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Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents. 一系列新的2,5-二取代-1,3,4-恶二唑衍生物的合成，作为潜在的抗氧化剂和抗菌剂。
Journal of Chemical Biology Pub Date : 2016-07-07 eCollection Date: 2016-07-01 DOI: 10.1007/s12154-016-0153-9
M Aruna Sindhe, Yadav D Bodke, R Kenchappa, Sandeep Telkar, A Chandrashekar
{"title":"Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.","authors":"M Aruna Sindhe,&nbsp;Yadav D Bodke,&nbsp;R Kenchappa,&nbsp;Sandeep Telkar,&nbsp;A Chandrashekar","doi":"10.1007/s12154-016-0153-9","DOIUrl":"https://doi.org/10.1007/s12154-016-0153-9","url":null,"abstract":"<p><p>A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported. </p>","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"9 3","pages":"79-90"},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12154-016-0153-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34733141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
JOCB Bulletin. JOCB公告。
Journal of Chemical Biology Pub Date : 2016-07-02 eCollection Date: 2016-07-01 DOI: 10.1007/s12154-016-0151-y
{"title":"JOCB Bulletin.","authors":"","doi":"10.1007/s12154-016-0151-y","DOIUrl":"https://doi.org/10.1007/s12154-016-0151-y","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"9 3","pages":"91-5"},"PeriodicalIF":0.0,"publicationDate":"2016-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12154-016-0151-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34733142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Homology modeling and virtual screening studies of FGF-7 protein-a structure-based approach to design new molecules against tumor angiogenesis. FGF-7蛋白同源性建模和虚拟筛选研究——一种基于结构的抗肿瘤血管生成新分子设计方法。
Journal of Chemical Biology Pub Date : 2016-06-18 eCollection Date: 2016-07-01 DOI: 10.1007/s12154-016-0152-x
Rajender Vadija, Kiran Kumar Mustyala, Navaneetha Nambigari, Ramasree Dulapalli, Rama Krishna Dumpati, Vishwanath Ramatenki, Santhi Prada Vellanki, Uma Vuruputuri
{"title":"Homology modeling and virtual screening studies of FGF-7 protein-a structure-based approach to design new molecules against tumor angiogenesis.","authors":"Rajender Vadija,&nbsp;Kiran Kumar Mustyala,&nbsp;Navaneetha Nambigari,&nbsp;Ramasree Dulapalli,&nbsp;Rama Krishna Dumpati,&nbsp;Vishwanath Ramatenki,&nbsp;Santhi Prada Vellanki,&nbsp;Uma Vuruputuri","doi":"10.1007/s12154-016-0152-x","DOIUrl":"https://doi.org/10.1007/s12154-016-0152-x","url":null,"abstract":"<p><p>Keratinocyte growth factor (KGF) protein is a member of the fibroblast growth factor (FGF) family, which is also known as FGF-7. The FGF-7 plays an important role in tumor angiogenesis. In the present work, FGF-7 is treated as a potential therapeutic target to prevent angiogenesis in cancerous tissue. Computational techniques are applied to evaluate and validate the 3D structure of FGF-7 protein. The active site region of the FGF-7 protein is identified based on hydrophobicity calculations using CASTp and Q-site Finder active site prediction tools. The protein-protein docking study of FGF-7 with its natural receptor FGFR2b is carried out to confirm the active site region in FGF-7. The amino acid residues Asp34, Arg67, Glu116, and Thr194 in FGF-7 interact with the receptor protein (FGFR2b). A grid is generated at the active site region of FGF-7 using Glide module of Schrödinger suite. Subsequently, a virtual screening study is carried out at the active site using small molecular structural databases to identify the ligand molecules. The binding interactions of the ligand molecules, with piperazine moiety as a pharmacophore, are observed at Arg67 and Glu149 residues of the FGF-7 protein. The identified ligand molecules against the FGF-7 protein show permissible pharmacokinetic properties (ADME). The ligand molecules with good docking scores and satisfactory pharmacokinetic properties are prioritized and identified as novel ligands for the FGF-7 protein in cancer therapy. </p>","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"9 3","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2016-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12154-016-0152-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34733140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
JOCB Bulletin. JOCB公告。
Journal of Chemical Biology Pub Date : 2016-04-01 DOI: 10.1007/s12154-016-0150-z
