Journal of Chemical Health Risks最新文献

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Larvicidal activity of Melaleuca leucadendra leaves extract against Aedes aegypti 千层桉叶提取物对埃及伊蚊的杀幼虫活性研究
Journal of Chemical Health Risks Pub Date : 2021-04-01 DOI: 10.22034/JCHR.2021.682033
Mitoriana Porusia, Desi Septiyana
{"title":"Larvicidal activity of Melaleuca leucadendra leaves extract against Aedes aegypti","authors":"Mitoriana Porusia, Desi Septiyana","doi":"10.22034/JCHR.2021.682033","DOIUrl":"https://doi.org/10.22034/JCHR.2021.682033","url":null,"abstract":"Dengue Hemorrhagic Fever (DHF) depends on controlling Aedes aegypti mosquitoes and larvae. Currently, larvicide control still uses temefos larvicide, though several studies have reported resistance. Insecticides from plants can be used as an alternative. One of the plants reported to have larvicide potency was Melaleuca leucadendra leaves. This study aimed to look at ethanol extract of M.leucadendra leaves activity in killing A. aegypti larvae and LC50 values ​​after a 24-h examination. This type of research was experimental design with post-test only control group design. M. leucadendra leaves was extracted through maceration process using 96% ethanol. The treatments consisted of 8 concentrations (mg L-1)  of 400 (0.04%); 1000 (0.1%); 1600 (0.16%); 2000 (0.2%); 10,000 (1%);  20,000 (2%); 30,000 (3%); 40,000 (4%) and the control group (0%). Each concentration was replicated four times and applied on twenty specimens of A. aegyptiat the third larval stage. The results showed that M.leucadendra has a lethal ability against A.aegypti. There was a correlation between the extract concentration and the larval mortality (p = 0.000; 95%). The extract concentrations of 0.04-0.2% caused 1%) of extract M. leucadendra caused turbid, greenish-gray color, and unpleasant smell on the water. Regarding the WHO bioassay guideline, etahnol extract of M. leucadendra leaves was less effective on killing A. aegypti larvae, though it causes lethal effect on it.","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"11 1","pages":"213-221"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42854359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The Possible Protective Role of Vitamin E on the Induced Silver Nanoparticles Toxicity on Filiform and Circumvallate Tongue Papillae of Albino Rats Histological and Immunohistochemical Study 维生素E对银纳米颗粒对白化病大鼠丝状和环状舌乳头毒性的保护作用的组织学和免疫组化研究
Journal of Chemical Health Risks Pub Date : 2021-03-01 DOI: 10.22034/JCHR.2021.1908602.1172
Nada Tarek Zaki, Mahmoud M Al Ankily, R. Amin, A. Halawa
{"title":"The Possible Protective Role of Vitamin E on the Induced Silver Nanoparticles Toxicity on Filiform and Circumvallate Tongue Papillae of Albino Rats Histological and Immunohistochemical Study","authors":"Nada Tarek Zaki, Mahmoud M Al Ankily, R. Amin, A. Halawa","doi":"10.22034/JCHR.2021.1908602.1172","DOIUrl":"https://doi.org/10.22034/JCHR.2021.1908602.1172","url":null,"abstract":"Silver nanoparticles; Nanotoxicity; Filiform; Circumvallate; Vitamin E ABSTRACT: Recently Silver nanoparticles (AgNPs) are widely used as in manufacturing of filters to purify drinking water, as a part of surgical prosthesis, splints, dental alloys and most importantly in the medical field as a bactericidal, fungicidal and as a therapeutic agent. Although these widely usage of AgNPs, can induce toxicity. to evaluate the protective role of vitamin E on the induced silver nanoparticles toxicity on filiform and circumvallate tongue papillae of albino rats. twenty-eight male albino rats weighing 200-250 grams were divided into; the control and the experimental groups, which is subdivided into, subgroup I receiving AgNPs and subgroup II receiving AgNPs and vitamin E. the experimental period were 28 days, then rats’ tongue was dissected to be stained by H&E and examined immunohistochemically for BCL-2. Histological examination of the epithelium covering both filiform and circumvallate papillae of subgroup I showed few epithelial cells vacuolations and signs of degeneration. Meanwhile the taste buds’ cells of the circumvallate