Journal of clinical lipidology最新文献

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Burden of atherogenic lipids and association with cardiac allograft vasculopathy in heart transplant recipients. 心脏移植受者的致动脉粥样硬化血脂负担及其与心脏异体移植血管病变的关系。
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-11-13 DOI: 10.1016/j.jacl.2024.10.005
Antoinette S Birs, Andrew S Kao, Elizabeth Silver, Eric D Adler, Pam R Taub, Michael J Wilkinson
{"title":"Burden of atherogenic lipids and association with cardiac allograft vasculopathy in heart transplant recipients<sup />.","authors":"Antoinette S Birs, Andrew S Kao, Elizabeth Silver, Eric D Adler, Pam R Taub, Michael J Wilkinson","doi":"10.1016/j.jacl.2024.10.005","DOIUrl":"10.1016/j.jacl.2024.10.005","url":null,"abstract":"<p><strong>Background: </strong>Cardiac Allograft Vasculopathy (CAV) is a leading cause of morbidity and mortality after heart transplantation. There are limited contemporary studies examining post-transplant lipid management and cardiometabolic health.</p><p><strong>Objective: </strong>We study the burden of cardiometabolic derangements post transplantation and its impact on CAV in a modern cohort of heart transplant recipients.</p><p><strong>Methods: </strong>All heart transplant (HTx) recipients between January 2019 and December 2020, with two lipid assessments and angiographic surveillance were included. Logistic regression was used to assess association of lipid levels with cardiovascular outcomes and CAV.</p><p><strong>Results: </strong>Among 87 HTx recipients, atherogenic lipids were significantly elevated after Htx. Median LDL-C increased from a baseline level of 69.5 mg/dL to 86.5 mg/dL, p = 0.002, non-HDL-C 91.5 mg/dL to 118 mg/dL, p < 0.001, triglycerides 94.5 mg/dL to 133 mg/dL, p < 0.001, and remnant cholesterol 19 mg/dL to 27 mg/dL, p < 0.001. Increases in non-HDL-C, triglycerides, and remnant cholesterol were significantly associated with increased risk of CAV (Stanford Grade 4 and intimal thickness). Increases in triglycerides and remnant-C were associated with increased risk of composite major adverse cardiovascular events.</p><p><strong>Conclusion: </strong>We demonstrate a significant increase in atherogenic lipids two years following transplantation with low use (20 %) of high-intensity statin. Increase in atherogenic lipids was associated with increased risk of CAV and increase in triglycerides and remnant cholesterol with increased MACE. Future studies examining cardiometabolic consequences of heart transplantation and optimal treatment strategies to reduce risk of CAV and MACE are needed.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of clinical criteria to identify familial chylomicronemia syndrome (FCS) in North America. 在北美制定和验证识别家族性乳糜微粒血症综合征(FCS)的临床标准。
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-11-12 DOI: 10.1016/j.jacl.2024.09.008
Robert A Hegele, Zahid Ahmad, Ambika Ashraf, Andrew Baldassarra, Alan S Brown, Alan Chait, Steven D Freedman, Brenda Kohn, Michael Miller, Nivedita Patni, Daniel E Soffer, Jian Wang, Michael S Broder, Eunice Chang, Irina Yermilov, Cynthia Campos, Sarah N Gibbs
{"title":"Development and validation of clinical criteria to identify familial chylomicronemia syndrome (FCS) in North America.","authors":"Robert A Hegele, Zahid Ahmad, Ambika Ashraf, Andrew Baldassarra, Alan S Brown, Alan Chait, Steven D Freedman, Brenda Kohn, Michael Miller, Nivedita Patni, Daniel E Soffer, Jian Wang, Michael S Broder, Eunice Chang, Irina Yermilov, Cynthia Campos, Sarah N Gibbs","doi":"10.1016/j.jacl.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.09.008","url":null,"abstract":"<p><strong>Background: </strong>Familial chylomicronemia syndrome (FCS) is an ultrarare inherited disorder. Genetic testing is not always feasible or conclusive. European clinicians developed a \"FCS score\" to differentiate between FCS and multifactorial chylomicronemia syndrome (MCS), a more common condition with overlapping features. A diagnostic score has not been developed for use in the North American context.</p><p><strong>Objective: </strong>To develop and validate a diagnostic score for North American patients based on signs, symptoms and biochemical traits of FCS.