{"title":"Retrospective comparative evaluation of airway management with different techniques of fiberoptic intubation in patients undergoing surgery for temporomandibular joint ankylosis","authors":"Varun Kumar Saini, Priyanka Saini, Priyanka Soni, Manish Khandelwal","doi":"10.18231/j.joapr.2024.12.1.25.41","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.25.41","url":null,"abstract":"Background: Temporomandibular fusion has devastating effects on the growth and development of an individual's jaws. Thus, surgical modality is seen as a last resort to its correction. Surgical management of temporomandibular ankylosis cases presents significant challenges to an anesthetist in maintaining airway patency. Thus, this retrospective study evaluated the techniques for combating airway management challenges, emphasizing developing an institutional protocol that effectively minimizes errors. Methods: This retrospective study was conducted in the RUHS College of Dental Sciences and attached to the RUHS College of Medical Sciences, Jaipur, Rajasthan, India, for a period of three years. The records of 94 patients who had undergone surgical correction of TMJ ankylosis and were intubated with fiberoptic intubation were compiled. The cases were divided into groups, Group General anesthesia (GA) and Group Regional anesthesia (RA), and analyzed for demographics, successful intubation, and complications. Results: In Group GA, 98 % of cases were successfully intubated. Patient movements were 0 in Group GA and 25% in Group RA. Coughing was present in 1.61% of cases of group GA and 98.38% of Group RA. Epistaxis occurred in 35% of cases, and 29% of cases suffered from sore throat after extubation in Group GA. Conclusion: The anesthetist dilemma of intubating awake or anesthetized always exists. However, a careful preoperative evaluation and assessment of the patient for mask ventilation helps in the successful anesthetic management of temporomandibular joint ankylosis cases. For the anticipated difficult airway awake, fiberoptic intubation is still the ‘gold standard’ technique.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"18 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the post-coital anti-fertility activity of Michelia champaca linn. aerial extract in female Wistar rat","authors":"Seema Devi, Chander Mohan","doi":"10.18231/j.joapr.2024.12.1.52.58","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.52.58","url":null,"abstract":"Background: The plant M. champaca L., commonly known as Champa, has traditionally been utilized for its medicinal properties, particularly in women's health, for managing sterility and birth control. Previous literature primarily focuses on the anti-fertility activity of leaf extracts, while limited research has explored the potential of other aerial parts, such as the bark and flowers. Therefore, this study aims to investigate the female anti-fertility actions of various aerial parts (including leaves, branches, bark, and flowers) of the M. champaca plant, expanding our understanding beyond the previously studied leaf extracts. Material and Method: The petroleum ether (PEAEMC), ethyl alcohol (EAEMC), and chloroform water (AAEMC) extracts of aerial parts of M. champaca at doses of 100 mg/kg and 200 mg/kg were administered to female Wistar rats by using an experimental model, i.e., anti-implantation and estrogenic/Anti-estrogenic activity. Result: All three extracts showed significant anti-implantation activity (p<0.01). Among all, only EAEMC Showed activity corresponding to the standard. EAEME caused an increase in the vaginal opening size and increased height and width of the endometrium in immature ovariectomized female rats; it showed an estrogen-like action when given alone, however when given along with Ethinylestradiol, it showed anti-estrogenic action. Conclusion: It was observed that EAEMC (the Ethyl alcohol extract of M. champaca) showed dose dependent anti-fertility activity. The chemical constituents like steroids, alkaloids, and flavonoids identified from the photochemical screening may be responsible for the anti-fertility activity of the aerial parts of M. champaca L.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lovkesh Bhatia, Amit Sharma, Rishu Kalra, Varun Kumar
{"title":"Cinnamomum impressinervium meisn.: antioxidant and antimicrobial activities","authors":"Lovkesh Bhatia, Amit Sharma, Rishu Kalra, Varun Kumar","doi":"10.18231/j.joapr.2024.12.1.100.107","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.100.107","url":null,"abstract":"Background: The Cinnamomum impressinervium (CI) Meisn. Tree, which belongs to the Lauraceae family and is endemic to India, is also called Assameses or Tejiya. Numerous pharmacological properties of this plant, including anti-tumor, anti-inflammatory, and antioxidant properties, have been demonstrated. Materials and method: This study examines the phytochemical profile of the leaf using qualitative and quantitative methods. Following the phytochemical analysis of the leaf, the antioxidant efficacy for scavenging free radicals (ABTS and DPPH) was measured. Using the agar well diffusion method, the antibacterial potential of the crude extract and its fractions (aqueous, methanolic, n-hexane, and chloroform) was investigated against six gram-negative, three gram-positive, and one fungal strain. Result and discussion: Antioxidant activities of various extracts viz: aqueous, hexane, chloroform, and ethanol were prepared and subjected to antioxidant and antimicrobial activities. Through qualitative analysis, several alkaloids, steroids, and flavones were identified. In the DPPH and ABTS assays, the aqueous extract had the most potent antioxidant activity, with IC50 values of 123.83±0.42 and 57.86±0.85 μg/mL, respectively. DNA nicking assay is a qualitative analysis that shows DNA protection from free radicals. All the extracts towards B. atropheous showed best inhibition activity but a maximum zone of inhibition was shown by aqueous extracts measuring 40 mm. Aqueous and methanolic extracts are completely inactive towards S. typhi. Conclusion: This study revealed the antioxidant and antimicrobial efficacy of various extracts of Cinnamomum impressinervium Meisn. Leaves In this paper, the antibacterial activity of leaf extracts from Cinnamomum impressinervium Meisn. were studied. The evaluated extracts showed varied levels of inhibitory zones against every tested bacterium.