Journal of Digestive Diseases最新文献

{"title":"A Novel Prognostic Score for 1-Year Adverse Outcomes in Non-ACLF Cirrhotic Patients After Discharge: A Multicenter Prospective Cohort Study.","authors":"Yue Xiang Bian, Xin Zhang, Xian Bo Wang, Xin Zheng, Wen Ting Tan, Xiu Hua Jiang, Yan Huang, Zhong Ji Meng, Yan Hang Gao, Zhi Ping Qian, Feng Liu, Xiao Bo Lu, Yu Shi, Yu Bao Zheng, Ying Li He, Jian Yi Wei, Pei Xuan Ji, Kai He, Adila Abuduaini, Ya Wen Lu, Liang Qiao, Hai Li","doi":"10.1111/1751-2980.70039","DOIUrl":"10.1111/1751-2980.70039","url":null,"abstract":"<p><strong>Objectives: </strong>Discharged cirrhotic patients hospitalized for acute decompensation (AD) without acute-on-chronic liver failure (ACLF) have heterogeneous long-term prognosis; however, reliable prognostic tools are lacking. We aimed to identify the risk factors associated with 1-year adverse outcomes including mortality and liver transplantation (LT) after patient's discharge and to develop an evidence-based prognostic model.</p><p><strong>Methods: </strong>We enrolled 1212 and 621 cirrhotic patients who clinically improved after AD without ACLF before discharge from the Chinese AcuTe-on-CHronic LIver FailurE (CATCH-LIFE) derivation and validation cohorts, respectively. The primary outcome was 1-year adverse outcomes (all-cause mortality or LT) post-discharge. Independent risk factors for 1-year post-discharge adverse outcomes were identified using multivariable analysis, and a prognostic model was derived and validated.</p><p><strong>Results: </strong>In the derivation cohort, 203 (16.7%) patients experienced 1-year adverse outcomes and 370 (30.5%) were readmitted within 90 days post-discharge. Age, prior decompensation, total bilirubin, international normalized ratio, albumin, and hemoglobin on discharge were independently associated with 1-year post-discharge adverse outcomes. The prognostic model achieved an area under the receiver operating characteristic curve (AUC) of 0.7767 (95% confidence interval [CI] 0.7408-0.8125) and 0.7274 (95% CI 0.6656-0.7892) in the derivation and validation cohorts. Using a risk threshold of ≥ 0.27, 17.70% of discharged non-ACLF cirrhotic patients with AD in the validation cohort were classified as high-risk, with 1-year adverse outcome rate being 43.96%.</p><p><strong>Conclusion: </strong>A prognostic model for predicting 1-year adverse outcomes in discharged non-ACLF cirrhotic patients was developed and validated, with a high-risk cut-off ≥ 0.27, which may effectively stratify adverse outcome risks at 1-year post-discharge and guide intensive post-discharge management.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"63-74"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Expert Consensus on the Clinical Management of Bile Acid Diarrhea (2026 Version).","authors":"","doi":"10.1111/1751-2980.70038","DOIUrl":"10.1111/1751-2980.70038","url":null,"abstract":"<p><p>Chronic diarrhea is a common symptom of the digestive system and also a frequent reason for consultation among patients in gastroenterology outpatient clinics. As one of the common etiologies of chronic diarrhea, bile acid diarrhea (BAD) has a relatively high incidence rate. However, due to the current limitations in physicians' awareness, medical standards, and diagnostic methods, BAD is often underdiagnosed or misdiagnosed; therefore, patients often fail to receive timely and appropriate treatment. To further improve clinicians' understanding and management of BAD, the Chinese Society of Gastroenterology, Chinese Medical Association, on the basis of drawing on domestic and international diagnostic and therapeutic experiences as well as guidelines and consensuses, has organized domestic experts to formulate this expert consensus focusing on the pathogenesis, clinical classification, diagnosis, and management of BAD.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"2-14"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Trends of Vascular Intestinal Disease in the Elderly (1990-2021): A Study on Its Causal Relationship With Hypertension.","authors":"Shao Han Li, Meng Zhen Yu, Hao Ming Xu, Si Qi Yang, Jia Wei Chen, Hong Li Huang, Yong Jian Zhou","doi":"10.1111/1751-2980.70041","DOIUrl":"10.1111/1751-2980.70041","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the disability-adjusted life-years (DALYs) and incidence of vascular intestinal disease (VID) in individuals aged 65 years and above and identify its causal relationship with hypertension.</p><p><strong>Methods: </strong>Analysis of VID burden focused on the incidence and DALYs in individuals aged 65 years and above. Socioeconomic inequalities were evaluated using the slope and concentration indices. Temporal trends of VID were evaluated with age-period-cohort (APC) modeling and Bayesian projections. Mendelian randomization (MR) analysis was employed to investigate the causal relationship between hypertension and VID.