Journal of Cytology and Histology最新文献

{"title":"Tuberculosis Drug Discovery and Development","authors":"Vinayak Singh","doi":"10.37421/2157-7099.21.12.594","DOIUrl":"https://doi.org/10.37421/2157-7099.21.12.594","url":null,"abstract":"","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"50 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73514790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Significance of Fine Needle Aspiration Smear and Cell Block Study in Skin and Subcutaneous Nodules","authors":"Raafat Am Hegazy, Abdelmonem A Hegazy","doi":"10.37421/2157-7099.21.12.593","DOIUrl":"https://doi.org/10.37421/2157-7099.21.12.593","url":null,"abstract":"Background: Evaluation of patients with skin or subcutaneous nodules, especially if it was multiple represents a major problem for the clinicians. But with full investigations, the problem becomes easier. However, the final diagnosis depends on pathological reports of tissue biopsy [1]. The easy access of the skin nodule provides the soil for performance fine needle aspiration cytology and taking the samples by the pathologists, or the clinicians. Smear cytology gives many defaults[2]. Performance of cell blocks was a trial to avoid these defaults and improve the diagnosis. The results of smear and cell block examinations were compared with examination of tissue biopsies. Methodology: Two hundred twenty five skin and subcutaneous nodules from 225 patients underwent the material of this study. The patients were selected from those referred topathology department, faculty of medicine Zagazig University, through the period between January 2018 and December 2020. Fine needle aspirations were performed utilizing the ordinary 22-gaugeneedle 10 cc syringes. Cell blocks were done utilizing the remnants in the syringe after performance of the smears. Histopathological examination was done using biopsies taken later on. Results: According to tissue biopsy examination: Benign lesions constitute the commonest findings (180 cases) 80% 0f cases: Lipoma35 cases (15.5%), Adipose tissue30 cases (13.3%), Fibrolipoma 20 cases (8.8%), Fibroma20 cases (8.8%), Juvenile fibroma 5 cases (2.2%), Neurofibroma 5 cases (2.2%), Sebaceous cyst in 25 cases (11.1%), Implantation cyst, or dermoid cyst 20 cases (8.8%), Pilomatrixoma 5 cases (2.2%), Seborrheic keratosis 10 cases (4.4%), Madura foot (actinomycosis) 5 cases (2.2%). Intermediate lesions: Atypical lipoma 5 cases (2.2%). Malignant lesions 25 cases (11.11%): Basal cell carcinoma10 cases (4.4%), squamous cell carcinoma 10 cases (4.4%), Basosquamous cell carcinoma 5cases (2.2%). For the FNAC smear examination, the sensitivity test was: 83.01%, the specificity test was: 16.66%. For the cell blocks examination, the sensitivity test was: 97.77%, specificity test was: 100%. Conclusion: Smear cytology is an easy, rapid test for diagnosis of skin nodule and performance of cell blocks improves its sensitivity and specificity outcome, but both must be attempted, because smear may be inefficient for some cases while cell block cannot be performed others.","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"31 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79151630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Boundaries in Management of Head & Neck Oncology-Pathologist Role","authors":"L. Agarwal, Manmohan Agrawal","doi":"10.37421/2157-7099.2021.12.579","DOIUrl":"https://doi.org/10.37421/2157-7099.2021.12.579","url":null,"abstract":"Oral cancer is one of the most common cancers prevalent in the world. The outcome of the patient’s treatment depends not only on the stage but also on various prognostic parameters. In this review article, prognostic factors which should be included in pathology report have been summarized.","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"45 1","pages":"0-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82574072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish Cytogenetics: Present / Future","authors":"A. Rossi","doi":"10.37421/2157-7099.2021.12.582","DOIUrl":"https://doi.org/10.37421/2157-7099.2021.12.582","url":null,"abstract":"","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"206 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76965933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Discrepancies between Intraoperative Cytological Frozen Section and Permeant Histopathological Diagnosis of Brain Tumors","authors":"M. Kurdi, Saleh Salem Baeesa, Yazid Maghrabi, A. Bardeesi, R. Saeedi, Taghreed Al-Sinani, A. Samkari, A. Lary","doi":"10.37421/2157-7099.2021.12.585","DOIUrl":"https://doi.org/10.37421/2157-7099.2021.12.585","url":null,"abstract":"Abstract Background: Intraoperative frozen section (IOFS) diagnosis of brain tumours plays an important role in assessing the adequacy of the sample and determining the treatment plan. Objective: To investigate the diagnostic accuracy between IOFS and permanent paraffin-embedded sections in the endpoint of surgery. Method: The authors reviewed the histopathological results of 383 brain tumours, including IOFS and permanent histological diagnosis. The cases were classified into three diagnostic compatibilities (i) Perfect fit; the diagnosis of IOFS was identical to the permanent diagnosis, (ii) Partial compatibility; IOFS diagnosis was not incorrect but was too broad to be considered full compatibility, (iii) Conflict; IOFS diagnosis is completely different from the permanent diagnosis. The permanent diagnosis used as a primary criterion was compared to the IOFS diagnosis and recurrence rate using different statistical methods. Results: The mean age of the whole cases was 37-years with male: female ratio 1:2. Around 84% of the patients underwent craniotomy and tumour resection, while 15% only underwent tumour biopsy. Approximately, 53.8% of the cases revealed perfect matching in the diagnosis between IOFSs and permanent sections, while 