Journal of Applied Pharmaceutical Research最新文献_第8页

Analgesic effect of intravenous versus intraperitoneal dexmedetomidine as an adjuvant to intraperitoneal bupivacaine (0.125%) in laparoscopic cholecystectomy: a randomized, double blind, interventional study 右美托咪定辅助布比卡因腹腔注射(0.125%)在腹腔镜胆囊切除术中的镇痛效果:一项随机、双盲、介入性研究

Journal of Applied Pharmaceutical Research Pub Date : 2022-09-30 DOI: 10.18231/j.joapr.2022.10.3.12.17

P. Jain, Pratibha Rathore, Harimohan Sharma, Shailja Bamniya

{"title":"Analgesic effect of intravenous versus intraperitoneal dexmedetomidine as an adjuvant to intraperitoneal bupivacaine (0.125%) in laparoscopic cholecystectomy: a randomized, double blind, interventional study","authors":"P. Jain, Pratibha Rathore, Harimohan Sharma, Shailja Bamniya","doi":"10.18231/j.joapr.2022.10.3.12.17","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.3.12.17","url":null,"abstract":"Background and Aims: Laparoscopic cholecystectomy has emerged as a gold standard technique for gall bladder stones. The aim of the present study was to compare the analgesic effect of intravenous (IV) vs intraperitoneal (IP) dexmedetomidine as an adjuvant to intraperitoneal (IP) bupivacaine in laparoscopy. Methods: A prospective, randomized, double blind, interventional study was conducted on 100 patients undergoing laparoscopic cholecystectomy where they were divided into following 2 groups: Group A: Patients received IV 1µg/kg dexmedetomidine diluted to 30 ml with normal saline over 10 min and 40 ml of 0.125% bupivacaine IP after removal of gall bladder. Group B: Patients received IV 30 ml of normal saline and 1µg/kg IP dexmedetomidine in 40 ml of 0.125% IP bupivacaine after removal of gall bladder. The primacy outcome was noted as a difference in mean duration for need of first rescue analgesia. The total consumption of analgesic in first 24hours was recorded and compared between the two groups. Results: Both the groups were comparable in terms of demographic profile and intraoperative hemodynamic parameters with no statistical difference. Comparison of time to first analgesic requirement between the two groups showed statistically significant results with unpaired t test The time of first rescue analgesia in Group A was 151.80 min ± 76.624. and in Group B was 94.80min ± 21.499. The total analgesic requirement in 24 hours in Group A was 136.64 ± 31.251 and in Group B was 144.12 ± 21.49. Conclusion: In our study we concluded that intravenous dexmetomidine provided superior analgesia as compared to intraperitoneal dexmetomidine when used as an adjuvant with Bupivacaine intraperitoneally.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82123503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of priming in preventing myoclonic movements after intravenous induction with etomidate in adult patients undergoing cardiac surgery: a randomised controlled interventional study 心脏手术成人患者静脉注射依托咪酯诱导后，启动对预防肌阵挛运动的影响:一项随机对照介入研究

Journal of Applied Pharmaceutical Research Pub Date : 2022-09-30 DOI: 10.18231/j.joapr.2022.10.3.39.45

Mukesh K Sunda, K. Chauhan, R. Dr., Krishna Boliwal

{"title":"Effect of priming in preventing myoclonic movements after intravenous induction with etomidate in adult patients undergoing cardiac surgery: a randomised controlled interventional study","authors":"Mukesh K Sunda, K. Chauhan, R. Dr., Krishna Boliwal","doi":"10.18231/j.joapr.2022.10.3.39.45","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.10.3.39.45","url":null,"abstract":"Etomidate is a hypnotic drug used as an intravenous anaesthetic induction agent. Etomidate causes myoclonic movements in 50-80% patients after induction which makes it less desirable for induction. Aim: Present study was to determine the effect of priming in preventing myoclonic movements after intravenous injection with etomidate in adult patients undergoing cardiac surgery. Materials and Methods: 108 patients ASA grade III scheduled for elective cardiac surgery were allocated randomly in two groups- Group A (n=54): Patients received induction dose of 0.3mg/kg I.V. etomidate, Group B (n=54): Patients received a priming dose of 0.03mg/kg etomidate I.V. followed after 1 minute by induction dose of 0.3 mg/kg I.V. etomidate over 20 seconds. 3 minutes after the start of induction with etomidate, patients in both groups were given injection fentanyl 4mcg/kg followed by injection Rocuronium (1mg/kg bodyweight) to facilitate tracheal intubation. The occurrence and intensity of myoclonus were observed for 3 min from the start of injection of the induction dose and graded clinically by a blinded observer as: 0=no myoclonus, 1=mild myoclonus, 2=moderate myoclonus and 3=severe myoclonus. Result: The average dose of etomidate used during induction and demographic variables were similar in both the groups. The incidence of myoclonus in priming Group (27/54 [50%] was significantly lower than in control Group (45/54 [83.33%].Myoclonus of moderate or severe grade occurred in significantly more patients in control Group (68.3%) than in priming Group (36.5%).Conclusion: Pre-treatment with etomidate (0.03 mg/kg), given 60 seconds before induction of anaesthesia is more effective in reducing the incidence of etomidate-induced myoclonus without related side-effects.\u0000","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89777954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on cost analysis of oral antihypertensive drugs available in India 印度口服降压药成本分析研究

