Journal of Clinical Anesthesia最新文献

{"title":"Impact of deep neuromuscular blockade on intraoperative NOL-guided remifentanil requirement during desflurane anesthesia in laparoscopic colorectal surgeries: A randomised controlled trial","authors":"Louis Morisson ,&nbsp;Hakim Harkouk ,&nbsp;Alexandra Othenin-Girard ,&nbsp;Walid Oulehri ,&nbsp;Pascal Laferrière-Langlois ,&nbsp;Marie-Eve Bélanger ,&nbsp;Moulay Idrissi ,&nbsp;Nadia Godin ,&nbsp;Olivier Verdonck ,&nbsp;Louis-Philippe Fortier ,&nbsp;Madeleine Poirier ,&nbsp;Margaret Henri ,&nbsp;Jean-François Latulippe ,&nbsp;Jean-François Tremblay ,&nbsp;Jean-Sebastien Trépanier ,&nbsp;Yves Bendavid ,&nbsp;Julien Raft ,&nbsp;Philippe Richebé","doi":"10.1016/j.jclinane.2024.111659","DOIUrl":"10.1016/j.jclinane.2024.111659","url":null,"abstract":"<div><h3>Study objective</h3><div>Evaluate the impact of deep neuromuscular blockade on intraoperative nociception Deep neuromuscular blockade has been shown to improve surgical conditions and postoperative outcomes compared to moderate neuromuscular blockade in laparoscopic surgery. Still, its impact on intraoperative nociception and opioid requirement has never been assessed.</div></div><div><h3>Design</h3><div>Monocentric randomised controlled trial.</div></div><div><h3>Setting</h3><div>Operating room.</div></div><div><h3>Patients</h3><div>We included 100 ASA I to III patients who underwent colorectal laparoscopic surgery with desflurane-remifentanil anesthesia.</div></div><div><h3>Interventions</h3><div>Patients were randomised into two groups to achieve either moderate (1–3 train of four response) or deep (1–2 post-tetanic count) neuromuscular block (NMB) with repeated boluses of rocuronium. The Nociception Level (NOL) index guided intraoperative remifentanil administration in both groups.</div></div><div><h3>Measurements</h3><div>The primary endpoint was total intraoperative remifentanil administration per hour of surgery. Secondary endpoints included, Leiden Surgical Rating Scale (L-SRS), intra-abdominal pressure, postoperative pain scores and opioids' consumption.</div></div><div><h3>Main results</h3><div>Ninety-three patients were analysed. Forty-five in the deep group and 48 patients in moderate group. Intraoperative administration of remifentanil was 348 (228–472) μg.h⁻¹ in the deep NMB group compared to 494 (392–618) μg.h⁻¹ in the moderate NMB group (<em>P</em> &lt; 0.001). Lowest L-SRS was 5 (4–5) in the deep NMB group versus 3 (2–5) (P &lt; 0.001) in the moderate NMB group. Mean intra-abdominal pressure was 11.9 (1.3) in the deep NMB group versus 13 (1.3) (P &lt; 0.001) in the moderate NMB group. Secondary postoperative outcomes including pain scores and analgesics administration were not significantly different.</div></div><div><h3>Conclusions</h3><div>This study shows that deep neuromuscular blockade reduces intraoperative NOL-guided administration of remifentanil in colorectal laparoscopic surgeries. It also improves surgical conditions.</div></div><div><h3>Trial registration</h3><div>The study was registered at <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> under <span><span>NCT03910998</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111659"},"PeriodicalIF":5.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of neuraxial hydromorphone: A systematic review and meta-analysis with trial sequential analysis","authors":"Sina Grape ,&nbsp;Kariem El-Boghdadly ,&nbsp;Cécile Jaques ,&nbsp;Eric Albrecht","doi":"10.1016/j.jclinane.2024.111664","DOIUrl":"10.1016/j.jclinane.2024.111664","url":null,"abstract":"<div><h3>Study objective</h3><div>Neuraxial hydromorphone provides postoperative pain relief. However, the magnitude of this effect and the optimal dose remain unknown. The objective of this study is to clarify these uncertainties.</div></div><div><h3>Design</h3><div>Systematic review and meta-analysis with trial sequential analysis.</div></div><div><h3>Setting</h3><div>Postoperative recovery area and ward, up to 24 h.</div></div><div><h3>Patients</h3><div>Any patient undergoing any type of surgery or being in labor.</div></div><div><h3>Interventions</h3><div>Neuraxial hydromorphone versus control.</div></div><div><h3>Measurements</h3><div>Our primary outcome was rest pain score (analogue scale, 0–10) at 24 h according to route of administration (epidural versus spinal) and type of surgery (orthopedic versus other). Secondary outcomes included rest pain score at 0–4 and 8–12 h; rates of postoperative nausea and vomiting, and pruritus at 24 h.