Journal of Clinical Anesthesia最新文献

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Minimally-invasive tracheostomy (MIT): A care bundle for safety improvement in high-risk critically ill patients 微创气管造口术(MIT):提高高危重症患者安全性的护理包
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-21 DOI: 10.1016/j.jclinane.2024.111631
Dennis Christoph Harrer , Patricia Mester , Clara-Larissa Lang , Tanja Elger , Tobias Seefeldt , Lorenz Wächter , Judith Dönz , Nina Doblinger , Muriel Huss , Georgios Athanasoulas , Lea U. Krauß , Johannes Heymer , Wolfgang Herr , Tobias Schilling , Stephan Schmid , Martina Müller , Vlad Pavel
{"title":"Minimally-invasive tracheostomy (MIT): A care bundle for safety improvement in high-risk critically ill patients","authors":"Dennis Christoph Harrer ,&nbsp;Patricia Mester ,&nbsp;Clara-Larissa Lang ,&nbsp;Tanja Elger ,&nbsp;Tobias Seefeldt ,&nbsp;Lorenz Wächter ,&nbsp;Judith Dönz ,&nbsp;Nina Doblinger ,&nbsp;Muriel Huss ,&nbsp;Georgios Athanasoulas ,&nbsp;Lea U. Krauß ,&nbsp;Johannes Heymer ,&nbsp;Wolfgang Herr ,&nbsp;Tobias Schilling ,&nbsp;Stephan Schmid ,&nbsp;Martina Müller ,&nbsp;Vlad Pavel","doi":"10.1016/j.jclinane.2024.111631","DOIUrl":"10.1016/j.jclinane.2024.111631","url":null,"abstract":"<div><h3>Background</h3><p>Detailed reports are scarce on minimally-invasive tracheostomy (MIT) techniques for critically ill patients with challenging anatomy or complex coagulopathies. In such high-risk patients, conventional percutaneous dilatational tracheostomy (PDT) may lead to severe complications.</p></div><div><h3>Methods</h3><p>Aiming to broaden the scope of MIT for patients previously excluded due to high risks, we developed a new care bundle (MIT technique), specifically designed for intensive care specialists. Our study examined the outcomes of MIT in 32 high-risk patients treated in an ICU of a University Hospital with specific focus on gastrointestinal and liver diseases.</p></div><div><h3>Results</h3><p>We have modified the conventional PDT technique by incorporating an initial skin incision, blunt dissection, diaphanoscopy-guided probe puncture, and continuous bronchoscopic monitoring. Our care bundle also introduces an anterolateral approach for tracheal entry, a significant advancement for patients with complex neck anatomy or dense vasculature, where an anterolateral trajectory avoids midline blood vessels. This enhanced method has proven to be safer than traditional PDT, with a notable absence of post-procedural hemorrhages, cannula misplacements, or infections.</p></div><div><h3>Conclusion</h3><p>The use of our refined care bundle enabled swift minimally-invasive tracheostomy in high-risk patients without the occurrence of serious complications.</p></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111631"},"PeriodicalIF":5.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952818024002605/pdfft?md5=73c90f2ccff19bd45f4af267857f346f&pid=1-s2.0-S0952818024002605-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor regarding “Assessing different brain oxygenation components in elderly patients under propofol or sevoflurane anesthesia: A randomized controlled study” 致编辑的信,内容涉及 "评估异丙酚或七氟醚麻醉下老年患者的不同脑氧合成分:随机对照研究"
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-21 DOI: 10.1016/j.jclinane.2024.111634
Guanyu Yang, Qinjun Chu
{"title":"Letter to the editor regarding “Assessing different brain oxygenation components in elderly patients under propofol or sevoflurane anesthesia: A randomized controlled study”","authors":"Guanyu Yang,&nbsp;Qinjun Chu","doi":"10.1016/j.jclinane.2024.111634","DOIUrl":"10.1016/j.jclinane.2024.111634","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111634"},"PeriodicalIF":5.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulated bupivacaine pharmacokinetics after labor epidural analgesia followed by transversus abdominis plane block with liposomal bupivacaine for intrapartum cesarean delivery 分娩硬膜外镇痛后使用脂质体布比卡因进行腹横肌平面阻滞以进行产内剖宫产的模拟布比卡因药代动力学研究
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-21 DOI: 10.1016/j.jclinane.2024.111589
Daniel Katz MD , Jia Song MS , Matthew Carangelo PharmD , Timothy Bergsma PhD , Roy Winston MD , Ruth Landau MD
