Journal of Drug Metabolism and Toxicology最新文献_第2页

Causes and Treatment of Hepatotoxicity 肝毒性的原因和治疗

Journal of Drug Metabolism and Toxicology Pub Date : 2021-01-01 DOI: 10.35248/2157-7609.21.12.E146

Swetha Bujangi

引用次数: 0

A Brief Note on Carbohydrate Metabolism 关于碳水化合物代谢的简要说明

Journal of Drug Metabolism and Toxicology Pub Date : 2021-01-01 DOI: 10.35248/2157-7609.21.12.E147

H. Ms

引用次数: 0

Pseudomonas aeruginosa Clinical Isolates: Antibiogram Profile and Biofilm Formation 铜绿假单胞菌临床分离:抗生素谱和生物膜形成

Journal of Drug Metabolism and Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2157-7609.20.11.247

R. Shrestha

{"title":"Pseudomonas aeruginosa Clinical Isolates: Antibiogram Profile and Biofilm Formation","authors":"R. Shrestha","doi":"10.35248/2157-7609.20.11.247","DOIUrl":"https://doi.org/10.35248/2157-7609.20.11.247","url":null,"abstract":"Background: The gram-negative bacterium, Pseudomonas aeruginosa belongs to a vast genus of obligate aerobic, nonfermenting, saprophytes, which are present in water, soil and on plants. Moreover, P. aeruginosa can be frequently isolated from tap water. In its natural habitat, this organism is endowed with weak pathogenic potential. However, its profound ability to survive on inert materials, its minimal nutritional requirement, tolerance to a wide variety of physical conditions and relative resistance to several antimicrobial agents and antiseptics, contribute enormously to its ecological success and its role as an effective opportunistic pathogen. P. aeruginosa is a notoriously difficult organism to control with antibiotics or disinfectants and has become increasingly recognized as an emerging opportunistic pathogen of clinical relevance. Multi-drug-resistant Pseudomonas aeruginosa (MDRPA) are often isolated from patients suffering from nosocomial infections, particularly those who are admitted to intensive care unit (ICU).[3] Thus, infections caused by P.aeruginosa especially in ICU patients are problematic because the organism apart from being inherently resistant to many drug classes, is able to acquire resistance to many effective antimicrobial drugs and therefore infections caused by P. aeruginosa are frequently life threatening and difficult to treat [4,5] Such multidrug resistance could be due to the slowly growing state of P. aeruginosa in the deeper layers of thick biofilms, which the organism has a tendency to form in many in vivo situations[6] Clinical isolates of Pseudomonas aeruginosa often exhibit multidrug resistance due to their inherent ability to form biofilms. Drug resistance in Pseudomonas aeruginosa is a major clinical problem, especially in the management of patients with nosocomial infections and those who are under indwelling medical devices. The man objective of this study is to evaluate the biofilm forming abilities of the clinical isolates of Pseudomonas aeruginosa and to correlate biofilm formation with multidrug resistance.","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"29 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83425352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical Method Development and Validation for the Estimation of Silodosin and Dutasteride in Capsule Dosage Form by RP-HPLC Method 反相高效液相色谱法测定胶囊剂型中西洛多辛和杜他雄胺含量的分析方法建立及验证

Journal of Drug Metabolism and Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2157-7609.20.11.245

Nataraj Ks, A. Srinivasarao, S. Harshitha, K. Pravallika

{"title":"Analytical Method Development and Validation for the Estimation of Silodosin and Dutasteride in Capsule Dosage Form by RP-HPLC Method","authors":"Nataraj Ks, A. Srinivasarao, S. Harshitha, K. Pravallika","doi":"10.35248/2157-7609.20.11.245","DOIUrl":"https://doi.org/10.35248/2157-7609.20.11.245","url":null,"abstract":"The present article is aimed to develop a new, simple, fast, rapid, accurate, efficient, reproducible, HPLC method for the method development and validation analysis of simultaneous estimation of silodosin and dutasteride capsules RP- HPLC as per ICH guidelines. The analytical method for the method development and validation estimation of silodosin and dutasteride capsules will be developed by RP-HPLC method by optimizing the chromatographic conditions WATERS 2695 separation module.PDA WATERS 2998 detector with the Empower software, Vacuum PR, Vacuum filter, Pump (MERCK), Ultrasonic bath. The developed method was validated based on ICH guidelines to detect and quantitate both silodosin and dutasteride in dosage form with use of HPLC system equipped with PDA detector. The silodosin peak run time is 2.4 min and the dutasteride runtime is 10.9 min, so the 20 min run time was decreased in 14 min run time. The drug silodosin in the concentration range of 20-120 μg/ml and the drug dutasteride in the concentration range of 1.25-7.5 μg/ml, linear regression was not more than 0.999. The linearity range of Silodosin and Dutasteride was found to be HPLC 20-120 μg/ml and 1.25-7.5 μg/ml respectively. The recovery of silodosin and dutasteride capsules was observed in the range of 99.70% to 100.10%. The results show the method was accurate, precise, sensitive, and economic. The HPLC method was more rapid. Method was successfully applied to the pharmaceutical dosage form (Silo Dart capsules).","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"23 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89878955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and Screening of Lactic Acid Bacteria From Fermented Camel Milk For Their Antimicrobial Activity Against Common Pathogens 骆驼发酵乳中乳酸菌的分离及对常见致病菌的抑菌活性研究

Journal of Drug Metabolism and Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2157-7609.20.11.251