</p><p><strong>Results: </strong>From 1990 to 2021, the global age-standardized DALYs rate (ASDR) and age-standardized incidence rate (ASIR) for VID declined, while the absolute number of incident cases increased. In 2021, the incident cases and DALYs reached 789 979 (95% uncertainty interval [UI] 615 343-978 593) and 1 116 683 (95% UI 996 036-1 210 921), with ASIR and ASDR of 105.59 per 100 000 (95% UI [82.43-130.50] per 100 000) and 151.66 per 100 000 (95% UI [134.58-164.67] per 100 000), respectively. Eastern Europe showed the highest DALYs rates. Bayesian APC projections indicated declining age-standardized rates but rising absolute numbers by 2040. MR analysis revealed hypertension as a significant causal risk factor for VID, with an odds ratio of 2.817 for inverse-variance-weighted and 3.618 for weighted median methods.</p><p><strong>Conclusion: </strong>Although VID burden remains high in high-income regions, its overall ASDR and ASIR have been declining. Meanwhile, hypertension is a causal factor for VID.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"50-62"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound Diagnosis and ERCP Treatment of Type III Choledochal Cyst: A Case Report and Review of Literatures.","authors":"Tong Li, Yuan Jian Jiang, Rui Xie","doi":"10.1111/1751-2980.70042","DOIUrl":"10.1111/1751-2980.70042","url":null,"abstract":"","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"99-102"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Score for Visceral Fat and Gallstone Disease Risk: A Multicenter Cohort Study and Mediation Analysis of Inflammatory Biomarkers.","authors":"Cui Hua Zhang, Meng Lin He, Hong Yu Li, Yi Jiang, Jing Luo, Hong Yang, Zi Jie Chen, Xuan Bai, Guo Heng Jiang, Lin Jun Xie, Yi Ting Xu, Xin Wang, Wen Qian Yu, Min Gao, Jiong Lu, Jin Zhou, Ding Zi Zhou, Jia Yuan Li, Xin Wang","doi":"10.1111/1751-2980.70044","DOIUrl":"10.1111/1751-2980.70044","url":null,"abstract":"<p><strong>Objectives: </strong>Gallstone disease (GSD), a prevalent digestive disorder, remains mechanistically underexplored in relation to visceral adipose. The Metabolic Score for Visceral Fat (METS-VF), a novel metric for quantifying visceral adipose tissue, has not yet been evaluated for its association with GSD in cohort studies. We aimed to investigate the METS-VF-GSD association across multicenter cohorts.</p><p><strong>Methods: </strong>Multicenter cohort analysis of 59 851 participants from two Chinese hospitals and 357 233 participants from the UK Biobank dataset was conducted using Cox models to investigate the association between METS-VF and GSD risk. Competing risk models were also applied to the UK Biobank cohort. Meta-analysis and mediation analysis were used to synthesize results from the cohort analysis and evaluate mediation effects of inflammatory biomarkers.</p><p><strong>Results: </strong>Cox models revealed a significant positive association between METS-VF and GSD risk, with a \"J-shaped\" nonlinearity, as confirmed by restricted cubic spline analysis (p < 0.05). Meta-analysis revealed that for each 1-unit and 1-standard deviation increase in METS-VF, GSD risk increased by 84% and 57%, respectively. Compared with participants in quantile 1 (Q1) of METS-VF, those in Q2 (pooled hazard ratio [HR] 1.65, 95% confidence interval [CI] 1.35-2.01), Q3 (pooled HR 2.16, 95% CI 1.83-2.54), and Q4 (pooled HR 3.00, 95% CI 2.82-3.19) were associated with progressively higher GSD risk. Mediation analysis revealed that certain inflammatory biomarkers partially mediated the effect of METS-VF on incident GSD.</p><p><strong>Conclusions: </strong>Increased METS-VF is associated with a higher risk of GSD. It may serve as an important indicator for identifying high-risk populations for GSD.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"87-98"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Asymmetric Dimethylarginine, Its Change, and Subclinical Carotid Atherosclerosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Wei Wang, Xin Tian Ren, Peng Fei Sun, Ting Ting Lyu, Yu Wang, Yan Fang Tan, Xin Yan Zhao, Min Li","doi":"10.1111/1751-2980.70045","DOIUrl":"10.1111/1751-2980.70045","url":null,"abstract":"<p><strong>Objective: </strong>To examine whether baseline levels and short-term changes of asymmetric dimethylarginine (ADMA) are associated with subclinical carotid atherosclerosis (SCA) and its progression in adults with metabolic dysfunction-associated steatotic liver disease (MASLD).