一系列新的2,5-二取代-1,3,4-恶二唑衍生物的合成,作为潜在的抗氧化剂和抗菌剂。

Journal of Chemical Biology Pub Date : 2016-07-07 eCollection Date: 2016-07-01 DOI:10.1007/s12154-016-0153-9
M Aruna Sindhe, Yadav D Bodke, R Kenchappa, Sandeep Telkar, A Chandrashekar
{"title":"一系列新的2,5-二取代-1,3,4-恶二唑衍生物的合成,作为潜在的抗氧化剂和抗菌剂。","authors":"M Aruna Sindhe,&nbsp;Yadav D Bodke,&nbsp;R Kenchappa,&nbsp;Sandeep Telkar,&nbsp;A Chandrashekar","doi":"10.1007/s12154-016-0153-9","DOIUrl":null,"url":null,"abstract":"<p><p>A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported. </p>","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"9 3","pages":"79-90"},"PeriodicalIF":0.0000,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12154-016-0153-9","citationCount":"18","resultStr":"{\"title\":\"Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.\",\"authors\":\"M Aruna Sindhe,&nbsp;Yadav D Bodke,&nbsp;R Kenchappa,&nbsp;Sandeep Telkar,&nbsp;A Chandrashekar\",\"doi\":\"10.1007/s12154-016-0153-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported. </p>\",\"PeriodicalId\":15296,\"journal\":{\"name\":\"Journal of Chemical Biology\",\"volume\":\"9 3\",\"pages\":\"79-90\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s12154-016-0153-9\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12154-016-0153-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2016/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12154-016-0153-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/7/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18

摘要

合成了一系列新的2,5-二取代-1,3,4-恶二唑衍生物,并对其抗菌和抗氧化活性进行了筛选。实验结果表明,化合物3c、3d和3i具有与一线药物相当的抗菌和抗氧化活性。并报道了所合成化合物的构效关系和分子对接研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.

Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.

Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.

Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.

A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信