Journal of Current Glaucoma Practice最新文献

{"title":"A Retrospective Cohort Study Analyzing Postoperative Safety and Efficacy of a Baerveldt Glaucoma Implant Modification for Earlier Intraocular Pressure Lowering, Compared to Nonmodified Baerveldt Implants at 3 Months.","authors":"Quinton H Christensen, Kristin L Davis, Joel A Vandelune, Danielle R Pellack, Ronak S Singh, Patrick J Donegan, Matthew D Meyer, Hend M Al-Kaylani, Erin A Boese, Andrew E Pouw","doi":"10.5005/jp-journals-10078-1514","DOIUrl":"10.5005/jp-journals-10078-1514","url":null,"abstract":"<p><strong>Aim and background: </strong>The Baerveldt glaucoma implant (BGI) is a tube shunt that has proven long-term safety and efficacy in lowering intraocular pressure (IOP). However, it requires temporary ligation for 6-8 weeks before it can take effect. This study compares the efficacy and safety of the BGI modified with a reversible ventilating mattress suture (vsBGI) to allow early flow with the unmodified BGI.</p><p><strong>Materials and methods: </strong>A retrospective cohort study was performed at the University of Iowa, including patients who underwent either an unmodified Baerveldt tube shunt (BGI) or a vsBGI between 2016 and 2023. Primary outcomes were IOP, number of glaucoma medications, and best-corrected visual acuity. Adverse events within 3 months postoperatively were recorded.</p><p><strong>Results: </strong>A total of 124 eyes from 114 patients were included in the study. The vsBGI group had 62 eyes from 58 patients, and the BGI group had 62 eyes from 56 patients. At baseline, median IOP was significantly higher in the vsBGI group compared to those receiving the standard BGI (<i>p</i> < 0.001), but on day 1 and week 1, the median IOP was significantly lower in the vsBGI group than BGI (<i>p</i> < 0.001). By month 3, there was no significant difference in IOP between the two groups. From week 1 through month 3, patients in the vsBGI group required significantly fewer topical medications compared to those with the standard BGI (all <i>p</i> ≤ 0.017), even though no baseline differences were observed. Visual acuity was not significantly different between the groups at any time point. The number of adverse events or rate of reoperations in the 3-month postoperative period were not statistically different between vsBGI and BGI.</p><p><strong>Conclusion: </strong>The reversible ventilating suture modification to the BGI tube shunt is a safe and effective method of allowing early aqueous humor flow and reducing IOP in the early postoperative period.</p><p><strong>Clinical significance: </strong>The ventilating suture modification to the BGI provides a practical approach to overcoming the delay in IOP lowering that accompanies traditional tube ligation. By permitting controlled early aqueous flow, the vsBGI achieves meaningful pressure reduction in the immediate postoperative period without increasing adverse events or reoperation rates.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 2","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Myopic Glaucoma-Beyond Structural Fragility and Diagnostic Challenges: Review Article.","authors":"Caroline K Diniz, Melissa A Meira, Luís Avas Gondim, Syril Dorairaj, Maria Bc Lemos, Fábio N Kanadani, Carolina Pb Graciatelli, Augusto Paranhos, Tiago S Prata","doi":"10.5005/jp-journals-10078-1504","DOIUrl":"10.5005/jp-journals-10078-1504","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aims and background: &lt;/strong&gt;Myopic glaucoma is a distinct subtype of glaucomatous optic neuropathy that is often underrecognized or misdiagnosed, particularly in younger patients whose intraocular pressures (IOP) fall within statistically normal ranges. High myopia presents complex structural, functional, and biomechanical challenges that hinder both early detection and effective disease management.This review summarizes current evidence on the pathophysiology, clinical presentation, diagnostic limitations, and tailored therapeutic strategies for myopic glaucoma, providing a practical clinical framework for improved