Journal of Clinical and Experimental Dentistry最新文献

{"title":"Approaches to Preoperative Assessment of Elderly Patients Undergoing Dental Surgical Interventions: A Systematic Review.","authors":"Aslan Ramazanovich Shurdumov, Artem Maksimovich Gusarov, Sergey Yuryevich Ivanov, Irina Vyacheslavovna Ivanova, Leonid Leonidovich Borozdkin, Shamsulvara Taymaskhanovich Kamilov, Alexey Mikhailovich Kuznetsov, Artem Dmitrievich Sviridenko","doi":"10.4317/jced.63672","DOIUrl":"10.4317/jced.63672","url":null,"abstract":"<p><strong>Background: </strong>Elderly patients represent a high-risk population for surgical dental interventions due to multimorbidity, frailty, and polypharmacy. Moreover, standard preoperative assessment protocols often fail to account for geriatric syndromes. Objective: To systematize and analyze contemporary approaches and tools for comprehensive preoperative assessment of elderly patients planning surgical dental procedures.</p><p><strong>Material and methods: </strong>A systematic review was conducted in accordance with the PRISMA 2020 guidelines. The review protocol was registered in the international PROSPERO registry (ID: CRD420251147418). Searches were performed in PubMed/MEDLINE, Scopus, Web of Science, ScienceDirect, Google Scholar, CyberLeninka, and eLibrary.ru up to January 31, 2025. Original studies including patients aged 60 years focused on preoperative assessment prior to dento-maxillofacial surgery were included. Two reviewers independently performed study selection, data extraction, and risk-of-bias assessment using the ROBINS-I tool for observational studies.</p><p><strong>Results: </strong>Of 312 identified records, 12 studies were included in the analysis. The most frequently evaluated domains were nutritional status (MNA, MNA-SF; 5 studies), cognitive function (Mini-Cog, MMSE; 5 studies), frailty (Fried Criteria, CFS; 6 studies), and oral health (CPI, PI, OHIP-14; 8 studies). Meta-analysis was not performed due to high clinical and methodological heterogeneity. Overall evidence quality, assessed using the GRADE system for key outcomes, was low, confirming methodological limitations in the current scientific literature in geriatric dentistry.</p><p><strong>Conclusions: </strong>Despite the availability of numerous geriatric assessment tools, a standardized preoperative protocol for dental surgery is lacking. The findings emphasize the need for development and validation of a dental-specific assessment algorithm based on comprehensive geriatric assessment (CGA). Limitations: The conclusions should be interpreted with caution due to methodological limitations of the included studies, their heterogeneity, and inclusion of general maxillofacial surgery data, which reduced specificity for dental practice. Risk of publication bias was not assessed.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 4","pages":"e561-e568"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of nano-hydroxyapatite-silica modified glass ionomer cement as a luting agent for stainless steel crowns using the Hall technique: An in vitro study.","authors":"Fadzlinda Baharin, Siti Nuramira Izzati Che Abdullah, Nik Rozainah Nik Abdullah Ghani, Aimi Kamarudin","doi":"10.4317/jced.63884","DOIUrl":"10.4317/jced.63884","url":null,"abstract":"<p><strong>Background: </strong>Nano-hydroxyapatite and silica incorporation into glass ionomer cements (GICs) have been proposed to enhance their physical and biological properties. In paediatric dentistry, the Hall technique relies heavily on the sealing ability of luting cements used for stainless steel crown (SSC) placement. This study aimed to compare the microleakage of nano-hydroxyapatite-silica incorporated glass ionomer cement (nano-HA-silica GIC) with conventional GIC and resin-modified glass ionomer cement (RMGIC) when used as luting agents for SSCs placed using the Hall technique.</p><p><strong>Material and methods: </strong>Thirty extracted human primary molars were randomly allocated into three groups (n = 10). Stainless steel crowns were cemented using conventional GIC, nano-HA-silica GIC, or RMGIC following the Hall technique protocol. Specimens were immersed in 2% methylene blue dye, sectioned longitudinally, and evaluated under a digital microscope to assess dye penetration. Microleakage values were statistically analysed using one-way ANOVA followed by the Games-Howell post hoc test.</p><p><strong>Results: </strong>Statistically significant differences in microleakage were observed among the three groups (p &lt; 0.001). RMGIC demonstrated significantly lower microleakage compared with both conventional GIC (mean difference = 1.568) and nano-HA-silica GIC (mean difference = 2.290). No statistically significant difference was observed between conventional GIC and nano-HA-silica GIC (mean difference = 0.722).