Journal of Applied Pharmacy最新文献_第8页

Cosmeceutical Consumption Behaviour amongst Males in Indian Market Analysisof Determinants and Influencing Factors 印度市场男性药妆消费行为的决定因素及影响因素分析

Journal of Applied Pharmacy Pub Date : 2017-02-13 DOI: 10.21065/1920-4159.1000236

Abdullah Bin Junaid, R. Nasreen

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引用次数: 3

Hypoglycemic and Antioxidant Effect of Morus alba L. Stem Bark Extracts in Streptozotocin-Induced Diabetes in Rats 桑树皮提取物对链脲佐菌素诱导的糖尿病大鼠的降糖和抗氧化作用

Journal of Applied Pharmacy Pub Date : 2017-01-30 DOI: 10.21065/1920-4159.1000234

A. Alanazi, Jamir Anwar, Niyaz Alam

{"title":"Hypoglycemic and Antioxidant Effect of Morus alba L. Stem Bark Extracts in Streptozotocin-Induced Diabetes in Rats","authors":"A. Alanazi, Jamir Anwar, Niyaz Alam","doi":"10.21065/1920-4159.1000234","DOIUrl":"https://doi.org/10.21065/1920-4159.1000234","url":null,"abstract":"The present study aims to evaluate the antidiabetic effect of Morus alba L. stem bark extract in experimental model of diabetes. The animals were divided into six groups as: control group (I); pathogenic control group (II) injected intravenously (i.v.) with single dose of STZ (60 mg/kg); morus alba stem bark extract (group-III; 200 mg/kg), and group-IV (400 mg/kg); group-V animals treated with glibenclamide (5 mg/kg, p.o.) following STZ treatment; group-VI, animals treated with bark extract per se (400 mg/kg). The results of this study showed a significant increase in lipid peroxidation, blood glucose level, glycosylated heamoglobin level, and reduction in glutathione and insulin level after STZ administration. These parameters were significantly (p<0.05) reversed by extracts dose dependently. The biochemical findings were also supported by histopathological studies of pancreas where STZ produced histological changes in pancreas and treatment with Morus alba stem bark extract restored these changes. Thus, we conclude that Morus alba stem bark extracts produced significant antidiabetic and antioxidant effect which might be due to the presence of bioactive components such as phenolic and flavonoid content in the extract. The study warrant the need for further evaluated in certain other models of diabetes","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"6 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74007387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Spectrophotometric Determination of Atorvastatin Calcium and RosuvastatinCalcium in Bulk and Dosage Form Using P-Dimethylaminobenzaldehyde 对二甲氨基苯甲醛分光光度法测定散装和剂型中阿托伐他汀钙和瑞舒伐他汀钙的含量

Journal of Applied Pharmacy Pub Date : 2017-01-05 DOI: 10.21065/1920-4159.1000233

Sobhy M. Al-Adl, L. Abdel-Aziz, M. Mohamed

引用次数: 11

Antimicrobial Activity of Flavone Analogues 黄酮类似物的抗菌活性

Journal of Applied Pharmacy Pub Date : 2017-01-01 DOI: 10.21065/1920-4159.1000232

