Journal of chemical technology and biotechnology最新文献

{"title":"N-Acetyl cysteine-loaded liposomes to reduce iron overload-induced toxicity in human kidney cells","authors":"Doohee Lee,&nbsp;Chaewon Bae,&nbsp;Suhyun Ryu,&nbsp;Kangwon Lee","doi":"10.1002/jctb.7695","DOIUrl":"10.1002/jctb.7695","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Iron overload in the body generates free radicals through the Fenton reaction, leading to adverse effects on various organs. Several antioxidants have been recommended to treat iron-related diseases effectively. <i>N</i>-Acetyl cysteine (NAC), a potent antioxidant, was investigated in this study for its potential to mitigate iron overload-induced cell death. A liposomal formulation was developed to encapsulate NAC, employing the reverse phase evaporation method, to enhance its delivery and effectiveness. The liposomal NAC was characterized by evaluating its size, zeta potential, morphology and release profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The protective effect of liposomal NAC against iron overload-induced toxicity was assessed in human kidney 2 (HK-2) cells. Cell viability assays (Cell Counting Kit 8) and reactive oxygen species assays (DCFDA assay) confirmed the effectiveness of liposomal NAC in inhibiting ferroptosis induced by slow iron uptake (1 mmol L⁻¹ ferric ammonium citrate). Additionally, liposomal NAC protected cells from toxicity resulting from rapid iron uptake (50 μmol L⁻¹ ferric ammonium citrate, 20 μmol L⁻¹ 8-hydroxyquinoline). The liposomal formulation demonstrated an enhanced protective effect compared to free NAC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>These findings suggest that liposomal NAC more effectively protects human kidney cells from toxicity caused by different iron uptake models than free NAC, highlighting its potential as a superior treatment option for iron overload-induced cellular damage. © 2024 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7695","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141342067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Nb-doping on the MnFeOx catalyst for NH3-SCR reaction at low-temperature","authors":"Zhenzhao Pei,&nbsp;Haiyang Zhao,&nbsp;Haipeng Wang,&nbsp;Zhuyue Fu,&nbsp;Kanghua Yang,&nbsp;Kang Mao,&nbsp;Yan Liu","doi":"10.1002/jctb.7692","DOIUrl":"10.1002/jctb.7692","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Manganese-based catalysts were considered the most promising catalysts for low-temperature selective catalytic reduction (NH₃-SCR) reactions. In this work, a series of Mn₃Fe₂Nb_yO_x catalysts were synthesized by co-precipitation method for low-temperature NH₃-SCR and SO₂ tolerance tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The catalysts were characterized by BET, SEM, XRD, XPS, H₂-TPR, and NH₃-TPD. Mn₃Fe₂Nb_0.01O_x exhibited exceptionally high activity with a conversion of almost 100% from 80°C to 240°C, and a NO conversion of more than 75% at 40°C, while the NO conversion at 140°C in the presence of 100 ppm SO₂ remained above 90% for 4 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>According to the characterization results, Nb modification can expand the specific surface area of the catalyst, improve the structure of the catalyst, and make the active components on the catalyst surface more dispersed. Moreover, the Nb-modified catalyst reduced the content of Mn²⁺ on the catalyst surface and strengthened the electronic interactions between elements. The synergistic effects among Mn, Fe, and Nb facilitate the formation of more chemically adsorbed oxygen, which enhances the reduction capacity of the catalyst. This facilitates the adsorption of NH₃ by the catalyst at low temperatures and promotes the process of low-temperature NH₃-SCR reaction. More importantly, the Nb-modified catalyst possessed more weak acid sites, and the higher surface acidity was conducive to the inhibition of SO₃ generation, which enhanced the sulfur poisoning resistance of the catalyst. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141350693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigation and thermomechanical performance evaluation of supercritical water oxidation of n-dodecane/tributyl phosphate","authors":"Zhaoxia Mi,&nbsp;Shuzhong Wang,&nbsp;Shenghan Sun,&nbsp;Yanhui Li,&nbsp;Fan Zhang,&nbsp;Yuanwang Duan","doi":"10.1002/jctb.7686","DOIUrl":"10.1002/jctb.7686","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Nuclear energy has brought immense benefits while also generating a large amount of wastewater that urgently needs to be processed. Supercritical water oxidation (SCWO) technology serves as an efficient method for wastewater treatment. In this study, a SCWO experiment was carried out with organic solvent of 30% tributyl phosphate (TBP) and 70% <i>n</i>-dodecane. This study investigated the operating parameters and the effects of enhanced oxidation techniques on chemical oxygen demand (COD) removal efficiency. An organic solvent SCWO process was developed, and its energy and exergy efficiencies were assessed using Aspen