</p><p><strong>Methods: </strong>Using the RAND/UCLA modified Delphi process, we convened ten US/Canadian physicians with experience recognizing and treating FCS and one adult patient with FCS. The panel developed and rated 296 scenarios describing patients with FCS. Linear regression analyses used median post-meeting ratings to develop score parameters. We tested the score's sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) in patients with classical FCS, functional FCS, and MCS from Western University's Lipid Genetics Clinic's registry.</p><p><strong>Results: </strong>Numerical scores were attributed based upon the following: age, hypertriglyceridemia onset, body mass index, history of abdominal pain/pancreatitis, presence of secondary factors, triglyceride (TG) levels, ratio of TG/total cholesterol, and apolipoprotein B level. Scores ≥60 indicate definite classical FCS; the score distinguished patients with FCS from MCS in a real-world registry (100.0 % specificity, 66.7 % sensitivity, 100.0 % PPV, 95.5 % NPV). Scores ≥45 were \"very likely\" to have classical FCS (96.9 % specificity, 88.9 % sensitivity).</p><p><strong>Conclusion: </strong>Given its simplicity and high specificity for distinguishing patients with FCS from MCS, the NAFCS Score could be used in lieu of - or while awaiting - genetic testing to optimize treatment.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and functional analysis of novel homozygous LMF1 variants in severe hypertriglyceridemia. 严重高甘油三酯血症中新型同源 LMF1 变体的鉴定和功能分析
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-19 DOI: 10.1016/j.jacl.2024.10.004
Candy Bedoya, Rishi Thomas, Anna Bjarvin, Wilbur Ji, Hanien Samara, Jody Tai, Laurie Green, Philip H Frost, Mary J Malloy, Clive R Pullinger, John P Kane, Miklós Péterfy
{"title":"Identification and functional analysis of novel homozygous LMF1 variants in severe hypertriglyceridemia.","authors":"Candy Bedoya, Rishi Thomas, Anna Bjarvin, Wilbur Ji, Hanien Samara, Jody Tai, Laurie Green, Philip H Frost, Mary J Malloy, Clive R Pullinger, John P Kane, Miklós Péterfy","doi":"10.1016/j.jacl.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.10.004","url":null,"abstract":"<p><strong>Background: </strong>The genetic basis of hypertriglyceridemia (HTG) is complex and includes variants in Lipase Maturation Factor 1 (LMF1), an endoplasmic reticulum (ER)-chaperone involved in the post-translational activation of lipoprotein lipase (LPL).</p><p><strong>Objective: </strong>The objective of this study was to identify and functionally characterize biallelic LMF1 variants in patients with HTG.</p><p><strong>Methods: </strong>Genomic DNA sequencing was used to identify biallelic LMF1 variants in HTG patients without deleterious variants in LPL, apolipoprotein C-II (APOC2), glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) or apolipoprotein A-V (APOA5). LMF1 variants were functionally evaluated by in silico analyses and assessing their impact on LPL activity, LMF1 protein expression and specific activity in transiently transfected HEK293 cells.</p><p><strong>Results: </strong>We identified four homozygous LMF1 variants in patients with severe HTG: two novel rare variants (p.Asn147Lys and p.Pro246Arg) and two low-frequency variants (p.Arg354Trp and p.Arg364Gln) previously reported at heterozygosity. We demonstrate that all four variants reduce the secretion of enzymatically active LPL by impairing the specific activity of LMF1, whereas p.Asn147Lys also diminishes LMF1 protein expression.</p><p><strong>Conclusion: </strong>This study extends the role of LMF1 as a genetic determinant in severe HTG and demonstrates that rare and low-frequency LMF1 variants can underlie this condition through distinct molecular mechanisms. The clinical phenotype of patients affected by partial loss of LMF1 function is consistent with Multifactorial Chylomicronemia Syndrome (MCS) and suggests that secondary factors and additional genetic determinants contribute to HTG in these subjects.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex dyslipidemia induced by Lorlatinib therapy: A case study. 罗拉替尼治疗诱发的复杂血脂异常:病例研究。
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-17 DOI: 10.1016/j.jacl.2024.10.003
Julianna West, Abhimanyu Garg