</p><p><strong>Methods: </strong>A total of 600 adults with MASLD were prospectively recruited and followed annually for 2 years. Serum ADMA was measured at baseline and 1-year follow-up. SCA, defined as increased carotid intima-media thickness or carotid plaque, was assessed at baseline, 1- and 2-year follow-up. Multivariable regression and propensity score-based analyses were performed to assess the associations between baseline ADMA or change in ADMA and SCA risk.</p><p><strong>Results: </strong>Increased baseline ADMA level was significantly associated with SCA. Each 1-standard deviation (SD) increase in baseline ADMA was associated with higher odds of SCA (odds ratio 2.24, 95% confidence interval [CI] 1.66-3.01), with a dose-response relationship across ADMA quartiles. Baseline ADMA was not associated with SCA progression; however, dynamic increase in ADMA over time was strongly associated with SCA progression at both 1 and 2 years. Each 1-SD increase in absolute and relative changes of ADMA was associated with higher risks of SCA progression at 1 year (relative risk [RR] 1.82, 95% CI 1.60-2.07; RR 1.44, 95% CI 1.29-1.61) and 2 years (RR 1.52, 95% CI 1.36-1.70; RR 1.31, 95% CI 1.20-1.42). Associations were more pronounced among participants with pre-existing SCA.</p><p><strong>Conclusion: </strong>ADMA is associated with the prevalence of SCA, and short-term dynamic changes in ADMA may represent early indicators for SCA progression in adults with MASLD.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"75-86"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcolonic Endoscopic Appendectomy: A Single-Step \"Two-In-One\" Approach for Recurrent Appendicitis With Appendiceal Orifice Lesions.","authors":"Hao Wu, Zhu Kai Chen, Ai Ping Xu, Yuan Chu, Li Zhang, Jing Jing Lian, Tao Chen, Mei Dong Xu","doi":"10.1111/1751-2980.70040","DOIUrl":"10.1111/1751-2980.70040","url":null,"abstract":"<p><strong>Objectives: </strong>Appendiceal orifice lesions are occasionally detected during colonoscopy in patients with recurrent appendicitis. Conventional surgery with partial cecal resection may cause unnecessary trauma. Transcolonic endoscopic appendectomy (TEA) has been proposed as a minimally invasive alternative. We aimed to evaluate the feasibility, safety, and efficacy of transcolonic endoscopic appendectomy and to compare through-the-scope twin clips (TTS-TC) combined with metal clips versus metal clips alone for defect closure.</p><p><strong>Methods: </strong>Twenty patients with recurrent appendicitis and no prior abdominal surgery who underwent transcolonic endoscopic appendectomy between December 2020 and December 2024 were included. Clinical and pathological variables, procedural parameters, and follow-up outcomes were analyzed. TTS-TC plus metal clips and metal clips alone for defect closure were compared.</p><p><strong>Results: </strong>All procedures were technically and clinically successful. Postoperative time to resume diet and length of hospital stay were 4.05 and 6.40 days, respectively. TTS-TC combined with metal clips reduced suture time (18 min [interquartile range {IQR} 15.5-20 min] vs. 25 min [IQR 20-30 min]), procedure time (85 min [IQR 72.5-92 min] vs. 115 min [IQR 110-124 min]), and number of clips used (7 [IQR 6.5-8] vs. 8 [IQR 7-9]) compared with metal clips alone. No adverse events were reported. Colonoscopy performed at 3 months post-procedure showed no residual lesions or recurrence.</p><p><strong>Conclusions: </strong>TEA is a feasible, safe, and effective approach for recurrent appendicitis with orifice lesions. It provides a minimally invasive dual-benefit strategy and can be facilitated by a novel closure method to streamline the procedure.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"31-39"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Fecal Bile Acid Profile and Intestinal Microbiota in Patients With Chronic Radiation Enteritis.","authors":"Xin Shen, Song Bo Li, Meng Jie Gao, Jiao Jiao Cao, Hua Yang, Wei Wei Li, Li Chun Wei, Min Chen, Jun Ye Liu, Yong Quan Shi","doi":"10.1111/1751-2980.70029","DOIUrl":"10.1111/1751-2980.70029","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the relationship between fecal bile acid (BA) profile and intestinal microbiota in patients with chronic radiation enteritis (CRE).</p><p><strong>Methods: </strong>Altogether 60 patients with cervical cancer (CC) who visited Xijing Hospital between December 2022 and September 2023 were enrolled, including 20 patients who did not undergo any treatment (the CC group), 20 patients who developed CRE after radical radiotherapy (the CRE group), and 20 patients who did not experience CRE after radical radiotherapy (the non-CRE [NRE] group). Patients' characteristics and fecal samples were collected. Fecal BA profiles were quantified, and intestinal microbiota were analyzed by using the 16S rRNA gene sequencing. Differentially expressed BAs and microorganisms were identified across groups, and their correlations were assessed using Spearman's correlation analysis.