Journal of Digestive Diseases最新文献

{"title":"Large Gastric Schwannoma Containing Patchy Hyperechogenicity on Endoscopic Ultrasound","authors":"Tian Cai Zhang, Ahemala Duishanbai, Xiao Wang, Yan Bo Yu","doi":"10.1111/1751-2980.70016","DOIUrl":"10.1111/1751-2980.70016","url":null,"abstract":"","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":"26 9-10","pages":"456-458"},"PeriodicalIF":2.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145445104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Oral–Gut Axis in Inflammatory Bowel Disease","authors":"Yi Wei Zhang,&nbsp;Ling Jiao Gong,&nbsp;Fei Liao","doi":"10.1111/1751-2980.70014","DOIUrl":"10.1111/1751-2980.70014","url":null,"abstract":"<div>\u0000 \u0000 <p>The global prevalence of inflammatory bowel disease (IBD) has been increasing in recent years, paralleling a growing recognition of gut dysbiosis as a pivotal etiological factor. Emerging evidence reveals intricate crosstalk between the oral and gut microbial ecosystems, with oral-derived microbiota potentially translocating to the intestinal tract through hematogenous or enteral routes. This microbial crosstalk has crystallized into an “oral–gut axis” pattern, providing novel mechanistic insights into the pathogenesis of IBD. In this review, we summarize currently available studies on the oral–gut axis and the relationship between the oral–gut axis and IBD to evaluate the role of the axis in the pathogenesis of IBD development.</p>\u0000 </div>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":"26 9-10","pages":"406-413"},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Celiac Disease in China Among High-Risk Populations: A Systematic Review and Meta-Analysis","authors":"Ying Lian Xiao,&nbsp;Ya Qi Jia,&nbsp;Li Qun Gu,&nbsp;Min Hu Chen","doi":"10.1111/1751-2980.70013","DOIUrl":"10.1111/1751-2980.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We conducted this systematic review and meta-analysis to summarize the prevalence of celiac disease (CeD) among high-risk populations in China.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, and four Chinese databases to identify studies published up to December 10, 2024 on the prevalence of CeD in different regions of China. The high-risk populations included patients with irritable bowel syndrome, gastrointestinal symptoms, autoimmune disease, low body mass index, short stature, etc. Data were extracted from the included studies by two reviewers independently using a standardized data extraction form. Regional prevalence estimates were weighted using China Population Census Yearbook 2020 data. The pooled prevalence of CeD was summarized using random-effects models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-eight studies involving 9531 individuals were included. Biopsy-confirmed prevalence and seroprevalence varied widely by region. Central China had the highest biopsy-confirmed prevalence of CeD in high-risk populations (4.55%, 95% confidence interval [CI] 0.66%–8.44%), followed by North China (3.60%, 95% CI 1.75%–6.08%) and East China (2.50%, 95% CI 1.39%–3.94%). Northeast China led in seroprevalence (7.10%, 95% CI 1.14%–13.05%), followed by Central China (4.42%, 95% CI 1.04%–9.98%), East China (4.37%, 95% CI 2.12%–7.38%), and North China (4.35%, 95% CI 2.39%–6.86%). The biopsy-confirmed prevalence and seroprevalence of CeD among high-risk populations in China were 3.69% and 4.43%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CeD prevalence appears to be significant among high-risk populations and varies by geographical regions in China.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":"26 9-10","pages":"414-427"},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-2980.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Accelerated Biological Aging as Measured by KDMAge and PhenoAge and Digestive System Cancer Risk: A Cross-Sectional Study Using NHANES Data (1999–2018)","authors":"Wei Yue Li,&nbsp;Huan Zhang,&nbsp;Song Bo Li,&nbsp;Dan Yang Zhao,&nbsp;Meng Qi Liang,&nbsp;Qi Qi Guo,&nbsp;Rong Yan,&nbsp;Lei Shang,&nbsp;Yong Quan Shi","doi":"10.1111/1751-2980.70015","DOIUrl":"10.1111/1751-2980.