{"title":"Simulated bupivacaine pharmacokinetics after labor epidural analgesia followed by transversus abdominis plane block with liposomal bupivacaine for intrapartum cesarean delivery","authors":"Daniel Katz MD ,&nbsp;Jia Song MS ,&nbsp;Matthew Carangelo PharmD ,&nbsp;Timothy Bergsma PhD ,&nbsp;Roy Winston MD ,&nbsp;Ruth Landau MD","doi":"10.1016/j.jclinane.2024.111589","DOIUrl":"10.1016/j.jclinane.2024.111589","url":null,"abstract":"<div><h3>Study Objective</h3><p>To simulate bupivacaine pharmacokinetics in scenarios of labor epidural analgesia (LEA) extended for intrapartum cesarean delivery (CD) with epidural or intrathecal boluses, followed by transversus abdominis plane (TAP) block with liposomal bupivacaine (LB) for postcesarean analgesia.</p></div><div><h3>Design</h3><p>Bupivacaine plasma concentrations were simulated using a 2-compartment distribution model fit to previous study data.</p></div><div><h3>Setting</h3><p>Virtual pharmacokinetic simulations.</p></div><div><h3>Patients</h3><p>Virtual individuals (1000, each scenario) had uniform weight (80 kg) but varying absorption parameters.</p></div><div><h3>Interventions</h3><p>The 6 scenarios varied in LEA infusion duration (6 or 24 h), local anesthetic used for bolus to extend LEA (epidural lidocaine or intrathecal bupivacaine), TAP block regimen, and time between bolus and TAP block.</p></div><div><h3>Measurements</h3><p>Scenario outcomes included geometric mean (GM) peak bupivacaine plasma concentration (C<sub>max</sub>) with 95% prediction interval (PI), median (range) C<sub>max</sub>, and number of virtual individuals (per 1000) with C<sub>max</sub> reaching estimated toxicity thresholds (neurotoxicity: 2000 μg/L; cardiotoxicity: 4000 μg/L).</p></div><div><h3>Main Results</h3><p>In simulated scenarios of LEA infusion for 24 h with an epidural bolus of lidocaine 400 mg for CD followed 1 h later by TAP block, the GM C<sub>max</sub> for the scenarios with TAP blocks including either LB 266 mg plus bupivacaine hydrochloride 52 mg or bupivacaine hydrochloride 104 mg was 1860 (95% PI, 1107–3124) and 1851 (95% PI, 1085–3157) μg/L, respectively. Among 1000 virtual individuals for each scenario, 404 and 401 had C<sub>max</sub> reaching 2000 μg/L, respectively; 1 and 0 had C<sub>max</sub> reaching 4000 μg/L, respectively. For other scenarios, GM C<sub>max</sub> remained &lt;1000 μg/L.</p></div><div><h3>Conclusions</h3><p>Across 6 different simulations of TAP blocks for intrapartum CD analgesia, LEA with bupivacaine (with or without boluses for extension and including a conservative modeling of lidocaine without epinephrine), followed by TAP block with LB and/or bupivacaine hydrochloride 0, 1, or 2 h after CD, is unlikely to result in bupivacaine plasma concentrations reaching local anesthetic systemic toxicity thresholds in healthy patients.</p></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111589"},"PeriodicalIF":5.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952818024002186/pdfft?md5=f1d5494a994edd8d9960ef488f753444&pid=1-s2.0-S0952818024002186-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor regarding “Efficacy of bilateral catheter superficial parasternal intercostal plane blocks using programmed intermittent bolus for opioid-sparing postoperative analgesia in cardiac surgery with sternotomy: A randomized, double-blind, placebo-controlled trial” 致编辑的信,内容涉及 "在胸骨切开术的心脏手术中使用双侧导管浅胸骨旁肋间平面阻滞和程序化间歇栓剂进行阿片类药物术后镇痛的疗效:随机、双盲、安慰剂对照试验"
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-20 DOI: 10.1016/j.jclinane.2024.111630
Fu-Shan Xue MD, Dao-Yi Lin MD, Xiao-Chun Zheng MD
{"title":"Letter to the editor regarding “Efficacy of bilateral catheter superficial parasternal intercostal plane blocks using programmed intermittent bolus for opioid-sparing postoperative analgesia in cardiac surgery with sternotomy: A randomized, double-blind, placebo-controlled trial”","authors":"Fu-Shan Xue MD,&nbsp;Dao-Yi Lin MD,&nbsp;Xiao-Chun Zheng MD","doi":"10.1016/j.jclinane.2024.111630","DOIUrl":"10.1016/j.jclinane.2024.111630","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111630"},"PeriodicalIF":5.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: “Efficacy of bilateral catheter superficial parasternal intercostal plane blocks using programmed intermittent bolus for opioid-sparing postoperative analgesia in cardiac surgery with sternotomy: A randomized, double-blind, placebo-controlled trial” 评论"双侧导管浅胸骨旁肋间平面阻滞使用程序化间歇栓剂用于胸骨切开术心脏手术术后阿片类药物稀释镇痛的疗效:随机、双盲、安慰剂对照试验"
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-20 DOI: 10.1016/j.jclinane.2024.111635
Xu-Nian Lin , Yu-Pin Huang , Cheng-Wei Lu
