver tumor tissue of experimental induced liver cancer in rats. By using intravital microscopy, a rapid deceleration of the blood flow into the target organ is observed immediately after application of DSM. The microspheres are stepwise degraded in the direction of the systemic blood flow and are totally dissolved after 25 minutes. These stepwise processes leave the degraded material during the degradation process within the vessels leading to temporally reciprocal blood flow via some of the side-arms of the major blood vessels. By using DMS in transarterial chemoembolization (TACE), severe adverse side effects like postembolization syndrome are rarely observed when compared to other embolization materials. The complete degradation of DSM causes only a short-lasting temporary vascular occlusion, which allows a repeat application of DSM in TACE. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/242060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31943023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells. 靶向cd44过表达肿瘤细胞的脂质纳米载体

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-03-07 DOI: 10.1155/2013/860780

Silvia Arpicco, Giuseppe De Rosa, Elias Fattal

引用次数: 55

Stealth properties to improve therapeutic efficacy of drug nanocarriers. 提高纳米药物载体疗效的隐形特性。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-03-07 DOI: 10.1155/2013/374252

Stefano Salmaso, Paolo Caliceti

{"title":"Stealth properties to improve therapeutic efficacy of drug nanocarriers.","authors":"Stefano Salmaso, Paolo Caliceti","doi":"10.1155/2013/374252","DOIUrl":"10.1155/2013/374252","url":null,"abstract":"Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the systemic side effects. By virtue of their small size they can be injected intravenously and disposed into the target tissues where they release the drug. Nanocarriers interact massively with the surrounding environment, namely, endothelium vessels as well as cells and blood proteins. Consequently, they are rapidly removed from the circulation mostly by the mononuclear phagocyte system. In order to endow nanosystems with long circulation properties, new technologies aimed at the surface modification of their physicochemical features have been developed. In particular, stealth nanocarriers can be obtained by polymeric coating. In this paper, the basic concept underlining the \"stealth\" properties of drug nanocarriers, the parameters influencing the polymer coating performance in terms of opsonins/macrophages interaction with the colloid surface, the most commonly used materials for the coating process and the outcomes of this peculiar procedure are thoroughly discussed.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40229804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb. 使用阳离子纳米乳液 novasorb 成功改善眼部给药。

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-02-27 DOI: 10.1155/2012/604204

Frederic Lallemand, Philippe Daull, Simon Benita, Ronald Buggage, Jean-Sebastien Garrigue

{"title":"Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb.","authors":"Frederic Lallemand, Philippe Daull, Simon Benita, Ronald Buggage, Jean-Sebastien Garrigue","doi":"10.1155/2012/604204","DOIUrl":"10.1155/2012/604204","url":null,"abstract":"Topical ophthalmic delivery of active ingredients can be achieved using cationic nanoemulsions. In the last decade, Novagali Pharma has successfully developed and marketed Novasorb, an advanced pharmaceutical technology for the treatment of ophthalmic diseases. This paper describes the main steps in the development of cationic nanoemulsions from formulation to evaluation in clinical trials. A major challenge of the formulation work was the selection of a cationic agent with an acceptable safety profile that would ensure a sufficient ocular surface retention time. Then, toxicity and pharmacokinetic studies were performed showing that the cationic emulsions were safe and well tolerated. Even in the absence of an active ingredient, cationic emulsions were observed in preclinical studies to have an inherent benefit on the ocular surface. Moreover, clinical trials demonstrated the efficacy and safety of cationic emulsions loaded with cyclosporine A in patients with dry eye disease. Ongoing studies evaluating latanoprost emulsion in patients with ocular surface disease and glaucoma suggest that the beneficial effects on reducing ocular surface damage may also extend to this patient population. The culmination of these efforts has been the marketing of Cationorm, a preservative-free cationic emulsion indicated for the symptomatic treatment of dry eye.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30577308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications. 聚乙二醇-前药偶联物:概念、设计和应用。

