Journal of Clinical Neuroscience最新文献

{"title":"Letter to the Editor: Comment on \"Risk factors for gastrointestinal bleeding in patients with intracerebral Hemorrhage: A propensity score matching analysis\".","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.jocn.2024.110835","DOIUrl":"https://doi.org/10.1016/j.jocn.2024.110835","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":" ","pages":"110835"},"PeriodicalIF":1.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static and dynamic changes in amplitude of Low-Frequency fluctuations in patients with Self-Limited epilepsy with centrotemporal Spikes (SeLECTS): A Resting-State fMRI study","authors":"Ahmed Ameen Fateh ,&nbsp;Muhammad Hassan ,&nbsp;Tong Mo ,&nbsp;Zhanqi Hu ,&nbsp;Abla Smahi ,&nbsp;Adam A. Q. Mohammed ,&nbsp;Jianxiang Liao ,&nbsp;Abdulqawi Alarefi ,&nbsp;Hongwu Zeng","doi":"10.1016/j.jocn.2024.110817","DOIUrl":"10.1016/j.jocn.2024.110817","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to explore differences in the static and dynamic amplitude of low-frequency fluctuations (sALFF and dALFF) in resting-state functional MRI (rs-fMRI) data between patients with Benign childhood epilepsy with centrotemporal spikes (SeLECTS) and healthy controls (HCs).</p></div><div><h3>Materials and methods</h3><p>We recruited 45 patient with SeLECTS and 55 HCs, employing rs-fMRI to assess brain activity. The analysis utilized a two-sample <em>t</em>-test for primary comparisons, supplemented by stratification and matching based on clinical and demographic characteristics to ensure comparability between groups. Post hoc analyses assessed the relationships between sALFF/dALFF alterations and clinical demographics, incorporating statistical adjustments for potential confounders and performing sensitivity analysis to test the robustness of our findings.</p></div><div><h3>Results</h3><p>Our analysis identified significant differences in sALFF and dALFF between patient with SeLECTS and HCs. Notably, increases in sALFF and dALFF were observed in the right middle temporal gyrus and left superior temporal gyrus among patient with SeLECTS, while a decrease in dALFF was seen in the right cerebellum crus 1. Additionally, a positive correlation was found between abnormal dALFF variability in specific brain regions and various clinical and demographic factors of patient with SeLECTS, with age being one such influential factor.</p></div><div><h3>Conclusion</h3><p>This investigation provides insights into the assessment of local brain activity in SeLECTS through both static and dynamic approaches. It highlights the significance of non-invasive neuroimaging techniques in understanding the complexities of epilepsy syndromes like SeLECTS and emphasizes the need to consider a range of clinical and demographic factors in neuroimaging studies of neurological disorders.</p></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"129 ","pages":"Article 110817"},"PeriodicalIF":1.9,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insufficient endplate-bone graft contact is a risk factor for high-grade cage subsidence occurring after lateral lumbar interbody fusion supplemented with lateral plate: An analysis of 121 cases","authors":"Ruijie Chen ,&nbsp;Zhengkuan Xu ,&nbsp;Qixin Chen ,&nbsp;Hao Li","doi":"10.1016/j.jocn.2024.110818","DOIUrl":"10.1016/j.jocn.2024.110818","url":null,"abstract":"<div><h3>Background</h3><p>Lateral lumbar interbody fusion (LLIF) is a minimally invasive fusion technique that can be performed with lateral plate. Insufficient contact between the endplate and bone graft may result in cage subsidence. This study aimed to investigate the potential risk factor for high-grade cage subsidence (HCS) occurring after LLIF supplemented with lateral plate.</p></div><div><h3>Methods</h3><p>Between June 2017 and February 2023, 121 patients (48 males, 73 females; mean age 63.0 years; minimum follow-up period 12 months) undergoing LLIF supplemented with lateral plate were retrospectively reviewed. The incidence of HCS was assessed, and patients were categorized into HCS group or non-HCS group based on the occurrence of HCS. A revision surgery of posterior pedicle screw fixation was performed in patients with cage subsidence and complained with intolerable back pain or radicular symptoms. Comparative analyses were performed on demographic characteristics, surgical variables, and parameters related to endplate-bone graft contact between the two groups. Multivariable logistic regression analysis was employed to identify the potential risk factors associated with HCS. The receiver operating characteristic (ROC) analysis was used to calculate the cutoff values for the risk factors. Clinical outcomes were evaluated using Oswestry Disability Index (ODI), and radiographic fusion at the final follow-up was assessed based on the Bridwell grading system.