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Digestive system cancer (DSC) continues to pose a significant global health challenge, and cost-effective biomarkers for its early detection remain scarce. We aimed to evaluate the potential of two biological aging indicators, namely the Klemera–Doubal method age (KDMAge) and the phenotypic age (PhenoAge), for predicting DSC risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using the National Health and Nutrition Examination Survey (NHANES) dataset (1999–2018), biological age acceleration for KDMAge and PhenoAge was calculated as residuals from linear regression models of each biological age on chronological age. Accelerated aging was defined as positive residuals. Their associations with DSC risk were evaluated using weighted logistic regression and restricted cubic spline (RCS) analysis. Predictive performance was assessed via area under the receiver operating characteristic curve (AUROC), and robustness was examined using propensity score matching (PSM) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant positive linear association was observed between KDMAge acceleration and DSC risk (odds ratio 1.59, 95% confidence interval 1.05–2.39, <i>p</i> = 0.027). While PhenoAge acceleration showed a U-shaped nonlinear relationship (<i>p</i> = 0.0197), with minimal risk at −2.95. Both indices showed moderate predictive accuracy (AUROC: KDMAge 0.683 and PhenoAge 0.682). PSM analysis confirmed the robustness of the nonlinear relationship between PhenoAge acceleration and DSC, although the linear trend of KDMAge was attenuated after matching.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There was a significant association between accelerated biological aging, as assessed by KDMAge acceleration and PhenoAge acceleration, and DSC risk. Given the cross-sectional study design, causal inference is precluded; however, both indices may be used to develop novel risk assessment tools and guide future research on interventional strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":"26 9-10","pages":"436-446"},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-2980.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Percutaneous Endoscopic Gastrostomy-Related Complications in Amyotrophic Lateral Sclerosis: A 19-Year Retrospective Study From a Tertiary Center.","authors":"Sang Pyo Lee, Jaeyoung Choi, Jin Hwa Park, Kang Nyeong Lee, Hang Lak Lee, Wonjae Sung","doi":"10.1111/1751-2980.70025","DOIUrl":"10.1111/1751-2980.70025","url":null,"abstract":"<p><strong>Objectives: </strong>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that inevitably leads to swallowing difficulties as the disease progresses. Percutaneous endoscopic gastrostomy (PEG) is recommended for optimal supportive management of dysphagia among these patients. We aimed to investigate PEG-related complications and risk factors in patients with ALS.</p><p><strong>Methods: </strong>Medical records of the ALS patients who underwent PEG from March 2006 to February 2025 in a single tertiary care center were retrospectively reviewed. PEG-related complications and risk factors were assessed through chart review, endoscopic reports and images, radiological findings, and follow-up data.</p><p><strong>Results: </strong>Altogether 501 ALS patients (262 men) underwent PEG, of whom 60 developed early complications and 82 developed late complications, including 11 patients who developed both. Pneumoperitoneum was more common in underweight patients (p = 0.004), and wound infection was more common in patients with pre-PEG ileus (p = 0.044). Multivariate analysis revealed that low albumin level, long procedure time, and ileus were significantly associated with early complications. Obesity and ileus were independent risk factors for buried bumper syndrome. Those with an internal bolster at the upper body of the stomach and with an external bolster in the midline of the abdomen were at significant risk of inadvertent PEG removal.</p><p><strong>Conclusions: </strong>Albumin and body mass index extremes are predictors of complications, and care is needed when PEG is performed on patients with pre-PEG ileus. To reduce such risks, the PEG tube should not be inserted into the upper body of the stomach or the midline of the abdomen.