Journal of critical care最新文献

{"title":"A method for real-time detection of change in pathophysiological dynamics from arterial blood gas analysis","authors":"Senthil Mudaliar , Lawrence A. Renna , George T. Harea , Dan S. Wendorff , Brendan M. Beely , Teryn R. Roberts , Bruce J. West , Andriy I. Batchinsky","doi":"10.1016/j.jcrc.2025.155370","DOIUrl":"10.1016/j.jcrc.2025.155370","url":null,"abstract":"","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155370"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a photoplethysmography-derived cardiovascular age metric for trauma and intensive care risk stratification","authors":"Ryan B. Felix , Kathalyn Urquizo , Meagan Watkins , William Gu , Bradford Burdette , Shiming Yang , Jamie Podell , John P. Fisher , William Teeter , Neeraj Badjatia , Peter Hu","doi":"10.1016/j.jcrc.2025.155384","DOIUrl":"10.1016/j.jcrc.2025.155384","url":null,"abstract":"","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155384"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prediction of life-saving interventions using pre-hospital vital signs","authors":"Shiming Yang , William Teeter , Meagan Watkins , Douglas Floccare , Samuel Galvagno , David Effon , Rosemary Kozar , Neeraj Badjatia , Thomas Scalea , Peter Hu","doi":"10.1016/j.jcrc.2025.155380","DOIUrl":"10.1016/j.jcrc.2025.155380","url":null,"abstract":"","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155380"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: “Evaluation of bromocriptine for the reduction of fever in patients with acute neurologic injury: A retrospective cohort study”","authors":"Nathan De Lissnyder , Sydney Blackman , Ilann Oueslati , Patrick M. Honore","doi":"10.1016/j.jcrc.2025.155409","DOIUrl":"10.1016/j.jcrc.2025.155409","url":null,"abstract":"","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155409"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: \"Sepsis-associated liver dysfunction confounds the association between circulating PCSK9 concentration and mortality in septic patients: A single-center retrospective cohort study”","authors":"Min Zhang, Xingyi Yang","doi":"10.1016/j.jcrc.2025.155417","DOIUrl":"10.1016/j.jcrc.2025.155417","url":null,"abstract":"","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155417"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic biotopes of intensive care units: How to listen and act effectively on the sounds of critical care with other listeners in mind","authors":"Elif Özcan , Judy Edworthy","doi":"10.1016/j.jcrc.2025.155359","DOIUrl":"10.1016/j.jcrc.2025.155359","url":null,"abstract":"","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155359"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can large language models approximate the results of meta-analyses in critical care? A meta-research study","authors":"Michael Pratte ,&nbsp;Shawn Thirukumar ,&nbsp;Caseng Zhang ,&nbsp;Marat Slessarev ,&nbsp;John Basmaji ,&nbsp;Ross Prager","doi":"10.1016/j.jcrc.2025.155358","DOIUrl":"10.1016/j.jcrc.2025.155358","url":null,"abstract":"<div><h3>Background</h3><div>Large language models (LLMs) are capable of processing extensive textual data and synthesizing evidence to answer complex clinical questions. The labor-intensive nature of systematic reviews with meta-analyses (SRMAs) present a unique opportunity to evaluate the utility of LLMs as a novel method for evidence synthesis.</div></div><div><h3>Objective</h3><div>This study assessed the ability of OpenAI's o3 DeepResearch model to approximate the direction of effect, magnitude of effect and certainty of evidence for clinical questions addressed by published meta-analyses in top critical care medicine journals.</div></div><div><h3>Methods</h3><div>We constructed standardized prompts based on the PICO (Population, Intervention, Comparator, Outcome) from a convenience sample of 23 systematic reviews with meta-analyses published in high-impact critical care journals. The LLM's estimates of effect size and certainty of evidence ratings were compared to those reported in the original SRMAs.</div></div><div><h3>Results</h3><div>The LLM demonstrated a concordance rate of 83 % (19 of 23 studies) for the magnitude of effect size and 91 % (21 of 23 studies) for the direction of effect. Concordance for certainty of evidence was also 91 %. Discrepancies were due to differences in study selection between the LLM and SRMAs, rather than model hallucination or misinterpretation.</div></div><div><h3>Conclusions</h3><div>LLMs show promise as a new tool for rapid evidence synthesis in critical care, with outputs comparable to traditional meta-analyses in many cases. While not a replacement for systematic reviews, LLMs may enhance clinical decision-making, perform rapid evidence synthesis, and streamline future research workflows.