</p><p><strong>Conclusions: </strong>Nano-hydroxyapatite-silica incorporated GIC exhibited comparable sealing ability to conventional GIC; however, RMGIC demonstrated superior resistance to microleakage when used as a luting cement for SSCs placed using the Hall technique. Further studies are required to evaluate the long-term clinical performance of nano-HA-silica modified GIC.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 4","pages":"e464-e468"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retention of fluoride in the oral cavity: A randomized clinical study with nanoencapsulated fluoride toothpaste.","authors":"Marcel Alves Avelino de Paiva, Helene Soares Moura, Matheus Barbosa de Medeiros Souza, Alexandre Almeida Júnior, Andressa Feitosa Bezerra de Oliveira, Fábio Correia Sampaio","doi":"10.4317/jced.63567","DOIUrl":"10.4317/jced.63567","url":null,"abstract":"<p><strong>Background: </strong>To evaluate in vivo fluoride retention in saliva and dental biofilm after the use of experimental toothpaste containing nanoencapsulated fluoride (NanoF).</p><p><strong>Material and methods: </strong>A triple-blind randomized clinical study involving sixty-one residents from a municipality without fluoridated drinking water. The toothpastes used in the study were: Group 1 (1100 ppm, 100% NanoF); Group 2 (1100 ppm, 50% free NaF + 50% NanoF); and Group 3 (1100 ppm, 100% free NaF). During the use of the toothpaste, samples of dental biofilm and stimulated saliva were collected. Collection times were 1 and 2 hours (h) post-brushing for biofilm, and 1, 5, 10, 15, 20, 30, 45, 60 minutes, and 2h for saliva. The fluoride [F] concentrations in saliva and dental biofilm were analyzed using a specific electrode through the hexamethyldisiloxane (HMDS) facilitated diffusion technique. The data were analyzed using the Kruskal-Wallis, Friedman, and Wilcoxon tests (p&lt;0.05).</p><p><strong>Results: </strong>The values of the area under the curve (AUC) for saliva over 0-60 minutes were: G3 (97.74) &gt; G2 (84.73) &gt; G1 (54.98). For dental biofilm, the highest fluoride [F] concentration was observed in G1 (35.26 mg/kg), followed by G3 (34.06 mg/kg) at the 1-hour mark; at 2 hours, the results were 24.88 mg/kg and 31.43 mg/kg, respectively, with a significant reduction in [F] observed only in G1 (p=0.02).</p><p><strong>Conclusions: </strong>The nanoencapsulated fluoride tested in this study exhibited a distinct pattern of fluoride release in saliva. However, in dental biofilm, the release pattern was similar to that of the free fluoride formulation (NaF).</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 4","pages":"e441-e448"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of different implant crown restorative materials on the detection of proximal caries of adjacent teeth in cone-beam computed tomography (CBCT) scans using various machines, metal artifact-reduction (MAR) algorithm, and exposure protocols.","authors":"Mina Morcos, Ben Bartlett, Rujuta Katkar, Taraneh Maghsoodi, Hassem Geha, Nikolaos Shinas","doi":"10.4317/jced.63883","DOIUrl":"10.4317/jced.63883","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate how artifacts from different restorative materials affect the detection of approximal caries in CBCT scans, using various machines, artifact-reduction (AR) algorithms, and exposure protocols.</p><p><strong>Material and methods: </strong>Ten permanent teeth (5 molars, 5 premolars) were selected and categorized into 3 intact and 7 with artificial carious lesions. The teeth were arranged in a human mandible with an ingot of material in-between and in the following approximal surfaces configurations: intact-ingot-intact, caries-ingot-caries, and intact-ingot-caries/caries-ingot-intact. Three different ingot materials were used (3Y and 5Y Zirconia, and E-Max) and the setup was scanned using two CBCT systems (Planmeca Mid and Prexion) with varying exposure protocols, with and without AR algorithm, thus resulting in 90 scans. Three observers of different experience levels evaluated the images and P and Kappa values were calculated.</p><p><strong>Results: </strong>Kappa and P values showed a significant positive association with the AR option, and a negative association without AR for zirconia 5Y. Zirconia 3Y had the highest positive association across all observers using both low and standard exposure settings on the Prexion®. The inter-observer agreement was insignificant, while intra-observer agreement was highly significant.</p><p><strong>Conclusions: </strong>The AR option improves the accuracy of approximal caries detection in CBCT scans for materials with higher yttria concentration but has no significant effect on lower yttria materials. The Prexion® scanner outperformed the Planmeca ProMax 3D Mid® in caries detection without AR.