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-05-07 DOI: 10.1155/2012/103973

Shashwat S Banerjee, Naval Aher, Rajesh Patil, Jayant Khandare

引用次数: 218

Triggered rapid degradation of nanoparticles for gene delivery. 引发了用于基因传递的纳米颗粒的快速降解。

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-06-19 DOI: 10.1155/2012/291219

José M Morachis, Enas A Mahmoud, Jagadis Sankaranarayanan, Adah Almutairi

{"title":"Triggered rapid degradation of nanoparticles for gene delivery.","authors":"José M Morachis, Enas A Mahmoud, Jagadis Sankaranarayanan, Adah Almutairi","doi":"10.1155/2012/291219","DOIUrl":"https://doi.org/10.1155/2012/291219","url":null,"abstract":"Effective gene delivery tools offer the possibility of addressing multiple diseases; current strategies rely on viruses or polyplexes. Encapsulation of DNA within nanoparticles is an attractive alternative method for gene delivery. We investigated the use of our recently developed Logic Gate Nanoparticle for gene delivery. The nanoparticles, composed of a dual pH response random copolymer (poly-β-aminoester ketal-2), can undergo a two-step \"in series\" response to endosomal pH. The first sep is a hydrophobic-hydrophilic switch, which is followed immediately by rapid degradation. Rapid fragmentation is known to increase cytoplasmic delivery from nanoparticles. Therefore, we hypothesized that our Logic Gate Nanoparticles would enable increased gene delivery and expression relative to nanoparticles that degrade more slowly such as PLGA-based nanoparticles. Passive nanoparticle entry into cells was demonstrated by delivering Cy5-labeled pDNA encoding EGFP into HCT116, a colon carcinoma cell line. Flow cytometry analysis showed that cells are positive for Cy5-DNA-nanoparticles and produced EGFP expression superior to PLGA nanoparticles. Inhibition of V-ATPases using bafilomycin A1 demonstrates that expression of EGFP is dependent on low endosomal pH. The advanced Logic Gate Nanoparticles offer new therapeutic possibilities in gene delivery and other applications where rapid release is important.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/291219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30750618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Utilisation of nanoparticle technology in cancer chemoresistance. 纳米粒子技术在癌症化学耐药中的应用。

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-11-14 DOI: 10.1155/2012/265691

Duncan Ayers, Alessandro Nasti

{"title":"Utilisation of nanoparticle technology in cancer chemoresistance.","authors":"Duncan Ayers, Alessandro Nasti","doi":"10.1155/2012/265691","DOIUrl":"10.1155/2012/265691","url":null,"abstract":"The implementation of cytotoxic chemotherapeutic drugs in the fight against cancer has played an invariably essential role for minimizing the extent of tumour progression and/or metastases in the patient and thus allowing for longer event free survival periods following chemotherapy. However, such therapeutics are nonspecific and bring with them dose-dependent cumulative adverse effects which can severely exacerbate patient suffering. In addition, the emergence of innate and/or acquired chemoresistance to the exposed cytotoxic agents undoubtedly serves to thwart effective clinical efficacy of chemotherapy in the cancer patient. The advent of nanotechnology has led to the development of a myriad of nanoparticle-based strategies with the specific goal to overcome such therapeutic hurdles in multiple cancer conditions. This paper aims to provide a brief overview and recollection of all the latest advances in the last few years concerning the application of nanoparticle technology to enhance the safe and effective delivery of chemotherapeutic agents to the tumour site, together with providing possible solutions to circumvent cancer chemoresistance in the clinical setting.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/265691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31097423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems. 胶原-模型三螺旋肽-两亲体在cd44靶向药物递送系统中的应用

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-11-14 DOI: 10.1155/2012/592602

Margaret W Ndinguri, Alexander Zheleznyak, Janelle L Lauer, Carolyn J Anderson, Gregg B Fields