management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This narrative review synthesizes current evidence from peer-reviewed clinical and basic science studies on myopic glaucoma. Drawing on a comprehensive literature search, it addresses the pathophysiology, clinical presentation, diagnostic limitations, and tailored therapeutic strategies for myopic glaucoma, with the aim of establishing a clinically relevant framework to inform optimized management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The global prevalence of myopia is increasing, with high myopia substantially elevating the risk of glaucoma, particularly among Asian populations. Structural alterations-including axial elongation, scleral thinning, lamina cribrosa deformation, and optic nerve head tilting-augment biomechanical vulnerability to glaucomatous damage, even when IOP remains within normal limits.Myopic glaucoma is often characterized by tilted optic discs, peripapillary atrophy, and early paracentral visual field defects, which may not be detected by standard perimetric methods. Diagnosis is complicated by the limitations of optical coherence tomography (OCT), including segmentation errors and the lack of normative databases specific to myopic eyes. Moreover, disease progression may occur even with low IOP, and distinguishing glaucomatous damage from myopia-induced structural changes remains a significant challenge. Recent advances, such as the identification of the crescent moon sign, implementation of 10-2 visual field testing, and use of biomechanically compensated tonometry, have improved diagnostic accuracy.Management requires lower IOP targets due to increased structural fragility, often necessitating combined medical therapy or early surgical intervention. However, surgery in young highly myopic patients carries a heightened risk of hypotony maculopathy.Emerging technologies, including artificial intelligence (AI)-based algorithms and widefield optical coherence tomography angiography (WF-OCTA), enhance diagnostic precision by addressing anatomical distortions and facilitating the early detection of glaucomatous changes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion and clinical significance: &lt;/strong&gt;Early identification and tailored management of myopic glaucoma are crucial to mitigate vision loss in this high-risk population. Awareness of the unique challenges posed by h","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucoma and Systemic Neurodegenerative Diseases: The Brain-Eye Continuum.","authors":"Priti Singh, Samendra Karkhur, Vidhya Verma, Saroj Gupta, Arushi Beri","doi":"10.5005/jp-journals-10078-1513","DOIUrl":"10.5005/jp-journals-10078-1513","url":null,"abstract":"<p><p>Glaucoma is a chronic, progressive optic neuropathy characterized by retinal ganglion cell (RGC) death and visual field loss. It is the leading cause of irreversible blindness globally, affecting more than 70 million people, and its prevalence is expected to rise with aging populations. Traditionally, glaucoma was defined primarily as a disease of intraocular pressure (IOP) dysregulation, but recent decades have reframed it as a complex neurodegenerative disorder involving multiple systemic and local risk factors. In parallel, systemic neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) pose immense healthcare and socioeconomic burdens. The concept of the \"eye as a window to the brain\" arises from the fact that the retina and optic nerve are direct extensions of the central nervous system (CNS). This has positioned the eye as a valuable site for studying neurodegenerative processes noninvasively, using advanced imaging modalities such as optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Glaucoma is a chronic neurodegenerative optic neuropathy, and the concept of the \"eye as a window to the brain\" highlights its overlap with systemic diseases such as AD, PD, and MS.</p><p><strong>How to cite this article: </strong>Singh P, Karkhur S, Verma V, <i>et al.</i> Glaucoma and Systemic Neurodegenerative Diseases: The Brain-Eye Continuum. J Curr Glaucoma Pract 2026;20(1):26-30.