Journal of Clinical and Experimental Dentistry最新文献

{"title":"HPV-Negative Oral Squamous Cell Carcinoma Arising from Oral Submucous Fibrosis with p16INK4A Positivity and Cellular Senescence: A Case Report.","authors":"Akhilanand Chaurasia, Pavlos Pantelis, Giorgos Theocharous, Dimitris Veroutis, Athanassios Kotsinas, Eva V Gorgouli, Eleni Georgakopoulou","doi":"10.4317/jced.62698","DOIUrl":"https://doi.org/10.4317/jced.62698","url":null,"abstract":"<p><strong>Background: </strong>Oral Submucous Fibrosis (OSF) is a chronic, progressive, and potentially malignant disorder primarily associated with areca nut chewing. While Oral Squamous Cell Carcinoma (OSCC) typically develops in the tongue and floor of the mouth, its occurrence in the buccal mucosa in the context of OSF is less common. The molecular mechanisms underlying OSF-associated OSCC remain unclear. p16INK4A is widely recognized as a surrogate marker for HPV-driven carcinogenesis; however, its role as an indicator of cellular senescence is increasingly acknowledged. Given that senescence contributes to various pathologies, including cancer, this case report explores its potential role in the pathogenesis of OSF-associated OSCC.</p><p><strong>Case presentation: </strong>We present the case of a 39-year-old male with a 10-year history of gutkha chewing, who developed clinically advanced OSF and a well-differentiated OSCC of the buccal mucosa. Immunohistochemical (IHC) analysis revealed strong p16INK4A expression, increased p21WAF1/cip1 levels, and low Ki67 proliferative activity. Notably, Polymerase Chain Reaction (PCR) testing for HPV was negative. Further staining with SenTraGor (GL13) confirmed the presence of senescent cells, suggesting that p16INK4A overexpression in this case reflects cellular senescence rather than an HPV-driven oncogenic process.</p><p><strong>Conclusions: </strong>This case highlights the necessity of thorough molecular assessment when interpreting p16INK4A positivity in OSF-associated OSCC. The HPV-negative status, coupled with senescence markers, suggests that p16INK4A expression in such cases may show a senescence-associated tumorigenic pathway rather than HPV-mediated carcinogenesis. These findings support the inclusion of cellular senescence markers like SenTraGor in the diagnostic evaluation of OSCC arising from OSF. <b>Key words:</b>Oral Submucous Fibrosis, OSCC, p16INK4A, Cellular Senescence, HPV-Negative, Buccal Mucosa, SenTraGor.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e479-e482"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific guided Deep Circumflex Iliac Artery free flap for mandibular reconstruction in an ameloblastoma case. Case report and insights on the current state of customized surgery in H&N reconstruction in China.","authors":"Íñigo Aragón Niño, Chongyang Zheng, Han Cheng, Yongjie Hu, Yue He","doi":"10.4317/jced.62693","DOIUrl":"https://doi.org/10.4317/jced.62693","url":null,"abstract":"<p><p>This article presents a case of recurrent mandibular ameloblastoma treated with customized reconstructive surgery using a microvascularized DCIA bone flap. Virtual surgical planning and customized surgery, which has become increasingly adopted in head and neck reconstruction, enhances precision in tumor resection, flap design, and fixation, leading to superior functional and aesthetic outcomes. The patient, initially treated with curettage in China (2017) and Japan (2021), presented with recurrence upon relocating to Shanghai. Imaging confirmed the diagnosis, and customized surgery was planned due to the complexity of the case. The surgical approach involved patient-specific cutting guides for both the mandibular resection and iliac crest flap harvesting, ensuring precise bone segmentation and reconstruction. Contouring guides were used to optimize bone alignment, and a pre-bent titanium reconstruction plate was employed. Despite the advantages of customized surgery, its widespread implementation in China faces regulatory and financial challenges. Restrictions on patient-specific implants and high costs limit accessibility, but alternative techniques, such as contouring guides, help improve outcomes. As regulations evolve and technology advances, customized surgery is expected to become a standard approach, improving reconstructive care in complex cases. <b>Key words:</b>Mandibular ameloblastoma, guided surgery, customized reconstruction, head and neck, surgery in China.