Journal of Clinical Neurophysiology最新文献

{"title":"EEG Revisited-Neuronal, Glial, and Network Mechanisms Across Scales.","authors":"Jan Kudlacek, Christos Panagiotis Lisgaras, John G R Jefferys, Marco de Curtis, Piotr Suffczynski, Premysl Jiruska","doi":"10.1097/WNP.0000000000001259","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001259","url":null,"abstract":"<p><strong>Summary: </strong>Electroencephalography (EEG) has been providing a window into human brain activity for nearly a century, yet its interpretation often remains empirical rather than mechanistic. This review revisits the cellular and biophysical foundations of EEG through a modern perspective, integrating advances from neurophysiology, computational modeling, and cellular neuroscience. We examine the fundamental physics of EEG generation, from transmembrane currents and dipole formation to the spatial summation. Electroencephalography results from coordinated cellular and network activity, reflecting the integrated contributions of excitatory and inhibitory synaptic events, intrinsic conductances, and tissue geometry, with pyramidal neurons acting as dominant generators, while interneurons play a role in rhythmogenesis and oscillatory coupling. Expanding beyond traditional Berger frequencies, we highlight the significance of high-frequency oscillations and the underlying cellular and network mechanisms that generate the high-frequency component of the EEG signal. Conversely, infra-slow fluctuations and direct current shifts reveal the roles of glial networks, ionic homeostasis, and spreading depolarizations in health and disease. Across these domains, EEG uniquely captures neural activity from submillisecond events to long-term state changes spanning days or years, offering an unparalleled temporal range for studying the human brain. Clinically, this multiscale capacity underpins the emergence of EEG-based biomarkers for epilepsy, psychiatric disorders, and disorders of consciousness, while guiding development of closed-loop neuromodulation and precision medicine strategies. With technological advances and the expanding field of machine learning, the role of EEG will continue to expand as we will gain deeper insights into its underlying mechanisms.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148329960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding of Rapid Ictal Blinking: Definition Criteria, Prevalence, and Localizing Value.","authors":"Saeideh Salehizadeh, Suraj Thyagaraj, Neel Fotedar, Naiara Garcia-Losarcos, Hans Lüders","doi":"10.1097/WNP.0000000000001248","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001248","url":null,"abstract":"<p><strong>Purpose: </strong>Ictal blinking is an undefined phenomenon of involuntary bilateral blinks during a seizure, at a higher frequency than baseline blinking that is not associated with other facial motor manifestations. In most reports, the epileptogenic zone has been identified in the occipital regions. The purpose of this study is to characterize ictal blinking and assess its potential localizing value.</p><p><strong>Method: </strong>EEG and EOG data from 45 patients with seizures from temporal, occipito-parietal, and fronto-central regions (15 per group) were analyzed. Blinks were quantified in 15-second epochs during ictal and baseline phases. Baseline duration matched the ictal phase or extended to 150 seconds. RIB is defined as the blinking rate at least 50% greater than the average baseline blinking during any ictal window. The ictal blinking rate ratio (BRR) was also calculated for each group, defined as the ratio of maximum ictal blinks to average baseline blinks. Ictal blink suppression (BS) was defined as no blinks in the first 30 seconds of a seizure.</p><p><strong>Results: </strong>The average blinking frequency during the baseline period was four blinks every 15-second page. The average ictal blinks for patients who met the criteria for RIB were seven per 15-second page. RIB occurs most frequently in temporal epilepsy (73%) and less commonly in frontal epilepsy (47%). Ictal BRR is highest (5.6) in occipital epilepsy. Ictal BS occurred in 22% of cohort.</p><p><strong>Conclusions: </strong>RIB is a frequent ictal phenomenon without significant localizing value. Ictal BRR was significantly higher for patients with occipital seizures. Based on the findings, a practical definition for RIB was proposed: seven or more blinks in any 15-second epoch during seizure.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Feasibility of Transcranial Motor-Evoked Potentials During Intraoperative Neurophysiologic Monitoring in Patients With Deep Brain Stimulators.","authors":"Nicholas Meyers, Mark Keroles, Sungho Charles Cho, Rohit Gummi, Scheherazade Le, Leslie Lee, Viet Nguyen, Ankita Tippur, Jaime R López, Felix Chang","doi":"10.1097/WNP.0000000000001249","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001249","url":null,"abstract":"<p><strong>Purpose: </strong>Transcranial motor-evoked potentials (TcMEPs) are routinely used for intraoperative neurophysiologic monitoring to assess corticospinal tract integrity. However, data regarding the use of TcMEPs in patients with implanted deep brain stimulator (DBS) devices remain limited. This study aims to evaluate the safety and feasibility of TcMEP monitoring in patients with implanted DBS systems undergoing a variety of surgical procedures.