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Effectiveness Outcomes of <i>Ab Interno</i> Canaloplasty in Open-angle Glaucoma: 10-year Results.","authors":"Norbert Koerber, Simon Ondrejka","doi":"10.5005/jp-journals-10078-1508","DOIUrl":"10.5005/jp-journals-10078-1508","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate long-term outcomes of <i>ab interno</i> canaloplasty in patients with open-angle glaucoma, focusing on intraocular pressure (IOP) control and medication use over a 10-year period.</p><p><strong>Materials and methods: </strong>This retrospective case series evaluated 27 eyes of 22 patients with pseudoexfoliative (PEX) or primary open-angle glaucoma (POAG) who underwent <i>ab interno</i> canaloplasty using the iTrack microcatheter (Nova Eye Medical, Fremont, CA, USA) between October 2014 and October 2016. The majority of procedures were performed in conjunction with cataract surgery (23 of 27 eyes). Main outcome measures were changes in mean IOP and number of glaucoma medications.</p><p><strong>Results: </strong>Over an average follow-up of 78.7 ± 37.0 months [last follow-up (LFU)], mean IOP (mm Hg) significantly decreased from 19.9 ± 5.2 at baseline to 14.7 ± 3.7 (-26%; <i>p</i> < 0.001) at LFU, while the mean medication use reduced from 1.9 ± 1.0 to 1.0 ± 1.1 (-50%; <i>p</i> = 0.004). Visual field mean deviation (VF MD) (dB) remained stable (-7.86 ± 6.90 to -7.61 ± 6.63; <i>p</i> = 0.498). Among the seven eyes followed for 10 years, IOP decreased from 19.4 ± 3.2 to 14.9 ± 2.3 (-24%, <i>p</i> = 0.010), while medication use remained stable (1.7 ± 0.9 to 2.0 ± 1.2, <i>p</i> = 0.604) with no serious complications or need for additional glaucoma surgery.</p><p><strong>Conclusion: </strong>iTrack <i>ab interno</i> canaloplasty achieved sustained reductions in IOP and medications, with no safety concerns. Seven eyes were followed up for 10 years, showing sustained IOP reduction.</p><p><strong>How to cite this article: </strong>Koerber N, Ondrejka S. Safety and Effectiveness Outcomes of <i>Ab Interno</i> Canaloplasty in Open-angle Glaucoma: 10-year Results. J Curr Glaucoma Pract 2026;20(1):11-13.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Preserflo MicroShunt Implantation after Descemet's Stripping Automated Endothelial Keratoplasty: A Case Report.","authors":"Francesco Della Lena, Niccolò Boni, Marco Messina, Myrta Lippera, Carlo Cagini","doi":"10.5005/jp-journals-10078-1455","DOIUrl":"10.5005/jp-journals-10078-1455","url":null,"abstract":"<p><strong>Aim and background: </strong>To describe a case of Preserflo MicroShunt implantation in both eyes of a patient with intraocular pressure (IOP) rise after receiving bilateral Descemet's stripping automated endothelial keratoplasty (DSAEK), with poor IOP control by medical treatment alone.</p><p><strong>Case description: </strong>A female patient, previously diagnosed with primary open-angle glaucoma (POAG) and Fuchs' corneal dystrophy in both eyes, developed bilateral bullous keratopathy in late 2021. The patient underwent combined DSAEK and cataract surgery in her right eye (RE) in December 2021 and in April 2022 in her left eye (LE). After the surgical procedures, we observed an IOP rise not controlled by medical treatment. Bilateral Preserflo MicroShunt implantation was chosen as the surgical option to reduce the IOP increase and was performed in June 2022 in the LE and in July 2022 in the RE. The Preserflo MicroShunt implantation was successful in reducing the IOP in both eyes after bilateral DSAEK without the need for any additional hypotonic medical treatment. We observed good positioning of the device and the maintenance of corneal graft transparency and adhesion in both eyes after a 6-month follow-up from the most recent procedure.</p><p><strong>Conclusion: </strong>Preserflo MicroShunt has the potential to be a safe and effective technique in cases of IOP increase after endothelial keratoplasty. Further investigations with larger patient samples are required to validate our findings.