{"title":"JOCB Bulletin.","authors":"","doi":"10.1007/s12154-016-0150-z","DOIUrl":"https://doi.org/10.1007/s12154-016-0150-z","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"9 2","pages":"65-8"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12154-016-0150-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34495311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An initial top-down proteomic analysis of the standard cuprizone mouse model of multiple sclerosis 对多发性硬化症标准铜酮小鼠模型进行初步自上而下的蛋白质组学分析
Journal of Chemical Biology Pub Date : 2016-01-01 DOI: 10.1007/s12154-015-0138-0
Melissa A. Partridge, Sumana Gopinath, S. Myers, J. Coorssen
{"title":"An initial top-down proteomic analysis of the standard cuprizone mouse model of multiple sclerosis","authors":"Melissa A. Partridge, Sumana Gopinath, S. Myers, J. Coorssen","doi":"10.1007/s12154-015-0138-0","DOIUrl":"https://doi.org/10.1007/s12154-015-0138-0","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"57 15 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76097221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Theoretical study of electron transfer process between fullerenes and neurotransmitters; acetylcholine, dopamine, serotonin and epinephrine in nanostructures [neurotransmitters].Cn complexes 富勒烯与神经递质之间电子传递过程的理论研究纳米结构[神经递质]中的乙酰胆碱、多巴胺、血清素和肾上腺素。Cn复合物
Journal of Chemical Biology Pub Date : 2016-01-01 DOI: 10.1007/s12154-015-0139-z
A. Taherpour, M. Rizehbandi, Fatemeh Jahanian, Ehsan Naghibi, Nosratollah Mahdizadeh
{"title":"Theoretical study of electron transfer process between fullerenes and neurotransmitters; acetylcholine, dopamine, serotonin and epinephrine in nanostructures [neurotransmitters].Cn complexes","authors":"A. Taherpour, M. Rizehbandi, Fatemeh Jahanian, Ehsan Naghibi, Nosratollah Mahdizadeh","doi":"10.1007/s12154-015-0139-z","DOIUrl":"https://doi.org/10.1007/s12154-015-0139-z","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"6 1","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87619859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis, antibacterial studies, and molecular modeling studies of 3,4-dihydropyrimidinone compounds 3,4-二氢嘧啶类化合物的合成、抗菌研究及分子模拟研究
Journal of Chemical Biology Pub Date : 2016-01-01 DOI: 10.1007/s12154-015-0142-4
V. Ramachandran, K. Arumugasamy, S. Singh, N. Edayadulla, P. Ramesh, S. Kamaraj
{"title":"Synthesis, antibacterial studies, and molecular modeling studies of 3,4-dihydropyrimidinone compounds","authors":"V. Ramachandran, K. Arumugasamy, S. Singh, N. Edayadulla, P. Ramesh, S. Kamaraj","doi":"10.1007/s12154-015-0142-4","DOIUrl":"https://doi.org/10.1007/s12154-015-0142-4","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"7 1","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82294900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
JOCB Bulletin
Journal of Chemical Biology Pub Date : 2016-01-01 DOI: 10.1007/s12154-015-0149-x
{"title":"JOCB Bulletin","authors":"","doi":"10.1007/s12154-015-0149-x","DOIUrl":"https://doi.org/10.1007/s12154-015-0149-x","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"144 1","pages":"53-56"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76802588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of siRNA-directed gene silencing with epigallocatechin-3-gallate (EGCG) reverses drug resistance in human breast cancer cells sirna定向基因沉默与表没食子儿茶素-3-没食子酸酯(EGCG)联合可逆转人乳腺癌细胞的耐药性
Journal of Chemical Biology Pub Date : 2016-01-01 DOI: 10.1007/s12154-015-0144-2
M. Esmaeili
{"title":"Combination of siRNA-directed gene silencing with epigallocatechin-3-gallate (EGCG) reverses drug resistance in human breast cancer cells","authors":"M. Esmaeili","doi":"10.1007/s12154-015-0144-2","DOIUrl":"https://doi.org/10.1007/s12154-015-0144-2","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"12 1","pages":"41-52"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73773359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Alternatives to the ‘water oxidation pathway’ of biological ozone formation 替代生物臭氧形成的“水氧化途径”
Journal of Chemical Biology Pub Date : 2016-01-01 DOI: 10.1007/s12154-015-0140-6
A. Onyango
{"title":"Alternatives to the ‘water oxidation pathway’ of biological ozone formation","authors":"A. Onyango","doi":"10.1007/s12154-015-0140-6","DOIUrl":"https://doi.org/10.1007/s12154-015-0140-6","url":null,"abstract":"","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"6 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80358939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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