</p><p><strong>Methods: </strong>A retrospective review was conducted using clinical and neurophysiologic data from patients with DBS devices who underwent surgery with TcMEP monitoring at a single institution between 2014 and 2024. Patient demographics, surgical and device information, TcMEP stimulation parameters, and intraoperative neurophysiologic monitoring documentation, as well as intraoperative and postoperative clinical notes were reviewed.</p><p><strong>Results: </strong>Sixteen patients were identified who underwent 19 surgical procedures with TcMEP monitoring. Reliable TcMEP signals were successfully obtained in all patients across a variety of surgical procedures, DBS targets, and stimulation parameters (80-520 V, 147-1,388 mA). No TcMEP-related intraoperative or postoperative complications were identified, and DBS device functionality remained preserved. However, active DBS stimulation during surgery generated electrical artifacts that interfered with other intraoperative neurophysiologic monitoring modalities, including somatosensory evoked potentials and EEG (electroencephalogram).</p><p><strong>Conclusions: </strong>Transcranial motor-evoked potentials monitoring is safe and feasible in patients with implanted DBS devices undergoing a variety of surgical procedures. Standard TcMEP stimulation parameters can be implemented without significant modification. To minimize interference with multimodal intraoperative neurophysiologic monitoring, DBS devices should be turned off during monitoring. Further studies are needed to establish standardized guidelines for TcMEP monitoring in patients with DBS and other intracranial neurostimulation devices.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Call for the Inclusion of Standardized Filter Parameters in the ACNS Standardized Critical Care EEG Terminology.","authors":"Fábio A Nascimento, Lawrence J Hirsch, Peter W Kaplan, Aatif Husain, Donald Schomer, Sándor Beniczky","doi":"10.1097/WNP.0000000000001180","DOIUrl":"10.1097/WNP.0000000000001180","url":null,"abstract":"","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"366-367"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of Neural Activity in the Upper and Middle Lumbar Spine Using Magnetospinography After Lateral Femoral Cutaneous, Saphenous, and Femoral Nerve Stimulation.","authors":"Hisato Higashikawa, Jun Hashimoto, Yuta Tanaka, Toru Sasaki, Hiroaki Onuma, Satoru Egawa, Yu Matsukura, Takashi Hirai, Yuko Hoshino, Taishi Watanabe, Yuki Miyano, Saeri Kaminaka, Yusuke Yamamoto, Yoshiaki Adachi, Miho Akaza, Shigenori Kawabata, Toshitaka Yoshii","doi":"10.1097/WNP.0000000000001219","DOIUrl":"10.1097/WNP.0000000000001219","url":null,"abstract":"<p><strong>Purpose: </strong>Magnetospinography provides a noninvasive and detailed visualization of neural currents. We previously reported that magnetospinography can be used to evaluate neural function in the lower lumbar spine in response to tibial, peroneal, and sciatic nerve stimulation. However, evaluating the neural function of the upper and middle lumbar spine is often difficult due to lower current intensity. We aimed to visualize the neural activity of the upper and middle lumbar spine using new stimulation methods and assess the foraminal current.</p><p><strong>Methods: </strong>Neural magnetic fields in 10 healthy volunteers were recorded after stimulation of the lateral femoral cutaneous nerve, saphenous nerve, femoral nerve, and peroneal nerve. The conduction velocity and current intensity in the spinal canal and intervertebral foramen were calculated and compared for each type of nerve stimulation.</p><p><strong>Results: </strong>Magnetospinography visualized the evoked magnetic fields in the lumbar region after each nerve stimulation method in all volunteers. The current intensity in the upper lumbar spine was significantly greater after femoral nerve stimulation. Magnetospinography revealed that action current flowed mainly along the L2 nerve root after lateral femoral cutaneous nerve stimulation and the L4 nerve root after saphenous nerve stimulation.</p><p><strong>Conclusions: </strong>Using a new stimulation method, magnetospinography enabled the noninvasive visualization of neural currents in the upper and middle lumbar spine. Femoral nerve stimulation is suitable for evaluating the spinal canal of the upper lumbar spine, and lateral femoral cutaneous nerve and saphenous nerve stimulations are suitable for evaluating the upper and middle lumbar intervertebral foramina, respectively.