Journal of Bone and Joint Infection最新文献

{"title":"A desirability of outcome ranking (DOOR) for periprosthetic joint infection - a Delphi analysis.","authors":"Brenton P Johns,&nbsp;David C Dewar,&nbsp;Mark R Loewenthal,&nbsp;Laurens A Manning,&nbsp;Amit Atrey,&nbsp;Nipun Atri,&nbsp;David G Campbell,&nbsp;Michael Dunbar,&nbsp;Christopher Kandel,&nbsp;Amir Khoshbin,&nbsp;Christopher W Jones,&nbsp;Jaime Lora-Tamayo,&nbsp;Catherine McDougall,&nbsp;Dirk Jan F Moojen,&nbsp;Jonathan Mulford,&nbsp;David L Paterson,&nbsp;Trisha Peel,&nbsp;Michael Solomon,&nbsp;Simon W Young,&nbsp;Joshua S Davis","doi":"10.5194/jbji-7-221-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-221-2022","url":null,"abstract":"<p><p><b>Background</b>: Treatment outcomes in studies on prosthetic joint infection are generally assessed using a dichotomous outcome relating to treatment success or failure. These outcome measures neither include patient-centred outcome measures including joint function and quality of life, nor do they account for adverse effects of treatment. A desirability of outcome ranking (DOOR) measure can include these factors and has previously been proposed and validated for other serious infections. We aimed to develop a novel DOOR for prosthetic joint infections (PJIs). <b>Methods</b>: The Delphi method was used to develop a DOOR for PJI research. An international working group of 18 clinicians (orthopaedic surgeons and infectious disease specialists) completed the Delphi process. The final DOOR comprised the dimensions established to be most important by consensus with <math><mrow><mi>></mi> <mn>75</mn></mrow> </math>  % of participant agreement. <b>Results</b>: The consensus DOOR comprised four main dimensions. The primary dimension was patient-reported joint function. The secondary dimensions were infection cure and mortality. The final dimension of quality of life was selected as a tie-breaker. <b>Discussion</b>: A desirability of outcome ranking for periprosthetic joint infection has been proposed. It focuses on patient-centric outcome measures of joint function, cure and quality of life. This DOOR provides a multidimensional assessment to comprehensively rank outcomes when comparing treatments for prosthetic joint infection.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":" ","pages":"221-229"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677339/pdf/jbji-7-221.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of disc space aspirate cell counts and differentials in the diagnosis of native vertebral osteomyelitis.","authors":"Talha Riaz,&nbsp;Matthew Howard,&nbsp;Felix Diehn,&nbsp;Aaron Joseph Tande,&nbsp;Courtney Ross,&nbsp;Paul Huddleston,&nbsp;Elie Berbari","doi":"10.5194/jbji-7-213-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-213-2022","url":null,"abstract":"<p><p><b>Background</b>: Aspiration of intervertebral disc space is often done to confirm the diagnosis of native vertebral osteomyelitis. A study has not been done examining the utility of cell counts and differentials of the aspirated fluid in diagnosing native vertebral osteomyelitis (NVO). <b>Methods</b>: In this feasibility study, we prospectively enrolled patients with a suspected diagnosis of NVO referred to the Division of Neuroradiology for image-guided needle aspiration of the intervertebral disc. In this study, manual cell count was done on the aspirated fluid, followed by a differential cytospin technique and touch prep. We obtained demographic, lab, and microbiologic data and used the receiver operating curve (ROC) for statistical analysis. <b>Results</b>: Over 12 months, we performed 17 aspirates on 14 patients. The median age was 70.5 years (range: 45-77). The median manual cell count on the aspirated fluid was 52 cells  <math><mrow><mi>µ</mi> <msup><mi>L</mi> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </mrow> </math> (range: 0-6656), the median neutrophil percentage on the touch prep slide was 73 % (range: 5 %-100 %), and the median neutrophil percentage on the cytospin slide was 82 % (range: 0 %-100 %). Routine bacterial cultures were positive in five cases, and the 16S ribosomal RNA gene polymerase