{"title":"Comment on: “Efficacy of bilateral catheter superficial parasternal intercostal plane blocks using programmed intermittent bolus for opioid-sparing postoperative analgesia in cardiac surgery with sternotomy: A randomized, double-blind, placebo-controlled trial”","authors":"Xu-Nian Lin ,&nbsp;Yu-Pin Huang ,&nbsp;Cheng-Wei Lu","doi":"10.1016/j.jclinane.2024.111635","DOIUrl":"10.1016/j.jclinane.2024.111635","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111635"},"PeriodicalIF":5.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erector spinae plane block for postoperative analgesia after laparoscopic nephrectomy 腹腔镜肾切除术后用于术后镇痛的脊柱后凸平面阻滞术
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-20 DOI: 10.1016/j.jclinane.2024.111629
Zhongpeng Sun MD
{"title":"Erector spinae plane block for postoperative analgesia after laparoscopic nephrectomy","authors":"Zhongpeng Sun MD","doi":"10.1016/j.jclinane.2024.111629","DOIUrl":"10.1016/j.jclinane.2024.111629","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111629"},"PeriodicalIF":5.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New set of indicators with consensus definition for anaesthesia-related severe morbidity: A scoping review followed by a Delphi study 麻醉相关严重发病率的一套新指标与共识定义:范围审查后的德尔菲研究
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-17 DOI: 10.1016/j.jclinane.2024.111626
Marie-Pierre Bonnet , Perrine Guckert , Cécile Boccara , Chafia Daoui , Hélène Beloeil , on behalf of the SFAR research network
{"title":"New set of indicators with consensus definition for anaesthesia-related severe morbidity: A scoping review followed by a Delphi study","authors":"Marie-Pierre Bonnet ,&nbsp;Perrine Guckert ,&nbsp;Cécile Boccara ,&nbsp;Chafia Daoui ,&nbsp;Hélène Beloeil ,&nbsp;on behalf of the SFAR research network","doi":"10.1016/j.jclinane.2024.111626","DOIUrl":"10.1016/j.jclinane.2024.111626","url":null,"abstract":"<div><h3>Study objective</h3><p>Monitoring anaesthesia-related severe morbidity constitutes a good opportunity for assessing quality and safety of care in anaesthesia. Several recent studies attempted to describe and define indicators for anaesthesia-related severe morbidity with limitations: no formal experts' consensus process, overlap with surgical complications, no consensual definitions, inapplicability in clinical practice. The aim of this study was to provide a set of indicators for anaesthesia-related severe morbidity based on outcomes and using clinically useful consensual definitions.</p></div><div><h3>Design</h3><p>1/ scoping review of studies published in 2010–2021 on outcomes of anaesthesia-related severe morbidity with different definitions;</p><p>2/ International experts' consensus on indicators for anaesthesia-related severe morbidity with specific definitions using a Delphi process.</p></div><div><h3>Main results</h3><p>After including 142 studies, 68 outcomes for anaesthesia-related severe morbidity were identified and organized in 34 indicators divided into 8 categories (cardiovascular, respiratory, sepsis, renal, neurological, medication error, digestive and others). The indicators were then submitted to the experts. After 2 Delphi rounds, the 26 indicators retained by the experts with their corresponding consensual definition were: acute heart failure, cardiogenic shock, acute respiratory distress syndrome, pulmonary embolism and thrombosis, bronchospasm or laryngospasm, pneumonia, inhalation pneumonitis, pneumothorax, difficult or impossible intubation, atelectasis, self-extubation or accidental extubation, sepsis or septic shock, transient ischemic attack, postoperative confusion or delirium, post-puncture headache, medication error, liver failure, unplanned intensive care unit admission, multiple-organ failure.</p></div><div><h3>Conclusions</h3><p>This study provides a new consensual set of indicators for anaesthesia-related severe morbidity with specific definitions, that could be easily applied in clinical practice as in research.</p></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111626"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952818024002551/pdfft?md5=be8df1715f6454db5d6d33e288b2039a&pid=1-s2.0-S0952818024002551-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased adoption of video laryngoscopy and the decrease in ‘difficult airway’ through the COVID-19 pandemic: A retrospective study 通过 COVID-19 大流行,视频喉镜的采用率增加,"困难气道 "减少:回顾性研究
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-17 DOI: 10.1016/j.jclinane.2024.111607
Matthew T. Hunter (MD) , David W. Boorman (MS) , Danielle McFarlane (MD) , Thanayi Barone Smith (MD)