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"492-508"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"A Study of a Novel Disposable Endoscopic Purse-String Suture Auxiliary Instrument for the Treatment of Full-Thickness Gastric Wall Defects\".","authors":"","doi":"10.1111/1751-2980.70024","DOIUrl":"10.1111/1751-2980.70024","url":null,"abstract":"","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"564"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Predictive Models for Survival in Colorectal Cancer Patients With Diabetes: A Cohort Study of 10 749 Subjects.","authors":"Junjie Huang, Claire Chenwen Zhong, Zhaojun Li, Yu Jiang, Zehuan Yang, Jinqiu Yuan, Jonathan Poon, Qi Dou, Martin C S Wong","doi":"10.1111/1751-2980.70019","DOIUrl":"10.1111/1751-2980.70019","url":null,"abstract":"<p><strong>Objectives: </strong>To identify the risk factors for the survival of colorectal cancer (CRC) patients with type 2 diabetes mellitus (T2DM), compare the predictive performance of models based on different algorithms, and develop a risk score system to predict the survival risk of the target population.</p><p><strong>Methods: </strong>We analyzed data from the Hong Kong Hospital Authority Data Collaboration Laboratory (HADCL), including 10 749 CRC patients with T2DM from 2000 to 2020. We employed traditional statistical methods and machine learning algorithms to compare their performance using the area under the receiver operating characteristic curve (AUC). The SHapley Additive exPlanations (SHAP) analysis was conducted to identify risk factors and attribute model outputs. A risk score system was developed using the AutoScore-Survival package for risk stratification.</p><p><strong>Results: </strong>Key predictors of CRC survival among T2DM patients included age at cancer diagnosis, sex, T2DM duration, alcohol consumption, central obesity, hypertension, levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and serum potassium, and anti-lipid drug usage. Among the models assessed, the random survival forest showed the best performance. The risk score system was calibrated as follows: age at diagnosis, T2DM duration, LDL-C, glycated hemoglobin, creatinine, and body mass index. The AUCs for 1, 3, and 5 years of the tuned risk score system were 0.746, 0.718, and 0.677, respectively.</p><p><strong>Conclusions: </strong>The random survival forest model provides superior survival prediction compared to other models evaluated. A validated risk score system has been established, facilitating risk stratification for clinicians to manage these patients.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"477-491"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the Treatment of Gastric Artificial Ulcers Following Endoscopic Submucosal Dissection (ESD).","authors":"Yue Yao Wu, Hai Feng Jin","doi":"10.1111/1751-2980.70023","DOIUrl":"10.1111/1751-2980.70023","url":null,"abstract":"<p><p>Endoscopic submucosal dissection (ESD) is the preferred treatment for early gastric cancer and gastric adenomas. However, ESD-induced artificial ulcers leads to pain, bleeding, and delayed healing. In recent years, advances have been made for the treatment of post-ESD ulcers. Currently available treatment options for post-ESD ulcers include proton pump inhibitors and potassium-competitive acid blockers, mucosal protective agents such as rebamimide, and novel biomaterials such as fibrin glue and hydrogel-based products. In addition, advanced imaging technologies such as Doppler probe ultrasound and infrared imaging systems have been adopted to assist in the detection of invisible vessels. These novel approaches have shown promising efficacies in promoting ulcer healing and reducing post-procedure adverse events. Here we review the factors that might influence ulcer healing after ESD and the recent advances in the management of ESD-induced iatrogenic gastric ulcers. Further investigation is warranted regarding their long-term safety, cost-effectiveness, and individualized treatment strategies.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"460-469"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal NLRP3 Deficiency Exacerbates MASLD in Male Mice via Reduced Butyrate Production.","authors":"Li Chen, Jing Li, Hao Yu Jia, Chun Liu, Shan Shan Li, Feng Shang Zhu, Chang Qing Yang","doi":"10.1111/1751-2980.70022","DOIUrl":"10.1111/1751-2980.70022","url":null,"abstract":"<p><strong>Objectives: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a major global health burden, yet its underlying mechanisms remain incompletely defined. We aimed to investigate the role of intestinal NOD-, LRR-, and pyrin-domain-containing protein 3 (NLRP3) inflammasome in the gut-liver axis to identify potential therapeutic targets for MASLD.