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 4","pages":"e534-e548"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Efficacy of Chlorhexidine Digluconate and Silver Nanoparticles Incorporated into Molloplast-B Silicone Soft Liner Against Candida albicans: An In Vitro Study.","authors":"Samira Soufiabadi, Mahsa Khodaparast, MohammadHossein Khodaparast, Sahar Khodaparast, Hoda Shabani Attar, Reihaneh Abedi","doi":"10.4317/jced.63625","DOIUrl":"10.4317/jced.63625","url":null,"abstract":"<p><strong>Background: </strong>Denture stomatitis is a common inflammatory condition among complete denture wearers and is primarily associated with Candida albicans colonization on denture base and soft lining materials. Conventional antifungal therapies often provide only temporary benefits due to limited patient compliance and rapid microbial recolonization. Therefore, intrinsic antifungal modification of silicone-based soft liners may represent a more effective preventive strategy.</p><p><strong>Material and methods: </strong>Standardized Molloplast-B silicone soft liner discs (6 mm × 1 mm; n = 10 per group) were modified with 1%, 2%, or 3% (w/w) chlorhexidine digluconate (CHX) or silver nanoparticles (AgNPs) using a solvent-assisted dissolution technique followed by heat polymerization. Unmodified Molloplast-B, solvent-processed Molloplast-B, pure CHX solution, and AgNP suspension served as control groups. Antifungal activity against Candida albicans ATCC 10231 was evaluated using an agar diffusion assay after 24-hour incubation at 37°C. Inhibition zones were measured by two blinded examiners. Data were analyzed using one-way ANOVA and Tukey's post-hoc test ( = 0.05).</p><p><strong>Results: </strong>All modified groups demonstrated significantly greater antifungal activity compared with the negative and solvent controls (P &lt; 0.001). CHX-modified specimens exhibited significantly larger inhibition zones than AgNP-modified specimens at all tested concentrations (P &lt; 0.001). The highest antifungal activity was observed in the 3% CHX group (22.6 ± 1.8 mm), followed by the 3% AgNP group (16.0 ± 1.1 mm). A clear dose-dependent increase in antifungal efficacy was observed for both antimicrobial agents.</p><p><strong>Conclusions: </strong>Incorporation of 3% chlorhexidine digluconate into Molloplast-B silicone soft liner resulted in superior short-term antifungal efficacy against Candida albicans compared with silver nanoparticles. This intrinsic modification approach may be a promising strategy for reducing fungal colonization and preventing denture stomatitis; however, further long-term and clinical studies are required.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 4","pages":"e504-e509"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The management of calcified teeth with iatrogenic errors with static-guided and freehand endodontic technique.","authors":"Afzal Ali, Anuja Ikhar, Ezgi Doğanay Yıldız, Hakan Arslan","doi":"10.4317/jced.63480","DOIUrl":"10.4317/jced.63480","url":null,"abstract":"<p><strong>Background: </strong>The endodontic management of teeth with pulp canal calcification (PCC) is challenging and may result in iatrogenic errors in the form of excessive tooth structure loss and perforation. The present case reports aims to describe the management of calcified teeth with iatrogenic canal deviation using static-guided (SG) and conventional free hand endodontic technique.</p><p><strong>Case presentation: </strong>A 23-year-old male patient referred to the clinic with the chief complaint of pain over the upper incisor teeth region. Periapical radiography and CBCT scan revealed pulp canal calcification (PCC) of maxillary central incisors (#11 and #21), and periapical radiolucency in relation to #21 and #22. The patient was informed about the treatment options including SG endodontic approach and the course of treatment was determined based on the patients' decisions. The endodontic treatment of teeth #21 and #22 was initiated with conventional free hand technique. After a perforation on the labial root wall, the patient opted for saving the tooth (#21) using SG endodontic technique. With the help of CBCT, intra-oral Scanner and a 3D printer, a guide was fabricated. The root canal was negotiated and the endodontic treatment was completed. Similarly, the endodontic treatment of a 21-year-old female patient with iatrogenic apical deviation was performed using the same endodontic protocol, except for the use of a static-guide. Follow-up examination revealed clinically asymptomatic patients with the radiographic signs of periapical healing in both the cases.</p><p><strong>Conclusions: </strong>Tooth substance loss during access cavity preparation plays a vital role in determining the prognosis of the tooth. The teeth with PCC are categorized as cases with a high difficulty level which are often prone to iatrogenic errors. SG endodontic technique is a safe approach and provides predictable outcome in the management of cases with high difficulty level.