使用女性志愿者血浆测量cyp1a2表型:关注咖啡因和副黄嘌呤作为探针

Journal of Applied Pharmacy Pub Date : 2016-11-01 DOI:10.21065/19204159.8.2.34

S. Rehman, S. Kamal, S. Kiran, I. Bibi, I. Hussain

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引用次数: 0

摘要

咖啡因都不会降低患癌症的风险，但它只是通过将细胞色素P-4501A2 (CYP1A2)转化为其代谢物，即副黄嘌呤，来观察其活性。本研究的目的是确定巴基斯坦当地健康女性志愿者中咖啡因及其代谢物表型及其与癌症风险的关系。代谢比[1,7-二甲基黄嘌呤(17X)和咖啡因1,3,7-三甲基黄嘌呤(137X)]平均值为1.182995 Â±0.21137。所有志愿者的BMI(用于区分超重、体重不足等)均为19.93Kg/m2。1,7-二甲基黄嘌呤(17DMX)和1,3,7 -三甲基黄嘌呤(137TMX)的保留时间分别为15和37 min。

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MEASUREMENT OF CYP1A2 PHENOTYPE USING FEMALE VOLUNTEER PLASMA: A FOCUS ON CAFFEINE AND PARAXANTHINE AS A PROBE

Caffeine neither causing didn't decrease the risk of cancer, yet it used just to note the activity of cytochrome P-4501A2 (CYP1A2) by converting into its metabolite i.e., paraxanthine. The purpose of the present study was to determine the caffeine and its metabolite phenotypes and their relation to cancer risk in healthy female volunteers of local population in Pakistan. The average value of metabolic ratio [(1,7-dimethylxanthine (17X) and Caffeine 1,3,7-trimethylxanthine (137X)] was found to be 1.182995 Â± 0.21137. BMI (used to categorize into different groups, i.e., overweight, underweight etc.) of all volunteers were found to be 19.93Kg/m2. Retention time was 15 and 37 min for 1,7-dimethylxanthine (17DMX) and 1,3,7 trimethylxanthine (137TMX), respectively.

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Journal of Applied Pharmacy

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