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"332-339"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Obstructive Sleep Apnea and Autonomic Failure.","authors":"Renata Maria de Carvalho Cremaschi, Fernando Morgadinho Santos Coelho, Sasha Moran, Chun-Yu Lee, Milena Pavlova, Peter Novak","doi":"10.1097/WNP.0000000000001216","DOIUrl":"10.1097/WNP.0000000000001216","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate daytime autonomic dysregulation in patients with obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>This retrospective study was conducted at Brigham and Women's Faulkner Hospital Autonomic Laboratory and evaluated adult patients with a history of orthostatic intolerance and sleep disturbances who completed autonomic testing (deep breathing test, Valsalva maneuver, tilt test) and polysomnography between 2018 and 2024. The Quantitative Scale for Grading of Cardiovascular Autonomic Reflex Tests scoring instrument graded autonomic tests and skin biopsies for the assessment of small fibers. The apnea-hypopnea index was used to assess OSA severity.</p><p><strong>Results: </strong>In total, 138 patients were evaluated in this study. Subjects with OSA (43 with mild and 29 with moderate/severe OSA) were compared with 66 subjects without OSA. Age, body mass index, and the prevalence of hypertension increased with the severity of sleep apnea. At least moderate autonomic failure was identified in 60% of patients without OSA and in 78% of those with OSA. Autonomic failure score was proportional to the severity of OSA (autonomic failure scores: no OSA 4.2 ± 2.54, mild OSA 5.44 ± 3.41, moderate/severe OSA 8.1 ± 4.3, P < 0.001). Small fiber neuropathy was found in 41.8% of patients without OSA and in 70.8% of patients with moderate/severe OSA.</p><p><strong>Conclusions: </strong>Autonomic failure associated with small fiber autonomic neuropathy is common in patients with OSA, and the degree of autonomic failure is proportional to the severity of sleep apnea. Autonomic failure can be an additional risk factor contributing to the cardiovascular complications observed in OSA.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"356-365"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Electrophysiologic Features of Ulnar Neuropathy at the Wrist: Analysis of 150 Consecutive Cases.","authors":"Federica Ginanneschi, Marianna Curcio, Alessandro Aretini, Mauro Mondelli","doi":"10.1097/WNP.0000000000001211","DOIUrl":"10.1097/WNP.0000000000001211","url":null,"abstract":"<p><strong>Purpose: </strong>To report clinical and electrodiagnostic (EDX) findings in ulnar neuropathy at the wrist (UNW).</p><p><strong>Methods: </strong>This is a monocentric study. We collected demographic and clinical data, history, symptom type, neurologic examination findings, EDX results, as well as causes and risk factors of UNW.</p><p><strong>Results: </strong>We enrolled 150 consecutive cases. Based on EDX findings, the most common UNW pattern involved the ulnar nerve at the entrance of Guyon canal, prior to its bifurcation into sensory and motor branches (44% of cases). We identified atypical topographic lesions involving the superficial sensory branch and motor fibers innervating the hypothenar (4.7% of cases) or the interossei muscles (12.8% of cases). The most frequent causes were compressive (20.7%) and traumatic (22%), mainly affecting males, blue-collar workers, and individuals aged ≤60 years. Ganglion was prevalent in females (66.7%). Cases of UNW with unknown etiology were significantly associated with age >60 years, the presence of muscle atrophy, and a history of carpal tunnel syndrome (CTS).</p><p><strong>Conclusions: </strong>Clinical and EDX characteristics of UNW depend on injury site at wrist or hand palm. It is not possible to determine the cause with certainty based solely on the type, although some causes tend to affect specific sites of nerve injury. The coexistence of Guyon canal syndrome and CTS is confirmed to be a fairly frequent finding. The awareness of the ulnar nerve anatomical variations should not lead to the exclusion of UNW if EDX abnormalities do not fall into any of the five classical types according to Wu's classification.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"347-355"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"24-Hour Video EEG in the Evaluation of the Seizure-Free Patient Before Antiseizure Medication Withdrawal.","authors":"Areej Nauman, Ahamed Lazim Vattoth, Gayane Melikyan, Musab Ali, Yaser Othman, Boulenouar Mesraoua, Hasan Al Hail, Soha Roger Dargham, Farhana Khan, Abdulraheem Alrabi, Ziyad Mahfoud, Naim Haddad","doi":"10.1097/WNP.0000000000001212","DOIUrl":"10.1097/WNP.0000000000001212","url":null,"abstract":"<p><strong>Purpose: </strong>In patients with epilepsy who achieve seizure freedom, physicians may consider discontinuing antiseizure medications, often using EEG beforehand to guide the decision. This study evaluates the gain in detection of epileptiform discharges (EDs) in 24-hour video EEG (VEEG) monitoring in seizure-free patients.</p><p><strong>Methods: </strong>The authors identified patients with epilepsy who were seizure free on antiseizure medications and had undergone 24-hour VEEG after an unrevealing routine EEG. The authors evaluated the yield and latency of observed EDs in the VEEG study. The authors compared the rate of ED detection during the first 60 minutes versus later in the recording.