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 4","pages":"e582-e588"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Wavelength on Light Transmittance, Heat Generation and Pulpal Cellular Response Across Different Restorative Procedures.","authors":"Sharanya Singh, Mateus Garcia Rocha, Alexandre Silvino, Shannon M Wallet, Mario Alexandre Coelho Sinhoreti, Dayane Oliveira","doi":"10.4317/jced.63873","DOIUrl":"10.4317/jced.63873","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effects of different wavelengths on light transmittance, heat generation, and pulpal cellular response across different restorative procedures.</p><p><strong>Material and methods: </strong>Standardized 5mmx5mm Class I preparations and dentin discs were prepared, leaving 0.5mm of dentin at the pulpal floor using extracted third molars. Direct restorations on the Class I preparations were performed using conventional or bulk-fill composites, and 1.5mm ceramic restorations were cemented onto the dentin discs with resin cement. Light-curing procedures were performed using blue (460nm), green (520nm), and red (620nm) wavelengths at 1000 mW/cm². The degree of conversion was assessed using FTIR-ATR (Nicolet iS20). Specimens were positioned above the input sensor of a spectrophotometer (MARC-LC) for the light-transmittance analyses or in a customized oral cavity chamber simulator for temperature variations analyses using an infrared thermal camera (FLIR ONE PRO), with measurements performed on the pulpal floor. Odontoblast-like cells (MDPC-23) were exposed to the same maximum radiant exposure that reached the pulp chamber, and cell viability was assessed using an MTT assay. A power analysis was conducted to determine the sample size to provide a power of at least 0.8 with =0.05. Statistical analyses were performed using one-way ANOVA and Tukey's test.</p><p><strong>Results: </strong>Degree of conversion did not differ across wavelengths/irradiance conditions (p&gt;0.09). Across all restorative procedures tested, light transmittance to the pulpal floor increased with longer wavelengths (p&lt;0.05). Increased material thickness resulted in significant reductions in transmittance across all wavelengths (p&lt;0.001), with longer wavelengths less affected by this attenuation. Thermal analysis demonstrated that shorter wavelengths produced significantly greater temperature increases within the pulp chamber (p&lt;0.05), while red light consistently produced the lowest changes (p&lt;0.01). Cell viability analysis revealed that red light maintained cell viability at levels statistically similar to those of non-irradiated controls (p=0.23); blue and green light significantly reduced cell viability (p&lt;0.05).</p><p><strong>Conclusions: </strong>Within the limitations of this in vitro model, it was possible to conclude that longer wavelengths demonstrate increased light transmission, lower temperature rise, and higher cell viability compared to shorter wavelengths delivered at equal exposure.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 3","pages":"e326-e334"},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How uncommon is the occurrence of orthokeratinized odontogenic cyst in the maxilla? A systematic review and a new case report.","authors":"Dhara Schrok Monteiro de Ataide, Kaique Alberto Preto, Gabriela Lopes Dos Santos, Beethoven Estevão Costa, Roberto Yoshio Kawakami, Denise Tostes Oliveira","doi":"10.4317/jced.63735","DOIUrl":"10.4317/jced.63735","url":null,"abstract":"<p><strong>Background: </strong>The orthokeratinized odontogenic cyst (OOC) is a benign intraosseous lesion, typically found in the posterior mandible in male patients in the third and fourth decades of life. Although there has been a growing number of documented cases in the last decade, the prevalence and unique characteristics of maxillary OOC remain poorly understood.</p><p><strong>Material and methods: </strong>To assess how uncommon is OOC occurrence in the maxilla, a systematic review of the literature was conducted using the major electronic databases and rigorous criteria, including a new case report involving a young male patient.</p><p><strong>Results: </strong>A total of 36 OOC located specifically in the maxilla was analyzed. The results demonstrated that OOC in the maxilla is a rare finding. Interestingly, the majority of instances are associated with an impacted tooth, mainly unerupted third molars and canines, a pattern previously unexplored in the literature. An isolated occurrence of an OOC in the posterior maxilla without involvement of a third molar tooth, as observed in this present case, is relatively uncommon and has been reported in only five other cases. Careful enucleation and curettage with removal of the impacted teeth, when present, followed by histopathological analysis, has proven to be the most effective approach for accurate diagnosis and clinical success.</p><p><strong>Conclusions: </strong>This study reinforces that orthokeratinized odontogenic cysts should be included in the differential diagnosis of intraosseous lesions in the maxilla, especially when associated with unerupted third molars and canines, which may clinically resemble dentigerous cysts.