</div></div>","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155358"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing sepsis care within a learning health system: qualitatively examining the perspectives of those involved in sepsis care","authors":"Eduardo R. Osegueda ,&nbsp;Ben Webber ,&nbsp;Joseph S. Koopmeiners ,&nbsp;Genevieve B. Melton ,&nbsp;Timothy J. Beebe ,&nbsp;Michael G. Usher ,&nbsp;Deborah L. Pestka","doi":"10.1016/j.jcrc.2025.155367","DOIUrl":"10.1016/j.jcrc.2025.155367","url":null,"abstract":"<div><h3>Background</h3><div>Improving early recognition and treatment of sepsis is key to decreasing patient mortality. The current study investigates barriers and facilitators to timely and appropriate sepsis care from the perspectives of care team members across different roles at a large academic health system.</div></div><div><h3>Methods</h3><div>We held focus groups with frontline staff involved with sepsis care grouped by roles, including nurses, physicians, residents, pharmacists, laboratory staff, and members of an interdisciplinary sepsis rapid response team. Surveys were distributed to participants unable to attend a focus group session. Two researchers independently coded interview transcripts and survey responses, and mapped codes onto the Consolidated Framework for Implementation Research.</div></div><div><h3>Results</h3><div>Twenty-two frontline staff participated in seven focus groups; six others completed supplementary surveys. We identified eighteen factors influencing sepsis care across four themes: (1) sepsis detection; (2) approach to sepsis care; (3) team dynamics; (4) awareness of sepsis protocols, best practices, and performance.</div></div><div><h3>Discussion</h3><div>This study adds important insights on how team dynamics and environmental pressures affect sepsis care delivery. By including multiple roles in our sample, this study provides unique insight regarding how the lack of shared mental models troubles sepsis care delivery.</div></div><div><h3>Conclusion</h3><div>Future efforts to optimize sepsis care should focus on assessing team dynamics and developing interventions to improve these shared understandings and communication across roles.</div></div>","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155367"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent differences in regional lung mechanics; A retrospective observational study","authors":"Eda Aydeniz ,&nbsp;Bas C.T. van Bussel ,&nbsp;Iwan C.C. van der Horst ,&nbsp;Inéz Frerichs ,&nbsp;Dennis C.J.J. Bergmans","doi":"10.1016/j.jcrc.2025.155366","DOIUrl":"10.1016/j.jcrc.2025.155366","url":null,"abstract":"<div><h3>Background</h3><div>Whether outcomes related to mechanical ventilation differ between men and women remains unclear. This study aims to investigate whether respiratory variables and regional lung mechanics in critically ill mechanically ventilated patients differ between men and women, and if so, whether anthropometric parameters could explain the difference.</div></div><div><h3>Methods</h3><div>In this retrospective observational study, mechanically ventilated patients who underwent an electrical impedance tomography measurement were included. During electrical impedance tomography measurements, incremental and decremental positive end-expiratory pressure trials were performed, and dynamic compliance, alveolar overdistension, and alveolar collapse were determined per positive end-expiratory pressure level. Respiratory and electrical impedance tomography variables were extracted, including total dynamic compliance/positive end-expiratory pressure steps per patient. Linear regression was used to compute differences in mean dynamic compliance/positive end-expiratory pressure steps between men and women.</div></div><div><h3>Results</h3><div>A total of 259 patients (190 men and 69 women) were included and eligible for analysis. Comparisons of respiratory variables showed that women had higher tidal volumes per predicted body weight compared to men (7.7 mL/kg [6.6; 8.7] vs. 6.4 mL/kg [5.7; 7.3], <em>p</em> &lt; 0.001). Women had lower dynamic compliance compared to men (4.8 mL/cmH₂O [−7.5; −2.1], <em>p</em> = 0.001), which was not statistically significant after adjusting for height (1.0 mL/cmH₂O [−4.6; 2.6], <em>p</em> = 0.593) and predicted body weight (0.5 mL/cmH₂O [−3.6; 4.7], <em>p</em> = 0.800).</div></div><div><h3>Conclusion</h3><div>The difference between dynamic compliance/positive end-expiratory pressure during electrical impedance tomography between men and women could be explained by the difference in height. These results provide insights into the ventilation management in ICU patients.</div></div>","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155366"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in mean arterial pressure trends after phenylephrine in anesthetized patients","authors":"Estefanía Žugelj Tapia ,&nbsp;Marko Žličar ,&nbsp;Borut Kirn","doi":"10.1016/j.jcrc.2025.155383","DOIUrl":"10.1016/j.jcrc.2025.155383","url":null,"abstract":"","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"92 ","pages":"Article 155383"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}