Journal of Child Neurology最新文献_第6页

Global Pediatric Stroke Epidemiology: A Systematic Review of the Literature and Meta-Analysis. 全球儿童中风流行病学：文献和荟萃分析的系统回顾。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-09-01 Epub Date: 2026-05-04 DOI: 10.1177/08830738261441084

Joseline Haizel-Cobbina, Stefan W Koester, Yusra Arafeh, Prabhat Poudel, Nancy Abu-Bonsrah, Nathan A Shlobin, Jeffrey Chen, Liping Du, Albert Isaacs, Michael C Dewan

{"title":"Global Pediatric Stroke Epidemiology: A Systematic Review of the Literature and Meta-Analysis.","authors":"Joseline Haizel-Cobbina, Stefan W Koester, Yusra Arafeh, Prabhat Poudel, Nancy Abu-Bonsrah, Nathan A Shlobin, Jeffrey Chen, Liping Du, Albert Isaacs, Michael C Dewan","doi":"10.1177/08830738261441084","DOIUrl":"10.1177/08830738261441084","url":null,"abstract":"The global burden of stroke in children is poorly characterized. We aimed to quantify the global burden of pediatric stroke. A systematic review and meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The estimated birth prevalence and incidence of perinatal and overall childhood stroke was used to calculate the worldwide stroke burden by World Bank Income Groups and World Health Organization (WHO) regions. The estimated birth prevalence of perinatal stroke (regardless of type) was 21.01 per 100 000 total births and estimated childhood incidence of stroke was 3.73 per 100 000 person-years. The childhood incidence of ischemic stroke and hemorrhagic stroke was 1.30 per 100 000 person-years and 0.99 per 100 000 person-years, respectively. There is a relatively greater burden of perinatal stroke birth prevalence. Epidemiologic data on pediatric stroke is concentrated in western HIC. Coordinated efforts are needed to better understand the burden of pediatric stroke in LMIC.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"1220-1228"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13421153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Survival: Parenting and Psychosocial Support in the New Era of Spinal Muscular Atrophy. 超越生存：脊髓性肌萎缩新时代的养育和社会心理支持。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-09-01 Epub Date: 2026-06-23 DOI: 10.1177/08830738261461701

Gül Yücel

引用次数: 0

The Cost of Fear for Pediatric Neurologic Care. 儿童神经病学护理的恐惧成本。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-09-01 Epub Date: 2026-06-27 DOI: 10.1177/08830738261460652

Christina Briscoe-Abath, Alison Christy, Yasmin Khakoo

引用次数: 0

Adolescent Patient with Cardiac Myxoma Causing Arterial Ischemic Stroke, Systemic Embolization, and Delayed Intracranial Aneurysms: Image Report. 青少年心脏黏液瘤引起动脉缺血性中风、全身栓塞和迟发性颅内动脉瘤：影像学报告。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-08-31 DOI: 10.1177/08830738261474053

Iason Georgios Stamatakis, Georgios Kalavrouziotis, Antonios Kallikourdis, Nikolaos Andreou, Georgia Mitropoulou, Aikaterini Michalopoulou, Marina Katsalouli

引用次数: 0

Cerebral Abscesses due to Aspergillus Following Cardioembolic Ischemic Stroke in an Immunocompetent Child With Scimitar Syndrome. 免疫功能正常的弯刀综合征儿童心脏栓塞性缺血性卒中后曲霉菌所致脑脓肿。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-08-30 DOI: 10.1177/08830738261483292

Rachel Vassar, Natalie Pierson, Yi Li

引用次数: 0

Diagnostic Overshadowing in Lennox-Gastaut Syndrome: Immerslund-Gräsbeck Syndrome Unmasked by Radiosurgical Stress. lenox - gastaut综合征的诊断性阴影：Immerslund-Gräsbeck放射外科应激揭示的综合征。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-08-30 DOI: 10.1177/08830738261474005