chain reaction was positive in two cases. The optimal cutoff for a cell count of 104 total nucleated cells offered a sensitivity and specificity of 86 %, and a neutrophil cutoff of 83 % was associated with a 71 % sensitivity and specificity. <b>Conclusion</b>: An image-guided aspirated specimen leukocyte differential of <math><mrow><mo>≥</mo> <mn>83</mn></mrow> </math>  % neutrophils or a leukocyte count of <math><mrow><mo>≥</mo> <mn>104</mn></mrow> </math>   <math><mrow><mi>µ</mi> <msup><mi>L</mi> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </mrow> </math> was a sensitive and specific test for diagnosing patients with suspected NVO. Additionally, more extensive studies are warranted to confirm the findings.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"7 5","pages":"213-219"},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673032/pdf/jbji-7-213.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40479891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcomes of culture-negative prosthetic joint infections from the Prosthetic Joint Infection in Australia and New Zealand Observational (PIANO) cohort study.","authors":"Sarah Browning, Laurens Manning, Sarah Metcalf, David L Paterson, James O Robinson, Benjamin Clark, Joshua S Davis","doi":"10.5194/jbji-7-203-2022","DOIUrl":"10.5194/jbji-7-203-2022","url":null,"abstract":"<p><p><b>Introduction</b>: Culture-negative (CN) prosthetic joint infections (PJIs) account for approximately 10 % of all PJIs and present significant challenges for clinicians. We aimed to explore the significance of CN PJIs within a large prospective cohort study, comparing their characteristics and outcomes with culture-positive (CP) cases. <b>Methods</b>: The Prosthetic joint Infection in Australia and New Zealand Observational (PIANO) study is a prospective, multicentre observational cohort study that was conducted at 27 hospitals between 2014 and 2017. We compared baseline characteristics and outcomes of all patients with CN PJI from the PIANO cohort with those of CP cases. We report on PJI diagnostic criteria in the CN cohort and apply internationally recognized PJI diagnostic guidelines to determine optimal CN PJI detection methods. <b>Results</b>: Of the 650 patients with 24-month outcome data available, 55 (8.5 %) were CN and 595 were CP. Compared with the CP cohort, CN patients were more likely to be female (32 (58.2 %) vs. 245 (41.2 %); <math><mi>p</mi></math>   <math><mo>=</mo></math>  0.016), involve the shoulder joint (5 (9.1 %) vs. 16 (2.7 %); <math><mi>p</mi></math>   <math><mo>=</mo></math>  0.026), and have a lower mean C-reactive protein (142 mg L <math><msup><mi></mi> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </math> vs. 187 mg L <math><msup><mi></mi> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </math> ; <math><mi>p</mi></math>   <math><mo>=</mo></math>  0.016). Overall, outcomes were superior in CN patients, with culture negativity an independent predictor of treatment success at 24 months (adjusted odds ratio, aOR, of 3.78 and 95 %CI of 1.65-8.67). Suboptimal diagnostic sampling was common in both cohorts, with CN PJI case detection enhanced using the Infectious Diseases Society of America PJI diagnostic guidelines. <b>Conclusions</b>: Current PJI diagnostic guidelines vary substantially in their ability to detect CN PJI, with comprehensive diagnostic sampling necessary to achieve diagnostic certainty. Definitive surgical management strategies should be determined by careful assessment of infection type, rather than by culture status alone.