{"title":"Complex dyslipidemia induced by Lorlatinib therapy: A case study.","authors":"Julianna West, Abhimanyu Garg","doi":"10.1016/j.jacl.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.10.003","url":null,"abstract":"<p><strong>Context: </strong>Lorlatinib is an anaplastic lymphoma kinase (ALK) inhibitor, which is currently used for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC). Previous reports have noticed an association between lorlatinib and hyperlipidemia, however the specific mechanisms for this side effect remain unknown. Some investigators have reported nephrotic syndrome to be the underlying cause of lorlatinib-induced hyperlipidemia.</p><p><strong>Case report: </strong>A 59-year-old female with NSCLC presented with marked elevation of lipid levels, including total cholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C), after initiation of lorlatinib therapy. Despite high dose atorvastatin and ezetimibe, lipid levels remained elevated. A 24-hour urine collection revealed only 226 mg of protein excretion.</p><p><strong>Conclusions: </strong>Lorlatinib induced a complex dyslipidemia in our patient with elevations of both LDL-C and HDL-C. The underlying mechanism of lorlatinib-induced hyperlipidemia remains unknown and is unlikely to be secondary to nephrotic syndrome in many patients.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipoprotein(a) in clinical practice: The role in long-term in-stent restenosis. 临床实践中的脂蛋白(a):在支架内长期再狭窄中的作用。
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-13 DOI: 10.1016/j.jacl.2024.10.002
Francesco Sbrana, Beatrice Dal Pino
{"title":"Lipoprotein(a) in clinical practice: The role in long-term in-stent restenosis.","authors":"Francesco Sbrana, Beatrice Dal Pino","doi":"10.1016/j.jacl.2024.10.002","DOIUrl":"10.1016/j.jacl.2024.10.002","url":null,"abstract":"","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to benefit of intensive lipid lowering therapy in individuals with cardiovascular disease. 心血管疾病患者从强化降脂治疗中获益的时间。
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-10 DOI: 10.1016/j.jacl.2024.09.014
Linjie Li, Chuanyi Huang, Wennan Liu, Jingge Li, Geru A, Xiaozhi Chen, Shichen Jiang, Yiwen Fang, Roger Sik-Yin Foo, Mark Yan-Yee Chan, Ying Yu, Yongle Li, Qing Yang, Xin Zhou
{"title":"Time to benefit of intensive lipid lowering therapy in individuals with cardiovascular disease.","authors":"Linjie Li, Chuanyi Huang, Wennan Liu, Jingge Li, Geru A, Xiaozhi Chen, Shichen Jiang, Yiwen Fang, Roger Sik-Yin Foo, Mark Yan-Yee Chan, Ying Yu, Yongle Li, Qing Yang, Xin Zhou","doi":"10.1016/j.jacl.2024.09.014","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.09.014","url":null,"abstract":"<p><strong>Background: </strong>The timing of the clinical benefit of intensive lipid-lowering therapy in reducing major adverse cardiovascular events (MACE) in individuals with established cardiovascular disease (CVD), both before and after the advent of novel medications (proprotein convertase subtilisin/kexin type 9 inhibitor [PCSK9i] and ezetimibe) in 2010, is unclear.</p><p><strong>Objective: </strong>To evaluate the time to benefit (TTB) from intensive lipid-lowering therapy.</p><p><strong>Methods: </strong>The investigators systematically searched for randomized controlled trials evaluating intensive lipid-lowering therapy. The primary outcome was MACEs. Utilizing reconstructed individual participant data, Weibull survival curves were fitted to estimate the TTB for specific absolute risk reduction thresholds (0.002, 0.005, and 0.01).</p><p><strong>Results: </strong>Seven trials randomizing 92,180 adults aged between 58.2 and 63.6 years were identified. A TTB of 19.6 months (95 % confidence interval [CI]: 12.3 to 31.4) of intensive lipid-lowering was needed to prevent 1 MACE per 100 patients. Before 2010, when statin as the only option, a TTB for high-intensity statin therapy of 15.2 months (95 % CI: 6.52 to 35.5) was needed. After 2010, the TTB for PCSK9i-based, ezetimibe-based intensive lipid-lowering on a background of statin therapy was 17.7 (95 % CI: 12.2 to 25.6) and 47.3 (95 % CI: 20.4 to 110) months, respectively.</p><p><strong>Conclusions: </strong>In contemporary practice, to prevent 1 MACE in 100 individuals with established CVD, a TTB of 17.7 and 47.3 months was needed for PCSK9i-based and ezetimibe-based intensive lipid-lowering therapy on a background of statin therapy, respectively. The observed variations across different drug regimens highlight the need for a personalized approach to treatment decisions.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of non-insulin-based insulin resistance indices with presence and extent of multi-territorial atherosclerosis: A cross-sectional study. 非胰岛素型胰岛素抵抗指数与多发性动脉粥样硬化的存在和程度的关系:一项横断面研究
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-03 DOI: 10.1016/j.jacl.2024.09.011