</p><p><strong>Clinical significance: </strong>IOP elevation after corneal transplantation can pose a challenge in the postoperative period and may lead to the need for glaucoma surgery. Our report on a case of bilateral Preserflo implantation after DSAEK highlights the potential benefits of this relatively new glaucoma surgical technique in the management of these patients.</p><p><strong>How to cite this article: </strong>Della Lena F, Boni N, Messina M, <i>et al.</i> Bilateral Preserflo MicroShunt Implantation after Descemet's Stripping Automated Endothelial Keratoplasty: A Case Report. J Curr Glaucoma Pract 2026;20(1):34-37.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Acute Angle Closure Glaucoma Following Phentermine Monotherapy.","authors":"Zaid Parekh, Arjav Shah, Philip Zhou, Anita Goyal","doi":"10.5005/jp-journals-10078-1507","DOIUrl":"10.5005/jp-journals-10078-1507","url":null,"abstract":"<p><strong>Aim and background: </strong>To report a case of bilateral acute angle closure glaucoma following phentermine monotherapy after prior topiramate discontinuation, highlighting the ocular risks of widely used weight loss medications, whether prescribed alone or in combination. Topiramate has a well-established role in acute bilateral angle closure glaucoma through ciliochoroidal permeability changes and choroidal effusion, while phentermine is contraindicated in glaucoma and has been implicated in bilateral angle closure glaucoma in one report. This case addresses a gap in recognizing phentermine's independent effects when used separately.</p><p><strong>Case description: </strong>A 31-year-old woman with a medical history of diabetes, hypertension, and migraines was prescribed topiramate 25 mg nightly and phentermine 15 mg daily for weight loss management. She discontinued topiramate after 2 days due to nausea, but continued phentermine. More than 1 week after topiramate cessation, she developed acute bilateral blurred vision, eye pain, and tearing. Examination revealed intraocular pressures (IOP) of 55 and 53 mm Hg in the right and left eyes, respectively. Gonioscopy demonstrated complete 360° angle closure bilaterally. B-scan ultrasonography confirmed bilateral choroidal effusions, suggesting a nonpupillary block mechanism similar to topiramate-induced angle closure. Management included immediate phentermine discontinuation and intensive medical therapy with cycloplegic agents and steroid drops, and maximum medical treatment including intravenous mannitol, systemic and topical carbonic anhydrase inhibitors, topical β-blockers, and α agonists. IOPs normalized within 48 hours, and gonioscopy demonstrated open angles bilaterally by day 2.</p><p><strong>Conclusions: </strong>This case demonstrates that phentermine monotherapy can be associated with bilateral acute angle closure glaucoma through mechanisms similar to topiramate-induced closure, occurring even after topiramate discontinuation. The temporal relationship and presence of choroidal effusions strongly implicate phentermine as the primary causative agent.</p><p><strong>Clinical importance: </strong>Comprehensive ocular risk assessment is essential for all weight loss medications, including phentermine when used alone, to identify drug-induced angle closure mechanisms and guide prompt management to prevent serious complications.</p><p><strong>How to cite this article: </strong>Parekh Z, Shah A, Zhou P, <i>et al.</i> Bilateral Acute Angle Closure Glaucoma Following Phentermine Monotherapy. J Curr Glaucoma Pract 2026;20(1):31-33.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"31-33"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucoma After Dark: Sleep, Circadian Stress, and Unmeasured Drivers of Disease.","authors":"Pranav Vasu, Shibal Bharitya, Syril K Dorairaj","doi":"10.5005/jp-journals-10078-1506","DOIUrl":"10.5005/jp-journals-10078-1506","url":null,"abstract":"<p><p><b>How to cite this article:</b> Vasu P, Bharitya S, Dorairaj SK. Glaucoma After Dark: Sleep, Circadian Stress, and Unmeasured Drivers of Disease. J Curr Glaucoma Pract 2026;20(1):1-3.