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e483-e487"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Different Bleaching Methods on Surface Roughness, Microhardness, and Tooth-Restoration Interface of Ormocer- and Methacrylate-based Restorative Systems.","authors":"Ali Ihsan Alkhuzaie, Mohamed Elshirbeny Elawsya, Naglaa Rizk Elkholany","doi":"10.4317/jced.62614","DOIUrl":"https://doi.org/10.4317/jced.62614","url":null,"abstract":"<p><strong>Background: </strong>The current study assessed the impacts of various in-office bleaching materials (light-activated and chemically-activated) on surface roughness, microhardness, and tooth-restoration interface of two composites restorative systems (ormocer-based and methacrylate-based).</p><p><strong>Material and methods: </strong>Sixty specimens were prepared for surface roughness and microhardness (2-mm-thickness, 10-mm-diameter) and classified according to restorative materials (n=30 for each group): group A (ormocer-based group) (Admira fusion, Voco, Cuxhaven, Germany) and group B (methacrylate-based group) (Tetric-N-Ceram, Ivoclar Vivadent, Schaan, Liechtenstein). Each group were subdivided into three subgroups (n=10) according to bleaching agent: subgroup 1 (control group, no bleaching), subgroup 2 (bleached with chemically-activated bleaching agent) (Opalescence Boost, Ultradent, USA), and subgroup 3 (bleached with light-activated bleaching agent) (Philips Zoom, Discus, USA). Eighteen maxillary central incisors teeth were subjected to a tooth-restoration interface evaluation (n=9 for each group) and (n=3 for each subgroup). All specimens were finished, polished, and bleached according to manufacturer's instruction. A three-dimensional optical profilometer (Wyko, Model NT 1100, Veeco, Tucson, USA) was used to measure surface roughness. The microhardness was assessed using Vickers tester (Model HVS-50, Laizhou Huayin Testing Instrument Co., Ltd. China) and a scanning electron microscope (SEM) (JEOL.JSM.6510LV, Japan) was used to evaluate tooth-restoration interface. The level of statistical significance was determined at <i>p</i><0.05.</p><p><strong>Results: </strong>For both bleaching agents. There was statistically significant increase of surface roughness for both composite materials after bleaching, and vice versa for microhardness (<i>p</i><0.05), and there was no significant difference between bleaching agents (<i>p</i>>0.05). A gap was formed after exposure to bleaching agents compared to control group for both restorative systems.</p><p><strong>Conclusions: </strong>Both bleaching techniques have bad effects on surface roughness, microhardness, and tooth-restoration interface for both ormocer-based and methacrylate-based restorative systems. <b>Key words:</b>Surface roughness, Microhardness, Tooth-restoration interface, In-office vital bleaching, Ormocer-based composite, Methacarylate-based composite.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e422-e431"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adhesive strength in cementing fiberglass posts using different adhesive systems.","authors":"Guilherme Do Amaral, Karina Andrea Novaes Olivieri, Rafael Pino Vitti, Clovis Stephano Pereira Bueno, William Cunha Brandt, Milton Edson Miranda","doi":"10.4317/jced.62131","DOIUrl":"https://doi.org/10.4317/jced.62131","url":null,"abstract":"<p><strong>Background: </strong>The objective of this work was to evaluate the influence of the Scotchbond MP and Clearfil SE adhesive systems on the bond strength in the push out test between the fiberglass post and the root canal.</p><p><strong>Material and methods: </strong>This <i>in vitro</i> study involved 20 human canine teeth extracted over a 12-month period. For inclusion in the sample, upper canine teeth with fully formed apices and curvatures less than 45° were considered. Teeth containing a calcified canal, with radiographically visible double curvature or that had undergone previous endodontic treatment were excluded from the sample. After selection, surface prophylaxis was performed using an ultrasound insert, followed by smoothing with a Gracey curette. Endodontic treatments were performed by a calibrated operator, following a pre-established protocol. Next, preparation of the root canal began to receive the Whitepost DC number 2 fiberglass post by removing 2/3 of this space. Next, the posts were prepared to be cemented, they were cleaned with 70% alcohol and conditioned with 37% phosphoric acid before receiving two layers of silane. From that moment on, the elements were randomly divided into two groups, according to the adhesive system, with RelyX ARC cement being used: Group SCB: Scotchbond MP and Group CFL: Clearfil SE. After cementing the fiber posts, the test specimens were prepared for mechanical testing using the push out test on the Universal Testing Machine (EMIC). Multiple comparisons were performed using the Tukey test. Statistical calculations were conducted adopting a significance level of 5%.