{"title":"On the Cover - P. Wang et al.","authors":"","doi":"10.1016/S0952-8180(26)00126-1","DOIUrl":"10.1016/S0952-8180(26)00126-1","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"112 ","pages":"Article 112248"},"PeriodicalIF":5.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed Khalil , Ahmed Al-Agaty , Osama Asaad , Mohsen Mahmoud , Amr S. Omar , Ahmed Abdelrazik , Mohamed Mostafa
{"title":"Retraction notice to ‘A comparative study between propofol and dexmedetomidine as sedative agents during performing transcatheter aortic valve implantation’ [Journal of Clinical Anesthesia 32 (2016) 242–247]","authors":"Mohamed Khalil , Ahmed Al-Agaty , Osama Asaad , Mohsen Mahmoud , Amr S. Omar , Ahmed Abdelrazik , Mohamed Mostafa","doi":"10.1016/j.jclinane.2026.112176","DOIUrl":"10.1016/j.jclinane.2026.112176","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"112 ","pages":"Article 112176"},"PeriodicalIF":5.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"“Further studies are needed”: Scientific convention or editorial evasion? A critical appraisal of an overused phrase in medical publishing","authors":"Zeynep Kayhan MD , Elvin Kesimci MD, PhD","doi":"10.1016/j.jclinane.2026.112141","DOIUrl":"10.1016/j.jclinane.2026.112141","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"111 ","pages":"Article 112141"},"PeriodicalIF":5.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zixuan Xu MD , Jiayi Zhang MD , Linyao Chen MD , Jianwen Ye MD , Yanan Wang MD , Lei Tan MD , Jiehao Sun MD
{"title":"Impact of different doses of remifentanil on postoperative pain and hyperalgesia: a prospective randomized controlled study and genotypic analysis","authors":"Zixuan Xu MD , Jiayi Zhang MD , Linyao Chen MD , Jianwen Ye MD , Yanan Wang MD , Lei Tan MD , Jiehao Sun MD","doi":"10.1016/j.jclinane.2026.112198","DOIUrl":"10.1016/j.jclinane.2026.112198","url":null,"abstract":"<div><h3>Background</h3><div>Remifentanil is commonly used for perioperative analgesia, but its role in postoperative pain and hyperalgesia is still debated. This study investigated the effect of different remifentanil doses on postoperative pain and hyperalgesia and the influence of SCN9A genetic variants on these outcomes.</div></div><div><h3>Methods</h3><div>A total of 268 patients who underwent laparoscopic surgery were included in the study. Eligible patients were randomly assigned to one of three groups: a high dose of remifentanil (Group H), a low dose of remifentanil (Group L), or no remifentanil (Group N). Postoperative pain intensity and mechanical pain thresholds were assessed after surgery, and side effects were recorded during follow-up. The single-nucleotide polymorphisms of SCN9A, rs16851799 and rs6746030, were also analyzed.</div></div><div><h3>Results</h3><div>There were no differences in postoperative pain scores among the three groups with different remifentanil doses (<em>P</em> = 0.969). However, the mechanical pain thresholds were significantly lower in Group H compared with the other groups postoperatively (<em>P</em> < 0.001). The A allele of rs6746030 was associated with higher pain scores (<em>P</em> = 0.002) and increased postoperative analgesic requirements (<em>P</em> = 0.013).</div></div><div><h3>Conclusions</h3><div>While high doses of remifentanil significantly induced detectable hyperalgesia in a laboratory phenomenon, RIH had zero clinical impact on the patient's actual pain experience or analgesic requirements after surgery. Additionally, the exploratory findings revealed that rs6746030 in SCN9A was a genetic marker for severe postoperative pain.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"111 ","pages":"Article 112198"},"PeriodicalIF":5.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expression of Concern to: \"Hydroxyethyl starch (HES) does not directly affect renal function in patients with no prior renal impairment\" [Journal of Clinical Anesthesia, Volume 13, Issue 2, March 2001, Pages 103-111].","authors":"","doi":"10.1016/j.jclinane.2026.112177","DOIUrl":"https://doi.org/10.1016/j.jclinane.2026.112177","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"111 ","pages":"112177"},"PeriodicalIF":5.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Unmasking the silent threat: Navigating the myocardial injury in oncological surgery” [Journal of Clinical Anesthesia 108 (2026) 112063]","authors":"Zhen-Zhen Xu, Dong-Liang Mu","doi":"10.1016/j.jclinane.2025.112111","DOIUrl":"10.1016/j.jclinane.2025.112111","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"111 ","pages":"Article 112111"},"PeriodicalIF":5.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the Cover - B Dost et al","authors":"","doi":"10.1016/S0952-8180(26)00088-7","DOIUrl":"10.1016/S0952-8180(26)00088-7","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"111 ","pages":"Article 112210"},"PeriodicalIF":5.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nethmi Rajapakse , Eric Rubenzahl , Aparna Saripella , Jun Won Lee , Sara Mansouri , Shirley Fan , Marina Englesakis , Frances Chung
{"title":"Preoperative alcohol use disorders and adverse outcomes in surgical patients: A systematic review and meta-analysis","authors":"Nethmi Rajapakse , Eric Rubenzahl , Aparna Saripella , Jun Won Lee , Sara Mansouri , Shirley Fan , Marina Englesakis , Frances Chung","doi":"10.1016/j.jclinane.2026.112194","DOIUrl":"10.1016/j.jclinane.2026.112194","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between preoperative unhealthy alcohol use (UAU), including alcohol use disorder and hazardous/risky alcohol use, and postoperative outcomes in adult surgical patients.</div></div><div><h3>Methods</h3><div>The Ovid MEDLINE, Embase, and Cochrane databases were searched for English-language studies involving adults undergoing surgery. Eligible studies compared patients with preoperative UAU to those with no UAU and reported at least one postoperative outcome within 12 months. Preoperative alcohol exposure was determined using validated assessment tools or self-reported alcohol use disorder. Random-effects meta-analyses were conducted to calculate risk ratios (RRs) or mean differences (MDs) with 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Thirty-five studies (<em>n</em> = 18,472,205) met inclusion criteria, and 35 studies were included in the meta-analyses. Preoperative alcohol use disorder was associated with a higher risk of respiratory complications (RR 2.59, 95% CI 1.51–4.45; <em>P</em> = 0.0005), infections/wound complications (RR 1.71, 95% CI 1.37–2.15; <em>P</em> < 0.0001), longer length of hospital stay (mean difference 0.76 days, 95% CI 0.24–1.29; <em>P</em> = 0.004), and higher in-hospital mortality (RR 1.67, 95% CI 1.21–2.29; <em>P</em> = 0.002).</div></div><div><h3>Conclusion</h3><div>Surgical patients with alcohol use disorder were associated with worse postoperative outcomes, including higher rates of respiratory complications and infections, longer length of hospital stay and increased in-hospital mortality. These findings support screening for alcohol use and preoperative optimization including cessation support and postoperative monitoring.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"111 ","pages":"Article 112194"},"PeriodicalIF":5.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}