Ece Koç, Elif Nalan Taş, Ebru Arhan, Tuğba Hirfanoğlu, Deniz Aslan

{"title":"Diagnostic Overshadowing in Lennox-Gastaut Syndrome: Immerslund-Gräsbeck Syndrome Unmasked by Radiosurgical Stress.","authors":"Ece Koç, Elif Nalan Taş, Ebru Arhan, Tuğba Hirfanoğlu, Deniz Aslan","doi":"10.1177/08830738261474005","DOIUrl":"https://doi.org/10.1177/08830738261474005","url":null,"abstract":"In complex neurodevelopmental disorders such as Lennox-Gastaut syndrome (LGS), treatable metabolic comorbidities may be masked by the severity of the primary phenotype. We report an 8-year-old boy with LGS and bilateral polymicrogyria whose underlying Imerslund-Gräsbeck syndrome was unmasked following a palliative Gamma Knife corpus callosotomy. Although the patient underwent Gamma Knife corpus callosotomy, his seizures remained uncontrolled. Consequently, vagus nerve stimulator implantation was planned; however, severe anemia (hemoglobin: 3.3 g/dL) was detected on admission for the procedure. Initially, the hematologic abnormalities were attributed to polypharmacy, prompting a dose reduction in antiepileptic medications. A concurrent anemia workup revealed vitamin B12 deficiency, and intramuscular B12 replacement therapy was initiated. However, because the macrocytic anemia was unexpectedly severe and other hematopoietic lineages remained unaffected, advanced investigations were performed. Genetic analysis revealed compound heterozygous missense variants in the CUBN gene. Following parenteral vitamin B12 replacement, the patient achieved not only hematologic recovery but also a remarkable reduction in seizure frequency over the subsequent 9 months. This case illustrates diagnostic overshadowing and underscores the necessity of considering comprehensive genetic and metabolic testing in refractory epilepsy, as addressing a metabolic second hit can significantly optimize neurologic outcomes.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738261474005"},"PeriodicalIF":1.6,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing the Fatigue Experience Among Children With Charcot-Marie-Tooth Disease. 儿童腓骨-玛丽肌病的疲劳体验特征。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-08-30 DOI: 10.1177/08830738261481654

Carl C Young, Joshua Burns, Manoj P Menezes, Gabrielle A Donlevy, Marnee J McKay, Jyoti Raghunandan, Monica Marzouk, Kayla M D Cornett

{"title":"Characterizing the Fatigue Experience Among Children With Charcot-Marie-Tooth Disease.","authors":"Carl C Young, Joshua Burns, Manoj P Menezes, Gabrielle A Donlevy, Marnee J McKay, Jyoti Raghunandan, Monica Marzouk, Kayla M D Cornett","doi":"10.1177/08830738261481654","DOIUrl":"10.1177/08830738261481654","url":null,"abstract":"Charcot-Marie-Tooth disease (CMT) comprises a heterogeneous group of inherited peripheral neuropathies with onset often in childhood. Activity-limiting fatigue is a common symptom of many neuromuscular disorders. The aim of this study was to explore the experience of activity-limiting fatigue among children with CMT and evaluate the utility of the generic Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS). Fifteen individuals aged 8-18 years with CMT and 12 parents participated in this study. Participants completed the PedsQL-MFS, and focus group interviews were conducted to gather feedback about the PedsQL-MFS and gain in-depth insights about their experiences of activity-limiting fatigue and impact on quality of life. Children with CMT and their parent-proxy reported significantly lower PedsQL-MFS fatigue scores (indicating greater fatigue) in comparison to normative values (P < .01), which, however, was deemed limited in scope to measure the full experience of fatigue in CMT. During in-depth interviews, 8 domains emerged as important considerations for assessing fatigue in CMT, including impact of fatigue on motor function, impact of fatigue on endurance and performance, recovery from physical activities, location of fatigue, muscle fatigue, timing of fatigue, impact of fatigue on behavior, and relationship to nutrition and hydration. These 8 domains may inform development of a disease-specific patient- and parent-reported outcome measure of fatigue.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738261481654"},"PeriodicalIF":1.6,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotype-Driven MRI Re-evaluation Reveals Subtle PAFAH1B1-Related Lissencephaly. 基因型驱动的MRI重新评估揭示了微妙的pafah1b1相关缺脑畸形。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-08-27 DOI: 10.1177/08830738261474042

Clara Xiol, Jonathan Olival, Loreto Martorell, Marta Gómez-Chiari, Juan Darío Ortigoza-Escobar