</p></div><div><h3>Results</h3><p>The HCS group comprised 12 patients, while the non-HCS group included 109 patients. The incidence of HCS occurring after LLIF supplemented with lateral plate was 9.9 %. Compared to non-HCS group, patients in HCS group had lower sagittal and coronal endplate-bone graft contact rates and larger cage-endplate angles. Low sagittal (OR, 1.099; 95 % CI, 1.033–1.169; <em>P</em>=0.003) and low coronal (OR, 1.149, 95 % CI, 1.061–1.243, <em>P</em>=0.001) endplate-bone graft contact rates were determined to be correlated with HCS. The cutoff value of the sagittal and coronal endplate-bone graft contact rate was 63.5 % and 60.9 %. Eleven (91.7 %) patients in HCS group underwent revision posterior pedicle screw fixation. Both HCS and non-HCS groups experienced significant improvements in ODI at the final follow-up, while there were no differences between groups. Ninety-five (87.2 %) patients in non-HCS group, and nine (81.8 %) of the 11 patients who underwent revision surgery in HCS group achieved radiographic fusion at the final follow-up.</p></div><div><h3>Conclusions</h3><p>The incidence of HCS occurring after LLIF supplemented with lateral plate was 9.9%. Insufficient endplate-bone graft contact is an important risk factor of HCS, and sagittal and coronal endplate-bone graft contact rates can be used as effective predictors for HCS.</p></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"129 ","pages":"Article 110818"},"PeriodicalIF":1.9,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing caregiver well being by integrating mindfulness and technology in amyotrophic lateral sclerosis care.","authors":"Riza Amalia, Aji Prasetya Wibawa, Ronal Surya Aditya, Rizky Andana Pohan, Basti Tetteng, Lutfiatus Zuhroh, Nur Ainy Sadijah","doi":"10.1016/j.jocn.2024.110819","DOIUrl":"https://doi.org/10.1016/j.jocn.2024.110819","url":null,"abstract":"<p><p>This letter discusses the pressing issue of caregiver burden in Amyotrophic Lateral Sclerosis (ALS) care, emphasizing the potential of mindfulness practices to alleviate stress and improve quality of life for caregivers. The integration of digital platforms, such as mindfulness apps, offers an accessible and effective solution, particularly in resource-limited settings. By adopting these strategies, we can enhance caregiver well-being and overall patient care, making it a crucial consideration for global health interventions.</p>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":" ","pages":"110819"},"PeriodicalIF":1.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 45-year journey into medulloblastoma: Observations and opportunities.","authors":"Imran Noorani","doi":"10.1016/j.jocn.2024.110827","DOIUrl":"https://doi.org/10.1016/j.jocn.2024.110827","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":" ","pages":"110827"},"PeriodicalIF":1.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT and neurosurgical education: A crossroads of innovation and opportunity","authors":"Saman Arfaie ,&nbsp;Mohammad Sadegh Mashayekhi ,&nbsp;Mohammad Mofatteh ,&nbsp;Crystal Ma ,&nbsp;Richard Ruan ,&nbsp;Mark A. MacLean ,&nbsp;Rena Far ,&nbsp;Jasleen Saini ,&nbsp;Irene E. Harmsen ,&nbsp;Taylor Duda ,&nbsp;Alwyn Gomez ,&nbsp;Alexander D. Rebchuk ,&nbsp;Alick Pingbei Wang ,&nbsp;Neilen Rasiah ,&nbsp;Eddie Guo ,&nbsp;Ali M. Fazlollahi ,&nbsp;Emma Rose Swan ,&nbsp;Pouya Amin ,&nbsp;Safraz Mohammed ,&nbsp;Jeffrey D. Atkinson ,&nbsp;Sunit Das","doi":"10.1016/j.jocn.2024.110815","DOIUrl":"10.1016/j.jocn.2024.110815","url":null,"abstract":"<div><p>Large language models (LLM) have been promising recently in the medical field, with numerous applications in clinical neuroscience. OpenAI’s launch of Generative Pre-trained Transformer 3.5 (GPT-3.5) in November 2022 and its successor, Generative Pre-trained Transformer 4 (GPT 4) in March 2023 have garnered widespread attention and debate surrounding natural language processing (NLP) and LLM advancements. Transformer models are trained on natural language datasets