Journal of Clinical and Experimental Cardiology最新文献

{"title":"Study the Pulmonary Hypertension among Heavy Smokers Young Adult Males before the Clinical Evidences of Chronic Lung Disease","authors":"H. Naser, N. Hadi, A. Ibrahim, A. Assad","doi":"10.4172/2155-9880.1000536","DOIUrl":"https://doi.org/10.4172/2155-9880.1000536","url":null,"abstract":"Background: Smoking is a well-known risk factor for development of COPD. Prevalence of smoking is high. Its effect on the pulmonary pressure before the development of COPD still needs to be explored on human model. \u0000Aim of the study: The aim of the study is to evaluate the pulmonary hypertension in young heavy smokers adult population prior to the development of the clinical and the abnormal pulmonary function test. \u0000Material and Methods: The study was carried out at Al Sader Najaf Teaching Hospital during the period April 2015 to April 2016 where 93 Smokers who smoke at least 2 packets/day for minimal two years period were included in the study with 93 non-smokers used as a control group. The age of the smokers group and non- smokers group was less than 40 year with mean age 25 ± 4.1 for smokers and 24.9 ± 3 for non –smokers. BMI for all was >30. All had their pulmonary function test with the clinical examination to exclude any evidences of the chronic lung disease. Transthoracic Echocardiography and Doppler study was done for the smokers and non-smokers groups to evaluate the Maximum tricuspid valve velocity, the Mean pulmonary pressure gradient and the Pulmonary artery pressure. \u0000Results: Mean tricuspid maximum velocity (TGmax) for smokers was 0.9 ± 0.1 and for non-smokers 0.60 ± 0.20 (p value less than 0.001). The mean pulmonary pressure gradient for smokers was 3.4 ± 1.0 and for non-smokers 1.5 ± 0.8 with p value less than 0.001. The mean pulmonary artery pressure for smokers group was 12.2 ± 1.6 and for non-smokers group 7.0 ± 1.2 with p value less than 0.001. \u0000Conclusion: There is an increase in the pulmonary arterial pressure among the heavy smokers young adults when was compared with the non-smokers young adults.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"108 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87626047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Predictive Value for Different Risk Scores forPredicting Contrast Induced Nephropathy and Short Outcome afterPrimary Percutaneous Coronary Intervention","authors":"M. Mokarrab, A. Ismail, M. Mostafa, Abdelrahman Elgendy, H. Sabry, A. Yousry","doi":"10.4172/2155-9880.1000535","DOIUrl":"https://doi.org/10.4172/2155-9880.1000535","url":null,"abstract":"Background: Meticulous risk stratification for contrast-induced nephropathy (CIN) is important for patients with ST-segment elevation myocardial infarction (STEMI) and treated with primary percutaneous coronary intervention (PPCI). \u0000Aim of the work: To compare between different risk scores for predicting contrast-induced nephropathy (CIN) and short outcome after primary percutaneous coronary intervention in patients with ST segment elevation myocardial infarction. \u0000Materials and methods: We prospectively enrolled 100 patients who presented with STEMI and treated with Primary PCI. Mehran, Gao, Chen, ACEF or AGEF (age, serum creatinine, or glomerular filtration rate, and ejection fraction); and GRACE (Global Registry for Acute Coronary Events) risk scores were calculated for each patient. The predictive accuracy of the 6 scores for CIN, in-hospital death and major adverse clinical events (MACEs) were assessed by Receiver operating characteristics (ROC) curve. CIN was defined as an absolute increase of serum creatinine by ≥ 0.5 mg/dl or a relative increase of serum creatinine by ≥ 25% from baseline value, at 48-72 h following the exposure to contrast media (CM). The data was analyzed using Chi-square test using SPSS (Statistical package for social science) software. \u0000Results: All risk scores had relatively good predictive accuracy for CIN (Area under the curve (AUC) ranged from 0.671 to 0.829) and performed well for prediction of in-hospital death (AUC ranged from 0.838 to 0.973) and MACEs (AUC ranged from 0.815 to 0.926). The Mehran and Gao risk scores had better predictive accuracy for CIN. While Mehran and GRACE risk scores had better predictive accuracy for in-hospital death and MACEs. \u0000Conclusion: Risk scores for predicting CIN perform well in stratifying the risk of CIN, in-hospital death and MACEs in patients with STEMI undergoing PPCI. The Gao, Mehran risk scores appear to have greater predictive value for CIN. While GRACE and Mehran scores had highest predictive accuracy for in hospital death and MACEs than the other risk scores.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"11 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2017-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75435838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging case for (much) lower than conventional (<140/90 mm Hg) blood pressure targets in hypertension treatment","authors":"J. Flack","doi":"10.4172/2155-9880-C1-073","DOIUrl":"https://doi.org/10.4172/2155-9880-C1-073","url":null,"abstract":"","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88657415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Peripheral Arterial Disease and Associated Factors among Adults in Jimma Town, South-West Ethiopia: A Community Based Survey","authors":"A. Hagos, Sintayehu Fekadu, T. Allison, M. Wondafrash, A. Workicho, H. Mulatu","doi":"10.4172/2155-9880.1000534","DOIUrl":"https://doi.org/10.4172/2155-9880.1000534","url":null,"abstract":"Background: Peripheral arterial