Clinical Medicine And Health Research Journal最新文献

{"title":"Confluence of Mendelian Randomization with Clinical Trials as To Very Low Levels of LDL Cholesterol","authors":"Ana Paula Marte Chacra, Anita L R Saldanha, Ana Paula Pantoja Margeotto, A. L. Valera Gasparoto, Mariela Siria Saavedra Ampuero, Luiza Ferrari De Castro, T. L. da Rocha Martinez","doi":"10.18535/cmhrj.v4i1.304","DOIUrl":"https://doi.org/10.18535/cmhrj.v4i1.304","url":null,"abstract":"Atherosclerotic disease and its clinical manifestations, including acute myocardial infarction and ischemic stroke, are the leading cause of morbidity and mortality worldwide. Among the atherogenic risk factors, the most well-documented and the one that determines a causal relationship with atherosclerotic disease is low-density lipoprotein cholesterol (LDL-C) values. It is essential to identify LDL-C as a therapeutic target to reduce cardiovascular risk, especially after the emergence of new drugs that further reduce LDL-C levels, with additional risk reduction. Our objective is to demonstrate that LDL-C is an important atherogenic risk factor and that any mechanism of reduction of plasma LDL-C concentrations reduces the risk of events proportional to the absolute reduction of LDL-C and the cumulative time of exposure to it. Mendelian randomization studies: even though the association between LDL-C and cardiovascular risk is well demonstrated and reproducible in meta-analyses of prospective cohort studies, such studies are not randomized and therefore susceptible to biases such as reverse causality and confounders. Mendelian randomization is used especially when randomized controlled trials to examine causality are not feasible. This method will assess the causal relationship between a modifiable exposure, or risk factor, and a clinically relevant outcome. The confluence of the results of both Mendelian randomization and clinical trials leads to the same proposition: the lower the LDL-C, the better for the prevention of atherosclerotic lesions.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"63 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic Rupture of The Descending Aorta After Coronary Angiography : A Case Report","authors":"Hanane Zouzou","doi":"10.18535/cmhrj.v4i1.301","DOIUrl":"https://doi.org/10.18535/cmhrj.v4i1.301","url":null,"abstract":"Rupture of descending aorta is a rare fatal complication after coronary angiography, we report a case of 65 years-old man who presented  acute coronary syndrome without ST segment elevation and underwent coronary angiography in a private hospital, he was admitted in cardiology departement  twelve days after coronary angiography for strong suspision of aortic dissection, Computed Tomography angiography of the chest performed immediately revealed  descending aorta dissection and its rupture in the left lung; surgically recused, the patient died few days later.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Various Imaging Modalities in the Diagnosis of Hepatic Cystic Lesions","authors":"Bassam Althaqafi, Hamad Alsuhime, Nawaf Hijazi, Osama Alsulimani, M. Alasmari, Khalid Asiri, Hamid Osman, Nouf Alzahrani, Abdullah Majed Hakami","doi":"10.18535/cmhrj.v4i1.295","DOIUrl":"https://doi.org/10.18535/cmhrj.v4i1.295","url":null,"abstract":"Background: Hepatic cysts (HCs) lesions are common in clinical practice. These lesions can be benign and have no clinical significance, or they can be malignant and potentially fatal. Aim: The current manuscript aimed to assess HCs with varying image modalities and the prevalence of it among gender as well as link the HCs with age, in the two main governmental hospitals in Taif city. Materials and methods: 100 confirmed diagnosed HCs were retrieved from period of 2020 to 2023, through picture archiving and communication system (PACs), they divided into groups according to gender and age, as well as dividing cysts according to their radiographic appearances Microsoft Excel was used to analyzed the data achieved. Results: The older age more than 46 years and female are more exposed to HCs than male and younger age respectively. The HCs types, appearances, classification and characterization in each image modality are tabulated in specific tables. While simple cysts were benign, complicated cysts, appeared as echinococcosis, and cystic neoplasms that, require early and accurate diagnosis. Conclusion: The findings of current study matched the findings of previous studies. More studies are required in the highlights of current findings.