引用次数: 0

Safety and Local Tolerability of Diazepam Nasal Spray for Children With Epilepsy Aged 2-5 Years: Final Results of a Phase 1/2a Trial. 地西泮鼻喷雾剂治疗2-5岁癫痫患儿的安全性和局部耐受性：1/2a期临床试验的最终结果

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-08-26 DOI: 10.1177/08830738261474614

Eric B Segal, James W Wheless, Steven M Wolf, Muhammad Zafar, J Ben Renfroe, Miguel A Lopez-Toledano, Leock Y Ngo, Adrian L Rabinowicz, Enrique Carrazana

{"title":"Safety and Local Tolerability of Diazepam Nasal Spray for Children With Epilepsy Aged 2-5 Years: Final Results of a Phase 1/2a Trial.","authors":"Eric B Segal, James W Wheless, Steven M Wolf, Muhammad Zafar, J Ben Renfroe, Miguel A Lopez-Toledano, Leock Y Ngo, Adrian L Rabinowicz, Enrique Carrazana","doi":"10.1177/08830738261474614","DOIUrl":"https://doi.org/10.1177/08830738261474614","url":null,"abstract":"Diazepam nasal spray is approved to treat seizure clusters in patients aged ≥2 years. A long-term safety study in patients aged 6-65 years found a safety profile similar to diazepam rectal gel. We conducted an open-label, phase 1/2a trial of diazepam nasal spray in children with epilepsy aged 2-5 years with motor seizures or seizures with clear alteration of awareness. After a pharmacokinetic period, caregivers were instructed to use diazepam nasal spray (0.5 mg/kg) as needed for frequent seizures or seizure clusters during 180-day safety and optional extension periods. Treatment-emergent adverse events (TEAEs) were assessed. Of 36 enrolled patients, 27 (86.1%) completed both treatment periods (mean duration 15.45 months). Treatment-related TEAEs occurred in 7 patients in the 180-day period and 1 in the optional extension period. No serious treatment-related TEAEs or TEAEs leading to discontinuation/death occurred. The safety profile aligns with patients aged ≥6 years, supporting use in this population.(ClinicalTrials.gov identifier: NCT05076838).","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738261474614"},"PeriodicalIF":1.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Psychological Intervention Embedded in a Pediatric Concussion Program: A Retrospective Cohort Study. 早期心理干预嵌入儿童脑震荡项目：一项回顾性队列研究。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-08-26 DOI: 10.1177/08830738261476151

Luisa Atunes Ortega, Gustavo Ignacio Rivas-Martínez, Laura Goldstein, Alex Stephano Aguirre, Relfa Proano, Alcy Torres

{"title":"Early Psychological Intervention Embedded in a Pediatric Concussion Program: A Retrospective Cohort Study.","authors":"Luisa Atunes Ortega, Gustavo Ignacio Rivas-Martínez, Laura Goldstein, Alex Stephano Aguirre, Relfa Proano, Alcy Torres","doi":"10.1177/08830738261476151","DOIUrl":"https://doi.org/10.1177/08830738261476151","url":null,"abstract":"ObjectiveTo compare outcomes among children and youth (3-21 years) with post-concussion syndrome (PCS) who received early (≤8 days) embedded psychological intervention (EI) after the index visit with those who received usual care (UC) in a pediatric concussion program.MethodsRetrospective cohort study at the Boston Medical Center Concussion Clinic (2015-2024) including 56 patients (EI n = 28; UC n = 28). Outcomes were follow-up time and recovery status at last follow-up. Mann-Whitney U and Fisher exact tests were used, with effect sizes (|r| and odds ratio [OR]).ResultsFollow-up time was shorter in EI (P < .001; |r|=0.72). Recovery was higher in EI (57.1% vs 10.7%; OR 10.58, 95% CI 2.40-67.50; P = .005). Between-group differences persisted in a sensitivity analysis restricted to UC participants without major neurologic or neurodevelopmental complexity; the association with recovery remained significant after adjustment (aOR 10.14, 95% CI 1.25-226.95; P = .048).ConclusionEarly embedded psychological intervention was associated with improved recovery outcomes in pediatric PCS.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738261476151"},"PeriodicalIF":1.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0