papillae also showed signs of degeneration together with amalgamated, illdefined serous acini of Von Ebner Salivary Gland (VESG). Subgroup II showed that the histological features of both tongue papillae were nearly comparable to that of the control group. Immunohistochemical examination showed minimum apoptotic changes in subgroup II as compared to subgroup I and nearly comparable to that of the control group. vitamin E showed an apparent protective role against the histological and apoptotic alterations caused by the toxic effect of AgNPs on both tongue papillae.","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"11 1","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42594067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Evaluation of Aflatoxin M1 and Heavy Metal in Raw Materials and Infant Formula Produced in Pegah Dairy Plants, IRAN 伊朗Pegah乳品厂生产的原料和婴儿配方奶粉中黄曲霉毒素M1和重金属的评价
Journal of Chemical Health Risks Pub Date : 2021-03-01 DOI: 10.22034/JCHR.2020.1907145.1166
Bahram Karimi Dehcheshmeh, A. Shakerian, E. Rahimi
{"title":"Evaluation of Aflatoxin M1 and Heavy Metal in Raw Materials and Infant Formula Produced in Pegah Dairy Plants, IRAN","authors":"Bahram Karimi Dehcheshmeh, A. Shakerian, E. Rahimi","doi":"10.22034/JCHR.2020.1907145.1166","DOIUrl":"https://doi.org/10.22034/JCHR.2020.1907145.1166","url":null,"abstract":"Aflatoxin M1; Cadmium; Infant formula; Lead; Iran ABSTRACT: This study was conducted to investigate the presence of lead (Pb), cadmium (Cd) and aflatoxin M1 in raw materials and all types of infant formula produced in Pegah Dairy Plants (PDPs) in Shahrekord, Iran. To this aim, 80 samples of raw cow’s milk, whey protein, starch, vitamin and all type of infant formula were collected for 6 months during 2018-2019. Cd and Pb were measured by Graphite Furnace Atomic Absorption Spectrophotometry. Aflatoxin M1 (AFM1) samples and analyzed by ELISA technique. The incidence of contamination of AFM1 in vitamins, raw cow’s milk, whey powder, and baby formula collected from Pegah dairy plants were ND, 34, 23 and 8 ppb, respectively. The result indicated that none of aflatoxin M1 in infant formula samples exceeded FDA lead consumption guidelines. In addition, maximum mean lead in maltodextrin, starch, vitamin, raw cow’s milk, whey powder, baby oil, infant formula, immediate, whole and skim was 20, 23, ND, 49, 20, 21, 17, 17, 12, and 17 ppb, respectively. Further, the maximum cadmium content was found to be 5.5, 9.5, ND, 14, ND, 6.3, 12.30, 7.6, 9.2 and 5.4 ppb, respectively, where the value of the samples was not above the maximum recommended limits by standard of Iran, European Community (EC) and Codex Alimentarius (CAC). The average of the heavy metal (Cd and Pb) and AFM1 in the maltodextrin, starch, vitamin, raw milk, whey powder and baby oil, and the types of infant formula produced by Pegah dairy Plants (PDPs) Shahrekord was below the recommended levels by Iran standard.","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"11 1","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44223949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Changes in the Level of Asprosin as a Novel Adipocytokine after Different Types of Resistance Training. 不同类型抗阻训练后新型脂肪细胞因子Asprosin水平的变化。
Journal of Chemical Health Risks Pub Date : 2021-01-01
Mohammad Jahangiri, Shahnaz Shahrbanian, Anthony C Hackney
{"title":"Changes in the Level of Asprosin as a Novel Adipocytokine after Different Types of Resistance Training.","authors":"Mohammad Jahangiri,&nbsp;Shahnaz Shahrbanian,&nbsp;Anthony C Hackney","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Obesity is at epidemic proportions in the world. Evidence supports increased physical activity and exercise are efficacious in controlling obesity, in part due to altering select adipocytokine levels. The present study aimed to compare the effect of 12 weeks of three resistance training methods (traditional, circular and interval) on the levels of the adipocytokine asprosin and body composition in sedentary men with obesity. Forty-four sedentary men with obesity, who were randomly divided into