Plus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The COD removal was about 96.18% at the experimental parameters of 500 °C, 10 min, 25 MPa, oxidation coefficient of 1.5 and material concentration of 4 wt%. COD removal increased by 3.09% with the addition of CeO₂. Finally, the overall energy and exergy efficiencies of the SCWO system were found to be 58.8% and 9.1% respectively by Aspen Plus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>It was found that the reaction temperature had the greatest effect on the COD removal rate compared with other reaction parameters. The decomposition of organic solvents can be divided into two stages, fast and slow, and the addition of alkali and catalyst can effectively promote the decomposition of waste organic solvents. The experiments showed that SCWO is feasible for the treatment of <i>n</i>-dodecane/TBP. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degradation of Anthraquinone dye wastewater by sodium percarbonate with CoO heterogeneous activation","authors":"Haoyu Fan,&nbsp;Yanzhao Xia,&nbsp;Cuizhen Sun,&nbsp;Rupeng Liu,&nbsp;Feiyong Chen,&nbsp;Meng Li,&nbsp;Weichen Zhu,&nbsp;Xinpeng Yang,&nbsp;Zhen Zhang","doi":"10.1002/jctb.7684","DOIUrl":"10.1002/jctb.7684","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Anthraquinone dyes have an anthraquinone structure as their nucleus, with one or more substituents forming different organic dyes. Anthraquinone dyes have a complex structure that allows them to exist stably in water environment, but also makes them more toxic than azo dyes. This results in varying degrees of harm to both humans and the environment as a result of residual dyes in the water or on the material’ surface. Sodium percarbonate (SPC) is a highly promising oxidant due to its green end product. Therefore, in this study, the catalytic performance and kinetic study of cobalt oxide (CoO) on SPC under different conditions were systematically investigated using RB19 as the target pollutant. The Box–Behnken Design (BBD) model was used to model the degradation of RB19 by CoO/SPC system, which gives the basis for practical application. The types of reactive oxygen species that effectively degrade RB19 and the potential degradation mechanism of the CoO/SPC system were revealed. At the same time, the CoO/SPC system was evaluated in terms of its practicality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In this work, the activation of SPC using CoO towards reactive blue 19 (RB19) degradation was explored. Experimental results showed that nearly 93.8% of RB19 could be removed within 30 min using 1 mmol L⁻¹ SPC and 30 mg L⁻¹ CoO. The three-factor interaction effects of SPC concentration, CoO dosage and initial pH were investigated. The BBD model was set up to obtain the optimum working conditions of 1.039 mmol L⁻¹ SPC, 33.35 mg L⁻¹ CoO and the initial pH of 7.82, which gave a degradation rate of 95.372%. Additionally, it was confirmed that the solubility of Co²⁺ is consistently &lt;150 μg L⁻¹, meeting the emission standard (1 ppm). The presence of Cl⁻, NO^3–, and HA had a similar profile, with a slight promoting effect in small amounts and an inhibitory effect when introduced in excess. The introduction of SO₄^2– had a negligible effect on RB19 degradation, whereas the presence of HCO₃⁻ produced a slight inhibitory effect. Furthermore, the presence of PO₄^3– showed a strong inhibitory effect. The CoO/SPC system is suitable for other organic dyes (32.7%–100%) and antibiotics (97.1–100%). Electron paramagnetic resonance (EPR) analysis and quenching experiments confirmed the presence and relative contribution of free radicals in the CoO/SPC system as CO₃•- (88.12%) &gt;O₂•- (51.11%) &gt;1O₂ (37.21%) &gt;•OH (5.27%) &gt; SPC (3.33%) &gt;CoO (0.09%). It has been confirmed that CoO activates SPC through electron transfer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 ","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of chiral acidic molecularly imprinted polymer for the enantioselective separation of (±)-DOPA","authors":"Rua B Alnoman","doi":"10.1002/jctb.7691","DOIUrl":"10.1002/jctb.7691","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The study focuses on developing a stable enantioselective matrix for the efficient chiral identification and enantioresolution of <span>l</span>-DOPA and (±)-DOPA. The matrix is derived from a copolymeric material made from poly[(vinylsulfonic acid)-<i>co</i>-(4-vinylpyridine)] crosslinked with divinylbenzene.