</p><p><strong>Results: </strong>The two-factor analysis of variance demonstrated that there was no statistically significant interaction between the factors studied, however the use of the SCB Group adhesive system produced higher RU values.</p><p><strong>Conclusions: </strong>It was concluded that greater bond strength was obtained between resin cement and root dentin when ScotchBond adhesive was used and there were no differences in RU in the different root portions. <b>Key words:</b>Fiberglass posts, Adhesive systems, Tensile strength, Cementation, Dental prosthesis.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e440-e446"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can arthrocentesis help reduce the displaced disc in patients with closed lock of the temporomandibular joint? A case review.","authors":"Jordi Borrás-Ferreres, Cosme Gay-Escoda","doi":"10.4317/jced.62613","DOIUrl":"https://doi.org/10.4317/jced.62613","url":null,"abstract":"<p><p>Arthrocentesis (joint lavage and lysis) and hydraulic distension of the temporomandibular joint have been described as effective options for reducing joint pain and improving function in patients with limited mouth opening (closed lock) due to disc displacement without reduction, fundamentally in the acute phase of the disorder. Despite controversy, some studies suggest that in addition to improving the range of opening and reducing joint pain, the disc can also be reduced in some cases. The present study was carried out to determine whether arthrocentesis could reduce the displaced disc in a woman with 6 weeks of closed lock, and to assess its efficacy in improving mouth opening and reducing joint pain. <b>Key words:</b>Arthrocentesis, closed lock, disc displacement, limited mouth opening, disc reduction, disc recapture.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e474-e478"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of composite resin core buildup translucency on the accuracy of an anterior CAD-CAM bridge fabricated with a digital impression.","authors":"Nguyen Chi Tran, Nhat Dinh Minh Nguyen, Nam Cong Nhat Huynh, Trang Thi Ngoc Tran, Hung Trong Hoang, Ding Han Wang, Ming Lun Hsu","doi":"10.4317/jced.62249","DOIUrl":"https://doi.org/10.4317/jced.62249","url":null,"abstract":"<p><strong>Background: </strong>Composite resin build-up translucency affects the accuracy of digital impressions generated by an intraoral scanning system (IOS). Here, we evaluated the influence of composite core translucency on the accuracy of a CAD-CAM bridge (Fixed Partial Denture) using an intraoral scanner.</p><p><strong>Material and methods: </strong>We investigated the accuracy (the trueness and precision) of 2 different composites (EverX Flow-EX and G-aenial Universal Injectable A3) for core build up in 3-unit CAD/CAM bridge on anterior teeth using an intra-oral scanner (Trios 3, 3Shape) and injectable technique. The fitting of crown within the clinical acceptable threshold of final restoration was also confirmed by CBCT superimposition.</p><p><strong>Results: </strong>The results illustrated that composite with high translucency (A3) expressed lower trueness value than one with low translucency. With a clinically acceptable threshold<50μm, the percentage of points over the threshold was lower in composite group with low translucency (EX). CAD/CAM restorations on high translucency composite-reconstructed abutments showed a poor fit compared with the low translucency group on both abutments.</p><p><strong>Conclusions: </strong>The use of low translucency reconstructive materials helps to reduce the errors of IOS, and at the same time, appropriate compensation should be used when designing restorations to provide the most accurate results. Clinical Significance: • Composite with high translucency (A3) expressed lower trueness value than one with low translucency (EX). • With a clinically acceptable threshold<50μm, the percentage of points overcoming the threshold was lower in composite group with low translucency (EX). • Appropriate compensation should be applied when designing CAD/CAM restoration to achieve the best results. <b>Key words:</b>Accuracy, intraoral-scanner, digital dentistry, resin composite, bridge prosthesis, CAD/CAM.