Kamlesh Kn, Sivakumar T, Afroze A

{"title":"Antimicrobial Activity of Flavone Analogues","authors":"Kamlesh Kn, Sivakumar T, Afroze A","doi":"10.21065/1920-4159.1000232","DOIUrl":"https://doi.org/10.21065/1920-4159.1000232","url":null,"abstract":"Background: Most of the available antimicrobial drugs have developed resistance; some of them suffer from severe toxicity, side effects. So, there is a need to discover novel compound(s) which should not only be potent, but also less toxic and cost effective. Objectives: The aim of the study is to develop new synthetic antimicrobial agents (Anti-bacterial and anti-fungal) such as 3-substituted flavone/flavanone derivatives, which should be significantly potent with low toxicity. Method: An attempt was made to synthesize a newer series of 3-methyl flavanone derivatives together with the synthesis of a series of 3-hydroxyl flavone analogues. The structures of the test compounds were elucidated and established by UV, IR, H-NMR1, C-NMR13 and mass spectrometry. The synthesized compounds were subjected for in vitro antimicrobial screening using cup plate methods, followed by the determination of zone of inhibitions. Results: Two series (each 10) of 3-methyl flavanone and 3-hydroxy flavone derivatives were synthesized. The structures of the test compounds were characterized and established by various spectroscopic methods. The synthesized compounds were screened for in vitro antibacterial and antifungal activity against different strains (3- Gram positive, 3-Gram negative and 2-fungal strains). Conclusion: Some of the 3-hydroxyl flavones derivatives (1b, 3b, 4b, and 5b) and 3-methyl flavanone derivatives (3a, 1a, 2a and 4a) were found to elicit potent antimicrobial activity. The study revealed that 3-hydroxy flavone derivatives were found to be most active against Gram negative, while 3-methyl flavanone derivatives were active against Gram positive bacteria.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"30 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84438839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Vancomycin Associated Eosinophilia & Red Man Syndromein a Tertiary Care Hospital 三级医院万古霉素相关嗜酸性粒细胞增多症和红人综合征

Journal of Applied Pharmacy Pub Date : 2016-11-01 DOI: 10.21065/19204159.8.1.7

A. Siddiqui, Zuhaib Jaffer Malik, S. Andleeb

引用次数: 2

CHEMICAL AND BIOLOGICAL STUDIES OF RUSSELIA EQUISETIFORMIS (SCH.&CHAM.) AERIAL PARTS 马尾松(russelia equisetiformis)的化学和生物学研究天线部分

Journal of Applied Pharmacy Pub Date : 2016-11-01 DOI: 10.21065/19204159.8.2.23

E. Ahmed, S. Y. Desoukey, M. Fouad, M. Kamel

引用次数: 2

HPTLC AND GC-MS PROFILE OF BARLERIA LUPULINA LINDL. EXTRACTS AND THEIR EFFECT ON ENTERIC BACTERIAL PATHOGENS 狼疮芽孢杆菌的hplc和gc-ms图谱。提取物及其对肠道病原菌的作用

Journal of Applied Pharmacy Pub Date : 2016-11-01 DOI: 10.21065/19204159.8.3.61

Reshma Kumari, R. Dubey

引用次数: 6

MEASUREMENT OF CYP1A2 PHENOTYPE USING FEMALE VOLUNTEER PLASMA: A FOCUS ON CAFFEINE AND PARAXANTHINE AS A PROBE 使用女性志愿者血浆测量cyp1a2表型:关注咖啡因和副黄嘌呤作为探针

Journal of Applied Pharmacy Pub Date : 2016-11-01 DOI: 10.21065/19204159.8.2.34

S. Rehman, S. Kamal, S. Kiran, I. Bibi, I. Hussain

引用次数: 0

FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE TABLETS OF NORFLOXACIN CONTAINING NATURAL POLYMER 含天然聚合物诺氟沙星黏附片的配方研制及评价

Journal of Applied Pharmacy Pub Date : 2016-11-01 DOI: 10.21065/19204159.8.1.8

Ritesh Rana, R. Bisht, M. Sarangi

引用次数: 0

Enhancement of Aqueous Solubility of Ezogabine: Preparation and Characterization of Ezogabine Nanosuspension Anticipated for Nose to Brain Targeting by 32 Factorial Design 提高艾索加滨的水溶性:艾索加滨纳米混悬液的制备和表征——通过32因子设计预测用于鼻脑靶向

Journal of Applied Pharmacy Pub Date : 2016-11-01 DOI: 10.21065/19204159.8.3.43

R. Anil, D. Pravin, R. P. Amol

引用次数: 0