Journal of Clinical Movement Disorders最新文献_第6页

Loss of visual feedback revealing motor impairment – an early symptom of Parkinson’s disease in two Irish farmers 视觉反馈的丧失揭示了运动障碍——这是两个爱尔兰农民帕金森病的早期症状

Journal of Clinical Movement Disorders Pub Date : 2016-08-01 DOI: 10.1186/s40734-016-0040-0

D. Olszewska, Conor Fearon, T. Lynch

引用次数: 0

Depressive symptoms can amplify embarrassment in essential tremor. 原发性震颤患者的抑郁症状会加重尴尬感。

Journal of Clinical Movement Disorders Pub Date : 2016-07-15 eCollection Date: 2016-01-01 DOI: 10.1186/s40734-016-0039-6

Elan D Louis, Stephanie Cosentino, Edward D Huey

{"title":"Depressive symptoms can amplify embarrassment in essential tremor.","authors":"Elan D Louis, Stephanie Cosentino, Edward D Huey","doi":"10.1186/s40734-016-0039-6","DOIUrl":"https://doi.org/10.1186/s40734-016-0039-6","url":null,"abstract":"Background: Embarrassment can be a considerable problem for patients with essential tremor (ET) and is a major motivator for treatment. Depression is also a common feature of ET; as many as 35 % of patients report moderate to severe depressive symptoms. Our goal was to assess the associations between these motor and psychosocial factors (tremor, depression, embarrassment) in ET, with a particular interest in more fully assessing the possible association between depression and embarrassment.Methods: Ninety one ET cases (age 70.4 ± 12.8 years) enrolled in a prospective, clinical-epidemiological study. Depressive symptoms were assessed with the Center for Epidemiological Studies Depression Scale (CESD-10, 0-30 [maximum]), embarrassment, with the Essential Tremor Embarrassment Assessment (ETEA, 0-70 [maximum]), and action tremor, with a detailed in-person neurological examination.Results: Higher CESD-10 score was significantly associated with higher ETEA score (p = 0.005), but not with increasing tremor severity (p = 0.94). In stratified analyses, cases with no or minimal depressive symptoms had the lowest ETEA scores, cases with moderate depressive symptoms had intermediate ETEA scores, and cases with severe depressive symptoms had the highest ETEA scores (p = 0.01). Furthermore, at each level of tremor severity, cases with more depressive symptoms had more embarrassment.Conclusions: Depressive symptoms seem to be more than a secondary response to the tremor in ET; they seem to amplify the level of embarrassment and, in addition to their own importance, seem to be a driver of other important clinical outcomes. Earlier treatment of depressive symptoms in ET patients could lessen the burden of secondary embarrassment.","PeriodicalId":15374,"journal":{"name":"Journal of Clinical Movement Disorders","volume":"3 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40734-016-0039-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34678884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Automatic behavior and communication due to pramipexole. 普拉克索导致的自动行为和交流。

Journal of Clinical Movement Disorders Pub Date : 2016-07-11 eCollection Date: 2016-01-01 DOI: 10.1186/s40734-016-0038-7

Ruth H Walker

引用次数: 1

Embouchure dystonia: a video guide to diagnosis and evaluation. 口部肌张力障碍:诊断和评估的视频指南。

Journal of Clinical Movement Disorders Pub Date : 2016-06-18 eCollection Date: 2016-01-01 DOI: 10.1186/s40734-016-0035-x

Steven J Frucht

引用次数: 12

Cautionary optimism: caffeine and Parkinson's disease risk. 谨慎乐观:咖啡因和帕金森病风险。

Journal of Clinical Movement Disorders Pub Date : 2016-06-06 eCollection Date: 2016-01-01 DOI: 10.1186/s40734-016-0037-8

Leonard L Sokol, Michael J Young, Alberto J Espay, Ronald B Postuma

引用次数: 3

Motor fluctuations due to interaction between dietary protein and levodopa in Parkinson's disease. 帕金森病患者饮食蛋白与左旋多巴相互作用引起的运动波动。

Journal of Clinical Movement Disorders Pub Date : 2016-05-26 eCollection Date: 2016-01-01 DOI: 10.1186/s40734-016-0036-9

Tuhin Virmani, Sirinan Tazan, Pietro Mazzoni, Blair Ford, Paul E Greene

{"title":"Motor fluctuations due to interaction between dietary protein and levodopa in Parkinson's disease.","authors":"Tuhin Virmani, Sirinan Tazan, Pietro Mazzoni, Blair Ford, Paul E Greene","doi":"10.1186/s40734-016-0036-9","DOIUrl":"https://doi.org/10.1186/s40734-016-0036-9","url":null,"abstract":"Background: The modulation of levodopa transport across the blood brain barrier by large neutral amino acids is well documented. Protein limitation and protein redistribution diets may improve motor fluctuations in patients with Parkinson's disease but the pharmacokinetics and pharmacodynamics of levodopa and amino acids are highly variable.Methods: Clinical records of 1037 Parkinson's disease patients were analyzed to determine the proportion of patients with motor fluctuations related to protein interaction with levodopa. Motor fluctuations due to protein interaction with levodopa were defined as dietary protein being associated with (i) longer time to levodopa effectiveness, (ii) reduced benefit or duration of benefit, (iii) dose failures or (iv) earlier wearing off from a previously effective dose. Dose failures, sudden, painful or behavioral wearing-off periods, gait freezing, nausea, hallucinations, orthostasis, and dyskinesias were taken as markers of motor fluctuations, disease severity, and levodopa side effects potentially influenced by protein.Results: 5.9 % of Parkinson's disease patients on levodopa, and 12.4 % with motor fluctuations on levodopa correlated their fluctuations with the relative timing of levodopa and protein intake. These patients were younger at disease onset, had worse motor fluctuations and had a higher incidence of family members with Parkinson's disease. Early wearing off or decreased dose efficacy were most commonly associated with protein interaction. 60 % of patients who modified their diets had weight loss.Conclusions: This study suggests that clinically significant protein interaction with levodopa may occur mostly in a subset of Parkinson's disease patients with earlier disease onset and those with familial disease.","PeriodicalId":15374,"journal":{"name":"Journal of Clinical Movement Disorders","volume":"3 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2016-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40734-016-0036-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34430254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Evolution of visual art with dopaminergic therapy 视觉艺术的演变与多巴胺能疗法

Journal of Clinical Movement Disorders Pub Date : 2016-03-21 DOI: 10.1186/s40734-016-0034-y

R. Walker

引用次数: 2

The effects of dopamine on digit span in Parkinson’s disease 多巴胺对帕金森病患者手指跨距的影响

Journal of Clinical Movement Disorders Pub Date : 2016-03-07 DOI: 10.1186/s40734-016-0033-z

Clara Warden, J. Hwang, A. Marshall, Michelle C. Fenesy, K. Poston

引用次数: 20

Agnosia for head tremor in essential tremor: prevalence and clinical correlates 原发性震颤中头震颤的失认症:患病率和临床相关性

Journal of Clinical Movement Disorders Pub Date : 2016-02-12 DOI: 10.1186/s40734-016-0032-0

H. N. Eken, E. Louis

引用次数: 6

Clinical signs in functional (psychogenic) gait disorders: a brief survey 功能性(心因性)步态障碍的临床症状:简要调查

Journal of Clinical Movement Disorders Pub Date : 2016-02-12 DOI: 10.1186/s40734-016-0031-1

Leonard L. Sokol, A. Espay

引用次数: 13