{"title":"Increased adoption of video laryngoscopy and the decrease in ‘difficult airway’ through the COVID-19 pandemic: A retrospective study","authors":"Matthew T. Hunter (MD) ,&nbsp;David W. Boorman (MS) ,&nbsp;Danielle McFarlane (MD) ,&nbsp;Thanayi Barone Smith (MD)","doi":"10.1016/j.jclinane.2024.111607","DOIUrl":"10.1016/j.jclinane.2024.111607","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111607"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor, “Effects of esketamine on postoperative negative emotions and early cognitive disorders in patients undergoing non-cardiac thoracic surgery: A randomized controlled trial” 致编辑的信,"艾司氯胺酮对非心脏胸外科手术患者术后负面情绪和早期认知障碍的影响:随机对照试验
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-17 DOI: 10.1016/j.jclinane.2024.111610
Uzay Cagatay, Mahindra Bandari
{"title":"Letter to the editor, “Effects of esketamine on postoperative negative emotions and early cognitive disorders in patients undergoing non-cardiac thoracic surgery: A randomized controlled trial”","authors":"Uzay Cagatay,&nbsp;Mahindra Bandari","doi":"10.1016/j.jclinane.2024.111610","DOIUrl":"10.1016/j.jclinane.2024.111610","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111610"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of intravenous steroids on subjective recovery quality after surgery: A meta-analysis of randomized clinical trials 静脉注射类固醇对术后主观恢复质量的影响:随机临床试验荟萃分析
IF 5 2区 医学
Journal of Clinical Anesthesia Pub Date : 2024-09-17 DOI: 10.1016/j.jclinane.2024.111625
Kuo-Chuan Hung , Li-Chen Chang , Chun-Ning Ho , Jheng-Yan Wu , Chih-Wei Hsu , Chien-Ming Lin , I-Wen Chen
{"title":"Impact of intravenous steroids on subjective recovery quality after surgery: A meta-analysis of randomized clinical trials","authors":"Kuo-Chuan Hung ,&nbsp;Li-Chen Chang ,&nbsp;Chun-Ning Ho ,&nbsp;Jheng-Yan Wu ,&nbsp;Chih-Wei Hsu ,&nbsp;Chien-Ming Lin ,&nbsp;I-Wen Chen","doi":"10.1016/j.jclinane.2024.111625","DOIUrl":"10.1016/j.jclinane.2024.111625","url":null,"abstract":"<div><h3>Study objective</h3><p>Quality of postoperative recovery is a crucial aspect of perioperative care. This meta-analysis aimed to evaluate the efficacy of intravenous steroids in improving the quality of recovery (QoR) after surgery, as measured by validated QoR scales.</p></div><div><h3>Design</h3><p>Meta-analysis of randomized controlled trials (RCTs).</p></div><div><h3>Setting</h3><p>Operating room.</p></div><div><h3>Intervention</h3><p>The use of a single dose of intravenous steroids as a supplement to general anesthesia.</p></div><div><h3>Patients</h3><p>Adult patients undergoing surgery.</p></div><div><h3>Measurements</h3><p>A literature search was conducted using electronic databases (e.g., MEDLINE and Embase) from their inception to June 2024. Randomized controlled trials (RCTs) comparing intravenous steroids with placebo or no treatment in adult patients undergoing surgery under general anesthesia were included. The primary outcome was the QoR scores on postoperative days (POD) 1 and 2–3, as assessed by validated QoR scales (QoR-15 and QoR-40). Secondary outcomes included QoR dimensions, analgesic rescue, pain scores, and postoperative nausea and vomiting (PONV).</p></div><div><h3>Main results</h3><p>Eleven RCTs involving 951 patients were included in this study. The steroid group showed significant improvements in global QoR scores on POD 1 (standardized mean difference [SMD]: 0.52; 95 % confidence interval[CI]: 0.22 to 0.82; <em>P</em> = 0.0007) and POD 2–3 (SMD: 0.50; 95 % CI: 0.19 to 0.81; <em>P</em> = 0.001) compared to the control group. Significant improvements were also observed in all QoR dimensions on POD 1, with the effect sizes ranging from small to moderate. Intravenous steroids also significantly reduced the analgesic rescue requirements (RR: 0.77; 95 % CI: 0.67 to 0.88; <em>P</em> = 0.0003), postoperative pain scores (SMD: -0.41; 95 % CI: −0.68 to −0.14; <em>P</em> = 0.003), and PONV incidence (RR: 0.73; 95 % CI: 0.56 to 0.95; <em>P</em> = 0.02).</p></div><div><h3>Conclusions</h3><p>Intravenous administration of steroids significantly improved QoR after surgery. The benefits of steroids extend to all dimensions of QoR and important clinical outcomes such as analgesic requirements, pain scores, and PONV. These findings support the use of steroids as an effective strategy to enhance the postoperative recovery quality.</p></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111625"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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