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e366-e373"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of postoperative pain with glycolic acid vs. ethylenediaminetetraacetic acid in endodontic treatment: A randomized clinical trial.","authors":"Bruna Tozzati Lago, Doglas Cecchin, Ulysses Lenz, Carlo Theodoro Raymundi Lago, Ana Paula Farina, Matheus Albino Souza, João Paulo de Carli, Yuri Dal Bello","doi":"10.4317/jced.62446","DOIUrl":"https://doi.org/10.4317/jced.62446","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate pain and analgesic intake after endodontic treatment using glycolic acid (GA) or ethylenediaminetetraacetic acid (EDTA) as the final irrigating solution.</p><p><strong>Material and methods: </strong>One hundred fifty patients were randomly assigned to two groups for smear layer removal: 17% GA or 17% EDTA. Postoperative pain was assessed at 24, 48 hours and 7 days. The need for analgesic intake was recorded. Descriptive analysis was performed to assess demographics (Student t, Chi-square and Fisher tests) and study outcomes (Mann Whitney, Friedman and Nemenyi) (<i>p</i><0,05).</p><p><strong>Results: </strong>Postoperative pain occurred in 52% of the cases. In the 24-hour period, GA had a significantly lower pain score (<i>p</i><0.05). There was no statistical difference between the groups regarding the use of analgesic pills.</p><p><strong>Conclusions: </strong>GA is associated with less postoperative pain at 24 hours compared to EDTA. No statistically significant difference was observed at 48 hours and 7 days. <b>Key words:</b>Postoperative pain, randomized controlled trial, ethylenediaminetetraacetic acid, glycolic acid, analgesic.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e432-e439"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of a patient with extensive odontogenic myxoma treated conservatively: A case report with 14 years of follow-up.","authors":"Ana L L M Paz, Cristhiane A Leite, Bruno A L A Mariz, Luiz E R Volpato, André C Rocha","doi":"10.4317/jced.62679","DOIUrl":"https://doi.org/10.4317/jced.62679","url":null,"abstract":"<p><p>Odontogenic myxoma is an odontogenic tumor of mesenchymal origin that presents locally invasive behavior. Its treatment is surgical, and the approach can be more conservative or radical. This article presents the rehabilitation of a patient with extensive odontogenic myxoma in the mandible treated conservatively with follow-up for 14 years. A 17-year-old male patient sought care with a painless swelling in the mandibular region causing facial asymmetry. Imaging exams showed a mixed image, with intralesional septa, involving the left anterior and posterior regions of the mandible with a small remaining basilar and lingual bone. An incisional biopsy was performed which confirmed the diagnosis of odontogenic myxoma. Due to the extent of the lesion, a conservative approach was chosen, with excision of the lesion and peripheral ostectomy, with recurrence of the lesion after 48 months, with a new approach being performed. After 14 years of follow-up, without further recurrence of the lesion, the patient was rehabilitated with dental implants and protocol-type prosthesis. Conservative treatment led to bone remodeling and enabled patient rehabilitation with oral implants and an implant-supported prosthesis. Thus, conservative treatment of odontogenic myxomas is a viable alternative for similar cases, and its longitudinal postoperative follow-up is essential. <b>Key words:</b>Conservative Treatment, Dental Implants, Myxoma; Oral Pathology, Oral Surgery.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e488-e492"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of low-fusing porcelain glaze as zirconia surface treatment on the adhesion of resin cement.","authors":"Hasan Skienhe, Ahmed Abdou, Jukka P Matinlinna, Marco Ferrari, Ziad Salameh","doi":"10.4317/jced.62601","DOIUrl":"https://doi.org/10.4317/jced.62601","url":null,"abstract":"<p><strong>Background: </strong>This laboratory study aimed to investigate the influence of a novel surface treatment method, utilizing a low-fusing porcelain glaze layer, on pre-sintered zirconia and the adhesion with resin composite cement. The study employed a primer containing a silane coupling agent and 10-methacryloyloxydecyl dihydrogen phosphate (MDP) to enhance the bond between the zirconia and resin composite cement.