</p><p><strong>Methods: </strong>Eight-week-old male mice were given a methionine-choline-deficient (MCD) diet for 4 weeks to induce MASLD-associated fibrosis. The functional role of NLRP3 was assessed using Vil1^creNlrp3^f/f mice with intestinal epithelial cell-specific Nlrp3 deletion. To evaluate the potential influence of the gut microbiota, Vil1^creNlrp3^f/f-MCD mice were co-housed with Nlrp3^f/f-MCD counterparts. The effect of butyrate was also evaluated in Vil1^creNlrp3^f/f-MCD mice via oral gavage for 3 weeks. The role of intestinal NLRP3 was further validated in a carbon tetrachloride (CCl₄)-induced liver fibrosis model.</p><p><strong>Results: </strong>Intestinal NLRP3 expression was markedly reduced in wild-type mice given MCD diet. Compared with Nlrp3^f/f-MCD mice, Vil1^creNlrp3^f/f-MCD mice developed more severe MASLD and exhibited impaired intestinal barrier integrity, whereas the co-housing condition alleviated hepatic pathology. Moreover, butyrate administration significantly improved hepatic steatosis and fibrosis in Vil1^creNlrp3^f/f-MCD mice. Mechanistic analysis revealed attenuated hepatic peroxisome proliferator-activated receptor α (PPARα) activation and enhanced hepatic activator protein (AP)-1 signaling in Vil1^creNlrp3^f/f-MCD mice, both of which improved under co-housing condition or butyrate treatment. Similarly, intestinal Nlrp3 deletion aggravated CCl₄-induced liver fibrosis.</p><p><strong>Conclusion: </strong>Loss of intestinal Nlrp3 diminished butyrate production, inhibited PPARα expression, and enhanced AP-1 signaling, collectively intensifying MASLD progression.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"544-558"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Trends of Liver Cancer in 1975-2019 and Projection for 2020-2024: A 50-Year Analysis Using SEER Database.","authors":"Yi-Xin Zou, Zhuo-Jun Ye, Zhuo-Ying Li, Yu-Xuan Xiao, Jun Chen, Yu-Xin Zhou, Hong-Lan Li, Qun Xu, Yong-Bing Xiang","doi":"10.1111/1751-2980.70021","DOIUrl":"10.1111/1751-2980.70021","url":null,"abstract":"<p><strong>Objectives: </strong>Primary liver cancer (PLC) is a leading cause of global cancer-related mortality, with rising incidence and survival disparities. We aimed to analyze its long-term survival trends that likely help establish future prevention and treatment strategies for PLC.</p><p><strong>Methods: </strong>Using the Surveillance, Epidemiology, and End Results (SEER) Program (1975-2019), we assessed long-term survival rates of PLC patients stratified by age groups, sex, race, and SEER tumor stage using period analysis. Model-based period analysis was employed to predict the 5-year relative survival rates (RSRs) during 2020-2024. Survival statistics included observed survival rates (OSRs), RSR, conditional RSR (CRSR), and age-standardized RSR (ARSR).</p><p><strong>Results: </strong>From 2015 to 2019, female patients with PLC had a higher 5-year ARSR of 27.26% compared to male patients (24.81%). The 5-year CRSR improved to 72.17% in women and 70.05% in men. The 5-year RSR declined with age and from localized tumor stage (41.45%) to distant cancer (5.52%) in men. In addition, black male patients had the lowest 5-year ARSR (19.61% vs. 23.86% in white males and 31.22% in men of other races). Long-term trends during 1975-2019 showed rising survival rates, yet disparities persisted. Projections for 2020-2024 estimated an overall 5-year RSR of approximately 30%, with persistent gaps for patients aged ≥ 75 years and black males.</p><p><strong>Conclusions: </strong>Despite improved PLC survival over the 45 years, persistent disparities in age, sex, race, and tumor stage underscore the need for early detection and equitable care. The converging prognosis among long-term survivors highlights the value of survivorship programs.</p>","PeriodicalId":15564,"journal":{"name":"Journal of Digestive Diseases","volume":" ","pages":"530-543"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}