to predict and generate sequences of characters. Using internal weights from training, they produce tokens that align with their understanding of the initial input. This paper delves into ChatGPT’s potential as a learning tool in neurosurgery while contextualizing its abilities for passing medical licensing exams and neurosurgery written boards. Additionally, possibilities for creating personalized case presentations and study material are discussed alongside ChatGPT’s capacity to optimize the research workflow and perform a concise literature review. However, such tools need to be used with caution, given the possibility of artificial intelligence hallucinations and other concerns such as user overreliance, and complacency. Overall, this opinion paper raises key points surrounding ChatGPT’s role in neurosurgical education.</p></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"129 ","pages":"Article 110815"},"PeriodicalIF":1.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of paramagnetic rim lesions in multiple sclerosis: A systematic review","authors":"Adon Toru Asahina ,&nbsp;Joe Lu ,&nbsp;Pooja Chugh ,&nbsp;Srishti Sharma ,&nbsp;Prakriti Sharma ,&nbsp;Sheryn Tan ,&nbsp;Joshua Kovoor ,&nbsp;Brandon Stretton ,&nbsp;Aashray Gupta ,&nbsp;Annabel Sorby-Adams ,&nbsp;Rudy Goh ,&nbsp;Adil Harroud ,&nbsp;Margareta A. Clarke ,&nbsp;Nikos Evangelou ,&nbsp;Sandy Patel ,&nbsp;Andrew Dwyer ,&nbsp;Marc Agzarian ,&nbsp;Stephen Bacchi ,&nbsp;Mark Slee","doi":"10.1016/j.jocn.2024.110810","DOIUrl":"10.1016/j.jocn.2024.110810","url":null,"abstract":"<div><p>The diagnostic potential of paramagnetic rim lesions (PRLs) has been previously established; however, the prognostic significance of these lesions has not previously been consistently described. This study aimed to establish the prognostic role of PRLs in MS with respect to the Expanded Disability Status Scale (EDSS) and rates of disability progression.</p><p>Databases of PubMed, EMBASE, Scopus and reference lists of selected articles were searched up to 29/04/2023. The review was conducted in accordance with PRISMA guidelines and was registered prospectively on PROSPERO (CRD42023422052).</p><p>7 studies were included in the final review. All of the eligible studies found that patients with PRLs tend to have higher baseline EDSS scores. Longitudinal assessments revealed greater EDSS progression in patients with PRLs over time in most studies. However, the effect of location of PRLs within the central nervous system were not assessed across the studies. Only one study investigated progression independent of relapse activity (PIRA) and showed that this clinical entity occurred in a greater proportion in patients with PRLs.</p><p>This review supports PRLs as a predictor of EDSS progression. This measure has widespread applicability, however further multicentre studies are needed. Future research should explore the impact of PRLs on silent disability, PIRA, take into account different MS phenotypes and the topography of PRLs in prognosis.</p></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"129 ","pages":"Article 110810"},"PeriodicalIF":1.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Epidemiological profile of stroke in Qatar: Insights from a seven-year observational study","authors":"Javeria Sheikh","doi":"10.1016/j.jocn.2024.110812","DOIUrl":"10.1016/j.jocn.2024.110812","url":null,"abstract":"<div><p>We have thoroughly engaged with the article titled “Epidemiological profile of stroke in Qatar: Insights from a seven-year observational study”. The author’s diligent efforts regarding this critical subject matter are greatly appreciated [1], which is worthy of reader acknowledgment. We sincerely appreciate the author’s ongoing efforts on this vital subject, which deserve recognition. The primary conclusion of the article is that the incidence of stroke is increasing. However, it remains relatively low compared to the rising trend observed in Western countries. We agree with this assessment. It highlights the multi-ethnic population and unique risk factors of the Qatari and expatriate populations that are associated with stroke. The necessity of investing in designated stroke care strategies and balanced care for all population groups is underscored by the improved emergency medical services and healthcare access that have contributed to improving stroke care. Based on this, there are a few additional elements that could have contributed to the article’s conclusion.</p></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"129 ","pages":"Article 110812"},"PeriodicalIF":1.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes zoster in patients with glioma treated with temozolomide","authors":"Alison Hiong ,&nbsp;Adam H. Lapidus ,&nbsp;Lucy Gately ,&nbsp;Grace Sinclair ,&nbsp;Malaka Ameratunga","doi":"10.1016/j.jocn.2024.110816","DOIUrl":"10.1016/j.jocn.2024.110816","url":null,"abstract":"<div><h3>Background</h3><p>The risk of herpes zoster in patients treated with temozolomide is poorly defined in the literature. We aimed to evaluate the incidence of and risk factors for herpes zoster in individuals receiving temozolomide for glioma.</p></div><div><h3>Methods</h3><p>A retrospective observational study was conducted on a series of patients treated with temozolomide for glioma at a single centre between 1 October 2018 and 30 September 2023.</p></div><div><h3>Results</h3><p>131 patients were treated with temozolomide for glioma with a median age of 55 years. 4 out of 131 patients (3.1 %) developed herpes zoster during temozolomide treatment. All cases of herpes zoster occurred in patients who had lymphocyte nadirs of less than 0.7 x 10⁹/L and were receiving corticosteroids concomitantly. The estimated herpes zoster incidence rates were 45.44 per 1000 person-years (95 % confidence interval (CI) 12.38–116.34 per 1000 person-years) in the overall study population and 224.97 per 1000 person-years (95 % CI 61.30–576.02 per 1000 person-years) in subjects who were treated with corticosteroids and had a lymphocyte nadir of less than 1.0 x 10⁹/L.</p></div><div><h3>Conclusion</h3><p>Use of temozolomide, particularly in conjunction with lymphopaenia or corticosteroid use, poses a risk of herpes zoster. Further research into the benefits of prophylactic antiviral measures in this population is recommended.</p></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"129 ","pages":"Article 110816"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensorimotor network ALFF markers as prognostic indicators of cervical spondylotic myelopathy post-decompression surgery outcomes","authors":"Meiying Jiang ,&nbsp;Shucheng Yang ,&nbsp;Yongming Tan ,&nbsp;Xiaofen Li ,&nbsp;Laichang He","doi":"10.1016/j.jocn.2024.110769","DOIUrl":"10.1016/j.jocn.2024.110769","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the prognostic value of amplitude of low-frequency fluctuations (ALFF) within the sensorimotor network (SMN) in patients with cervical spondylotic myelopathy (CSM) following decompression surgery.</p></div><div><h3>Methods</h3><p>Eighty-three presurgical CSM patients (pre-CSM), 60 of the same group followed-up 3 months after decompression surgery (post-CSM) and 83 healthy controls (HC) matched for age, sex and level of education underwent resting-state functional magnetic resonance imaging scans by 3.0 T MR. Then, ALFF values measurements were compared and ALFF alterations were assessed among pre- or postsurgical CSM patients and HC, as well as correlations with clinical indexes by Pearson correlation.</p></div><div><h3>Results</h3><p>Compared with HC, the ALFF value of left inferior parietal marginal angular gyrus was decreased and the bilateral medial frontal gyrus was increased within pre-CSM (GRF correction). Compared with HC, the ALFF values of the left precentral gyrus, superior marginal gyrus, inferior parietal marginal angular gyrus, parietal lobule and postcentral gyrus decreased, while the ALFF value of the left auxiliary motor area, right anterior cuneiform lobule and right parietal lobule increased within post-CSM. Compared with pre-CSM patients, post-CSM patients had lower ALFF value in bilateral precuneus and precentral gyrus, but increased ALFF value in left medial superior frontal gyrus (Frontal_Sup_Medial_L). The ALFF value of the bilateral precuneus was positively correlated with the mJOA improvement rate, and the ALFF value of Frontal_Sup_Medial_L was positively correlated with the upper and lower limb scores within post-CSM.</p></div><div><h3>Conclusion</h3><p>Functional impairment and plasticity of SMN exist in CSM patients before and after surgery. ALFF within the SMN serves as a potential biomarker for predicting recovery outcomes.</p></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"129 ","pages":"Article 110769"},"PeriodicalIF":1.9,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}