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Mechanism and Clinical Role and Application of DNA Methyltransferase Inhibitors Combination Therapy for the Treatment of Solid Tumor DNA甲基转移酶抑制剂联合治疗实体瘤的机制、临床作用及应用
Journal of Chemistry and Applications Pub Date : 2021-11-11 DOI: 10.36811/jca.2021.110021
Elena Locci, Silvia Raymond
{"title":"Mechanism and Clinical Role and Application of DNA Methyltransferase Inhibitors Combination Therapy for the Treatment of Solid Tumor","authors":"Elena Locci, Silvia Raymond","doi":"10.36811/jca.2021.110021","DOIUrl":"https://doi.org/10.36811/jca.2021.110021","url":null,"abstract":"According to the results of a global phase 2 clinical trial, the new drug sotorasib reduces tumor size and promises to improve and increase survival in patients with lung tumors caused by specific DNA mutations. It is designed to counteract the effects of mutations that are seen in about 13% of patients with non-small cell lung adenocarcinoma (a common type of lung cancer). The Food and Drug Administration (FDA) on May 28 approved the drug as a targeted treatment for patients with small cell lung cancer whose tumors express a specific mutation called G12C in the KRAS gene. Small cell lung cancer accounts for more than 80% of lung cancers. More than 200,000 new cases of nonsmall cell lung cancer are diagnosed in the United States each year.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81488954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Screening for Lung Cancer with Low Dose Computed Tomography (LDCT) 低剂量ct筛查肺癌的研究
Journal of Chemistry and Applications Pub Date : 2021-11-11 DOI: 10.36811/jca.2021.110029
Alireza Heidari, E. Locci, Silvia Raymond
{"title":"Screening for Lung Cancer with Low Dose Computed Tomography (LDCT)","authors":"Alireza Heidari, E. Locci, Silvia Raymond","doi":"10.36811/jca.2021.110029","DOIUrl":"https://doi.org/10.36811/jca.2021.110029","url":null,"abstract":"Using samples of small cell lung tumors, a research team led by biologist Dr. Raymond discovered two new ways to induce tumor cell death. By activating ferroptosis, one of two subtypes of tumor cells can be targeted: first, iron-dependent cell death due to oxidative stress, and second, oxidative stress. Therefore, cell death can also be induced in a different way. Both types of cell death must be caused by drugs at the same time to eliminate the majority of the tumor mass.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78192086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
Cryoablation and Cryolocalization in the Prevention, Prognosis, Diagnosis, Imaging, Screening, Treatment and Management of Breast Cancer 冷冻消融和冷冻定位在乳腺癌的预防、预后、诊断、成像、筛查、治疗和管理中的应用
Journal of Chemistry and Applications Pub Date : 2021-11-11 DOI: 10.36811/jca.2021.110024
Elena Locci, Silvia Raymond
{"title":"Cryoablation and Cryolocalization in the Prevention, Prognosis, Diagnosis, Imaging, Screening, Treatment and Management of Breast Cancer","authors":"Elena Locci, Silvia Raymond","doi":"10.36811/jca.2021.110024","DOIUrl":"https://doi.org/10.36811/jca.2021.110024","url":null,"abstract":"Unprecedented studies have shown that slow-growing breast cancers can be treated with highly targeted tumor cryopreservation technology without the need for surgery. Experiments show that this method is effective in women with low-risk breast cancer over the age of 60. Cryoablation is a solution that eliminates breast tumors safely, quickly and painlessly or without the need for surgery. Takes. This method exposes the patient's tissues to severe cold to remove them without the need for anesthesia in the clinic. The new study, which involved about 200 women, found that after eliminating low-risk breast cancer, patients were left without cancer for three years. This treatment can be used to treat cancers of the bone, kidney, prostate and other types. Unlike lumpectomy or mastectomy, which involves removing the breast from the body, cryoectomy or cryopreservation of tumors preserve breast size, reduce the risk of infection and prevent scarring, and allow patients to function normally quickly, the researchers said. Resume yourself.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79975976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Impact of COVID-19 Pandemic on Lung Cancer Treatment Scheduling COVID-19大流行对肺癌治疗计划的影响
Journal of Chemistry and Applications Pub Date : 2021-11-11 DOI: 10.37473/dac/10.1101/2020.06.09.20126995
Elena Locci, Silvia Raymond
