Journal of chemical technology and biotechnology最新文献

{"title":"Solvent screening for the purification of monoterpenoids by countercurrent and centrifugal partition chromatography","authors":"Sérgio M Vilas-Boas,&nbsp;João AP Coutinho,&nbsp;Simão P Pinho,&nbsp;Olga Ferreira","doi":"10.1002/jctb.7762","DOIUrl":"https://doi.org/10.1002/jctb.7762","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC) are efficient techniques to purify terpenoids from essential oils. These methods require suitable solvent systems for the partition between the two immiscible liquid phases. In this study, using the analytical shake-flask method, we measured the partition coefficients of three model monoterpenoids, namely carvone, eucalyptol and thymol, in 11 biphasic solvent systems, at 298.2 K. Moreover, the predictive COSMO-RS model was applied to represent the partition coefficients of data measured in this work and retrieved from the literature, the liquid–liquid equilibrium (LLE) data of three solvent families suitable for CCC/CPC separations (i.e., Arizona, Modified Arizona and Green Arizona) and the solute's partition coefficients in the three solvent families.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The partition coefficients obtained for thymol and eucalyptol are the first partition data available in the literature. The obtained root mean square deviations (RMSDs) between the experimental and predicted partition coefficients (log basis) varied between 0.28 and 0.49. For LLE, RMSDs of 0.040 and 0.048 were achieved for the Arizona and Green Arizona families, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The predictive COSMO-RS model describes the monoterpenoid partition coefficients and the LLE data of the solvent families well. The most favorable solvent systems to perform the separations were identified, showing that systems with low and intermediate-to-low polarities are the most promising options for separating the selected monoterpenoids from their natural matrices by CCC/CPC techniques. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"166-175"},"PeriodicalIF":2.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cassava stem biochar (CSB) for chromium removal from produced water: sustainable adsorption and environmental implications","authors":"Vasu Gajendiran,&nbsp;Prabu Deivasigamani,&nbsp;Selvaraju Sivamani,&nbsp;Saikat Banerjee,&nbsp;B.S. Naveen Prasad","doi":"10.1002/jctb.7761","DOIUrl":"https://doi.org/10.1002/jctb.7761","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Produced water, a byproduct of oil and gas extraction, often contains elevated levels of heavy metals, including chromium, posing significant environmental and health risks. Cassava stem biochar (CSB) was prepared by pyrolysis of cassava stem and its potential has been investigated for the removal of chromium (Cr) from produced water. Batch adsorption experiments were conducted to evaluate the adsorption capacity of CSB under various conditions of pH, contact time, initial produced water concentration, adsorbent dosage, agitation speed, temperature and particle size.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>From the experiment results, it was found that CSB showed good adsorption capacity of chromium ions from produced water. The adsorption process was found to be highly pH-dependent, with maximum removal efficiency observed at a pH of 4.0. Equilibrium data were fitted to the Freundlich isotherm models, indicating multilayer adsorption on a heterogeneous surface. The kinetic data demonstrated that the adsorption process followed pseudo-first-order as well as pseudo-second-order kinetics, suggesting a physisorption and chemisorption mechanism. The thermodynamic parameters, including changes in enthalpy (ΔH), and entropy (ΔS), were evaluated to gain insights into the spontaneity and feasibility of the adsorption process. The negative ΔH values indicated that the adsorption of Cr onto CSB was non-spontaneous and exothermic in nature. The negative ΔS value suggested the adsorption is feasible.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>This comprehensive study demonstrates the potential of cassava stem biochar as an effective and environmentally friendly adsorbent for the removal of chromium from produced water. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"155-165"},"PeriodicalIF":2.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic removal of aldrin and dieldrin using graphene oxide and TiO2-doped CuFe2O4","authors":"Sevil Akçağlar","doi":"10.1002/jctb.7759","DOIUrl":"https://doi.org/10.1002/jctb.7759","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Conventional treatment processes and existing photocatalysts have proven insufficient in efficiently removing aldrin and dieldrin. Consequently, this study aimed to investigate the removal of aldrin and dieldrin from surface water using a titanium dioxide/graphene oxide/copper ferrite (TiO₂/GO/CuFe₂O₄) nanocomposite.