Journal of Chemistry and Applications最新文献_第3页

Implications for Treatment Strategies in Cancer and Infectious Diseases 对癌症和传染病治疗策略的启示

Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110012

Elena Locci, Silvia Raymond

引用次数: 6

Targeting the Prion-Like Aggregation of Mutant p53 to Combat Cancer 靶向突变p53的朊样聚集以对抗癌症

Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110014

Alireza Heidari, E. Locci, Silvia Raymond

{"title":"Targeting the Prion-Like Aggregation of Mutant p53 to Combat Cancer","authors":"Alireza Heidari, E. Locci, Silvia Raymond","doi":"10.36811/jca.2021.110014","DOIUrl":"https://doi.org/10.36811/jca.2021.110014","url":null,"abstract":"The team first screened a set of protein mimics originally designed to target Alzheimer's disease and type 2 diabetes. The results identify a mimicry of the protein that potentially isolates the mutated p53 material and prevents further protein accumulation. The researchers then showed that segregation of mutated p53 grains by protein mimicking restored the suppressive function of the p53 tumor, leading to the death of a wide range of cancer cells. Importantly, protein mimicry therapy effectively reduces tumors that contain mutated p53 while showing no significant toxins for healthy tissue, resulting in significantly longer survival. \"As the prevalence of cancer increases worldwide, there is an urgent need for new cancer therapies to complement or replace existing therapies,\" said the study's lead author. Here we show the first successful use of a small molecule amyloid inhibitor as an anticancer agent. We believe that this will have a far-reaching impact, as it effectively bridges the gap between amyloid disease and cancer and is the basis for passing on information approaches in the design of new and robust cancer mutation therapies for the p53 mutation.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89426629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of DNA Damage Induced by Alkylating Agents and Repair Pathways by Cooperating Mechanisms Driving the Formation of Colorectal Adenomas and Adenocarcinomas Using DNA Alkylation and DNA Methylation 利用DNA烷基化和DNA甲基化研究烷基化剂诱导的DNA损伤及其修复途径在驱动结直肠腺瘤和腺癌形成中的协同机制

Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110018

Elena Locci, Silvia Raymond

引用次数: 1

Pediatric Brain Tumors Diagnosis and Treatment 儿童脑肿瘤的诊断和治疗

Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110017

Elena Locci, Silvia Raymond

引用次数: 1

Noncomunicable/Aging Diseases with the Perspective of Quantum Physics 量子物理学视角下的非传染性/衰老疾病

Journal of Chemistry and Applications Pub Date : 2021-07-03 DOI: 10.36811/JCA.2021.110010

P. Bullón

{"title":"Noncomunicable/Aging Diseases with the Perspective of Quantum Physics","authors":"P. Bullón","doi":"10.36811/JCA.2021.110010","DOIUrl":"https://doi.org/10.36811/JCA.2021.110010","url":null,"abstract":"The leading cause of illness in aging is a group known as Noncommunicable Diseases. There should be some meeting points that modify the cells homeostasis and impaired the cell physiology developing different diseases. Quantum physics studied the atomic and subatomic particles and revolutionized the reality perception with paradoxical and weird concepts. Heisenberg's uncertainty principle established that it is not possible to determine the two characteristic properties of particles with accuracy. Subatomic particles have a wave-particle duality. Two subatomic particles are entangled, something happening over here can have an instantaneous effect over there, no matter how far away there are. All these concepts have tried to apply to biology and life sciences, quantum biology is behind photosynthesis, mitochondrial respiration, enzyme activity, the sense of smell, animal migration, heredity's fidelity, and consciousness. We can apply all these concepts to diseases pathogeny. So, we describe quantum phenomena in oxidative stress, calcification, signal transduction, vitamin D production and cancer mutations. Aging diseases also could be explained by applying quantum physics concepts. It is a new, hard to believe, and an incredible path to be built, but we need to open the treatment options to our patients with new perspectives. Keywords: Oxidative stress; Calcification; Signal transduction; Vitamin D; Cancer mutations; Quantum phenomena","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90478926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyanoacetamide derivatives as corrosion inhibitors; Synthesis, Characterization, DFT and Monte Carlo simulation 氰乙酰胺衍生物缓蚀剂;合成，表征，DFT和蒙特卡罗模拟

Journal of Chemistry and Applications Pub Date : 2021-05-07 DOI: 10.36811/JCA.2021.110009