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"7 5","pages":"203-211"},"PeriodicalIF":1.8,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562689/pdf/jbji-7-203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40559823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous antibiotic duration in the treatment of prosthetic joint infection: systematic review and meta-analysis.","authors":"Nour Bouji, Sijin Wen, Matthew J Dietz","doi":"10.5194/jbji-7-191-2022","DOIUrl":"10.5194/jbji-7-191-2022","url":null,"abstract":"<p><p><b>Introduction</b>: Long antibiotic courses, including intravenous (IV) and oral administrations, are utilized in prosthetic joint infection (PJI) treatment. This meta-analysis examines the non-inferiority of short courses ( <math><mo><</mo></math>  4 weeks) of IV antibiotics compared to long courses in treating PJI. Critical review of IV treatment is necessary due to the clinical, physical, and financial burden associated with it and its continued prolonged use in the US without much evidence to support the practice. <b>Methods</b>: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), databases were searched using predefined medical subject headings (MeSH). <b>Results</b>: The nine included studies reported 521 total hip arthroplasties (THAs) and 530 total knee arthroplasties (TKAs). There was no significant difference in the overall success rate in short- vs. long-duration IV antibiotics for PJI treatment: odds ratio (OR) of 1.65, 95 % confidence interval (CI) of 0.78-3.46, and <math><mrow><mi>p</mi> <mo>=</mo> <mn>0</mn></mrow> </math> .18. However, due to the moderate to high heterogeneity ( <math> <mrow><msup><mi>I</mi> <mn>2</mn></msup> <mo>=</mo> <mn>68</mn></mrow> </math>  %, <math><mi>p</mi></math>   <math><mo><</mo></math>  0.01) amongst studies, an adjusted success rate was calculated after the exclusion of two studies. This showed a statistically significant difference between both groups (OR of 2.45, 95 % CI of 1.21-4.96, <math><mi>p</mi></math>   <math><mo><</mo></math>  0.001) favoring a short course of antibiotics and reflecting a more homogenous population ( <math> <mrow><msup><mi>I</mi> <mn>2</mn></msup> <mo>=</mo> <mn>51</mn></mrow> </math>  %, <math><mrow><mi>p</mi> <mo>=</mo> <mn>0</mn></mrow> </math> .06). <b>Conclusion</b>: This study highlights the limited data available for evaluating IV antibiotic duration in the setting of PJI. We found that a shorter duration of IV antibiotics was non-inferior to a longer duration, with an improved OR of 2.45 for treatment success, likely shortening inpatient stay as well as lessening side effects and antimicrobial resistance with a lower cost to patients and overall healthcare.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"7 5","pages":"191-202"},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562697/pdf/jbji-7-191.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40559822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lysins - a new armamentarium for the treatment of bone and joint infections?","authors":"Parham Sendi,&nbsp;Tristan Ferry","doi":"10.5194/jbji-7-187-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-187-2022","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"7 5","pages":"187-189"},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of the microbiology profile for periprosthetic joint infection of knee arthroplasty and lower-limb endoprostheses in tumour surgery.","authors":"Robert A McCulloch,&nbsp;Amirul Adlan,&nbsp;Neil Jenkins,&nbsp;Michael Parry,&nbsp;Jonathan D Stevenson,&nbsp;Lee Jeys","doi":"10.5194/jbji-7-177-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-177-2022","url":null,"abstract":"<p><p><b>Aims</b>: this study compared the patient and microbiological profile of prosthetic joint infection (PJI) for patients treated with two-stage revision for knee arthroplasty with that of lower-limb endoprostheses for oncological resection. <b>Patient and methods</b>: a total of 118 patients were treated with two-stage revision surgery for infected knee arthroplasty and lower-limb endoprostheses between 1999 and 2019. A total of 74 patients had two-stage revision for PJI of knee arthroplasty, and 44 had two-stage revision of oncology knee endoprostheses. There were 68 men and 50 women. The mean ages of the arthroplasty and oncology cohorts were 70.2 years (range of 50-89) and 36.1 years (range of 12-78) respectively ( <math><mrow><mi>p</mi> <mo><</mo> <mn>0</mn></mrow> </math> .01). Patient host and extremity criteria were categorized according to the Musculoskeletal Infection Society (MSIS) host and extremity staging system. The patient microbiological culture, the incidence of polymicrobial infection, and multidrug resistance (MDR) were