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Short-term Results of Trabeculectomies by Specialists and Trainees in an Indian Tertiary Care Eye Hospital.","authors":"Anugya Sharma, Monica Gandhi, Darshana Daga, Julie Pegu, Suneeta Dubey","doi":"10.5005/jp-journals-10078-1512","DOIUrl":"10.5005/jp-journals-10078-1512","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the outcomes of trabeculectomies between glaucoma specialists and trainees at a tertiary eye care hospital in North India.</p><p><strong>Materials and methods: </strong>A retrospective evaluation of charts of patients undergoing primary trabeculectomy by either specialist consultants or glaucoma service trainees between October 2019 and March 2022 was conducted. Outcome measures were complete success, qualified success, and failure.</p><p><strong>Results: </strong>The study included 511 trabeculectomy surgeries, of which consultants performed 360 (70.4%) cases, and trainees performed 151 (29.5%) cases, with the consultants operating on more secondary glaucoma cases. The trainees had a significantly higher intraocular pressure (IOP) postoperatively; however, complete success, qualified success, and failure rates at 3 and 6 months were comparable between the two groups. The complication rate was also similar between the two groups, with the trainees showing a higher rate of return to OT.</p><p><strong>Conclusion: </strong>The high glaucoma burden in India emphasizes the necessity for more surgeons proficient in glaucoma procedures. This need can be met through organized training programs. A well-structured training program, incorporating hands-on wet-lab experience and supervised intraoperative training, enables trainees to achieve outcomes comparable to those of experienced glaucoma specialists when proctored. And thus, help increase the number of glaucoma specialists. This study emphasizes the need for such training programs while alleviating concerns about trainees performing surgeries that are perceived to be at higher risk.</p><p><strong>How to cite this article: </strong>Sharma A, Gandhi M, Daga D, <i>et al.</i> Comparison of Short-term Results of Trabeculectomies by Specialists and Trainees in an Indian Tertiary Care Eye Hospital. J Curr Glaucoma Pract 2026;20(1):14-19.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular Pressure after Uneventful Phacoemulsification in Diabetic and Nondiabetic Patients: A Prospective Observational Study.","authors":"Zois Papadopoulos","doi":"10.5005/jp-journals-10078-1505","DOIUrl":"10.5005/jp-journals-10078-1505","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Phacoemulsification cataract surgery, the standard treatment for visually significant cataracts, has been shown to influence intraocular pressure (IOP); however, the extent and underlying mechanisms of this effect may differ in patients with systemic conditions such as diabetes mellitus. Although some evidence exists, studies have reported conflicting results regarding whether diabetic and nondiabetic patients exhibit differences in postoperative IOP changes following phacoemulsification. Therefore, this study aimed to evaluate and compare postoperative IOP alterations in diabetic and nondiabetic patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A prospective observational study was conducted among 208 adults aged ≥50 years with cataract, including 104 diabetic and 104 nondiabetic patients. The study adhered to STROBE guidelines. IOP was measured preoperatively and at 1 and 6 weeks postoperatively using Goldmann applanation tonometry. Data normality was assessed with the Shapiro-Wilk test, sphericity with Mauchly's test, and variance homogeneity with Levene's test. Repeated measures ANOVA evaluated changes in IOP over time and between groups, including time × group interactions, while linear mixed-effects modeling accounted for repeated measurements and estimated the magnitude of postoperative IOP changes. A &lt;i&gt;p&lt;/i&gt;-value &lt; 0.05 was considered statistically significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Repeated measures ANOVA showed significant effects of time (&lt;i&gt;F&lt;/i&gt; = 610.5, &lt;i&gt;p&lt;/i&gt; = 0.003), diabetes (&lt;i&gt;F&lt;/i&gt; = 32.1, &lt;i&gt;p&lt;/i&gt; = 0.041), and the time × diabetes interaction (&lt;i&gt;F&lt;/i&gt; = 55.2, &lt;i&gt;p&lt;/i&gt; = 0.002), indicating IOP decreased over time in all patients, with greater reductions in nondiabetics. Linear mixed-effects modeling confirmed significant postoperative IOP decreases: nondiabetic patients showed reductions of 1.2 mm Hg at 1 week (β = -1.20, 95% CI:-1.88 to -0.52) and 2.5 mm Hg at 6 weeks (β =-2.50, 95% CI:-3.34 to -1.66), whereas diabetic patients had smaller reductions (1 week × diabetes: β = 0.90, 95% CI: 0.16-1.64; 6 weeks × diabetes: β = 1.75, 95% CI: 0.97-2.53). Among diabetics, higher HbA1c (β = 1.70, 95% CI: 0.82-2.58) and diabetes duration (β = 1.30, 95% CI: 0.56-2.04) were significantly associated with change in postoperative IOP.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Phacoemulsification effectively lowers IOP in older adults with cataract; however, the reduction is smaller in diabetic patients and is influenced by HbA1c levels and diabetes duration. Careful postoperative monitoring of IOP is recommended in diabetic individuals. A randomized controlled trial is &lt;b&gt;recommended&lt;/b&gt; to further investigate these differences and the impact of glycemic control on postoperative IOP outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;How to cite this article: &lt;/strong&gt;Papadopoulos Z. Intraocular Pressure after Uneventful Phacoemulsification in Diabetic and Nondiabetic Patients: A Prospective Observational Study. J Curr Glaucoma Pract 2","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"20 1","pages":"4-10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Hemodialysis on Ocular Pressure Dynamics: An Observational Study on IOP and OPP Changes.","authors":"Venkata Sai Sweeya Donepudi, M Meera Alias Devasena, Radha Annamalai, Pavan Krishna Reddy Sannareddy, E Ram Prasad","doi":"10.5005/jp-journals-10078-1497","DOIUrl":"10.5005/jp-journals-10078-1497","url":null,"abstract":"<p><strong>Background: </strong>Hemodialysis (HD) is a life-saving therapy for patients with end-stage renal disease (ESRD), yet its impact on ocular hemodynamics remains insufficiently characterized. Intraocular pressure (IOP) and ocular perfusion pressure (OPP) are critical determinants of ocular health, and their fluctuation during HD may predispose patients to complications, particularly in glaucoma.</p><p><strong>Objective: </strong>To assess the effect of HD on IOP and OPP in patients on maintenance dialysis.</p><p><strong>Materials and methods: </strong>This observational study included 50 ESRD patients undergoing regular HD. IOP was measured using a noncontact tonometer, and OPP was calculated before and after dialysis sessions. Demographic, clinical, and hemodynamic parameters were recorded. Pre- and postdialysis values were compared using paired statistical tests.</p><p><strong>Results: </strong>Hemodialysis significantly increased IOP [right eye (RE): 13.56 ± 2.75 to 16.06 ± 1.97 mm Hg, <i>p</i> < 0.001; left eye (LE): 13.68 ± 2.67 to 16.51 ± 1.53 mm Hg, <i>p</i> < 0.001] and reduced OPP (RE: 49.2 ± 6.5 to 42.7 ± 5.8 mm Hg; LE: 47.6 ± 6.1 to 41.5 ± 5.7 mm Hg; both <i>p</i> < 0.001), with a mean decline of 7.6 mm Hg.</p><p><strong>Conclusions: </strong>Hemodialysis significantly alters ocular pressure dynamics, with increased IOP and reduced OPP suggesting compromised ocular perfusion. Hypertension (HTN) and diabetes mellitus (DM) may exacerbate these effects. Although no acute ocular complications were observed, reduced OPP may increase the risk in patients with glaucoma or vascular disease. Routine ophthalmic monitoring and structured follow-up should be integrated into dialysis care.</p><p><strong>How to cite this article: </strong>Donepudi VSS, Devasena M MA, Annamalai R, <i>et al.</i> The Influence of Hemodialysis on Ocular Pressure Dynamics: An Observational Study on IOP and OPP Changes. J Curr Glaucoma Pract 2025;19(4):182-185.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"19 4","pages":"182-185"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}