Journal of Angiotherapy最新文献_第9页

Targeting Microtubules by Phytoestrogens for the Treatment of Cancer: An Overview 植物雌激素靶向微管治疗癌症的研究进展

Journal of Angiotherapy Pub Date : 2022-02-01 DOI: 10.25163/angiotherapy.625313

Fan Xu, N. Samad, N. M. Ansor, Abdul Samad, Nurhuda Mohamad

{"title":"Targeting Microtubules by Phytoestrogens for the Treatment of Cancer: An Overview","authors":"Fan Xu, N. Samad, N. M. Ansor, Abdul Samad, Nurhuda Mohamad","doi":"10.25163/angiotherapy.625313","DOIUrl":"https://doi.org/10.25163/angiotherapy.625313","url":null,"abstract":"Phytoestrogens are naturally occurring compounds that have similar molecular structure to estrogen hence able to exert estrogenic activities by binding to estrogen receptors (ERs), ERα and ERβ. Phytoestrogens have been reported to suppress cancer cell survival and growth in various types of cancers including lung cancer, breast cancer and prostate cancer. Moreover, phytoestrogens have been shown to inhibit cancer cell migration and invasion by targeting multiple pathways. These cellular processes are closely regulated by microtubule cytoskeleton, hence it is interesting to gain more understanding regarding the effects of phytoestrogen on microtubules structure and dynamics. In this review, we summarize reported effects of some phytoestrogens that bind directly to tubulin at various binding site and disrupt the microtubule dynamics, either by promoting microtubule polymerization or enhancing microtubule depolymerization. We also discuss the effects of phytoestrogens in combination with established chemotherapeutic drugs, including the MTAs. Evidence found is crucial for the development of phytoestrogens to be used as monotherapy or combination therapy (as adjuvant).","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131113219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Targeting on Death Pathways in Glioblastoma 胶质母细胞瘤死亡途径的靶向治疗

Journal of Angiotherapy Pub Date : 2022-02-01 DOI: 10.25163/angiotherapy.624312

Pavithra Suppiah, J. Joseph, Rolla Al-Shalabi, Nik Nur, Syazni Nik, Mohamed kamal, N. Samad

引用次数: 0

Hepatoprotective effect of Hydro-alcohol extract of Mimusops elengi root against antitubercular drug-induced hepatotoxicity in rats 芒萁水醇提取物对抗结核药物致大鼠肝毒性的保护作用

Journal of Angiotherapy Pub Date : 2022-02-01 DOI: 10.25163/angiotherapy.625314

P. Dabadi, Fouad Saleih, Resq Al-Suede, V. Chandrashekhar, M. Shalavadi, Ashok Gnanasekaran, Hanagal Shri

{"title":"Hepatoprotective effect of Hydro-alcohol extract of Mimusops elengi root against antitubercular drug-induced hepatotoxicity in rats","authors":"P. Dabadi, Fouad Saleih, Resq Al-Suede, V. Chandrashekhar, M. Shalavadi, Ashok Gnanasekaran, Hanagal Shri","doi":"10.25163/angiotherapy.625314","DOIUrl":"https://doi.org/10.25163/angiotherapy.625314","url":null,"abstract":"Introduction: Nowadays, different chemicals and drugs are causing liver injuries including first-line antitubercular drugs (ATDs). There is a need to find safe and potent moieties of hepatoprotective drugs against liver diseases from different natural resources including medicinal plants. So, the current study aimed to evaluate the hepatoprotective property of Mimusops elengi root. Methodology: Mimusops elengi root extract (200-400mg/kg) was evaluated in an induced hepatotoxicity model of oxidative stress in Wistar rats by ATDs orally for 14 days. Markers indicating oxidative stress and hepatic damage such as serum transaminase (SGOT / SGPT), and alkaline phosphatase (ALP) were measured. Biomarkers of antioxidant status, superoxide dismutase, catalase, glutathione reductase, and marker of lipid peroxidation, were evaluated using standard procedures. The hematological lipid profile, bilirubin, glucose, and histopathological examination were also assessed. Results: intoxication with ATDs markedly reduced the hematological indices and elevated the biochemical enzyme markers (SGOT, SGPT, ALP p<0.001) and lipid profile (p<0.001), decreased and glucose was elevated. However, pretreatment with Mimusops elengi root extract significantly (p<0.001, p<0.01) improved this alteration and sustained the antioxidant potential. The Histopathological and biochemical data support hepatoprotective action. Conclusion: The results of the current study reinforced the extract of Mimusops elengi possesses significant hepatoprotective and antioxidant activity against ATDs- induced hepatotoxicity.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121818817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Factors and Predictors of Mortality in Patients with Critical Limb Ischemia: A Current Clinical Perspective 危重肢体缺血患者的预后因素和死亡率预测因素:当前的临床观点