the 4 equal groups: traditional, circular, and interval resistance training as well as a control group. Results showed that there was a significant interaction between the type of training used and time on asprosin levels (F (1,40)= 13353.03, P= 0.001, ES= 0.99). All types of resistance training decreased asprosin levels and improved body composition parameters in comparison to the control group (F (3, 40) = 34.60, P = 0.001, ES= 0.77). Interval resistance training had the greatest effect on reducing asprosin levels and improving body composition related outcomes (body mass: P=0.001, ES=0.633, body mass index: P=0.001, ES=0.632, percent body fat: P=0.001, ES=0.647, waist to hip ratio: P=0.001, ES=0.786). The results of the present study support the benefits of resistance training as a non-pharmacological approach in reducing asprosin levels and improving body composition in individuals with obesity.</p>","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"11 Spec","pages":"179-188"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802312/pdf/nihms-1771636.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39580645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Dusts on Liver Enzymes and Kidney Parameters of Serum in Male Rats in Khuzestan, Iran 粉尘对伊朗胡齐斯坦地区雄性大鼠血清肝酶和肾脏参数的影响
Journal of Chemical Health Risks Pub Date : 2020-12-01 DOI: 10.22034/JCHR.2020.1902789.1148
N. Soleimani, Hassan Faridnouri, M. Dayer
{"title":"The Effect of Dusts on Liver Enzymes and Kidney Parameters of Serum in Male Rats in Khuzestan, Iran","authors":"N. Soleimani, Hassan Faridnouri, M. Dayer","doi":"10.22034/JCHR.2020.1902789.1148","DOIUrl":"https://doi.org/10.22034/JCHR.2020.1902789.1148","url":null,"abstract":"Dusts; Kidney and liver enzymes; Metals toxicity; Khuzestan province; Iran ABSTRACT: The present study aimed to investigate the effect of dusts on rat specimens in Southern Iran, Khuzestan, focusing on serum enzymes (Alpha-Amylase, Alkaline phosphatase, Alanine transaminase, Lactate dehydrogenase, and Aspartate transaminase) and kidney parameters (creatinine and urea). The study was conducted on 30 adult male rats that were divided into six groups, including one as the control group, and five as the experimental groups (Ahvaz, Ramhormoz, Andimeshk, Abadan, and Susangerd). Results showed that alanine aminotransferase increased in the groups of Ramhormoz, Andimeshk, Abadan, and Susangerd while Ahvaz showed a decrease. Alkaline phosphatase activity in all treated groups showed a significant increase compared to the control group. The activity of lactate dehydrogenase decreased in all samples, but only in Ahvaz and Susangerd groups it was significant compared to control group. Alpha-amylase activity was significantly increased in the groups of Ramhormoz, Andimeshk, Abadan, but decreased significantly in Ahvaz group, indicating a different value of harmful substances in dust particulates of these five cities. Serum urea level increased in all groups except Ahvaz, which was only significant in the group of Ramhormoz. Also, creatinine level decreased in all groups except Ahvaz. The results of this study showed that, the effect of fine dust was more evident in three cities of Ahvaz, Andimeshk and Ramhormoz due to the large amounts of total concentrations of heavy metals. Also, both the liver and the kidney were affected by both particulate matter, but it seems that the effect on the liver was more than the kidney.","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"10 1","pages":"315-326"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44857437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Residual Concentration of Lead, Iron and Calcium in Chicken Meat Paste: Indicative Parameters for Identifying Deboning Procedure and Health Risk Assessment 鸡肉膏中铅、铁、钙残留浓度:识别去骨过程和健康风险评估的指示性参数
Journal of Chemical Health Risks Pub Date : 2020-12-01 DOI: 10.22034/JCHR.2020.1891362.1100
E. Molaee-aghaee, B. Akbari‐adergani, N. Akramzadeh, H. Hosseini, Mohammad Ahmady