A. Cali

{"title":"Isolation and Screening of Lactic Acid Bacteria From Fermented Camel Milk For Their Antimicrobial Activity Against Common Pathogens","authors":"A. Cali","doi":"10.35248/2157-7609.20.11.251","DOIUrl":"https://doi.org/10.35248/2157-7609.20.11.251","url":null,"abstract":"The study was undertaken to isolate and character lactic acid bacteria (LAB) from fermented camel milk and to screen their ability as a probiotic agent. In this research, 12 camel milk samples were collected and a total of 40 isolates were isolated on a MRS and M17 selective Medias. From MRS media, two genera belonging to Lactobacillus and Pediococcus were isolated while M17 media, Lactococcus and Leuconostoc were isolated based on their morphological and biochemical characteristics. Lactobacillus and Lactococcus were divided into two (group A and B) and three (group A, B and C) respectively on the basis of their sugar fermentation pattern of fructose, galactose, glucose, maltose, sorbitol, sucrose and D-xylose. All of LAB isolates were further screened for their antimicrobial activity against E. coli and S.aureus. Based on the zone of inhibition, 9 isolates were selected for further identification using Biolog system: Enterococcus haemoperoxidus and Lactoccus garvieae species were found as LABs. Hence, from these findings the LAB isolate can be used as biological agent against some pathogens. Further studies should be conducted to characterize probiotic properties of LAB and molecular and phenotypic techniques should be employed for species identification of LABs.","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"116 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89309088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methanol Intoxication: The Importance of Early Diagnosis 甲醇中毒:早期诊断的重要性

Journal of Drug Metabolism and Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2157-7609.20.11.248

B. D. A. Iriarte

{"title":"Methanol Intoxication: The Importance of Early Diagnosis","authors":"B. D. A. Iriarte","doi":"10.35248/2157-7609.20.11.248","DOIUrl":"https://doi.org/10.35248/2157-7609.20.11.248","url":null,"abstract":"Methanol intoxication is an unfrequented condition associated with high morbidity that can cause severe metabolic disturbances, blindness, and important neurological dysfunction potentially life-threatening. Therefore, early diagnosis and treatment is required to obtain the best possible result for the patient. Recently, an increase in cases of methanol intoxication has been observed in our environment (50% in the last year) and in our hospital, as in most of them, specific analysis techniques for methanol are not available. That is why in this article we present four recent clinical cases that occurred in our hospital: to analyze the most relevant information derived from the management of these patients and their clinical and laboratory data. Our objective is to develop a valid strategy in order to facilitate obtaining an early diagnosis sometimes difficult to achieve. Due to the potential mortality of this poisoning and the existence of treatment, it is important to recognize methanol intoxication immediately. After analyzing the exposed clinical cases, the results indicated that a high index of suspicion and the presence of metabolic acidosis associated with an elevated anion gap and osmol gap are characteristic findings that allow an early diagnosis. The relationship between the clinician and the analyst has also been fundamental in incorporating these tests into the profile of the intoxicated patient, which has resulted in better patient management and rapid introduction of specific treatment.","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"13 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74342782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium Supplementation in the Prevention of Coronavirus Infections 补充硒预防冠状病毒感染

Journal of Drug Metabolism and Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2157-7609.20.11.246

B. Lipinski

引用次数: 3

Management of Herbicide Induced Methemoglobinemia 除草剂致高铁血红蛋白血症的处理

Journal of Drug Metabolism and Toxicology Pub Date : 2018-05-30 DOI: 10.4172/2157-7609.1000235

V. Sudheer, R. Krishnapriya, N. V. Kumar, R. Umarani

引用次数: 2

Digestion and Our Metabolism 消化和新陈代谢

Journal of Drug Metabolism and Toxicology Pub Date : 2018-04-20 DOI: 10.4172/2157-7609.1000234

Pramod Stephen

{"title":"Digestion and Our Metabolism","authors":"Pramod Stephen","doi":"10.4172/2157-7609.1000234","DOIUrl":"https://doi.org/10.4172/2157-7609.1000234","url":null,"abstract":"Stomach is the main part of the body because by the stomach our whole body gets nutrients. If our stomach gets disturbed, the all body gets disturbed. We know that most of the people suffering from stomach problems, some have gastric problem, some have indigestion, some time vomiting, some time pains and other kind disturbance occurs. \u0000To keep our stomach fit we are taking many kind of medicine, going for consulting doctors and doing research and by research, daily new medicine comes in the market but still we failed to cure our digestive diseases and metabolic disorders by medicine and new problems also occurs day by day. Then we should think that, why this new problems arise and again we are doing research. We never think to solve the problem naturally and change the habits of eating foods, spicy foods, food on time and how much to eat to keep our stomach fit. Due to stomach problem our body gets much kind of diseases. Our body gets disturbance due to our way of leaving, types of food and the way we are eating, Time for the eating and cleanliness also. \u0000Now we see that many kind of metabolic disturbance comes out day by day and we give only substitutes but we fails to cure it and stop the substitutes. It is the time for us to change our eating system and living system to keep our digestive system and metabolism correct.","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85977513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Drug-Drug Interaction Studies of Apixaban with Atorvastatin by HPTLC Method hplc法研究阿哌沙班与阿托伐他汀的体外相互作用

Journal of Drug Metabolism and Toxicology Pub Date : 2018-01-01 DOI: 10.4172/2157-7609.1000241

S. Rk, Ravindran Tk

引用次数: 0