</p><p><strong>Results: </strong>Of the 27 patients, aged 19 to 51 years, 10 (37%) exhibited EDs on 24-hour VEEG. The latency to the first EDs ranged from 52 to 748 minutes, with a median of 164 minutes. Nine of these 10 patients (90%) had their EDs appear only after the first 60 minutes of recording. In other words, prolonging the EEG beyond 1 hour yielded an additional 33.3% of patients with EDs that a 1-hour recording would have missed. Younger age and presence of EDs on a past EEG were predictive of the presence of EDs on VEEG ( P = 0.040 and P = 0.039 respectively).</p><p><strong>Conclusions: </strong>The results suggest that 24-hour VEEG is more sensitive in detecting EDs than routine EEG in seizure-free patients and thus may be superior in individualized risk assessments for seizure recurrence on potential antiseizure medication discontinuation.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"283-288"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdural Stimulation for the Identification of a Dehiscent Geniculate Ganglion in Intradural Middle Cranial Fossa Surgery: A Proof-of-Principle Study.","authors":"Sebastian Niedermeyer, Andrea Szelenyi, Christian Schichor","doi":"10.1097/WNP.0000000000001204","DOIUrl":"10.1097/WNP.0000000000001204","url":null,"abstract":"<p><strong>Purpose: </strong>Facial nerve injury is a potential complication in intradural middle cranial fossa surgery, particularly because of dehiscence of the geniculate ganglion, exposing the nerve to thermal injury. Identifying the geniculate ganglion during surgical approaches is crucial for preserving facial nerve function. This study aimed to evaluate the feasibility and efficacy of transdural stimulation in identifying the geniculate ganglion during intradural approaches to improve the preservation of facial nerve function.</p><p><strong>Methods: </strong>We conducted a retrospective analysis on patients who underwent surgery for middle cranial fossa lesions using intraoperative neuromonitoring including facial motor evoked potentials and transdural direct nerve stimulation of the geniculate ganglion, from January 2016 to January 2024.</p><p><strong>Results: </strong>We identified eight consecutive patients with various pathologies of the middle cranial fossa who underwent surgery with direct nerve stimulation of the geniculate ganglion. Specific responses from facial muscles were registered in four out of eight patients, with stimulation intensity varying between 0.5 and 2 mA. None of the patients who underwent surgery with direct nerve stimulation experienced facial palsy. Notably, even when CT scans suggested bony covering of the geniculate ganglion, the facial nerve could still be stimulated.</p><p><strong>Conclusions: </strong>This proof-of-principle study demonstrates that transdural stimulation is a promising technique for identifying the geniculate ganglion during intradural middle cranial fossa surgery. This approach has the potential to improve preservation of facial nerve function and reduce the risk of postoperative facial palsy.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"319-323"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language Mapping by Magnetoencephalography in Patients With Refractory Epilepsy: A Cohort Study.","authors":"Vatsala Lakshmi, Ravindrandh Chowdary Mundlamuri, Mariyappa Narayanan, Rajasekaran Aravind Kumar, Kenchaiah Raghavendra, Ajay Asranna, Lakshminarayanapuram Gopal Vishwanathan, Karthik Kulanthaivelu, Jitender Saini, Rose Dawn Bharath, Sanjib Sinha","doi":"10.1097/WNP.0000000000001215","DOIUrl":"10.1097/WNP.0000000000001215","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop and validate magnetoencephalography paradigms for presurgical language mapping in patients with drug-resistant epilepsy.</p><p><strong>Methods: </strong>This prospective observational study of 30 patients with drug-resistant epilepsy included two trials involving visual picture naming and auditory word recognition tasks. Language activation was analyzed using dynamic statistical parametric mapping for beta desynchronization and a fixed time window (350-500 ms). Concordance across trials, analysis methods, and functional MRI comparisons were also assessed.</p><p><strong>Results: </strong>Primary visual and auditory cortex activation occurred in 66.6 and 80% of the patients, respectively. Language-specific area activation was observed in 56.7% of the picture naming task patients and 70% of the auditory word recognition task patients. Lateralization was predominantly left sided in 41.1% (picture naming) and 61.9% (auditory word recognition) of cases, with some bihemispheric patterns. Beta desynchronization and fixed-time window analyses had comparable detection rates but with limited concordance. Magnetoencephalography-functional MRI lateralization agreement was 56.25% (Cohen kappa = 0.15). No significant correlations were found between the epilepsy parameters and language activation.</p><p><strong>Conclusions: </strong>Magnetoencephalography provides valuable insights into language localization and functional reorganization in patients with epilepsy. Although task-specific activations highlight their utility, further studies with larger cohorts and gold-standard validations are needed to enhance their clinical applicability in presurgical planning.</p>","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"305-312"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}