Yanli Zhang, Mengxing Wang, Xueli Cai, Aoming Jin, Jing Jing, Suying Wang, Xia Meng, Shan Li, Qi Zhou, Xuan Wang, Tiemin Wei, Yongjun Wang, Yuesong Pan
{"title":"Associations of non-insulin-based insulin resistance indices with presence and extent of multi-territorial atherosclerosis: A cross-sectional study.","authors":"Yanli Zhang, Mengxing Wang, Xueli Cai, Aoming Jin, Jing Jing, Suying Wang, Xia Meng, Shan Li, Qi Zhou, Xuan Wang, Tiemin Wei, Yongjun Wang, Yuesong Pan","doi":"10.1016/j.jacl.2024.09.011","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.09.011","url":null,"abstract":"<p><strong>Background: </strong>Non-insulin-based insulin resistance (IR) indices, simple and reliable surrogates for IR calculated without insulin level, have been reported to be associated with cardiovascular and cerebrovascular diseases.</p><p><strong>Methods: </strong>Participants without diabetes from the cross-sectional baseline survey of the PRECISE (Poly-Vascular Evaluation for Cognitive Impairment and Vascular Events) cohort study were included in present study. Non-insulin-based IR indices, including triglyceride and glucose (TyG) index, triglyceride glucose-body mass (TyG-BMI) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) index, were calculated and stratified into quartiles. Intracranial, extracranial, coronary, subclavian, aorta, renal, ilio-femoral, and peripheral arteries were also assessed at baseline.</p><p><strong>Results: </strong>Of 2759 included participants, the average age was 60.9 ( ± 6.6) years, and 1460 (52.9 %) were female. Compared with the first quartile of TyG index, the fourth quartile of TyG index was associated with an increased presence and extent of atherosclerotic plaques (OR, 3.51; 95 %CI,1.30-1.87; cOR, 2.22; 95 %CI,1.76-2.79) and presence and extent of atherosclerotic stenosis (OR, 1.60; 95 %CI,1.24-2.06; cOR, 1.66; 95 %CI,1.30-2.12). Such associations were also observed for the relationship of TyG-BMI index, TG/HDL-C ratio, and METS-IR index with the presence and extent of atherosclerotic plaques and stenosis. Addition of 4 non-insulin-based IR indices to the basic model with traditional risk factors improved the predictive performance of the presence of atherosclerotic plaque and stenosis.</p><p><strong>Conclusions: </strong>Elevated non-insulin-based IR indices levels were associated with an increased risk of presence and extent of atherosclerotic plaques and stenosis in non-diabetic, older individuals in the PRECISE study. Further, these IR surrogate markers have certain predictive performance to assess the risk of multi-territorial atherosclerosis.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a homozygous variant in ABCG5 by panel sequencing in a Pakistani family with sitosterolemia: Genotype-phenotype correlation and management considerations. 在一个巴基斯坦坐骨神经油血症家族中,通过面板测序鉴定出 ABCG5 的一个同源变体:基因型与表型的相关性及管理注意事项。
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-03 DOI: 10.1016/j.jacl.2024.09.012
Wajahat Bin Naeem, Mehreen Ali Khan, Zaineb Akram, Tehseen Ullah Khan Afridi, Tariq Azam Khattak, Muhammad Asghar Khan, Muhammad Yousaf, Humayoon Shafique Satti
{"title":"Identification of a homozygous variant in ABCG5 by panel sequencing in a Pakistani family with sitosterolemia: Genotype-phenotype correlation and management considerations.","authors":"Wajahat Bin Naeem, Mehreen Ali Khan, Zaineb Akram, Tehseen Ullah Khan Afridi, Tariq Azam Khattak, Muhammad Asghar Khan, Muhammad Yousaf, Humayoon Shafique Satti","doi":"10.1016/j.jacl.2024.09.012","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.09.012","url":null,"abstract":"<p><p>Sitosterolemia is a rare autosomal recessive disorder characterized by impaired excretion of plant sterols, leading to their accumulation in tissues and organs. We identified a hitherto unreported homozygous variant, in ATP-binding cassette sub-family G member 5 (ABCG5) (NM_022436.3) c.274A>G p.(Lys92Glu), segregating in two affected sibs (Sit1C and Sit1F) of a consanguineous Pakistani family, during genetic workup for hereditary hemolytic anemia. Both patients had anemia, history of gum bleed and easy bruising. Peripheral film revealed stomatocytes and macrothrombocytopenia. Plasma sitosterol level was found to be significantly high (27.7 mg/dL and 25.1 mg/dL for Sit1C and F respectively), confirming diagnosis of sitosterolemia in both patients. Treatment with Ezetimibe, a sterol absorption inhibitor, resulted in significant decrease in sitosterol as well as LDL-cholesterol, in these patients. This study confirms the potential of panel sequencing as a diagnostic tool for sitosterolemia. Definitive diagnosis has significant clinical implications for genetic counseling and management strategies, such as dietary modifications and successful management with Ezetimibe.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertriglyceridemia-induced acute pancreatitis in pregnancy associated with CREB3L3 mutation. 与CREB3L3基因突变有关的高甘油三酯血症诱发的妊娠急性胰腺炎