disease (PAD) is defined as an ankle-brachial index (ABI) ≤ 0.90 in individuals aged 40 years or over. So far, the prevalence of PAD in Ethiopia is not known. We assessed the prevalence of PAD among Ethiopians using ABI and thus evaluated its applicability as a screening tool at the community level. \u0000Methods: A cross-sectional community based survey was conducted on 178 sampled individuals aged 40 years and above in Jimma town, Southwest Ethiopia from June 15 to July 15, 2011. Conventional cardiovascular risk factors and intermittent claudication (with Edinburgh Claudication assessment tool) were assessed using a structured questionnaire. Blood pressure was measured using a mercury sphygmomanometer and a hand held Doppler flow detector at arm and ankle respectively. The ABI was calculated from the ratio of higher ankle systolic blood pressure and the higher of the two brachial systolic pressure measurements. Descriptive statistics and chi-square or Fischer’s exact test, were used for data analysis and interpretation. Predictors of PAD were estimated using univariate and multivariate regression models. \u0000Results: The overall prevalence of peripheral arterial disease was 10.8%. But, none of the participants with peripheral arterial disease fulfilled the criteria for claudication. The traditional risk factors identified were; hypertension, diabetes mellitus, and current cigarette smoking accounting for 29.5%, 6.8% and 12.5% of participants respectively. Female sex, current smoking and diabetes mellitus were significantly associated with increased risk of PAD. \u0000Conclusion: Peripheral arterial disease is common among Ethiopians aged 40 years and above. Intermittent claudication was found to be insensitive in the detection of peripheral arterial disease. Female sex, current smoking and diabetes mellitus were predictors of PAD.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"43 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76364141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of Endovascular Management of Isolated Internal Iliac Artery Aneurysm","authors":"Ben Jmaà Hèla, J. Hassen, Cheikhrouhou Hichem, M. Aiman, E. Nizar, Masmoudi Sayda, F. Imed","doi":"10.4172/2155-9880.1000533","DOIUrl":"https://doi.org/10.4172/2155-9880.1000533","url":null,"abstract":"The isolated internal iliac artery aneurysm is rare, but can be fatal if non-diagnosed. Endovascular treatment of these aneurysms, ideally with exclusion of the sac from antegrade and retrograde perfusion, provides a minimally invasive alternative that avoids the direct operative morbidity. \u0000We present a case of a patient treated with embolization with coils of an aneurysm of the left internal iliac artery. Then, 6 months after the procedure, the patient suffered from recurrence of abdominal pain. CT scan confirmed patency of the aneurysmal sac. Therefore, he underwent second endovascular exclusion by an external iliac artery stentgraft by ipsilateral femoral access. \u0000In the angiography post-implantation, an endoleak was diagnosed. So, a second distal stentgraft was implanted in the external iliac artery. After implantation, a total exclusion of the aneurysm was obtained. The follow-up is now 3 months. The patient is asymptomatic.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"50 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91200047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Occurrence of Congenital Coronary Ectasia Combined with Ventricular Septal Defect","authors":"T. Huang, W. Lu, K. Chien","doi":"10.4172/2155-9880.1000532","DOIUrl":"https://doi.org/10.4172/2155-9880.1000532","url":null,"abstract":"Idiopathic or congenital coronary artery ectasia (CAE) is an uncommon form of coronary artery disease. In adults, coronary artery ectasia is usually associated with atherosclerotic change and is well recognized clinical entity encountered during cardiac catheterization. Coronary artery dilatation in pediatric is usually associated with the sequelae of Kawasaki disease. Congenital coronary artery ectasia is uncommon and rarely reported in children. We present a case of an infant who have dilated coronary artery, she also had ventricular septal defect (VSD) and heart failure who had received VSD repair at infancy. There was no obstructive coronary artery disease, and no cause for the lesions could be identified. The prognosis and optimal management of such patients remains unknown. Antiplatelet therapy might be necessary for the patient to remain free of myocardiac ischemia.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"101 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84762036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Valsalva Sinus Aneurysm on Infection Tuberculous","authors":"Ibrahima Sory 2 Sylla, Simon Antoine Sarr, F. Aw, M. Bodian, Y. Diouf, A. A. Ngaidé, M. Dioum, Serigne Mor Beye, Cheikh Tidiane Ndao, Mouhamadou Bamba Ndiaye, A. Kane, M. Diao, Abdoul Kane, Serigne Abdou Ba","doi":"10.4172/2155-9880.1000531","DOIUrl":"https://doi.org/10.4172/2155-9880.1000531","url":null,"abstract":"Sinus of Valsalva Aneurysm (SVA) is a localized dilatation of the aortic wall, forming a sacral ectasia, located just above the aortic cusps between the valve and the sino-tubular junction [1-3]. It is a rare condition that is congenital or acquired and whose frequency is less than 1% according to the literature [1]. The aneurysm most often involves the right coronary sinus (65-85% of cases), more rarely the posterior sinus (10-30%) and exceptionally the left coronary sinus (<5%) [4]. we report a case of an unruptured left SVA in an 18-year-old patient in a context of disseminated tuberculosis associated with rheumatic valvulopathy.