</p><p><strong>Results: </strong>In patients with CRE, BA metabolism was characterized by increased proportions of primary BAs and decreased proportions of secondary BAs, particularly lithocholic acid and its isomers. In addition, the abundance of beneficial bacterial genera, such as Bifidobacterium and Megasphaera, was reduced, whereas that of potentially pathogenic genera, including Megamonas and Dorea, was increased. Furthermore, a bidirectional relationship between BA metabolism and intestinal microbiota was observed.</p><p><strong>Conclusions: </strong>Patients with CRE present notable alterations in BA metabolism and intestinal microbiota. CRE may trigger a harmful feedback mechanism driven by the interaction between these two factors. Targeted regulation of BA metabolism and intestinal microbiota may be a promising therapeutic approach for the management of CRE.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT05728060.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":"27 1-2","pages":"40-49"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Characteristics of Gastric Cancer in China: A 16-Year Single-Center Retrospective Clinical Study","authors":"Chu Yi Zheng,&nbsp;Yong Jie Tan,&nbsp;Cheng Bei Zhou,&nbsp;Jing-Yuan Fang,&nbsp;Yun Cui","doi":"10.1111/1751-2980.70018","DOIUrl":"10.1111/1751-2980.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Factors such as \u0000 <i>Helicobacter pylori</i>\u0000 eradication and the implementation of widespread early cancer screening have significantly influenced clinicopathological features and patient outcomes in gastric cancer (GC) in China. We aimed to evaluate the characteristics of GC and their evolving trends over 16 years (2007–2022) at a single center in China.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Altogether 14 943 patients diagnosed with primary gastric adenocarcinoma who underwent endoscopic or surgical resection from 2007 to 2022 were included. Clinicopathological data of these patients were collected, and the patients were divided into three groups according to the time period when GC was diagnosed, with broken line charts illustrating trends.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was a significant increase in the detection rates of early gastric cancer (EGC) and stage I GC over time, as well as a considerable increase in T1 GC. Although there was a male predominance in GC (69.85%), the proportion of female patients also increased over time. The age of patients with GC also significantly increased. There was a marked increase in differentiated EGC, while there was also an increase in poorly differentiated advanced GC. Gastric body cancer showed a gradual increase over the years. The size of both EGC and advanced GC decreased gradually. Furthermore, the rates of lymph node metastasis and vascular involvement significantly reduced.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The clinicopathological characteristics of GC in China have undergone significant changes over the past 16 years. This suggests the potential progress made through EGC screening initiatives in China.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":"26 9-10","pages":"447-455"},"PeriodicalIF":2.3,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory Role of Protein Ubiquitination in the Pathogenesis and Progression of Ulcerative Colitis","authors":"Ya Long Zhu,&nbsp;Chang Zheng Liu,&nbsp;Yue Li","doi":"10.1111/1751-2980.70017","DOIUrl":"10.1111/1751-2980.70017","url":null,"abstract":"<div>\u0000 \u0000 <p>Ulcerative colitis (UC) is a multifactorial inflammatory bowel disease influenced by genetic susceptibility, environmental triggers, impaired intestinal epithelial barrier function, dysbiosis of gut microbiota, and immune dysregulation. Ubiquitination, a crucial post-translational modification, plays a significant role in the initiation and progression of UC. Gaining a deeper understanding of the molecular mechanisms underlying ubiquitination may help establish novel therapeutic strategies for UC. This review emphasizes the role of ubiquitination in regulating the intestinal epithelial barrier, nuclear factor (NF)-κB signaling, and immune responses, with the aim of providing new perspectives and potential directions for targeted therapies in UC.</p>\u0000 </div>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":"26 9-10","pages":"398-405"},"PeriodicalIF":2.3,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}