analysed and recorded. <b>Results</b>: polymicrobial infection was reported in 16 % (12 patients) of knee arthroplasty PJI cases and in 14.5 % (8 patients) of endoprostheses PJI cases ( <math><mrow><mi>p</mi> <mo>=</mo> <mn>0</mn></mrow> </math> .783). There was a significantly higher incidence of MDR in endoprostheses PJI, isolated in 36.4 % of cultures, compared with knee arthroplasty PJI (17.2 %, <math><mrow><mi>p</mi> <mo>=</mo> <mn>0</mn></mrow> </math> .01). Gram-positive organisms were isolated in more than 80 % of cultures from both cohorts. Coagulase-negative <i>Staphylococcus</i> (CoNS) was the most common Gram-positive organism, and <i>Escherichia coli</i> was the most common Gram-negative organism in both groups. According to the MSIS staging system, the host and extremity grades of the oncology PJI cohort were significantly worse than those for the arthroplasty PJI cohort ( <math><mrow><mi>p</mi> <mo><</mo> <mn>0</mn></mrow> </math> .05). <b>Conclusion</b>: empirical antibiotic prophylaxis against PJI in orthopaedic oncology is based upon PJI in arthroplasty, despite oncology patients presenting with worse host and extremity staging. CoNS was the most common infective organism in both groups; however, pathogens showing MDR were significantly more prevalent in oncological PJI of the knee. Therefore, empirical broad-spectrum treatment is recommended in oncological patients following revision surgery.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":" ","pages":"177-182"},"PeriodicalIF":0.0,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33442357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally delivered antistaphylococcal lysin exebacase or CF-296 is active in methicillin-resistant <i>Staphylococcus aureus</i> implant-associated osteomyelitis.","authors":"Melissa Karau,&nbsp;Suzannah Schmidt-Malan,&nbsp;Jay Mandrekar,&nbsp;Dario Lehoux,&nbsp;Raymond Schuch,&nbsp;Cara Cassino,&nbsp;Robin Patel","doi":"10.5194/jbji-7-169-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-169-2022","url":null,"abstract":"<p><p><b>Introduction</b>: <i>Staphylococcus aureus</i> is the most common cause of orthopedic infections and can be challenging to treat, especially in the presence of a foreign body. The antistaphylococcal lysins exebacase and CF-296 have rapid bactericidal activity, a low propensity for resistance development, and synergize with some antibiotics. <b>Methods</b>: Rabbit implant-associated osteomyelitis was induced by drilling into the medial tibia followed by locally delivering exebacase, CF-296, or lysin carrier. A titanium screw colonized with methicillin-resistant <i>S. aureus</i> (MRSA) IDRL-6169 was inserted. Intravenous daptomycin or saline was administered and continued daily for 4 d. On day 5, rabbits were euthanized, and the tibiae and implants were collected for culture. Results were reported as log <math><msub><mi></mi> <mn>10</mn></msub> </math> colony forming units (cfu) per gram of bone or log <math><msub><mi></mi> <mn>10</mn></msub> </math>  cfu per implant, and comparisons among the six groups were performed using the Wilcoxon rank sum test. <b>Results</b>: Based on implant and bone cultures, all treatments resulted in significantly lower bacterial counts than those of controls ( <math><mrow><mi>P</mi> <mo>≤</mo> <mn>0.0025</mn></mrow> </math> ). Exebacase alone or with daptomycin as well as CF-296 with daptomycin were more active than daptomycin alone ( <math><mrow><mi>P</mi> <mo>≤</mo> <mn>0.0098</mn></mrow> </math> ) or CF-296 alone ( <math><mrow><mi>P</mi> <mo>≤</mo> <mn>0.0154</mn></mrow> </math> ) based on implant cultures. CF-296 with daptomycin was more active than either CF-296 alone ( <math><mrow><mi>P</mi> <mo>=</mo> <mn>0.0040</mn></mrow> </math> ) or daptomycin alone ( <math><mrow><mi>P</mi> <mo>=</mo> <mn>0.0098</mn></mrow> </math> ) based on bone cultures. <b>Conclusion</b>: Local delivery of either exebacase or CF-296 offers a promising complement to conventional antibiotics in implant-associated infections.