</div></div><div><h3>Main results</h3><div>Six trials, including 436 patients, were identified. Rest pain score at 24 postoperative hours was significantly reduced in the hydromorphone group, with a mean difference (95 %CI) of −0.4 (−0.8 to −0.1), I² = 74 %, <em>p</em> = 0.01. Neuraxial hydromorphone did not increase postoperative nausea and vomiting (risk ratio [95 %CI]: 1.2 [0.8–1.8], I² = 27 %, <em>p</em> = 0.47), but increases pruritus (risk ratio [95 %CI]: 3.1 [1.6–5.9], I² = 0 %, <em>p</em> = 0.0005). The quality of evidence was very low for our primary and secondary outcomes. In conclusion, there is very low level of evidence that neuraxial hydromorphone provides effective analgesia after surgery or labor, at the expense of an increased rate of pruritus. The improvement in pain scores appears to be clinically insignificant. With only six trials published over a period of 30 years, we were unable to perform a meta-regression.</div></div><div><h3>Conclusions</h3><div>If neuraxial hydromorphone is to be used regularly, trials focusing on the optimal dose and side-effects should be performed before widely administering this medication into the neuraxial space.</div><div>More trials focusing on the optimal dose and side-effects should be performed before widely administering this medication into the neuraxial space.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111664"},"PeriodicalIF":5.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal cord ischemia after ESP block","authors":"Alessandro De Cassai","doi":"10.1016/j.jclinane.2024.111662","DOIUrl":"10.1016/j.jclinane.2024.111662","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111662"},"PeriodicalIF":5.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale for assessing preoperative anxiety as part of the preoperative evaluation process.","authors":"Paul F White, Ofelia Loani Elvir-Lazo","doi":"10.1016/j.jclinane.2024.111656","DOIUrl":"https://doi.org/10.1016/j.jclinane.2024.111656","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":" ","pages":"111656"},"PeriodicalIF":5.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of emergence delirium on long-term survival in older patients after major noncardiac surgery: A longitudinal prospective observational study","authors":"Bing-Yan Cai M.D. ,&nbsp;Shu-Ting He M.D. ,&nbsp;Yan Zhang M.D. ,&nbsp;Jia-Hui Ma Ph.D ,&nbsp;Dong-Liang Mu M.D. ,&nbsp;Dong-Xin Wang M.D., Ph.D","doi":"10.1016/j.jclinane.2024.111663","DOIUrl":"10.1016/j.jclinane.2024.111663","url":null,"abstract":"<div><h3>Study objective</h3><div>To test the hypothesis that emergence delirium might be associated with worse long-term survival.</div></div><div><h3>Design</h3><div>A longitudinal prospective observational study.</div></div><div><h3>Setting</h3><div>A tertiary hospital in Beijing, China.</div></div><div><h3>Patients</h3><div>A total of 942 patients aged 65–90 years who were admitted to post-anesthesia care unit (PACU) after major noncardiac surgery under general anesthesia.</div></div><div><h3>Exposures</h3><div>Emergence delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit during PACU stay.</div></div><div><h3>Measurements</h3><div>Patients were followed up once a year for at least 3 years. Our primary endpoint was overall survival. Secondary endpoints included recurrence-free and event-free survivals. Associations between emergence delirium and long-term survivals were analyzed with the Cox proportional hazard models.</div></div><div><h3>Main results</h3><div>Among enrolled patients, 915 completed perioperative assessments; 906 completed long-term follow-up (mean age 72 years; 60 % [545/906] male; 73 % [660/906] cancer surgery). At the end of follow-up (median 43 months), there were 69 deaths in 331 patients (21 %) with emergence delirium versus 114 deaths in 575 patients (20 %) without: unadjusted hazard ratio 1.10 (95 % CI: 0.81 to 1.48); <em>P</em> = 0.547; adjusted hazard ratio 0.96 (95 % CI: 0.70 to 1.32); <em>P</em> = 0.797. Recurrence-free survival was 73/331 (22 %) in patients with emergence delirium versus 121/575 (21 %) without: unadjusted hazard ratio 1.08 (95 % CI: 0.81 to 1.45); <em>P</em> = 0.598; adjusted hazard ratio 0.94 (95 % CI: 0.69 to 1.28); <em>P</em> = 0.695. Event-free survival was 159/331 (48 %) in patients with emergence delirium versus 268/575 (47 %) without: unadjusted hazard ratio 1.06 (95 % CI: 0.87 to 1.29); <em>P</em> = 0.563; adjusted hazard ratio 0.98 (95 % CI: 0.80 to 1.21); <em>P</em> = 0.875.</div></div><div><h3>Conclusions</h3><div>We did not find significant association between emergence delirium and worse long-term survival in older patients after general anesthesia and major surgery mainly for cancer. The effects of emergence delirium on long-term outcomes deserve further investigation.</div><div><strong>Clinical trial registrations</strong>: <span><span>www.chictr.org.cn</span><svg><path></path></svg></span>; ChiCTR-OOC-17012734.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111663"},"PeriodicalIF":5.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The perioperative care in liver transplantation multicenter database: Building the foundation for research collaboration in liver transplantation","authors":"Dieter Adelmann M.D., Ph.D. ,&nbsp;Mallika Reddy ,&nbsp;George P. Zhou M.D. ,&nbsp;Kyota Fukazawa M.D., Ph.D. ,&nbsp;Ryan Wang M.D. ,&nbsp;Cale Kassel M.D. ,&nbsp;Christine Nguyen-Buckley M.D. ,&nbsp;Javier Bastidas M.D., M.Sc ,&nbsp;Lorenzo De Marchi M.D., FASE ,&nbsp;Elizabeth A. Wilson M.D. ,&nbsp;Ryan Nazemian M.D., Ph.D. ,&nbsp;Ana Fernandez-Bustamante M.D., Ph.D., FASA ,&nbsp;Alexandra Anderson M.D. ,&nbsp;Ryan M. Chadha M.D. ,&nbsp;Jiapeng Huang M.D., Ph.D. ,&nbsp;Marina Moguilevitch M.D. ,&nbsp;Elizabeth Townsend M.D., Ph.D. ,&nbsp;David M. Rosenfeld M.D. ,&nbsp;Rishi P. Kothari M.D.","doi":"10.1016/j.jclinane.2024.111651","DOIUrl":"10.1016/j.jclinane.2024.111651","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111651"},"PeriodicalIF":5.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative quality of recovery comparison between ciprofol and propofol in total intravenous anesthesia for elderly patients undergoing laparoscopic major abdominal surgery: A randomized, controlled, double-blind, non-inferiority trial","authors":"Zenghui Liang MMed ,&nbsp;Jing Liu MMed ,&nbsp;Shuhan Chen MMed ,&nbsp;Xiaona Zhao MMed ,&nbsp;Gezi Chen MMed ,&nbsp;Yanle Xie MMed ,&nbsp;Dongmei Wang MMed ,&nbsp;Fei Xing MMed ,&nbsp;Yuanyuan Mao MMed ,&nbsp;Wei Zhang MD ,&nbsp;Zhongyu Wang MD ,&nbsp;Jingjing Yuan MD","doi":"10.1016/j.jclinane.2024.111660","DOIUrl":"10.1016/j.jclinane.2024.111660","url":null,"abstract":"<div><h3>Study objectives</h3><div>We conducted a non-inferiority study to assess the postoperative quality of recovery (QoR) in elderly patients receiving ciprofol or propofol total intravenous anesthersia(TIVA)after elective laparoscopic major abdominal surgery, with QoR-15 scores as the main measure.</div></div><div><h3>Design</h3><div>A prospective, double-blind, randomized non-inferiority trial was conducted in the theater, post-anesthesia care unit (PACU), and the ward.</div></div><div><h3>Participants</h3><div>144 elderly patients (age ≥ 65 years) were randomly assigned to either the ciprofol group or the propofol group.</div></div><div><h3>Interventions</h3><div>The ciprofol group received continuous infusion of ciprofol with remifentanil, and the propofol group received infusion of propofol with remifentanil.</div></div><div><h3>Outcome measures</h3><div>The primary outcome was the QoR-15 on the first postoperative day (POD1), assessed in both intention-to-treat and per-protocol populations, with the mean difference between groups compared to a non-inferiority threshold of −8. Additional assessments included QoR-15 scores on POD2, 3, and 5 for both analysis sets. Other evaluated perioperative value factors included hemodynamic parameters and injection discomfort in the intention-to-treat analysis. A linear mixed model was utilized to examine the impact of group-time interactions on hemodynamic data and QoR-15.</div></div><div><h3>Main results</h3><div>The QoR-15 scores on POD1 in the ciprofol group were non-inferior to those in the propofol group both in intention-to-treat set (mean [95 %CI], 95.9[93.7–98.2] vs. 95.6 [93.3–97.8]; mean difference [95 % CI], 0.4 [−2.8–3.5]; <em>P</em>&lt;0.001 for noninferiority) and per-protocol set (mean [95 %CI], 96.7 [94.4–99.0] vs. 95.7 [93.4–98.0]; mean difference [95 % CI], 1.0 [−2.2–4.3]; <em>P</em>&lt;0.001 for noninferiority). Comparable outcomes were noted on postoperative days 2, 3, and 5 following the procedure in both analysis sets. Additionally: compared with propofol group, the occurrence of injection pain was lower (2.8 % vs. 27.8 %, <em>P</em> &lt; 0.001); the hypotension was less frequent (33.3 % vs. 54.2 %, <em>P</em> = 0.012); the bradycardia was more common (38.9 % vs. 23.6 %, <em>P</em> = 0.048).