{"title":"Residual Concentration of Lead, Iron and Calcium in Chicken Meat Paste: Indicative Parameters for Identifying Deboning Procedure and Health Risk Assessment","authors":"E. Molaee-aghaee, B. Akbari‐adergani, N. Akramzadeh, H. Hosseini, Mohammad Ahmady","doi":"10.22034/JCHR.2020.1891362.1100","DOIUrl":"https://doi.org/10.22034/JCHR.2020.1891362.1100","url":null,"abstract":"1 International Branch, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Food and Drug Laboratory Research Center, Food and Drug Organization, Ministry of Health and Medical Education, Tehran, Iran 3 Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4 Department of food Science and technology, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran ) 2020 May 20 Accepted: 20 20 February 2 (Received:","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"10 1","pages":"277-285"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42984034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Isolation of Cerebroside from Gynura procumbens Leaves and Biological Activities of the Leaves Extracts 原春草叶中脑苷的分离及提取物的生物活性研究
Journal of Chemical Health Risks Pub Date : 2020-12-01 DOI: 10.22034/JCHR.2020.1908719.1174
Md Saddam Hossain, Maniruzzaman, M. M. Chowdhuary, J. Ahmed, M. Badal, M. A. Yousuf
{"title":"Isolation of Cerebroside from Gynura procumbens Leaves and Biological Activities of the Leaves Extracts","authors":"Md Saddam Hossain, Maniruzzaman, M. M. Chowdhuary, J. Ahmed, M. Badal, M. A. Yousuf","doi":"10.22034/JCHR.2020.1908719.1174","DOIUrl":"https://doi.org/10.22034/JCHR.2020.1908719.1174","url":null,"abstract":"","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"10 1","pages":"353-363"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43728874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Plasmonic Nanosilver Synthesis Using Sonneratia apetala Fruit Extract and Their Catalytic Activity in Organic Dye Degradation 无瓣海桑果实提取物等离子体合成纳米银及其对有机染料降解的催化活性
Journal of Chemical Health Risks Pub Date : 2020-12-01 DOI: 10.22034/JCHR.2020.1904366.1155
M. Mamun, M. Hossain, J. Naime, P. Dhar
{"title":"Plasmonic Nanosilver Synthesis Using Sonneratia apetala Fruit Extract and Their Catalytic Activity in Organic Dye Degradation","authors":"M. Mamun, M. Hossain, J. Naime, P. Dhar","doi":"10.22034/JCHR.2020.1904366.1155","DOIUrl":"https://doi.org/10.22034/JCHR.2020.1904366.1155","url":null,"abstract":"Nanosilver; Green synthesis; Surface plasmon; Resonance; Catalytic activity; Degradation; Sonneratia apetala ABSTRACT: Comparing to the chemical and physical techniques, biosynthesis of nanoparticles is being facilitated due to its nontoxic and economically feasible availability. In this present study, plant-mediated silver nanoparticles (AgNPs) were synthesized using the fruit extract of Sonneratia apetala from the silver nitrate (AgNO3) solution. Among different physiological conditions, effect of reaction time was investigated during the AgNPs synthesis. Surface Plasmon Resonance (SPR) characterization was conducted for verifying the nanoparticles size and morphology. A distinct band centered around 400-480 nm in the UV-Visible spectroscopy represented the formation of AgNPs. FTIR spectroscopy revealed that –OH group may play important role for the reduction of Ag to AgNPs. XRD revels the face-centered cubic geometry of AgNPs. AFM image analysis helped to find out the shape of the synthesized AgNPs is sphereical. The efficiency of AgNPs as a promising catalyst through electron transfer in the degradation of methyl orange and methyl red was investigated. This catalytic activity of AgNPs can be used to synthesis different chemical intermediates and organic transformations.","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"10 1","pages":"287-296"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47771375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Evaluation of fluoride concentration at inlet and outlet household water treatment systems and bottled water distributive high consumption Ardabil city, Iran 伊朗阿达比尔市家庭水处理系统入口和出口及高消耗瓶装水分配的氟化物浓度评价
Journal of Chemical Health Risks Pub Date : 2020-12-01 DOI: 10.22034/JCHR.2020.1906134.1163
Zahra Poorakbar, A. Mahvi, H. Sadeghi, M. Vosoughi, S. A. Mokhtari, A. Dargahi