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of toxicity studies of Sesbania grandiflora leaves extracts in Wistar albino rats","authors":"Sharad Sharma, B. Semwal, Avijit Mazumder","doi":"10.18231/j.joapr.2024.12.1.42.51","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.42.51","url":null,"abstract":"Objective: Sesbania grandiflora is a well-known medicinal plant belonging to the family Fabaceae, and it is used to treat several disorders. The current investigation aims to analyze the negative consequences of short and long-term administration of hydroalcoholic extract of S. grandiflora leaf in experimental animals. Materials and Methods: Acute and subacute toxicity were the two phases in which the entire examination was completed. In phase first, acute toxicity was performed at the dose of (2000, mg/kg) and adverse effect was recorded. However, in sub-acute toxicity the effect of different doses of (1000, 2000 and 5000 mg/kg) were studied for twenty-eight days. Animals were euthanized on the last day of the investigation, and selected internal body organs and samples of the blood were taken from each animal for histological, biochemical, and haematological analysis. Results: The result of the current investigation showed that the LD50 of S. grandiflora was observed more than 2000 mg/kg, Furthermore, experimental animals did not experience any mortality or alterations in their behavioral patterns when S. grandiflora was administered repeatedly at 1000, 2000, and 5000 mg/kg or in a single dose of 2000 mg/kg. Besides this, S. grandiflora also did not significantly modify any of the biochemical or haematological markers, or the histological analyses of selected organs. Conclusion: The results of the above research revealed that the orally administration of S. grandiflora extract did not exhibit any apparent harmful effects in experimental animals. Hence, S. grandiflora could be regarded as a safe and can be used for the therapeutic purpose in human being.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation and evaluation of mucoadhesive microspheres of metronidazole","authors":"D. Chechare, M. Siddaiah","doi":"10.18231/j.joapr.2024.12.1.93.99","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.93.99","url":null,"abstract":"Objective: Develop and evaluate mucoadhesive microspheres using Chitosan, Sodium alginate, and Sodium carboxymethyl cellulose (NaCMC) for sustained oral delivery of Metronidazole, aiming to improve bioavailability. Methods: Metronidazole-loaded microspheres were prepared via ionotropic gelation method with varying polymer ratios. Particle size, entrapment efficiency, swelling index, mucoadhesion (sheep mucosae), morphology (SEM), in-vitro wash-off test, drug release profile, and stability (6 months) were evaluated. Results: Chitosan content positively correlated with microsphere size. Entrapment efficiency ranged from 51.43% to 94.15%. Chitosan-based formulations, especially MTZ-7 (Chitosan:NaCMC, 3:1), displayed the highest mucoadhesion. SEM analysis revealed rough, spherical microspheres with a continuous polymeric coat. In-vitro wash-off test demonstrated prolonged residence time for Chitosan formulations. Sustained drug release was observed throughout the study, with MTZ-7 exhibiting the most desirable release profile. Stability studies showed no significant changes in drug release for selected formulations after 6 months. Conclusions: Chitosan-based microspheres, particularly MTZ-7, demonstrated superior mucoadhesive properties, sustained and controlled drug release, and desirable stability. These findings suggest the potential of Chitosan-based microspheres as a promising oral drug delivery system for Metronidazole, potentially addressing bioavailability concerns and improving therapeutic efficacy.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical investigations to calculate nuchal translucency using F-LNET","authors":"Kalyani Chaudhari, Shruti Oza","doi":"10.18231/j.joapr.2024.12.1.59.64","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.59.64","url":null,"abstract":"Background: According to ongoing research, assessing nuchal translucency (NT) in ultrasound pictures can help to identify fetal development that deviates from the norm. The chance of chromosomal abnormalities in a newborn is predicted by the nuchal translucency (NT) width in ultrasound sonography pictures performed on the child between 11 and 14 weeks of gestation. Method: Deeply learned convolutional networks have recently significantly improved NT region detection performance. This paper discusses a novel approach to learning a cutting-edge NT Region identification algorithm. To address the difficulty of improving the accuracy of NT recognition in various lighting and posture conditions, a Framework Learning Network (F-LNET) is employed. Discussion: The limitations of the current NT estimating technique include findings that are unpredictable and intra-personal, inter-personal, and inter-variation restrictions. On the other hand, existing solutions have a high processing overhead and are, hence, unsuitable for rapid NT limiting and localization, which is critical for reliable recognition. However, current methods could be better for quick NT limiting and localization, which is essential for trustworthy identification schemes because of their significant processing overhead. The suggested automated clinical finding approach, which computes the error between human and automated measurements, is very beneficial to both doctors and society at large. Conclusion: The suggested way reduces the error to 0.42, whereas the error of other methods ranges from 0.8 to 1.1.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"94 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Supraja Nagarathinam, R. Umadevi, Angeline Grace G, Raghul Saravanan