</div></div><div><h3>Conclusions</h3><div>Ciprofol is not inferior to propofol in QoR. Ciprofol can be suitably administered to elderly patients undergoing elective laparoscopic major abdominal surgery.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111660"},"PeriodicalIF":5.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Effect of remimazolam versus propofol on hypotension after anesthetic induction in patients undergoing coronary artery bypass grafting: A randomized controlled trial”.","authors":"Jie Wang MD,&nbsp;Xiaocou Wang MD,&nbsp;Congcong Huang MD","doi":"10.1016/j.jclinane.2024.111658","DOIUrl":"10.1016/j.jclinane.2024.111658","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111658"},"PeriodicalIF":5.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric insufflation with and without an inserted gastric tube in second-generation laryngeal mask airways: A randomized controlled cross-over trial.","authors":"Johannes Hell MD ,&nbsp;Grischa Schelker ,&nbsp;Stefan Schumann PhD ,&nbsp;Axel Schmutz PhD","doi":"10.1016/j.jclinane.2024.111653","DOIUrl":"10.1016/j.jclinane.2024.111653","url":null,"abstract":"<div><h3>Study objective</h3><div>Second-generation laryngeal mask airways are equipped with an additional lumen for a gastric tube, with the intention to reduce the risk of aspiration by draining gastric content. However, the effect of an inserted gastric tube through the gastric channel on gastric insufflation, a substantial part of the pathomechanism of aspiration, during positive-pressure ventilation is not clear. We hypothesized, that an inserted gastric tube increases the risk of gastric insufflation.</div></div><div><h3>Design</h3><div>Single center, prospective, randomized-controlled cross-over trial.</div></div><div><h3>Setting</h3><div>Tertiary academic hospital in Germany.</div></div><div><h3>Patients</h3><div>152 patients, ASA I-III, scheduled for general anesthesia with a laryngeal mask airway.</div></div><div><h3>Interventions</h3><div>Gastric insufflation was investigated during an incremental pressure trial up to a maximum airway pressure of 30 cmH₂O and during oropharyngeal leak pressure measurement with and without an inserted gastric tube while one of two laryngeal mask airways with different cuff designs (inflatable or thermoelastic) was used.</div></div><div><h3>Measurements</h3><div>Gastric insufflation was detected with real-time ultrasound.</div></div><div><h3>Main results</h3><div>Frequency of gastric insufflation was higher with than without inserted gastric tube during the incremental pressure trial (10.9 % (16/147) vs. 2.7 % (4/147), <em>p</em> = 0.009) and during oropharyngeal leak pressure measurement (16.3 % (24/147) vs. 5.4 % (8/147), <em>p</em> = 0.004). Risk of gastric insufflation didn't differ between the two cuff-types (<em>p</em> = 0.100). Flow over the open gastric channel was associated with gastric insufflation during positive-pressure ventilation (<em>p</em> = 0.003) and during oropharyngeal leak pressure measurement (<em>p</em> = 0.049). Incidence of postoperative nausea and vomiting was higher in patients in which gastric insufflation was detected, compared to others (17.1 % (6/35) vs. 5.4 % (6/112), <em>p</em> = 0.037).</div></div><div><h3>Conclusion</h3><div>Placement of a gastric tube through the gastric channel of a second-generation laryngeal mask airway, independent of the cuff-type, increases the risk of gastric insufflation. Flow over the gastric channel indicate a higher risk of gastric insufflation and gastric insufflation may increase the risk of postoperative nausea and vomiting.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111653"},"PeriodicalIF":5.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Intraoperative hypotension during liver transplantation and postoperative outcomes: Retrospective cohort study”","authors":"Luyuan Yao ,&nbsp;Zhihuan Luo","doi":"10.1016/j.jclinane.2024.111655","DOIUrl":"10.1016/j.jclinane.2024.111655","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"99 ","pages":"Article 111655"},"PeriodicalIF":5.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}