{"title":"Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems.","authors":"Margaret W Ndinguri, Alexander Zheleznyak, Janelle L Lauer, Carolyn J Anderson, Gregg B Fields","doi":"10.1155/2012/592602","DOIUrl":"https://doi.org/10.1155/2012/592602","url":null,"abstract":"Cancer treatment by chemotherapy is typically accompanied by deleterious side effects, attributed to the toxic action of chemotherapeutics on proliferating cells from nontumor tissues. The cell surface proteoglycan CD44 has been recognized as a cancer stem cell marker. The present study has examined CD44 targeting as a way to selectively deliver therapeutic agents encapsulated inside colloidal delivery systems. CD44/chondroitin sulfate proteoglycan binds to a triple-helical sequence derived from type IV collagen, α1(IV)1263-1277. We have assembled a peptide-amphiphile (PA) in which α1(IV)1263-1277 was sandwiched between 4 repeats of Gly-Pro-4-hydroxyproline and conjugated to palmitic acid. The PA was incorporated into liposomes composed of DSPG, DSPC, cholesterol, and DSPE-PEG-2000 (1 : 4 : 5 : 0.5). Doxorubicin-(DOX-)loaded liposomes with and without 10% α1(IV)1263-1277 PA were found to exhibit similar stability profiles. Incubation of DOX-loaded targeted liposomes with metastatic melanoma M14#5 and M15#11 cells and BJ fibroblasts resulted in IC(50) values of 9.8, 9.3, and >100 μM, respectively. Nontargeted liposomes were considerably less efficacious for M14#5 cells. In the CD44(+) B16F10 mouse melanoma model, CD44-targeted liposomes reduced the tumor size to 60% of that of the untreated control, whereas nontargeted liposomes were ineffective. These results suggest that PA targeted liposomes may represent a new class of nanotechnology-based drug delivery systems.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/592602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31101151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis. 与IgG-Fc融合的氯毒素通过受体介导的内吞作用抑制胶质母细胞瘤细胞运动。

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-12-05 DOI: 10.1155/2012/975763

Tomonari Kasai, Keisuke Nakamura, Arun Vaidyanath, Ling Chen, Sreeja Sekhar, Samah El-Ghlban, Masashi Okada, Akifumi Mizutani, Takayuki Kudoh, Hiroshi Murakami, Masaharu Seno

{"title":"Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis.","authors":"Tomonari Kasai, Keisuke Nakamura, Arun Vaidyanath, Ling Chen, Sreeja Sekhar, Samah El-Ghlban, Masashi Okada, Akifumi Mizutani, Takayuki Kudoh, Hiroshi Murakami, Masaharu Seno","doi":"10.1155/2012/975763","DOIUrl":"https://doi.org/10.1155/2012/975763","url":null,"abstract":"Chlorotoxin is a 36-amino acid peptide derived from Leiurus quinquestriatus (scorpion) venom, which has been shown to inhibit low-conductance chloride channels in colonic epithelial cells. Chlorotoxin also binds to matrix metalloproteinase-2 and other proteins on glioma cell surfaces. Glioma cells are considered to require the activation of matrix metalloproteinase-2 during invasion and migration. In this study, for targeting glioma, we designed two types of recombinant chlorotoxin fused to human IgG-Fcs with/without a hinge region. Chlorotoxin fused to IgG-Fcs was designed as a dimer of 60 kDa with a hinge region and a monomer of 30 kDa without a hinge region. The monomeric and dimeric forms of chlorotoxin inhibited cell proliferation at 300 nM and induced internalization in human glioma A172 cells. The monomer had a greater inhibitory effect than the dimer; therefore, monomeric chlorotoxin fused to IgG-Fc was multivalently displayed on the surface of bionanocapsules to develop a drug delivery system that targeted matrix metalloproteinase-2. The target-dependent internalization of bionanocapsules in A172 cells was observed when chlorotoxin was displayed on the bionanocapsules. This study indicates that chlorotoxin fused to IgG-Fcs could be useful for the active targeting of glioblastoma cells.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/975763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31150399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22