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 3","pages":"e394-e401"},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Oral Epithelial Dysplasia with Sociodemographic and Clinical Characteristics in Individuals with Oral Lichen Planus and Oral Lichenoid Lesion.","authors":"Letícia Côgo Marques, Simone Sant'Anna Gonçalves Barbosa, Danielle Nobre Lopes, Karin Soares Cunha, Arley Silva Junior, Danielle Castex Conde","doi":"10.4317/jced.63588","DOIUrl":"10.4317/jced.63588","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are potentially malignant disorders that share clinical and histopathological features. Oral epithelial dysplasia (OED) is a key indicator of malignant transformation risk in these disorders. This study aimed to investigate possible associations between the severity of OED and sociodemographic variables, hepatitis C infection, and clinical aspects in patients with OLP and OLL.</p><p><strong>Material and methods: </strong>The sample comprised 65 biopsies from 56 participants with OLP or OLL, classified according to the criteria of the American Academy of Oral and Maxillofacial Pathology (excluding the absence of OED as a diagnostic criterion for OLP). Data were retrieved from electronic medical records, and photographs taken at the time of biopsy were independently reviewed by two stomatologists and one oral pathologist to classify the clinical patterns. The presence and severity of OED were assessed according to the 2017 World Health Organization system and evaluated independently by two oral pathologists.</p><p><strong>Results: </strong>A statistically significant association was observed between OED severity and patient age (p=0.004). No significant associations were found with sex, skin color, harmful habits, hepatitis C history, clinical pattern, or anatomical site.</p><p><strong>Conclusions: </strong>Older patients were more likely to present moderate/severe OED, highlighting the importance of age as a risk factor for progression in OLP and OLL.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 3","pages":"e386-e393"},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of alveolar ridge preservation using collagen and platelet-rich fibrin: A systematic review.","authors":"Julia Gil-Morales, Cosimo Galletti, Javier Flores-Fraile, Alice Rose Greethurst, Fulvia Galletti, Francisco Real-Voltas","doi":"10.4317/jced.63789","DOIUrl":"10.4317/jced.63789","url":null,"abstract":"<p><strong>Background: </strong>Alveolar ridge resorption following tooth extraction may compromise future implant placement and aesthetic outcomes. Several biomaterials have been proposed to limit post-extraction dimensional changes, among which collagen-based materials and platelet-rich fibrin (PRF) are widely used. The aim of this systematic review was to evaluate the effectiveness of collagen and PRF in alveolar ridge preservation compared with spontaneous healing.</p><p><strong>Material and methods: </strong>This systematic review was conducted according to PRISMA 2020 guidelines and registered in PROSPERO (CRD42024489237). An electronic search was performed in PubMed, Scopus to identify randomized controlled trials (RCTs) published from 2014 onwards. Studies conducted in adult humans that evaluated horizontal and/or vertical alveolar ridge changes after tooth extraction were included. Risk of bias was assessed using the Cochrane RoB 2 tool.</p><p><strong>Results: </strong>Sixteen RCTs were included. Collagen-based interventions, particularly when combined with bone grafts such as deproteinized bovine bone mineral (DBBM), demonstrated a significant reduction in vertical and horizontal bone loss compared with spontaneous healing in several studies. PRF-based protocols showed heterogeneous results regarding dimensional bone preservation, with limited benefit when PRF was used alone. However, PRF-especially advanced or recurrent applications-was consistently associated with improved soft tissue healing and reduced postoperative pain. Considerable heterogeneity was observed in biomaterial preparation, application protocols, follow-up duration, and outcome assessment.</p><p><strong>Conclusions: </strong>Both collagen and PRF can contribute to alveolar ridge preservation after tooth extraction, although their clinical benefits differ. Collagen, particularly when combined with bone grafts, appears more effective in preserving alveolar dimensions, while PRF provides greater advantages in soft tissue healing and postoperative pain control. The choice of biomaterial should be guided by the clinical objective and extraction site. Further well-designed, standardized long-term RCTs are needed to establish definitive clinical recommendations.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"18 3","pages":"e402-e412"},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}