M Aruna Sindhe, Yadav D Bodke, R Kenchappa, Sandeep Telkar, A Chandrashekar
{"title":"一系列新的2,5-二取代-1,3,4-恶二唑衍生物的合成,作为潜在的抗氧化剂和抗菌剂。","authors":"M Aruna Sindhe, Yadav D Bodke, R Kenchappa, Sandeep Telkar, A Chandrashekar","doi":"10.1007/s12154-016-0153-9","DOIUrl":null,"url":null,"abstract":"<p><p>A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported. </p>","PeriodicalId":15296,"journal":{"name":"Journal of Chemical Biology","volume":"9 3","pages":"79-90"},"PeriodicalIF":0.0000,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12154-016-0153-9","citationCount":"18","resultStr":"{\"title\":\"Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.\",\"authors\":\"M Aruna Sindhe, Yadav D Bodke, R Kenchappa, Sandeep Telkar, A Chandrashekar\",\"doi\":\"10.1007/s12154-016-0153-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported. </p>\",\"PeriodicalId\":15296,\"journal\":{\"name\":\"Journal of Chemical Biology\",\"volume\":\"9 3\",\"pages\":\"79-90\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s12154-016-0153-9\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12154-016-0153-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2016/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12154-016-0153-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/7/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.
A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported.