Journal of critical care最新文献_第7页

The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study 氯胺酮对脓毒症ICU患者死亡率的影响：一项回顾性队列研究。

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jcrc.2025.155422

Yifei Liu , Jie Yue , Guangdong Wang , Yuxia Jiang , Aihua Shu

{"title":"The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study","authors":"Yifei Liu , Jie Yue , Guangdong Wang , Yuxia Jiang , Aihua Shu","doi":"10.1016/j.jcrc.2025.155422","DOIUrl":"10.1016/j.jcrc.2025.155422","url":null,"abstract":"<div><h3>Background</h3><div>Sepsis represents a systemic inflammatory response syndrome triggered by infection, potentially resulting in critical organ dysfunction with life-threatening consequences. Ketamine demonstrates efficacy in suppressing the release of inflammatory factors, thereby contributing significantly to the mitigation of inflammatory response of patients with sepsis while preserving vital organ functionality.</div></div><div><h3>Objective</h3><div>This study aims to examine the effect of ketamine administration on the ICU mortality rate of patients with sepsis.</div></div><div><h3>Methods</h3><div>This retrospective analysis utilized data from the MIMIC-IV database (<em>n</em> = 25,252 ICU patients). Primary outcomes were 7-day and 14-day ICU mortality rates, while secondary outcomes included ICU and total hospital length of stay. Covariates were adjusted using propensity score matching (PSM), and statistical analysis was performed using R software.</div></div><div><h3>Results</h3><div>After PSM, the analysis cohort included 2612 patients. Ketamine administration was significantly associated with reduced 7-day ICU mortality (HRs: 0.65 [0.48, 0.89], 0.63 [0.46, 0.86], 0.62 [0.45, 0.85]; all <em>P</em> < 0.05). No significant differences were observed in 14-day mortality. ICU and total hospital stays were longer in the ketamine group.</div></div><div><h3>Conclusion</h3><div>In this retrospective cohort, ketamine exposure was associated with lower 7-day ICU mortality; however, residual confounding and heterogeneity in timing, dose, and indication for ketamine use cannot be excluded. The longer hospital and ICU stays observed in ketamine-treated patients further underscore the need for prospective trials to clarify efficacy, optimal timing, and safety before routine adoption.</div></div>","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155422"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor “The association between albumin-corrected anion gap and in-hospital mortality in critically ill COPD patients: A multicenter retrospective study from eICU collaborative research database” 致编辑的信“危重COPD患者白蛋白校正阴离子间隙与住院死亡率的关系：来自eICU合作研究数据库的多中心回顾性研究”。

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2025-12-22 DOI: 10.1016/j.jcrc.2025.155410

Susu He , Yongkang Wang

引用次数: 0

Recovery of motor functions and cognitive functions in patients with intensive care unit–acquired weakness: Methodological considerations and future directions 重症监护病房获得性虚弱患者运动功能和认知功能的恢复：方法学考虑和未来方向。

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2025-11-12 DOI: 10.1016/j.jcrc.2025.155349

Tian Ruan

{"title":"Recovery of motor functions and cognitive functions in patients with intensive care unit–acquired weakness: Methodological considerations and future directions","authors":"Tian Ruan","doi":"10.1016/j.jcrc.2025.155349","DOIUrl":"10.1016/j.jcrc.2025.155349","url":null,"abstract":"<div><div>The recent article by Aoyama and colleagues on recovery of motor and cognitive functions in ICU-acquired weakness provides important insights into patient outcomes following critical illness. Their use of linear mixed modeling and rigorous stratification strengthens the evidence base for understanding cognitive-motor relationships in this vulnerable population. However, several methodological and statistical opportunities merit consideration for future investigations.This letter offers three evidence-based recommendations. First, longitudinal neuropsychological assessments using multidomain instruments (MoCA, MMSE) throughout post-ICU recovery could enhance precision in characterizing cognitive trajectories beyond single time-point FIM scores. Second, advanced statistical techniques such as propensity score matching or inverse probability weighting may better address baseline heterogeneity and residual confounding inherent in observational studies. Third, detailed documentation of post ICU rehabilitation protocols, including frequency, intensity, and patient adherence, using standardized reporting frameworks would clarify the contribution of specific interventions to both cognitive and motor recovery.These enhancements would strengthen future research in ICU-acquired weakness, ultimately optimizing patient recovery and informing clinical practice standards.</div></div>","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155349"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beat-to-beat blood pressure variability in PCI cohort PCI队列中次搏动血压变异性

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.jcrc.2025.155375

Ebenezer Tolman , Ethan Brovman , Jack Nickles , Jessa Deckwa , Timothy Ruchti

引用次数: 0

Hidden Markov Model and long short-term memory models for therapy response prediction in septic patients using routinely collected sequential data 隐马尔可夫模型和长短期记忆模型在脓毒症患者治疗反应预测中的应用

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.jcrc.2025.155382

Camilla Volterra , Marta Carrara , Diletta Guberti , Riccardo Asnaghi , Manuela Ferrario

引用次数: 0

Learning and evaluating improved reinforcement learning-based policies for sepsis treatment on MIMIC-IV 学习和评估改进的基于强化学习的MIMIC-IV脓毒症治疗策略

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.jcrc.2025.155385

Mohammad MahdiAzarbeik , Lorenz Kapral , Richard Weiss , Clemens Heitzinger , Oliver Kimberger

引用次数: 0

Predicting ventricular tachycardia in ICU patients using a timeseries foundation model and multimodal waveforms 使用时间序列基础模型和多模态波形预测ICU患者室性心动过速

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.jcrc.2025.155379

Konstantinos Kalpakis , Shiming Yang , William Teeter , Xiangxiang Kong , Meagan Watkins , Bradford Burdette , Kathalyn Urquizo , Timm Dickfeld , Bradley A. Maron , Peter Hu

引用次数: 0

Letter to the editor: “The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial” 致编辑的信：“孟鲁司特与辅酶Q10在成年脓毒症患者中的临床结果：一项随机对照临床试验”。

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2025-12-01 DOI: 10.1016/j.jcrc.2025.155294

Lulu Wang , Jinying Cheng

引用次数: 0

“He is so much more than just his illness” using the Patient Dignity Question (PDQ) to elicit personhood and enhance dignity in the intensive care unit (ICU): A feasibility study examining family and healthcare professional feedback “他不仅仅是他的疾病”，使用病人尊严问题（PDQ）在重症监护室（ICU）引出人格和提高尊严：一项检查家庭和医疗保健专业人员反馈的可行性研究

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2025-11-29 DOI: 10.1016/j.jcrc.2025.155360

Kendiss Olafson , Salina Pirzada , Lucas Mosienko , Kelsey Papineau , Lily Pankratz , Gagan Gill , Tim Hiebert , Maia S. Kredentser , Kristin Reynolds , James M. Bolton , Renée El-Gabalawy , Christian La Rivière , Harvey Max Chochinov

{"title":"“He is so much more than just his illness” using the Patient Dignity Question (PDQ) to elicit personhood and enhance dignity in the intensive care unit (ICU): A feasibility study examining family and healthcare professional feedback","authors":"Kendiss Olafson , Salina Pirzada , Lucas Mosienko , Kelsey Papineau , Lily Pankratz , Gagan Gill , Tim Hiebert , Maia S. Kredentser , Kristin Reynolds , James M. Bolton , Renée El-Gabalawy , Christian La Rivière , Harvey Max Chochinov","doi":"10.1016/j.jcrc.2025.155360","DOIUrl":"10.1016/j.jcrc.2025.155360","url":null,"abstract":"<div><h3>Purpose</h3><div>To test the feasibility of a novel approach for eliciting personhood in ICUs.</div></div><div><h3>Materials and methods</h3><div>A multi-method study in ICUs examining the Patient Dignity Question (PDQ): “What do I need to know about you/your family member as a person to take the best care of you/them as possible?”. The PDQ was used with family members of critically ill ICU patients. Brief interview summaries were placed at the bedside for the healthcare team to read. Feedback was obtained from families and staff through surveys utilizing Likert scales (1 strongly disagree, 5 strongly agree) and open-ended questions.</div></div><div><h3>Results</h3><div>Thirty-three family members reported PDQ participation was highly meaningful (Mean 4.8, SD 0.4), should be offered to other patients and families (Mean 4.8, SD 0.5), the PDQ information was accurate (Mean 4.9, SD 0.3), provided important information for the health care team (Mean 4.8, SD 0.4), and would impact their loved one's care (Mean 4.3, SD 0.8). Thirty-six ICU staff members reported the PDQ told them new information (Mean 4.5, SD 0.8), influenced their empathy (Mean 3.7 SD 1.1) and connectedness to the patient (Mean 3.9 SD 0.7). Despite this shift in tone of care, most felt it did not influence their physical care (Mean 2.8 SD 1.1). Qualitative themes from staff feedback include: 1) Knowing the whole person, tailoring care; 2) Increased empathy; and 3) Beyond the patient, impacting family interactions.</div></div><div><h3>Conclusions</h3><div>Families and staff reported PDQs were highly valued, providing a novel way of improving dignity conserving care in ICUs.</div></div>","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155360"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging RNA-Seq data to identify molecular distinctions in patients with complex traumatic injuries: Foundations for advanced clinical support 利用RNA-Seq数据识别复杂创伤性损伤患者的分子差异：先进临床支持的基础

IF 2.9 3区医学

Journal of critical care Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.jcrc.2025.155377

Seth A. Schobel , Ninh Vu , Sreya Mukerjee , Daniel C. Thompson , Eric Elster

引用次数: 0