</p><p><strong>Material and methods: </strong>Zirconia blocks were sectioned, polished, and randomly divided into six groups based on surface treatment before sintering: Group CA50: Pre-sintered specimens were grit-blasted with 50 µm Al2O3 particles; Group CS25: Pre-sintered specimens were grit-blasted with 25 µm high-purity fused silica particles; Group B: Specimens similar to Group CA50 were sintered, glazed, and fired, followed by etching with 9.5% hydrofluoric acid (HF); Group C: Specimens similar to Group CA50 were sintered, glazed, and fired, followed by re-blasting with grit-blasted with 50 µm Al2O3 particles, Group D: Specimens similar to Group CS25 were sintered, glazed, and fired, followed by HF, Group E: Specimens in Group CS25 were sintered, glazed, and fired, followed by sandblasting with 50 µm Al2O3 particles. Microstructural analysis, surface roughness analysis, and shear bond strength testing (SBS) were conducted.</p><p><strong>Results: </strong>The surface treatment significantly increased the surface roughness with all surface treatments compared to CA50 and CS25. The shear bond strength of group C showed the highest significant SBS compared to all other groups.</p><p><strong>Conclusions: </strong>Alumina sandblasting of the glazed zirconia as pretreatment of sintered zirconia can improve the bonding to silane primer and resin cement. <b>Key words:</b>Glass beads, Alumina blasting, Pre-sintered zirconia, Silane.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e407-e415"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Dyslipidemias a risk factor for Peri-Implant complications? A Systematic review and meta-analysis.","authors":"Barbara Gurgel, Roberta Souza, André Vajgel, Maria Fernanda Cabral, Marina Almeida, Renata Almeida","doi":"10.4317/jced.62241","DOIUrl":"https://doi.org/10.4317/jced.62241","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia, characterized by high levels of lipids in the blood, can influence bone metabolism, interfere with the osseointegration of dental implants, and favor peri-implant complications. This systematic review aimed to analyze whether elevated serum levels of total cholesterol and its fractions, as well as triglycerides, constitute a risk factor for peri-implant complications.</p><p><strong>Material and methods: </strong>This systematic review was conducted by PRISMA and was registered in PROPSPERO under CRD number 42023456517. The search strategy was performed in the Medline (Pubmed), Embase, Scopus, Web of Science, Cochrane Library, and LLACS/BVS databases. Additional searches were conducted in the gray literature, as well as manual searches. Experimental and observational studies of patients undergoing dental implants, in which their lipid levels were analyzed and in which the outcomes of peri-implantitis, implant loss, or bone resorption were evaluated. The assessment of methodological quality was performed using the JBI Instrument, and the assessment of the certainty of the evidence was performed using GRADE.</p><p><strong>Results: </strong>The database search strategy resulted in 2,714. After removing duplicates and reading titles and abstracts, 48 were read in full. Of these, eight were included in the systematic review, in addition to three articles included from additional searches, totaling 11 studies, and a total of 1704 patients constituted the sample. Nine studies identified a significant association between elevated lipid levels and peri-implant complications. The meta-analysis demonstrated a strong association between peri-implantitis and dyslipidemia (OR 12.36; 95% CI: 7.85-19.46; <i>P</i>< 0.00001).</p><p><strong>Conclusions: </strong>Dyslipidemia was identified as a risk factor for peri-implant complications. This can be explained by the interference that high levels of cholesterol and its fractions can cause in bone metabolism, making it deficient due to an exacerbated inflammatory response. Cholesterol and triglyceride levels must be assessed and controlled preoperatively to reduce peri-implant complications. <b>Key words:</b>Dyslipidemias, Hyperlipidemias, Dental implants, Peri-Implantitis, Systematic Review.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 4","pages":"e461-e473"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}