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":" ","pages":"169-175"},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33442359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Mycobacterium fortuitum</i> osteomyelitis of the cuboid bone treated with CERAMENT G and V: a case report.","authors":"Kilian Fraga,&nbsp;Miriam Maireles,&nbsp;Marc Jordan,&nbsp;Laura Soldevila,&nbsp;Oscar Murillo","doi":"10.5194/jbji-7-163-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-163-2022","url":null,"abstract":"<p><p>We present the rare case of a 61-year-old female with <i>Mycobacterium fortuitum</i> osteomyelitis of the cuboid bone following penetrating plantar trauma. The patient underwent a single-stage surgery for the condition, including lesion debridement and bone defect filling with absorbable, gentamicin-/vancomycin-loaded, calcium sulfate-hydroxyapatite biocomposites, that resolved favorably 5 months after intervention.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":" ","pages":"163-167"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33442358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected positive intraoperative cultures (UPIC) at index osseointegration do not lead to increased postoperative infectious events.","authors":"Jason S Hoellwarth,&nbsp;Taylor J Reif,&nbsp;Michael W Henry,&nbsp;Andy O Miller,&nbsp;Austin C Kaidi,&nbsp;S Robert Rozbruch","doi":"10.5194/jbji-7-155-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-155-2022","url":null,"abstract":"<p><p><b>Introduction</b>: The most common complication following transcutaneous osseointegration for amputees is infection. Although an obvious source of contamination is the permanent stoma, operative site contamination at the time of implantation may be an additional source. This study investigates the impact of unexpected positive intraoperative cultures (UPIC) on postoperative infection. <b>Methods</b>: Charts were reviewed for 8 patients with UPIC and 22 patients with negative intraoperative cultures (NIC) who had at least 1 year of post-osseointegration follow-up. All patients had 24 h of routine postoperative antibiotic prophylaxis, with UPIC receiving additional antibiotics guided by culture results. The main outcome measure was postoperative infection intervention, which was graded as (0) none, (1) antibiotics unrelated to the initial surgery, (2) operative debridement with implant retention, or (3) implant removal. <b>Results</b>: The UPIC vs. NIC rate of infection management was as follows: Grade 0, 6/8 <math><mo>=</mo></math> 75 % vs. 14/22 <math><mo>=</mo></math> 64 %, <i>p</i> <math><mo>=</mo></math> 0.682; Grade 1, 2/8 <math><mo>=</mo></math> 25 % vs. 8/22 <math><mo>=</mo></math> 36.4 % (Fisher's <i>p</i> <math><mo>=</mo></math> 0.682); Grade 2, 1/8 = 12.5 % vs. 0/22 <math><mo>=</mo></math> 0 % (Fisher's <i>p</i> <math><mo>=</mo></math> 0.267); Grade 3, 0/8 <math><mo>=</mo></math> 0 % vs. 1/22 <math><mo>=</mo></math> 4.5 % (Fisher's <i>p</i> <math><mo>=</mo></math> 1.000). No differences were statistically significant. <b>Conclusions</b>: UPIC at index osseointegration, managed with directed postoperative antibiotics, does not appear to increase the risk of additional infection management. The therapeutic benefit of providing additional directed antibiotics versus no additional antibiotics following UPIC is unknown and did not appear to increase the risk of other adverse outcomes in our cohort.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":" ","pages":"155-162"},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40700891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Corrigendum to</i> \"Assessment of risk factors for early-onset deep surgical site infection following primary total hip arthroplasty for osteoarthritis\" published in J. Bone Joint Infect., 6, 443-450, 2021.","authors":"Jonathan Bourget-Murray,&nbsp;Rohit Bansal,&nbsp;Alexandra Soroceanu,&nbsp;Sophie Piroozfar,&nbsp;Pam Railton,&nbsp;Kelly Johnston,&nbsp;Andrew Johnson,&nbsp;James Powell","doi":"10.5194/jbji-7-151-2022","DOIUrl":"https://doi.org/10.5194/jbji-7-151-2022","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":" ","pages":"151-153"},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40630295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}