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The highest photodegradation efficiencies for aldrin (100%) and dieldrin (99%) were achieved with a TiO₂/GO/CuFe₂O₄ nanocomposite dosage of 1.3 mg L⁻¹, at a sunlight intensity of 9 W m⁻² and an optimal photodegradation time of 25 min. The maximum UV absorption wavelength of the TiO₂/GO/CuFe₂O₄ nanocomposite was observed at 365 nm. The quantum yield of the nanocomposite was recorded as 2.69 × 10² mol einstein⁻¹, and its bandgap energy was determined to be 3.31 eV. The first-order kinetic rate constants for aldrin and dieldrin were calculated as 0.05 and 0.047 min⁻¹, respectively. X-ray diffraction analysis confirmed the crystal structure of CuFe₂O₄/TiO₂, while Fourier transform infrared spectroscopy detected carboxylic, epoxy, carbonyl and other oxygenated groups within the TiO₂/GO/CuFe₂O₄ nanocomposite. Scanning electron microscopy and transmission electron microscopy images revealed that CuFe₂O₄ was situated on the outer layer of GO. Energy-dispersive X-ray analysis identified the elemental composition of the TiO₂/GO/CuFe₂O₄ nanocomposite as comprising GO, C, Cu, Fe, Ti and O. A reusability study demonstrated that the nanocomposite maintained excellent performance, achieving 99% removal efficiency after 79 cycles and 97% after 100 cycles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSIONS</h3>\u0000 \u0000 <p>The TiO₂/GO/CuFe₂O₄ nanocomposite effectively removed aldrin and dieldrin from surface water. This nanocomposite holds promise for the remediation of other aquatic ecosystems, such as bays, rivers and ocean waters. © 2024 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"138-154"},"PeriodicalIF":2.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-frequency (470 kHz) ultrasonics-assisted room temperature CO2 stripping and fate of Sono exposed solvent","authors":"Manikandan Shanmugam,&nbsp;Ambedkar Balraj,&nbsp;Ravichandar Babarao","doi":"10.1002/jctb.7763","DOIUrl":"https://doi.org/10.1002/jctb.7763","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The conventional CO₂ stripping process in solvent-based postcombustion CO₂ capture (PCCC) process uses heating to strip the CO₂ (~120 °C). However, the challenges associated with this method are high energy consumption in degassing the CO₂ from solvent, solvent loss and degradation resulting from the high –temperatures, resulting in high energy consumption typical of solvent-based PCCC. The present study demonstrates the use of bath-type sonication (470 kHz frequency) to remove CO₂ from CO₂ loaded 30 wt% Monoethanolamine under controlled temperature conditions. Solvent performance was evaluated following exposure to 2 h conventional heating and 75 h sonication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In a batch sono-assisted process, CO₂ stripping became possible at 17.5 °C compared to 102.2 °C using the conventional method. Increasing the sonication time led decreased carbon loading and increased stripping efficiency. The stripping rate was high at the initial stages of treatment. Evaluation of sono-exposed solvents exhibited decreased pH during CO₂ loading and decreased absorption capacity of the conventionally heated sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The sono-assisted method consumes 3.57-foldless energy than conventional heating. Its CO₂ stripping rate was found to be higher within 5 min of sonication. Notably, the maximum temperature reached for the 1 h intervening mode of sonication at 470 kHz was 49.49 °C. The reduction in absorption capacity per hour of conventional heating was 24.5%, whereas for sonication it was &lt;0.4% and solvent loss was 19.7% lower than conventional. There was no significant change in the color, pH and density of the sample. A 20.4% higher surface tension than that of the virgin sample was observed. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"176-186"},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas–liquid mixing performance of a non-Newtonian fluid in a multiple-impeller agitated tank","authors":"Angus Shiue,&nbsp;Qiang Hu,&nbsp;Yu-Jie Ye,&nbsp;Jyh-Cheng Jeng,&nbsp;Graham Leggett","doi":"10.1002/jctb.7757","DOIUrl":"https://doi.org/10.1002/jctb.7757","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>This target is to decide power input and gas hold-up for gas–liquid mixing aqueous CMC solutions. The analysis considers the impact by varying the impeller speed and gas flow rates in a stirred tank bioreactor of three kinds of multiple impellers. The effects of the impeller type, rheology, and operating conditions were investigated on power drawn, relative power demand (RPD), gas holdup, and volumetric mass transfer coefficient.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULT</h3>\u0000 \u0000 <p>Compared to the Rushton turbine (6RT) and 4-pitch blade (4PBT) impeller, the propeller (3PP) impeller presented a minimal event of the gassing on the RPD. 4PBT impeller has shown a higher gas hold-up compared to the Rushton turbine and propeller impellers. The aerated agitated tank was established a dimensionless correlation for the RPD as a function of flow number and web number. Besides, the gas–liquid agitated system was also introduced a dimensionless correlation to compute the overall gas hold-up as a function of specific power consumption. For the maximum dispersion mixing intensity, the impeller structure with low RPD looks to be more adequate. Further, maximizing gas holdup in the structures with high RPD is advantageous. The effects of impeller speed, gas superficial velocity, and rheology on the volumetric mass transfer coefficient were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The volumetric mass transfer coefficient increased with an increase in impeller speed, gas superficial velocity, and power consumption per unit volume and decreased as rheology increased. The averaged kLa for each multiple-impeller was correlated well with the specific gassed power consumption and gas superficial velocity. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"104-120"},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing properties of PSF membrane via a simple two-step coating of PDA and PVP for separating oil/water emulsions","authors":"Rosyiela Azwa Roslan,&nbsp;Woei Jye Lau,&nbsp;Nadiene Salleha Mohd Nawi,&nbsp;Edward Ndumiso Nxumalo,&nbsp;Ahmad Fauzi Ismail","doi":"10.1002/jctb.7752","DOIUrl":"https://doi.org/10.1002/jctb.7752","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hydrophilic modification is a promising method to inhibit fouling formation on ultrafiltration membranes. Many relevant studies have been documented; however, most of these methods are either overly intricate or require costly chemicals, thus constraining their practical utility. In this work, we proposed a straightforward approach to modify a commercial polysulfone ultrafiltration membrane via a two-step coating process involving polydopamine (PDA) followed by polyvinylpyrrolidone (PVP). The influences of PVP molecular weight and concentration on the surface properties of the membrane were studied for oil/water emulsion treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Despite the fact that the introduction of a PVP layer adversely impacted the pure water permeability of the commercial membrane, its water flux during oil/water emulsion treatment was improved due to its improved antifouling properties, which can be attributed to a lower water contact angle. It was found that increasing the PVP concentration in the coating solution could improve the water flux and oil rejection during the treatment process. This enhancement is attributed to the augmented surface hydrophilicity combined with a reduction in membrane surface pore size. Additionally, the best-performing PVP-modified membrane exhibited significantly higher flux recovery rate, with its value for the second and third cycles at 89.4% and 80.4%, respectively, compared to the control membrane, which recorded 80.3% and 73.9%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Modifying a membrane surface with PDA/PVP coating has been proven to enhance the surface wettability and antifouling properties significantly. These modifications led to improved oil removal efficiencies, demonstrating superior performance in oil/water emulsion treatment. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"37-49"},"PeriodicalIF":2.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption behavior of graphite-like walnut shell biochar modified with ammonia for ciprofloxacin in aqueous solution","authors":"Qingkun Wang,&nbsp;Yanping Zhang,&nbsp;Fen Li,&nbsp;Wenxiao Liu,&nbsp;Liran Ma","doi":"10.1002/jctb.7756","DOIUrl":"10.1002/jctb.7756","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Graphite-like biochar of NWSC600K was prepared at 900 °C using walnut shell as the raw material and aqueous ammonia (NH₃·H₂O) as an activator, and characterized using transmission and scanning eletron microscopy (TEM, SEM), X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET), Raman spectroscopy and Fourier transform infrared (FTIR). The study investigated the adsorption performance and mechanism of NWSC600K for ciprofloxacin (CIP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The results showed that extremely tiny pores were found on the surface of NWSC600K, which increased its specific surface area to 823.91 m² g⁻¹, whereas the average pore size of NWSC600K decreased to 3.23 nm. The results of TEM, XRD and Raman spectroscopy detected well-arranged lattice stripes as well as characteristic peaks corresponding to the graphite lattice appearing on the surface of NWSC600K. Moreover, the <i>I</i>_D/<i>I</i>_G value for NWSC600K was 1.429. The FTIR results showed that functional groups including the amino group were formed on NWSC600K.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The adsorption capacity of NWSC600K for CIP was 158.14 mg g⁻¹ and the corresponding removal rate was 97.5% at pH 7. The pH value impact on the removal efficiency of CIP greatly, and the removal rate of CIP decreased linearly with increasing pH. The coexisting ions also would inhibit the adsorption of CIP on NWSC600K. Results obtained from kinetic and isotherm models, thermodynamics and characterization analyses suggested that pore-filling, π–π stacking, hydrogen bonding, hydrophobicity and electrostatic interaction existed during the adsorption process. The adsorption was a nonspontaneous exothermic reaction. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"90-103"},"PeriodicalIF":2.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the physiology of Pichia pastoris grown on glycerol/glucose using polyurethane foam slabs as solid support","authors":"Josué Zárate-Bonilla,&nbsp;Divanery Rodríguez-Gómez,&nbsp;Gustavo Viniegra-González,&nbsp;Marcos López-Pérez","doi":"10.1002/jctb.7754","DOIUrl":"https://doi.org/10.1002/jctb.7754","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Growth physiology and metabolic flux of <i>Pichia pastoris</i> were analyzed using glass columns containing slabs of polyurethane foam as a solid support and culture medium with glycerol or glucose as a carbon source.