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"51 4 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87696979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Outcomes of Beta Blocker Therapy as a Treatment of Palpitations","authors":"Miri Secagoi, M. Thomson, Mouhamed Amr Sabouni, A. Hila, Alon Yarkoni","doi":"10.4172/2155-9880.1000537","DOIUrl":"https://doi.org/10.4172/2155-9880.1000537","url":null,"abstract":"Introduction: Beta blocker therapy is considered the primary treatment for palpitations caused by supraventricular or ventricular ectopy. The safety of beta blocker therapy during pregnancy is somewhat controversial and not well studied. \u0000Objective: Examine the outcomes of beta blocker therapy for heart palpitations in pregnant women. \u0000Methods: We conducted a retrospective review of 3778 pregnant patients between January 2014 and January 2016. The patients’ ages ranged between 18 to 40 years old. 227 patients had complaints of palpitation. 52 patients were eligible for inclusion and were dichotomized into two groups based on their treatment status, Eight patients received treatment with a non-selective beta blocker. The second group did not receive beta blocker therapy. Primary and secondary outcomes based on data collected from the patients’ electronic medical records were compared between the two groups. \u0000Results: Beta-blocker exposure during pregnancy was found to be associated with increased risk of small for gestational age (SGA) (OR 7.663, p-value 0.033) as well as a tendency towards increased risk of pregnancy induced hypertension (PIH) (OR 10.87, p-value 0.052). There was no statistical difference in the rates of preterm birth, stillbirth, postpartum haemorrhage, gestational diabetes, need for blood transfusion or the method of delivery between the two groups. \u0000Conclusion: The data indicates that exposure to beta-blockers during pregnancy was associated with a significant increase in the risk of both SGA and PIH. This Finding should be explored further with a large randomized controlled trial.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"73 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86387407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sildenafil Postconditioning in a Rat Model of Ventricular Fibrillation/Resuscitation","authors":"W. Vanagt, Hesam Amin, A. Brouwers, Chantal C H Pöttgens, T. Wolfs, J. Cleutjens, Q. Swennen, T. Delhaas, F. Prinzen","doi":"10.4172/2155-9880.1000530","DOIUrl":"https://doi.org/10.4172/2155-9880.1000530","url":null,"abstract":"Objective: To evaluate the multi-organ postconditioning potential of sildenafil during resuscitation. Circulatory arrest/resuscitation induces ischemia/reperfusion (I/R) injury in all organs. I/R injury can be reduced using postconditioning during reperfusion. Sildenafil has proven strong single-organ postconditioning properties.Methods: Ventricular fibrillation (VF) was induced and left untreated for 6 min in anesthetized adult male Wistar rats. During resuscitation, placebo (n=10) or intravenous sildenafil 0.2 mg/kg (n=10) was administered. Troponin-i release, lactate release, blood gases and hemodynamic parameters were assessed. After 3 h of reperfusion, rats were euthanized; brain and heart were removed for infarct staining with triphenyltetrazolium chloride. Urinary kidney injury molecule (KIM-1) was assessed. Data expressed as median (interquartile range), p<0.05 significant.Results: Resuscitation/defibrillation resulted in return of spontaneous circulation in all rats. Compared with the sildenafil group, the control group showed higher overall troponin release (Control 50 (32-60) versus Sildenafil 16 (12-42) h·microg/L, p=0.032) and higher left ventricular infarct percentage (Control 19 (16-24) versus Sildenafil 16 (12-18)%, p=0.039). There was no significant difference between the groups with respect to mortality, hemodynamic recovery, cerebral cortex infarct percentage, lactate release, blood gas values and urinary KIM-1 release. Three rats in the sildenafil group developed pulmonary edema versus none in the control group.Conclusions: Sildenafil postconditioning during resuscitation significantly reduces cardiac injury but does not affect mortality, cerebral and renal injury after resuscitation.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"1 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76342567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Very Late Bare-Metal Coronary Stent Thrombosis Two Weeks after Aspirin Discontinuation, Histopathologic Thrombus Findings and Clinical Considerations","authors":"G. Tanzilli, N. Viceconte, G. Truscelli, M. Scappaticci, E. Mangieri","doi":"10.4172/2155-9880.1000528","DOIUrl":"https://doi.org/10.4172/2155-9880.1000528","url":null,"abstract":"There have been consistent evidences that atherosclerotic changes occur inside bare metal stents (BMS) during an extended period after implantation. This report describes the histopathologic features of aspirated material harvested from a patient with definite very late stent thrombosis of a BMS implanted 18 years prior. The patient presented with a recurrent anterior acute myocardial infarction 14 day after aspirin discontinuation. We suggest that vulnerable neointimal tissue inside the stent struts of BMS may be one potential trigger of thrombosis when the protection of aspirin treatment is ceased.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"44 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88871287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}