{"title":"Impact of COVID-19 Pandemic on Lung Cancer Treatment Scheduling","authors":"Elena Locci, Silvia Raymond","doi":"10.37473/dac/10.1101/2020.06.09.20126995","DOIUrl":"https://doi.org/10.37473/dac/10.1101/2020.06.09.20126995","url":null,"abstract":"Early and timely diagnosis of any disease, especially cancer; Increases the chances of treatment and recovery; Therefore, it is better to be aware of the symptoms of lung cancer in the continuation of this article. It is advisable to first get acquainted with the causes of lung cancer so that we can assess our situation. The most important causes of lung cancer are smoking and other tobacco products, genetic mutations and family history. Second- and third-hand cigarette smoke and environmental pollutants such as air pollution also play a role in the development of this cancer. Of course, the role of colorless gas and the smell of radon and occupational exposure to compounds such as asbestos, arsenic and nickel should not be overlooked. Once we know the causes of lung cancer, we can look at its symptoms in our body. The most important symptoms of lung cancer are persistent cough, fatigue and lack of energy, and unexplained weight loss. Coughs such as coughing up blood and shortness of breath are other important symptoms of this cancer. Stomach, back, shoulder, and chest pain, as well as pain in the head, neck, and jaw, are other symptoms. In order to prevent lung cancer, special points should be considered, which we will mention in the following. The main advice is to avoid smoking and also not to be exposed to secondhand smoke; therefore, avoid using any tobacco and quit if you smoke. People who are in work situations and exposure to things like asbestos should try to minimize this exposure and use breathing masks. Opening windows and covering cracks in walls and floors is important to reduce radon concentrations. It is recommended to eat more vegetables and fruits, especially cabbage, orange vegetables and garlic. It is important to note that awareness of the symptoms of the disease is very important for early diagnosis and thus increase the chances of treatment.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89089022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Epigenetic Regulation of Hematopoiesis and Acute Leukemia 造血与急性白血病的表观遗传调控
Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110015
Alireza Heidari, E. Locci, Silvia Raymond
{"title":"Epigenetic Regulation of Hematopoiesis and Acute Leukemia","authors":"Alireza Heidari, E. Locci, Silvia Raymond","doi":"10.36811/jca.2021.110015","DOIUrl":"https://doi.org/10.36811/jca.2021.110015","url":null,"abstract":"The cell cycle of such a subject has been thoroughly studied, yet here we are examining for the second time that we have entered a new phase; Biology always has new insights to show us. This data was amazing. This map is based on this beautiful circular pattern that we have identified as all the different stages of the cell cycle. Have a disease. When Placer and colleagues used the ccAF tool to analyze cell data for glioma tumors, we found that tumor cells were often in the G0 or G1 nerve growth state. With tumor aggression, fewer cells remain at rest in the G0 nerve state. This means that more cells are growing and growing in the tumor.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80391459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Modernized Screening Technology for Cancer Non-Invasive Biodiversified Biosensors 一种现代化的肿瘤无创生物多样性传感器筛选技术
Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110020
Elena Locci, Silvia Raymond
{"title":"A Modernized Screening Technology for Cancer Non-Invasive Biodiversified Biosensors","authors":"Elena Locci, Silvia Raymond","doi":"10.36811/jca.2021.110020","DOIUrl":"https://doi.org/10.36811/jca.2021.110020","url":null,"abstract":"By placing a soft, sensitive device on the skin, you may be able to quickly detect non-invasive skin disorders in real time. A research team led by a scientist from California South University (CSU) has designed a simple electromechanical device that can be used to automatically and non-invasively diagnose deep tissue pathology such as psoriasis. These findings form the basis for future applications in the clinical evaluation of skin cancers or skin diseases.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89969543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Progress and Challenges of Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer 纳米颗粒给药治疗肺癌的进展与挑战
Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110019
Elena Locci, Silvia Raymond