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-02 DOI: 10.1016/j.jacl.2024.10.001
Chen Gurevitz, Jeffrey I Mechanick, Ron Do, Robert S Rosenson
{"title":"Hypertriglyceridemia-induced acute pancreatitis in pregnancy associated with CREB3L3 mutation.","authors":"Chen Gurevitz, Jeffrey I Mechanick, Ron Do, Robert S Rosenson","doi":"10.1016/j.jacl.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.10.001","url":null,"abstract":"<p><p>A 40-year-old woman at 35 weeks of gestation presented with abdominal pain and hypertriglyceridemia of above 5000 mg/dL. Following lab tests and imaging studies, she was diagnosed with hypertriglyceridemia-related acute pancreatitis in pregnancy. She was managed with NPO, IV insulin, and peripheral parenteral nutrition, but her condition further complicated with preeclampsia, and she was induced and delivered at 36 weeks of gestation. Genetic testing revealed a heterozygous variant in the CREB3L3 gene predisposing to severe hypertriglyceridemia. Postpartum lifestyle modifications, including a low-fat diet and routine exercise, significantly improved her lipid profile.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel pathogenic variant in the LCAT gene in a compound heterozygous patient with fish-eye disease and a mild phenotype. 一名患有鱼眼病和轻度表型的复合杂合子患者的 LCAT 基因新致病变体。
IF 3.6 3区 医学
Journal of clinical lipidology Pub Date : 2024-10-02 DOI: 10.1016/j.jacl.2024.09.013
Masaaki Miyata, Masayuki Kuroda, Junko Miyoshi, Mika Kirinashizawa, Rora Nagasawa, Misato Yamamoto, Yuichi Akasaki, Kensuke Utatsu, Yoshiro Maezawa, Koutaro Yokote, Mitsuru Ohishi
{"title":"Novel pathogenic variant in the LCAT gene in a compound heterozygous patient with fish-eye disease and a mild phenotype.","authors":"Masaaki Miyata, Masayuki Kuroda, Junko Miyoshi, Mika Kirinashizawa, Rora Nagasawa, Misato Yamamoto, Yuichi Akasaki, Kensuke Utatsu, Yoshiro Maezawa, Koutaro Yokote, Mitsuru Ohishi","doi":"10.1016/j.jacl.2024.09.013","DOIUrl":"https://doi.org/10.1016/j.jacl.2024.09.013","url":null,"abstract":"<p><strong>Background and objective: </strong>Low HDL-cholesterol and corneal opacity are associated with fish-eye disease (FED), familial LCAT deficiency (FLD), ApoAI deficiency, and Tangier disease. The differential diagnosis is made by clinical and biochemical tests. Measuring the LCAT activity is the ideal way to distinguish conditions caused by LCAT gene variants (FED and FLD) from the other two diseases. However, this is not accessible from all clinics. The CE/TC ratio, which is below the reference range in most cases with LCAT gene variants, has been proposed as an alternative. We report a case of compound heterozygous FED with a CE/TC ratio within the reference range.</p><p><strong>Methods: </strong>LCAT activity assays and genetic analyses were performed using patients' blood samples. Identified LCAT gene variants were examined by an in vitro expression assay.</p><p><strong>Results: </strong>The proband showed approximately 20 % LCAT α-activity relative to the normolipidemic controls, whereas a patient with a typical FED-causing variant (p.Thr147Ile) showed only 3 % activity. We identified compound heterozygous variants (c.101C>T/c.460A>G) resulting in a p.Pro34Leu/p.Asn154Asp amino acid residue substitution in the LCAT gene of the proband. The former variant has been reported previously, but the latter was newly identified. An in vitro expression assay demonstrated that the LCAT α-activity of the p.Asn154Asp variant significantly decreased regarding the wild type, but it was relatively well preserved compared to the typical FED-causing variants (p.Pro34Leu and p.Thr147Ile).</p><p><strong>Conclusion: </strong>These results suggest that the residual 20 % LCAT α-activity is sufficient to normalize CE/TC, but not sufficient to prevent the development of corneal opacity in FED.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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