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><span>l</span>-DOPA-vinylsulfonamide was synthesized and characterized. This chiral sulfonamide was copolymerized with 4-vinylpyridine in the presence of a divinylbenzene crosslinker, using azobisisobutyronitrile as a thermal initiator. Post-polymerization, the polymeric particles were treated with NaOH and subsequently washed with acid to remove the integrated <span>l</span>-DOPA species. Scanning electron microscopy and Fourier transform infrared spectroscopy confirmed the imprinted <span>l</span>-DOPA-IP particles. The manufactured <span>l</span>-DOPA-IP demonstrated a tenfold greater affinity for <span>l</span>-DOPA compared to <span>d</span>-DOPA. Langmuir adsorption experiments at pH 6 showed a maximum capacity of 162 mg g⁻¹. Enantiomeric excess values for <span>l</span>- and <span>d</span>-DOPA, determined through optical separation using a column approach, were 94% and 82%, respectively, in the loading and recovery solutions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The developed copolymeric material effectively served as an enantioselective matrix, exhibiting high selectivity and capacity for <span>l</span>-DOPA. The process demonstrated efficient chiral identification and separation, achieving significant enantiomeric excess values for both <span>l</span>- and <span>d</span>-DOPA. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Image, Volume 99, Issue 7","authors":"Feride Ece Kutlar,&nbsp;Iskin Engin,&nbsp;Yasemin Dilsad Yilmazel","doi":"10.1002/jctb.7694","DOIUrl":"https://doi.org/10.1002/jctb.7694","url":null,"abstract":"<p>The cover image is based on the Research Article <i>Nutrient recovery from manure digestate by using waste magnesite powder and bone meal as sustainable substitutes for struvite precipitation</i> by Feride Ece Kutlar et al., https://doi.org/10.1002/jctb.7661.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7694","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141292649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of palm oil and palm oil effluent as a carbon source for the production of polyhydroxybutyrate co-polyhydroxyhexanoate P(HB-co-HHx) a biopolymer in bacillus sp","authors":"Vrunda N Katagi,&nbsp;Roopashri N Arekal,&nbsp;M Somashekara Divyashree","doi":"10.1002/jctb.7689","DOIUrl":"10.1002/jctb.7689","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Biodegradable polymers are gaining a reputation as demand is increasing globally. Amongst these Polyhydroxyalkanoates (PHA) are attracting market attention as a consequence of their properties similar to those of conventional plastics. PHA is a natural polyester that is stored as an intracellular carbon (C) energy reserve of bacteria. This biopolymer can be extracted and used in place of petrochemical plastic. Medium chain-length (mcl) PHA, specifically poly hydroxybutyrate-co-hydroxyhexanoate P (HB-co-HHx) copolymer produced by <i>Bacillus</i>, has gained practical attention owing to its superior physicochemical properties compared to the commonly synthesized PHB homopolymer. Co-polymer production is dependent on C sources provided in the growth medium. In the present study we have employed palm oil and palm oil effluent as C source.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In the current study, it was observed that a significant amount of PHA and biomass was produced when the effluent was prepared at a concentration of 100% instead of water for preparing the growth medium. The production of biomass and PHA showed a range of 4.8–8and 1.5–4 g L⁻¹, respectively. This means that the PHA yield obtained using the effluent was 50–80% of the control, whereas the control yielded only 40–50%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>Palm industry waste can be used as a substrate in bioprocessing industries. Proton nuclear magnetic resonance analysis of PHA obtained herein indicates that it consists of the mcl polymer P (HB-co-HHx). © 2024 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7689","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the biodegradation of bis(2-hydroxyethyl) terephthalate by an IsPETasePA and MHETase dual-enzyme system","authors":"Yingtong Gao,&nbsp;Yunxin Zheng,&nbsp;Zixin Qi,&nbsp;Yufan Pan,&nbsp;Yu Zhou,&nbsp;Shengping You,&nbsp;Rongxin Su,&nbsp;Wei Qi,&nbsp;Mengfan Wang","doi":"10.1002/jctb.7688","DOIUrl":"10.1002/jctb.7688","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Environmental and ecological hazards caused by the accumulation of polyethylene terephthalate (PET) are becoming a global concern. The use of enzymes to address the plastic crisis has achieved many successes, but the difficulty in degrading high-crystallinity PET has limited its application. Numerous studies have investigated the degradation of PET with arbitrary crystallinity to bis-2-(2-hydroxyethyl) terephthalate (BHET) using chemical pre-treatment methods such as glycolysis, but few have tested its biocompatibility with enzymatic alliances.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Herein, we report the enzymatic characterization and subsequent engineering of the state-of-the-art <i>Is</i>PETase^PA and MHETase (where MHET is mono(2-hydroxyethyl) terephthalate), a dual-enzyme system which can be used for the degradation from BHET to a single-product terephthalate (TPA). Modulators, including surfactants, organic solvents and metal ions, enhanced the enzyme activity of <i>Is</i>PETase^PA and MHETase by up to 1.1-fold and 2.3-fold, respectively. 