A. N. El-hoshoudy, M. El-raouf, M. Attya, A. Fadda, M. Waly

{"title":"Cyanoacetamide derivatives as corrosion inhibitors; Synthesis, Characterization, DFT and Monte Carlo simulation","authors":"A. N. El-hoshoudy, M. El-raouf, M. Attya, A. Fadda, M. Waly","doi":"10.36811/JCA.2021.110009","DOIUrl":"https://doi.org/10.36811/JCA.2021.110009","url":null,"abstract":"Corrosion behavior of X65-type carbon steel exposed to 1M HCl aqueous solution was studied in the absence and presence of various concentrations of new synthesized 3-(4-chlorophenyl)-2-cyano-N-(4-hydroxyphenyl) acrylamide, abbreviated as (P2), and 6-amino-4-(4-chlorophenyl)-1-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile, abbreviated as (P3), at 25oC. Potentiodynamic polarization data indicated that the synthesized Cyanoacetamide derivatives suppress both anodic and cathodic reactions via adsorption on the carbon steel surface and blocking the active sites. The adsorption of the inhibitor molecules forms a protective film which decreases the surface heterogeneity. Electrochemical impedance spectroscopy (EIS) measurements reveal that as the inhibitor concentration is increased, both the inhibition efficiency (η%) and the charge transfer resistance (Rt) are increased while the electrochemical double layer capacity (Cdl) is decreased. The experimental impedance data were analyzed according to a proposed equivalent circuit model for the electrode/electrolyte interface. Chemical descriptors are calculated through the density functional theory (DFT), also adsorption of inhibitors on the metal surface investigated through Monte Carlo simulation. The mechanism of corrosion inhibition was discussed given the obtained results of surface analysis and the molecular structure of the additive obtained from quantum chemical calculations.\u0000\u0000Keywords: Corrosion inhibition; Polarization; Electrochemical impedance spectroscopy (EIS); Surface analysis; Quantum chemical calculations","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81778454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of oil recovery enhancement through surfactant flooding; Experimental and feasibility studies 表面活性剂驱提高采收率评价实验及可行性研究

Journal of Chemistry and Applications Pub Date : 2021-03-10 DOI: 10.36811/JCA.2021.110008

Gameil Sameh, M. Ismaiel, A. Fakhry, Omar Hesham, Felopateer Magdy, A. A. El-hoshoudy

{"title":"Assessment of oil recovery enhancement through surfactant flooding; Experimental and feasibility studies","authors":"Gameil Sameh, M. Ismaiel, A. Fakhry, Omar Hesham, Felopateer Magdy, A. A. El-hoshoudy","doi":"10.36811/JCA.2021.110008","DOIUrl":"https://doi.org/10.36811/JCA.2021.110008","url":null,"abstract":"Chemical flooding is one of the major enhanced oil recovery (EOR) techniques particularly for reservoirs where thermal methods are not applicable, that chemical flooding may be polymer flooding, alkaline flooding, surfactant flooding, or a combination of them. The application of designing a chemical flooding program is strongly affected by the current economics, reservoir oil type, and crude oil price. In this project, mechanisms of different chemical methods will be discussed, and design chemical flooding program by using a laboratory scale and programming method. This project is mainly about making a design of surfactant flooding program, through choosing the optimum surfactant concentration. Also, economic study is very important in designing the program to know if the project is profitable or not to identify its efficiency, and choosing the better type of surfactant flooding in the reservoir. The results of this project proved that the surfactant has good effect on rock wettability to more water- wet, so increase the hydrocarbon recovery.\u0000\u0000Keywords: Surfactant flooding; Enhanced Oil Recovery; Economic profit","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87266498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural and Synthetic Estrogens Regulate Human Health 天然和合成雌激素调节人体健康

Journal of Chemistry and Applications Pub Date : 2020-12-23 DOI: 10.36811/jca.2020.110007

PD Gupta

引用次数: 0

A Dft Pursuit on Tandem Cycloaddition-Cycloreversion of 2-Pyrone and 1,4-Oxazinone with Strained Alkynes 2-吡咯酮和1,4-恶嗪酮与应变炔串联环加成-环还原反应的Dft研究

Journal of Chemistry and Applications Pub Date : 2020-08-29 DOI: 10.36811/jca.2020.110006

L Akilandeswari, P. Kalpana, P. Venuvanalingam

引用次数: 0

First step concerning improvement of arsenic removal by adapted Kanchan filters in the lowlands of Nepal 第一步是关于尼泊尔低地改良坎赞过滤器去除砷的改进

Journal of Chemistry and Applications Pub Date : 2020-01-29 DOI: 10.36811/jca.2020.110005

B. Mueller

{"title":"First step concerning improvement of arsenic removal by adapted Kanchan filters in the lowlands of Nepal","authors":"B. Mueller","doi":"10.36811/jca.2020.110005","DOIUrl":"https://doi.org/10.36811/jca.2020.110005","url":null,"abstract":"In the Terai region of Nepal (the southern lowlands of the country) the arsenic concentration of extracted ground water used as drinking water frequently exceeds the actual World Health Organization (WHO) drinking water guideline concentration of 10 μg/L. Single household filters (so called Kanchan filters) are employed to eliminate as from the well water. Being assembled to remove as utilizing zero-valent (ZVI) media, their efficiency was observed to vary to a high degree depending on design, ground water composition and the current operating conditions. Based on these concerns three field campaigns were organized in order to test ground water composition and filter handling on spot. This report depicts for the first time the results of this screening regarding removal efficiencies and clearly disclose future adaptation of the design and enhancement of the Kanchan filters uniquely used in Nepal. Removal efficiency varied between 5.81 % to 97.1 % depending on material, usage and mode of operation. The measurements of improvement include the replacement of nails and sand regularly; increasing the contact time between ground water and nails; preventing the nails from drying in order to maintain oxidizing settings; proper and regularly repeated instructions of the users.\u0000\u0000Keywords: Arsenic; Kanchan filters; Removal efficiency","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76947185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6