Journal of Angiotherapy Pub Date : 2022-02-01 DOI: 10.25163/angiotherapy.625321

M. Chowdhury, Syeda Humayra, Sohel Mahmud, Yukihito Higashi, YD Singh

{"title":"Prognostic Factors and Predictors of Mortality in Patients with Critical Limb Ischemia: A Current Clinical Perspective","authors":"M. Chowdhury, Syeda Humayra, Sohel Mahmud, Yukihito Higashi, YD Singh","doi":"10.25163/angiotherapy.625321","DOIUrl":"https://doi.org/10.25163/angiotherapy.625321","url":null,"abstract":"Critical limb ischemia (CLI) is an end-stage peripheral arterial disease (PAD). Mortality, limb loss, pain, and diminished health-related quality of life are highly prevalent in CLI patients. 20 to 50% CLI Mortality is intensely observed within the first six months to five years of CLI diagnosis, respectively. Prognostic treatments, including autologous bone marrow mononuclear cell implantation (BMMNCI), low-intensity pulsed ultrasound (LIPUS) technology, and medication therapy using Cilostazol, are available. In addition, required prognostic factors such as timely access to medical care can control the death. Impaired mobility, old age, low BMI, CKD (end-stage), T2DM, COPD (oxygen-dependent), HF, smoking, high Wound, Ischemia, and Foot Infection are the additional predictors for CLI-related mortality. Due to the poor survival and prognosis, it is crucial to identify the prognostic factors that will lead to better clinical benefits, including amputation-free survival rate and improved quality of life. This review highlights the current clinical perspective on the prognostic factors and predictors of mortality in CLI patients.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126043359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Herbal Medicine as Adjunctive Therapy for Skin Cancer 中药辅助治疗皮肤癌的疗效观察

Journal of Angiotherapy Pub Date : 2022-02-01 DOI: 10.25163/angiotherapy.624310

Norbayu Mansor, Julia Joseph, Rolla Al, Nozlena Binti, Abdul Samad

{"title":"Efficacy of Herbal Medicine as Adjunctive Therapy for Skin Cancer","authors":"Norbayu Mansor, Julia Joseph, Rolla Al, Nozlena Binti, Abdul Samad","doi":"10.25163/angiotherapy.624310","DOIUrl":"https://doi.org/10.25163/angiotherapy.624310","url":null,"abstract":"Skin cancer is a condition in which the skin's cells grow abnormally. Skin cancer is one of the most common types of cancer worldwide. It is more frequently found in locations exposed to sunlight, although it can also occur in areas that are not normally exposed to sunlight. Numerous studies have investigated the efficacy of herbal medicine as adjuvant therapy for skin cancer. Herbal medicine utilises plants, or combinations of plant extracts, to treat illness and promote health. Herbal medicine has grown in popularity over the last few decades due to its critical role in cancer prevention and therapy. As a result, herbal treatments are increasingly being studied and utilised extensively to treat skin cancers worldwide. This article aims to discuss the anticancer capabilities of herbal medicine as an adjuvant therapy for skin cancer and the potential for their bioactive components to increase immunity and kill cancer cells. In addition, this study will present an overview of anti-cancer compounds produced from plants that have been proven to have potential anti-carcinogenic characteristics in various skin cancer cell lines and animal models. This review aims to increase awareness of herbal medicine as an adjuvant therapy for cancer and to provide further data for developing more effective anti-cancer medicines. Research utilising herbal medicine in various forms and at various levels in the future with more carefully designed studies will need to be conducted, including rigorous quality control and standardised models at the cellular, organic, animal, and clinical levels to combat skin cancer.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"162 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123027585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoglobulin G Seroprevalence of Lassa Fever Virus Among Individuals Residing Along the Banks of River Niger in Anambra State, Nigeria. 尼日利亚阿南布拉州尼日尔河沿岸居民中拉沙热病毒免疫球蛋白G血清阳性率