100% TPA yield (BHET of 25 g L⁻¹) was achieved within 5 h. We also analyzed the mechanism of optimal ion modulator modification by dynamics simulation, and it synergistically achieved enhancement of MHET degradation ability by improving stability and binding energy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The introduction of modulators improves the efficiency of the dual-enzyme system in degrading BHET. This work provides a valuable strategy for the complete degradation of BHET to TPA, laying the groundwork for the realization of PET recycling. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141269767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A perspective on downstream processing performance for recovery of bioalcohols","authors":"Tamara Janković,&nbsp;Adrie JJ Straathof,&nbsp;Anton A Kiss","doi":"10.1002/jctb.7690","DOIUrl":"10.1002/jctb.7690","url":null,"abstract":"<p>Even though industrial biotechnology is successfully used for the production of some chemicals, for many other chemicals it is not yet competitive with conventional petrochemical production. Usually, fermentation as well as downstream processing requires improvement. Downstream processing has to deal with low product concentrations, microorganisms, impurities and thermodynamic constraints (e.g., azeotropes), which often makes it very challenging and expensive, especially on a large scale. However, downstream processing of biochemicals has not attracted as much attention as upstream fermentation processes. In that context, this perspective paper offers a lightly referenced scholarly opinion about the downstream processing performance of different bioalcohols after fermentation. Due to the stronger toxicity effects on microbes, the achievable concentrations of monohydric aliphatic alcohols in the fermentation broth decrease with the increasing chain length. Specifically, the concentrations used here are 6.14, 5.00, 1.61 and 0.24 wt% of ethanol, isopropanol, isobutanol and hexanol, respectively. More dilute fermentation broths lead to more complex recovery processes. According to our previous work, the total purification costs increase from 0.080 USD kg⁻¹ for ethanol, 0.109 USD kg⁻¹ for isopropanol and 0.161 USD kg⁻¹ for isobutanol to 0.529 USD kg⁻¹ for hexanol. A similar trend is noticeable for the energy usage (0.960, 1.348, 2.018 and 3.069 kW_thh kg⁻¹, respectively) and the related CO₂ emissions (0.164, 0.221, 0.449 and 0.555 kg_CO2 kg⁻¹, respectively). This work shows that advanced separation and purification based on process intensification principles are crucial for overall efficient production processes. The achievable product concentration in the fermentation broth – and not so much the alcohol chain length – has the biggest influence on the performance of downstream processing. Therefore, simultaneous development of both upstream and downstream processing is necessary to ensure the competitiveness and viability of industrial fermentation processes. © 2024 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141195273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of anaerobic digestion of dairy wastewater by addition of conductive materials with or without the combination of external voltage application","authors":"Michail S Fountoulakis,&nbsp;Zuzana Frkova,&nbsp;Sébastien Lemaigre,&nbsp;Xavier Goux,&nbsp;Magdalena Calusinska,&nbsp;Jimmy Roussel","doi":"10.1002/jctb.7685","DOIUrl":"10.1002/jctb.7685","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The addition of conductive materials or the application of external voltage is a promising novel methodology to enhance methane production in anaerobic digesters. However, there is limited knowledge about their individual or combined effects on the anaerobic digestion of dairy wastewater. The aim of this study was to examine the effects of granular activated carbon (GAC) or magnetite addition and external voltage application, both individually and in combination, for the anaerobic digestion of real, undiluted dairy wastewater.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The results showed that the estimated maximum methane production rate increased significantly (<i>P</i> &lt; 0.05) from 143 ± 8 mL gVS_added⁻¹ day⁻¹ in the control reactors to 163 ± 11 mL gVS_added⁻¹ day⁻¹ and 166 ± 11 mL gVS_added⁻¹ day⁻¹ in the reactors containing GAC, with or without the combination of external voltage, respectively. The addition of GAC, in both cases, resulted in higher consumption rate of acetate, indicating a promotion of the methanogenesis step. By contrast, the application of external voltage or the addition of magnetite had no significant effect on either methane production rate nor methane yield. Moreover, the analysis of the microbial community showed that the addition of GAC resulted in the enrichment of <i>Desulfobacterota</i>, <i>Methanosarcina</i>, <i>Candidatus Methanofastidiosum</i> and <i>Methanolinea.</i></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>Overall, GAC addition seems a promising strategy to increase methane production in anaerobic digesters treating dairy wastewater. © 2024 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7685","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141195315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}