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"24 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic and Histological Trends of Breast Lumps in A Sub-Saharan African Population: A Cross-Sectional Study in A Surgical Oncology Department","authors":"Ulrich Igor Mbessoh Kengne, Jaafar Ibn Abou Talib Thiam, Salif Balde, Mamadou Ndiaye, Amacoumba Fall, Esaie Kasokota, Awa Niasse, Amadou Amadi Sow, Mamadou Sow, Mohammed Ezzet Charfi, Sidy Ka","doi":"10.18535/cmhrj.v3i6.288","DOIUrl":"https://doi.org/10.18535/cmhrj.v3i6.288","url":null,"abstract":"Objective: The purpose of the study was to present histological profile of both benign breast tumors (BBT) and breast cancer (BC) in our setting and highlight age trends in the occurrence of BBT. Methods: A retrospective cross-sectional study was conducted in the surgical oncology unit of the Dalal Jamm University Hospital from January to July 2023. Dalal Jamm University Hospital is a teaching hospital based in Dakar, Senegal. Results: The median age was 45 years for BC and 31.5 years for BBT. The main histological types of BC were invasive ductal carcinoma (93.2%) and invasive lobular carcinoma (4.5%) whereas it was fibroadenoma (66.6%) for BBT. Fibroadenoma and benign phyllodes tumor was more common in adolescents and under 40 years (p = 0.046) old while fibrocystic changes were more prevalent during perimenopause (p < 0.001). Conclusion: Invasive ductal carcinoma and fibroadenoma are the most common breast tumors in sub-Saharan African setting. Fibroadenoma and benign phyllodes tumor are more prevalent in adolescents and under 40 years while fibrocystic changes occur most within the fourth and fifth decades of life.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"107 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139174923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Successful Closure of Aoto-Atrial Fistula Between the Descending Aorta and Right Atrium in Symptomatic 3-Month-Old Infant","authors":"M. Abdelbaki, M. Touati","doi":"10.18535/cmhrj.v3i6.277","DOIUrl":"https://doi.org/10.18535/cmhrj.v3i6.277","url":null,"abstract":"A 3-month-old infant presented to our clinic with heart failure secondary to an abnormal communication between the descending aorta and the right atrium. The anomaly was successfully closed via cardiac catheterization using an ADO II AS 5/6 AGA Occluder. Subsequent follow-up revealed relief of symptomatology.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"147 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139213257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Challenge in The Emergency Department: Dysarthria-Clunky Hand Syndrome.","authors":"Dr. Eric Miguel Pozos Gutiérrez, Dr. Ignacio Alberto Mendez de Jesus, Dr. Tabatta Gabriela Orejel Feria, Dr. Iliana Patricia Dawn Martínez, Dr. Jackeline Fajardo Cervantes, Dr. Diana Hernández Sánchez","doi":"10.18535/cmhrj.v3i6.283","DOIUrl":"https://doi.org/10.18535/cmhrj.v3i6.283","url":null,"abstract":"Background: Small vessel vascular disease can present as different entities including lacunar infarctions. Dysarthria-clumsy hand syndrome is the rarest classic lacunar syndrome, this syndrome is described as the combination of dysarthria with clumsiness of the hand, manifested as slowing in fine manipulation, difficulty in writing, along with hesitant ataxia in the finger-nose test that differed from the cerebellar type. Clinical case: A 59-year-old female attended the continuous admission service due to acute neurological deterioration characterized by dysarthria and right hemiparesis, performing a neurological physical examination where moderate dysarthria was evident, slight deviation of the left labial commissure, decreased strength in the right upper extremity, latero drive of the march to the right, in angiotomographic study it was reported absence of flow in left perforating artery,  Diagnosis of lacunar ischemic vascular event, dysarthria-clumsy hand syndrome. Conclusions: Dysarthria-clumsy hand syndrome is a rare syndrome with a good prognosis, however, as first contact physicians we must be prepared for the different variants of cerebrovascular disease that may present to the emergency area, never delaying the diagnosis with a view to early treatment to limit the damage.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139235711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cardiovascular Risk in Patients with Type 1 Diabetes: How Ankle Brachial Index Can Be Usefull?","authors":"M. Abdelbaki, Assia Meftah, H. Baghous, Said Ali, Aissa Boudiba","doi":"10.18535/cmhrj.v3i6.275","DOIUrl":"https://doi.org/10.18535/cmhrj.v3i6.275","url":null,"abstract":"Background: Patients with type 1 diabetes (T1D) face a significantly higher mortality risk compared to the general population, primarily due to elevated rates of cardiovascular disease (CVD). Detecting cardiovascular disease at its preclinical stage is essential for effective primary prevention in this relatively young population. This study aims to assess the link between steno-risk and subclinical atherosclerotic disease, as detected by the Ankle-Brachial Index (ABI), in T1D patients and determine the prevalence of these abnormalities among them. Methods: A cohort of 312 adults with T1D (151 males and 161 females, mean age 31 ± 12 years) was examined. Patients were categorized based on their ABI values (ABI < 0.9 indicating peripheral arterial disease (PAD), ABI ≥ 1.3 indicating