Journal of Angiotherapy Pub Date : 2022-02-01 DOI: 10.25163/angiotherapy.626323

Umezurike Kingsley Chimuanya, Chukwuma Oluchukwu Mariagoretti, Ochiabuto Mary Barbara, Manafa Patrick Onochie, Ntum Ifeanyichukwu Michael, Chukwuma George Okechukwu

{"title":"Immunoglobulin G Seroprevalence of Lassa Fever Virus Among Individuals Residing Along the Banks of River Niger in Anambra State, Nigeria.","authors":"Umezurike Kingsley Chimuanya, Chukwuma Oluchukwu Mariagoretti, Ochiabuto Mary Barbara, Manafa Patrick Onochie, Ntum Ifeanyichukwu Michael, Chukwuma George Okechukwu","doi":"10.25163/angiotherapy.626323","DOIUrl":"https://doi.org/10.25163/angiotherapy.626323","url":null,"abstract":"Background – Lassa fever (LF) is an acute viral haemorrhagic fever caused by the Lassa virus belonging to the Arenaviridae family. It is a zoonotic infection that is widespread in West Africa. Transmission occurs through exposure to rodent excreta and secretions and via the bodily fluids of an infected person. This study aimed to determine the Lassa fever-specific IgG seroprevalence among individuals who reside along the banks of River Niger in Anambra state, Nigeria. Materials and methods – Ethical approval was obtained from the ethics committee of the College of Health Sciences, Nnamdi Azikiwe University Awka. Informed consent was sought and a questionnaire was administered. For this study, 90 subjects were recruited from the Okpoko community of Ogbaru LGA of Anambra state, Nigeria. Blood samples were collected and analysed at the Molecular Research laboratory using the Enzyme-linked Immunosorbent Assay (ELISA) technique to screen for LF-specific IgG. Results – LF-specific IgG was detected in 14 out of 90 Subjects, giving a prevalence rate of 15.6%. In addition, some risk factors were ascertained, and the relationship between LF IgG seroprevalence and age, gender, and Body Mass Index (BMI) were assessed though there were no significant relationships. Conclusion – A significant LF seroprevalence was revealed among the sampled population, which could pose a serious public health threat. Intervention strategies should be implemented to check possible LF outbreaks in the sampled area, and further epidemiologic studies should be done to determine the means of spread and risk factors of Lassa fever.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122722256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental and physiological angiogenesis in causing CVD with oxidative pattern 环境和生理性血管生成与氧化模式引起CVD

Journal of Angiotherapy Pub Date : 2022-02-01 DOI: 10.25163/angiotherapy.622129

Md. Fakruddin, Md. Asaduzzaman Shishir, Kumkum Rahman Mouree, Shamsuddin Sultan Khan

引用次数: 0

Gamma Glutamyl Transferase as A Marker of Metabolic Syndrome 谷氨酰转移酶作为代谢综合征的标志物

Journal of Angiotherapy Pub Date : 2021-12-09 DOI: 10.25163/angiotherapy.52121602920201221

Priya Santharam, Priya Bindu D

引用次数: 0

Guillain-Barre´ Syndrome 格林-巴利´综合症

Journal of Angiotherapy Pub Date : 2021-12-09 DOI: 10.25163/angiotherapy.52621592920201221

引用次数: 0

Hypothyroidism Presenting as Reversible Renal Impairment 甲状腺功能减退表现为可逆性肾功能损害

Journal of Angiotherapy Pub Date : 2021-12-09 DOI: 10.25163/angiotherapy.52621612920201221

Srivalsa Bhaskaran, Kamaal Mohideen, Karthik V Khan, Mani Shanthini

引用次数: 0