{"title":"Evaluation of fluoride concentration at inlet and outlet household water treatment systems and bottled water distributive high consumption Ardabil city, Iran","authors":"Zahra Poorakbar, A. Mahvi, H. Sadeghi, M. Vosoughi, S. A. Mokhtari, A. Dargahi","doi":"10.22034/JCHR.2020.1906134.1163","DOIUrl":"https://doi.org/10.22034/JCHR.2020.1906134.1163","url":null,"abstract":"Water Quality; Fluoride; Household Water Treatment Systems; Bottled Water; Ardabil ABSTRACT: Fluoride is needed for better health, but it can cause adverse health effects if used at higher levels. There are different sources for the uptake of the fluoride, and drinking water is its primary resource. The aim of this study is the evaluation of fluoride concentration at the inlet and outlet of household water treatment systems and highly consumed bottled water distributed in Ardabil city in 2020. This descriptive cross-sectional study was performed on 60 water samples (30 samples of bottled water from 10 distribution brands of Ardabil city and 30 samples of inlet and outlet of household water treatment system). The concentration of fluoride was measured using the SPADNS standard method and spectrophotometer techniques. The SPSS version 22 software was used for analyzing the data. The concentration of fluoride in all samples was obtained to be in the range of 0 to 0.87 mg.l, with an average of 0.35 mg.l, which was less than the standard. According to the results, the concentration of fluoride in the studied groups was significantly different (P = 0.001). Moreover, the efficiency of the household water treatment system in the reduction of fluoride was observed to be 67.25%. Although the concentration of fluoride in most samples was lower than standard, further studies on other sources of fluoride, such as vegetables, tea, and so on, are required for accurate comment on fluoride deficiency in drinking water of one area.","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"10 1","pages":"327-335"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46366315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quercetin Fatty Acid Esters: from Synthesis to the Mushroom Tyrosinase Inhibition 槲皮素脂肪酸酯:从合成到蘑菇酪氨酸酶抑制
Journal of Chemical Health Risks Pub Date : 2020-07-01 DOI: 10.22034/JCHR.2020.1876369.1045
Z. Jamali, GolamReza Rezaei Behbahan, K. Zare, N. Gheibi
{"title":"Quercetin Fatty Acid Esters: from Synthesis to the Mushroom Tyrosinase Inhibition","authors":"Z. Jamali, GolamReza Rezaei Behbahan, K. Zare, N. Gheibi","doi":"10.22034/JCHR.2020.1876369.1045","DOIUrl":"https://doi.org/10.22034/JCHR.2020.1876369.1045","url":null,"abstract":"New complexes of quercetin esterification with alpha linolenic acid (ALA) and linoleic acid (LA) were applied as inhibitor of tyrosinase as the main melanogenesis.enzyme The most abundant flavonoid compound, quercetin was considered as the base of esterification with poly unsaturated fatty acids (PUFA). The new derivatives including quercetin- ALA (complex I) and quercetin- LA (complex II) were designed and their impacts on mushroom tyrosinase (MT) were assessed by experimental and theoretical studies. The new complexes I and II were induced competitive inhibition on tyrosinase enzyme with Ki of 0.59 and 0.40 mM, respectively. The molecular analysis of docking revealed that the complex II has a better ability to interact with enzyme than the complex I and the nature of interactions was obeyed from hydrophobic manner. So, the esterification of quercetin by above mentioned fatty acids achieved strength inhibitors against tyrosinase and because of their abundant in natural sources and importance in lifestyle, it is proposed to utilize them in medicine, cosmetics, agriculture and food industries. Their other biological properties need more investigations.","PeriodicalId":15347,"journal":{"name":"Journal of Chemical Health Risks","volume":"10 1","pages":"185-193"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44242145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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