arterial calcification (AC), and ABI between 0.9 and 1.3 indicating normal ABI). The study analyzed the relationship between ABI anomalies and cardiovascular risk factors and their association with the steno-risk category. Results: Among the patients, 138 (44.2%) had a normal ABI, 112 (35.9%) had PAD, and 62 (19.9%) had AC. AC was more prevalent in men than in women (p = 0.006). A family history of stroke was common in both the PAD and AC groups (p = 0.042 and p = 0.046, respectively). Patients with AC were often older (36 ± 13 vs. 30 ± 12; P = .012), had a longer duration of diabetes (20 ± 11 vs. 14 ± 9; P < 0.001), a higher prevalence of hypertension (25.8% vs. 14.5%, P = 0.05), and a higher prevalence of smoking (19.3% vs. 9.4%, P = 0.046). A higher number of subjects with AC were found in the Steno-Risk 10–20% and Steno-Risk ≥20% categories compared to the Steno-Risk < 10% (37.5 vs. 15.5; 29 vs. 15.5, p = 0.0106, respectively). Conclusion: This study demonstrates that an ABI > 1.30 is more common in older patients with type 1 diabetes and is associated with a longer duration of diabetes, male gender, smoking, hypertension, and a family history of stroke. Furthermore, an ABI > 1.30, indicating arterial calcification, is significantly linked to moderate and high cardiovascular risk assessed by steno-risk in patients with type 1 diabetes. The ABI may serve as a straightforward tool for screening atherosclerosis in T1D.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"31 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Management of Chronic Heart Failure","authors":"H. Benalikhoudja, M. Abdelbaki","doi":"10.18535/cmhrj.v3i6.279","DOIUrl":"https://doi.org/10.18535/cmhrj.v3i6.279","url":null,"abstract":"Chronic heart failure is associated with a nutritional syndrome which is often complicated by a state of cachexia. This nutritional syndrome plays a pejorative role. When obesity is moderate, it has favorable consequences on morbidity and mortality. Nutritional syndrome results directly from two processes linked to the development of heart failure. The first results in a neuroendocrine disruption which leads to a reduction in anabolic factors and an increase in catabolizing factors, resulting in a hypercatabolic state and leading to cachexia. The second is the reduction of caloric consumption and absorption with a decrease in energy production and an increase in demand. Specific dietary intakes or supplements have been carried out with some success, but a consensus remains to be established.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"57 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139246358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile of Hypertensives at The Cardiology Consultation","authors":"M. Abdelbaki, N. Khelafi, A. El hachemi, H. BEN MESSAOUD","doi":"10.18535/cmhrj.v3i6.273","DOIUrl":"https://doi.org/10.18535/cmhrj.v3i6.273","url":null,"abstract":"Systemic hypertension is a global public health problem. It affects all parts of the population. In Algeria, according to the TAHINA 1 study, high blood pressure is the most common chronic pathology (24.8%). Despite numerous recommendations from learned societies 2.3.4.5 and the existence of effective therapies, a high percentage of patients remains uncontrolled 6.7.8. Our work aimed to study the clinical profile of hypertensives who presented to our cardiology consultation at the EPH in Laghouat. This is a longitudinal observational study running from October 2022 to June 2023. We collected 560 patients during daily consultations, lasting 10 months. The results made it possible to describe the present risk factors, dietary habits and socioeconomic conditions.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"179 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Nutrition in Coronary Bypass Surgery","authors":"H. Benalikhoudja, M. Abdelbaki, E. Boudiaf","doi":"10.18535/cmhrj.v3i6.281","DOIUrl":"https://doi.org/10.18535/cmhrj.v3i6.281","url":null,"abstract":"Preventive nutrition in cardiology has a bright future ahead of it, as there is abundant data to justify its importance in secondary prevention. Practitioners must appropriate these simple data to meet patients' expectations. Our work consisted in showing the interest of nutrition and moderate physical activity in the secondary prevention of risk factors of coronary disease after coronary bypass surgery. Our study included 20 patients, all of whom were operated on according to the same therapeutic protocol. We will also review the effects of several nutrients, foods, and dietary patterns. The results found are correlated with those found in the literature. The Mediterranean diet has accumulated the most evidence. The challenge is to change patients' habits, but this depends in part on the conviction and motivation of doctors.","PeriodicalId":155428,"journal":{"name":"Clinical Medicine And Health Research Journal","volume":"232 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}