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Media with glycerol produced an average of 30.91% more biomass than media where glucose was used. However, the specific growth rate registered higher values for media with glucose than those with glycerol at low substrate concentrations: 0.46 <i>versus</i> 0.22 h⁻¹. Media with glycerol produced a large amount of <span>d</span>-arabitol, whereas ethanol and citrate were the predominant metabolites in media with glucose. Both types of culture systems generated biphasic curves in terms of the respiratory quotient value, whose inflection point coincided with the transition from aerobic metabolism to a mixed one.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>Adequate oxygen transfer occurred in both culture systems; therefore, the differences found in growth physiology can be explained by the transport mechanism that internalizes glycerol, the access point to primary metabolism, and the degree of glycerol oxidation. The arrangement of cells in the polyurethane matrix allowed an attenuation of the repression phenomenon due to excess substrate for both carbon sources. This is the first work to study metabolic flux comparisons using this system. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"67-79"},"PeriodicalIF":2.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly approaches for synthesis of indolyl 1H-pyrroles using rice-husk-derived carbonaceous sulfonation as the green catalyst","authors":"Linh Dieu Nguyen,&nbsp;Khanh Ha Nguyen,&nbsp;Phat Ngoc Nguyen,&nbsp;Kim Nguyen Tran,&nbsp;Diep Dinh Le,&nbsp;Phuong Hoang Tran,&nbsp;Hai Truong Nguyen","doi":"10.1002/jctb.7758","DOIUrl":"10.1002/jctb.7758","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Amorphous carbon-bearing sulfonic acid groups (AC–SO₃H) are a kind of solid acid that exhibits high acidity and belongs to the new generation of solid acids. The presence of acidic functional groups, including carboxylic acid, phenolic and sulfonic acid groups, allows for several key activities such as strong Brønsted acid properties, high surface area, stability, reusability and recyclability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In this work, we synthesized indolyl 1<i>H</i>-pyrroles from indoles, phenylglyoxal monohydrate, 1,3-diketones and ammonium acetate using rice-husk-derived carbonaceous sulfonation (AC–SO₃H) as a catalyst. We explored the impact of catalyst quantity, reaction time, solvent, mineral acid and temperature in order to determine the optimal reaction conditions. Additionally, indolyl 1<i>H</i>-pyrrole derivatives were also synthesized based on the optimal conditions that were completely investigated, and the structure of these synthetic compounds was characterized by ¹H- and ¹³C-nuclear magnetic resonance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The yield of indolyl 1<i>H</i>-pyrroles was up to 84% in 6 h at 100 °C with the activity of 30 mg AC–SO₃H. Besides, based on the optimal conditions, 21 indolyl 1<i>H</i>-pyrrole derivatives were formed with the high-yield and green method. The catalyst could be reused multiple times without a significant decrease in catalytic performance. According to the findings from the experiments, a potential mechanism that included a radical process has been suggested. This eco-friendly approach provided a straightforward and efficient method to produce a variety of indole–pyrrole conjugates in a single step. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"121-137"},"PeriodicalIF":2.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of neutrophil-activating protein conservation on diagnostic tests and vaccine design","authors":"Lídia MD Gonçalves,&nbsp;António J Almeida,&nbsp;Cecília RC Calado","doi":"10.1002/jctb.7755","DOIUrl":"10.1002/jctb.7755","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The neutrophil activating protein (NAP) is a highly immunogenic and virulence factor of <i>Helicobacter pylori</i>, presenting inflammatory and immunomodulatory activity. Consequently, NAP has been explored as a diagnostic and therapeutic target. However, when evaluating a target protein to design diagnostic methods or vaccines, it is critical to determine the protein conservation among the bacterial population, as well the impact of alterations of amino acid residues on the protein antigenic profile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In the present work, NAP conservation and theoretical antigenicity were determined among 51 sequences from <i>H. pylori</i> isolated from patients worldwide. A high NAP conservation (83%) was observed, where 17 amino acid residues, among the 144 residues of the protein, were polymorphic. Alterations at these polymorphic sites had a theoretically low impact on predicted antigenicity, where only 5 NAPs out of 51 NAPs presented a slightly different antigenic profile in relation to the consensus sequence. According to that, it was possible to recognize in western blotting 93% of NAP from different bacteria (<i>n</i> = 15) using polyclonal antibodies developed against a specific NAP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSIONS</h3>\u0000 \u0000 <p>It was predicted that when working with polyclonal antibodies or large NAP fragments for diagnostic and vaccine design, slight variation in protein sequence will have a minimal impact on NAP recognition. However, if a NAP monoclonal antibody or small NAP epitopes are considered, it is critical to select the most conserved and antigenic NAP regions, to maximize the coverage of NAP variants. © 2024 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"100 1","pages":"80-89"},"PeriodicalIF":2.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}