{"title":"Progress and Challenges of Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer","authors":"Elena Locci, Silvia Raymond","doi":"10.36811/jca.2021.110019","DOIUrl":"https://doi.org/10.36811/jca.2021.110019","url":null,"abstract":"According to the results of a global phase 2 clinical trial, the new drug sotorasib reduces tumor size and promises to improve and increase survival in patients with lung tumors caused by specific DNA mutations. It is designed to counteract the effects of mutations that are seen in about 13% of patients with non-small cell lung adenocarcinoma (a common type of lung cancer). The Food and Drug Administration (FDA) on May 28 approved the drug as a targeted treatment for patients with small cell lung cancer whose tumors express a specific mutation called G12C in the KRAS gene. Small cell lung cancer accounts for more than 80% of lung cancers. More than 200,000 new cases of non-small cell lung cancer are diagnosed in the United States each year.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85337114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Smart Approach of Modern Therapeutics to Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nano formulations 利用特异性药物及其纳米制剂治疗癌症细胞中溶酶体功能失调的现代治疗方法
Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110011
Elena Locci, Silvia Raymond
{"title":"A Smart Approach of Modern Therapeutics to Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nano formulations","authors":"Elena Locci, Silvia Raymond","doi":"10.36811/jca.2021.110011","DOIUrl":"https://doi.org/10.36811/jca.2021.110011","url":null,"abstract":"The research team made the discovery by conducting an in-depth mechanical study of lysosomes, which are membrane-bound organs in all cells. Lysosomes were once thought to be just \"waste\" stem cells, waste recycling, regulating cell regeneration and the same function on all cell types, but the PM team's research is based on new knowledge about lysosomes that shows they act as the main messaging centers and regulates long-term hematopoietic stem cells.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76977634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Visualizing Metabolic Processes at the Single-Cell Level - Using Genetically Encoded Biosensor and Biomarker 可视化代谢过程在单细胞水平-使用基因编码的生物传感器和生物标志物
Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110016
Elena Locci, Silvia Raymond
{"title":"Visualizing Metabolic Processes at the Single-Cell Level - Using Genetically Encoded Biosensor and Biomarker","authors":"Elena Locci, Silvia Raymond","doi":"10.36811/jca.2021.110016","DOIUrl":"https://doi.org/10.36811/jca.2021.110016","url":null,"abstract":"Understanding cellular metabolism (how cells use energy) can be key in treating a wide range of diseases, including vascular disease and cancer. Although many techniques can measure these processes in tens of thousands of cells, researchers have not been able to measure them at the single-cell level. Researchers have used a genetically encoded biosensor with artificial intelligence to measure glycolysis. (Process of converting glucose to energy, single endothelial cells, blood vessel cells).\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76489758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Unlocking the Potential of Vaccines Built on Messenger RNA 释放基于信使RNA的疫苗潜力
Journal of Chemistry and Applications Pub Date : 2021-11-03 DOI: 10.36811/jca.2021.110013
Alireza Heidari, E. Locci, Silvia Raymond
{"title":"Unlocking the Potential of Vaccines Built on Messenger RNA","authors":"Alireza Heidari, E. Locci, Silvia Raymond","doi":"10.36811/jca.2021.110013","DOIUrl":"https://doi.org/10.36811/jca.2021.110013","url":null,"abstract":"In recent years, immunotherapy has revolutionized the treatment of cancer; however, inflammatory reactions in healthy tissues often have side effects that can be serious and lead to permanent discontinuation of treatment. This toxicity is not yet well understood and is a major obstacle to the use of immunotherapy. When the immune system is so severely activated, the resulting inflammatory reaction can have detrimental effects and sometimes serious damage to healthy tissue. We wanted to know if there was a difference between an optimal immune response that aims to kill cancer and an unwanted response that could affect healthy tissue. Identifying the distinctive elements between these two immune responses allows the development of new, more effective and less toxic therapeutic approaches.\u0000\u0000Keywords: Cancer; Cells; Tissues, Tumors; Prevention, Prognosis; Diagnosis; Imaging; Screening; Treatment; Management","PeriodicalId":15265,"journal":{"name":"Journal of Chemistry and Applications","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74572686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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