Journal of Applied Pharmaceutical Research Pub Date : 2022-06-30 DOI: 10.18231/j.joapr.2022.14.18

Avanthi E, A. Rodrigues, Abhishek Achar, Mahesh G K, Anand Koppal

{"title":"A study on cost analysis of oral antihypertensive drugs available in India","authors":"Avanthi E, A. Rodrigues, Abhishek Achar, Mahesh G K, Anand Koppal","doi":"10.18231/j.joapr.2022.14.18","DOIUrl":"https://doi.org/10.18231/j.joapr.2022.14.18","url":null,"abstract":"The major health care problem in developing world is shifting from communicable diseases to non-communicable disease which causes morbidities more than mortality affecting the personal efficiency. Hypertension is a major health care burden in developing countries like India causing both morbidity and mortality. Few studies shows that the hypertension prevalence has raised from 2% to 15% in rural population and 2% to 25% in urban population in last six decades in India. This research work aims to enumerate the price of commonly available oral antihypertensive drugs in India. It also aims to study the cost variation of oral antihypertensive drugs. The present study was carried out in the department of Pharmacology in a tertiary care medical college in south India. The cost analysis of individual drugs by different manufacturers were done. Percentage of cost variation was analysed. The variation in cost of most of the antihypertensive drugs is more than 100%. It’s found maximum in Amlodipine (5mg) with cost variation of 625%, Atenolol 100 mg with cost variation of 413%. In India there is a wide price variation among antihypertensive drugs. The major gap in the cost variation of antihypertensive drugs to be narrowed for the benefit of the patients. So the government and the prescribing doctors should think about the huge difference in cost and work in the direction of benefitting the patient.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81272103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thysanolaena maxima (roxb.) kuntze: a therapeutically less explored plant from northeastern India 菊花:产于印度东北部的一种治疗性较少的植物

Journal of Applied Pharmaceutical Research Pub Date : 2022-06-30 DOI: 10.18231/j.joapr.2022.9.13

Safal Sharma, Bibhas Pandit, Sushilta Pradhan, J. P. Mohanty

引用次数: 0

Development and validation of UV-spectrophotometric method for the determination of folic acid in bulk and tablet dosage forms 紫外分光光度法测定散装和片剂中叶酸含量的建立与验证

Journal of Applied Pharmaceutical Research Pub Date : 2022-06-30 DOI: 10.18231/j.joapr.2022.19.23

Takreem A. Elkhazein, Tahani A. Abdeljabar, Amal N. Abdelrahman, M. Adam, S. Shantier

引用次数: 1

Perioperative anaesthetic challenges in coronavirus disease associated mucormycosis: A retrospective study 冠状病毒病相关毛霉病围手术期麻醉挑战:一项回顾性研究

Journal of Applied Pharmaceutical Research Pub Date : 2022-06-30 DOI: 10.18231/j.joapr.2022.32.37

M. Khandelwal, S. Meena, S. Morwal, Priyanka S. Jain, Yogesh Modi

引用次数: 0

Formulation and evaluation of theophylline sustained release matrix tablets using synthetic polymers 合成聚合物制备茶碱缓释片及评价

Journal of Applied Pharmaceutical Research Pub Date : 2022-06-30 DOI: 10.18231/j.joapr.2022.24.31

N. Kaur, M. Kumar

引用次数: 0

Use of artificial pancreas in management of diabetes mellitus 人工胰腺在糖尿病治疗中的应用

Journal of Applied Pharmaceutical Research Pub Date : 2022-06-30 DOI: 10.18231/j.joapr.2022.1.8

Dr.G.V.S. Abhishek, Sourav Pahwa

引用次数: 0

A brief review on different plant parts used as immunity boosting agent 不同植物部位用作免疫增强剂的研究综述

Journal of Applied Pharmaceutical Research Pub Date : 2022-03-31 DOI: 10.18231/j.joapr.2022.1.6

Debgopal Ganguly, Soumyadip Ghosh, M. Banerjee, Anasuya Mandal, Sarmistha Panja, Ananta Choudhury

引用次数: 0

Investigation of bioactive compounds and antimicrobial sensitivity of pawpaw (Carica papaya) leave extracts against morbific micro-organisms 木瓜(Carica papaya)叶提取物对致病微生物的生物活性成分及抗菌敏感性研究

Journal of Applied Pharmaceutical Research Pub Date : 2022-03-31 DOI: 10.18231/j.joapr.2020.21.28

O. Ogidi, P. Tobia, D. N. Ijere, U. M. Akpan, O. Omu, H. E. Carbom, A. R. Iyosayi

引用次数: 1