16.2% of the cases revealed complete mismatching in the diagnosis between the sections. The remaining 30% of the cases showed partial compatibility in the diagnosis between the two diagnostic methods. There was no significant difference in recurrence rate among all cases of different diagnostic compatibility (P-value= 0.54). Conclusion: There is a diagnostic discrepancy between IOFSs and permanent sections. However, cases that revealed no consensus in the diagnoses showed no negative effect on the patient outcome. Further studies should be conducted to explore the reasons of this conflict in the diagnosis between the two diagnostic methods. Keywords: Brain tumor • Histopathology • Frozen section • Diagnostic compatibility","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"1 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90854769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Cycles of Eukaryotic Microbes","authors":"Catherine J. Merrick","doi":"10.37421/2157-7099.21.12.595","DOIUrl":"https://doi.org/10.37421/2157-7099.21.12.595","url":null,"abstract":"","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"63 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86140255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytology of Soft Tissue Tumors","authors":"V. Iyer","doi":"10.37421/2157-7099.2021.12.578","DOIUrl":"https://doi.org/10.37421/2157-7099.2021.12.578","url":null,"abstract":"","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"27 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89922794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological, Biochemical and Genetic Profile Post Application of Free Silver Nanoparticles and H2O2 Combined Form in Vitro Study","authors":"Adel-El-bialy, A. Mansour, Tamer M. M. Abu-Amara, M. Amer, Rania I Shbel, E. Matar, Mohamed Abulghait, A. Mohamed","doi":"10.37421/2157-7099.2021.12.564","DOIUrl":"https://doi.org/10.37421/2157-7099.2021.12.564","url":null,"abstract":"Current studyaimed to evaluate the antiviral activities of free silver nanoparticles (AgNPs) and hydrogen peroxide combined silver nanoparticles(AgNP-H2O2) compared to standard IFN-α2a against Herpes simplex virus type-1 (HSV-1), Vesicular stomatitis virus (VSV) and Middle East respiratory syndrome-coronavirus (MERS-CoV). The related biochemical and pathological changes as well asthe expression levels of antiviral biomarkers, namely Mx-A and 2'-5'-oligoadenylate synthetase (2'-5'-OAS)were investigated. Cytotoxicity of AgNPs and AgNP-H2O2 was monitored against Vero cellsusing MTT assay. Data revealed that the toxicity was concentration dependent and AgNP-H2O2was significantly (P<0.05)toxicthan AgNPs recording an IC50value of 0.864 and7μM/ml, respectively. Oxidative stress markers showed elevated reactive oxygen species and decreased lactate dehydrogenase post treatment with AgNPs and AgNP-H2O2 compared to untreated cellcontrol. Assessment of the antiviral activity of tested particles prior to infection showed thatAgNP-H2O2exhibited higher reduction in the viralinfectivity titer in the order of 76.21% and 57.89% compared to that recorded post infection (34.11% and 36.84%) against HSV-1 and VSV, respectively. Similar pattern was observed in case of AgNPs but with lower depletion rate while, the highest depletion was in case of IFN-α2a. The percentage reduction in the plaque forming units against MERS-CoV were 33.3%, 66.6% and 87.5% post treatment with AgNPs, AgNP-H2O2 and IFN-α2a, respectively.MxA and2'-5'-OAS genes exhibited a signifinat (P<0.05) up-regrulationin. Pathological changes post treatment with tested particles showed signs of apoptosis indicating that although these particles exhibited promising antiviralpotentials, buttheir toxicity profile should be considered.","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"12 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75026424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Medicine for Diabetes: Beyond Stem Cell Approach","authors":"A. Peloso","doi":"10.37421/2157-7099.2021.12.588","DOIUrl":"https://doi.org/10.37421/2157-7099.2021.12.588","url":null,"abstract":"","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79789560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Regeneration: A Role of Stem Cells","authors":"S. Kimura","doi":"10.37421/2157-7099.21.12.589","DOIUrl":"https://doi.org/10.37421/2157-7099.21.12.589","url":null,"abstract":"Many tissues if not all are thought to contain undifferentiated cells that are answerable for recovery and fix of the tissue after injury. Dysregulation of tissue recovery might bring about different obsessive conditions, among which malignant growth is the most broadly considered. Remarkably, the supposed malignancy undifferentiated organisms or tumor-starting cells, have been concentrated to comprehend the components of carcinogenesis and additionally metastasis. In any case, the idea of disease immature microorganisms, not to mention typical stem/forebear cells, especially those of the thyroid remaining parts subtle. There stays a hole in information between grown-up thyroid stem/forebear cells and disease immature microorganisms of the thyroid, and if as well as how they are identified with one another. Comprehension of the component for thyroid recovery and method of investment of typical grown-up thyroid stem/forebear cells in this cycle will ideally yield a more complete comprehension of the idea of thyroid malignant growth foundational microorganisms, as well as assist with understanding the pathogenesis of other thyroid sicknesses. This audit sums up the current comprehension of grown-up thyroid stem/begetter cells, with specific accentuation on how they add to thyroid recovery.","PeriodicalId":15528,"journal":{"name":"Journal of Cytology and Histology","volume":"8 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82215593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}