{"title":"A cross-sectional study to assess the barriers to teleconsultations among doctors in Chennai","authors":"Supraja Nagarathinam, R. Umadevi, Angeline Grace G, Raghul Saravanan","doi":"10.18231/j.joapr.2024.12.1.29.34","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.29.34","url":null,"abstract":"Background: A doctor's communication and interpersonal skills encompass gathering information to facilitate accurate diagnosis, counsel appropriately, give therapeutic instructions, and establish caring relationships with patients. While face-to-face consultations have been the norm, tele-consultations and enrolment in telemedicine apps have become necessary. Tele-consultations have been on the rise significantly during the COVID-19 lockdown. This study aims to assess the barriers to tele-consultations among doctors in Chennai. Methodology: This study uses a cross-sectional design to assess the barriers to tele-consultations among doctors in Chennai using a convenience sampling technique. Data was entered in Microsoft Excel and analyzed using SPSS software version 23. Results: 81.6% of the participants feel that teleconsultations have reduced face-to-face consultations. Only about 6% of the study participants preferred teleconsultation in the future. About a third of the doctors in the study could not treat/manage chronically ill patients through teleconsultations. About 70% of the doctors could follow up with their patients through telecommunication, but 70% failed to follow up. Conclusion: From this study, we conclude that only about 6% of the study participants would prefer teleconsultation in the future. Treating medical emergencies and assessment of surgical patients were considered as top 2 important barriers in this study with about half of them facing this barrier during their telecommunication.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"92 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. N. Surya, Akshaya Radhakrishnan, Vijayalakshmi S, A. H. Narayanan, S. M. Kumar, B. Venkatesh, Rehana Syed
{"title":"Cinnamomum impressinervium meisn.: antioxidant and antimicrobial activities","authors":"B. N. Surya, Akshaya Radhakrishnan, Vijayalakshmi S, A. H. Narayanan, S. M. Kumar, B. Venkatesh, Rehana Syed","doi":"10.18231/j.joapr.2024.12.1.108.115","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.108.115","url":null,"abstract":"Background: Medical interns develop apprehensions about the vulnerability of their exposure to infection while treating COVID-19 patients, which may further affect their work patterns and efficiency. Studies have shown that the outbreak of infectious diseases would result in mental health issues. Because of this, our study aims to assess psychosocial factors such as anxiety, depression, stress, relationships with peers, and changes in personal roles among medical interns at a private medical college. Methodology: This cross-sectional was conducted among 248 medical interns using a simple random sampling method. Depression, anxiety, and stress were assessed using a standardized 21-item depression, anxiety, and stress questionnaire (DASS– 21). A pretested semi-structured questionnaire was used to acquire information regarding the study participants' socio-demographic data and social elements. Results: The overall prevalence of Depression [58%], Anxiety [70%], and Stress [44%] were found among the 248 study participants. Around [70.6%] of the study participants reported that their social life had been affected. The prevalence of various factors associated with depression, anxiety, and stress were assessed. Conclusion: This study reports higher levels of psychosocial distress among the study participants. Adequate knowledge about the pandemic and stress management measures will be the top priority among these budding medicos during such unfavorable pandemic situations.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"57 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Innovative approach for improved sustained delivery of metformin hydrochloride for its anti-hyperglycemic activity","authors":"M. K. Pillai, S. Pillai, S. Jain","doi":"10.18231/j.joapr.2024.12.1.1.9","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.1.9","url":null,"abstract":"Metformin hydrochloride, an antidiabetic agent, is useful in reducing the blood glucose concentration in Type II diabetes. It is also finding its use as a repurposed drug. The formulations consisted of micro drug delivery systems prepared by emulsification method and were evaluated in-vitro and in-vivo. Process variables like amount of polymer, speed of agitation and stirring, presence or absence of surfactant and cross linker offered a versatile approach towards obtaining the formulation though affected physicochemical properties of formulations. Discrete, spherical, and free-flowing microspheres, in the size range and granularity of 250 to 700µ were used to control the drug release rate. Drug release was diffusion controlled as evident from the Higuchi kinetics. The physical characteristics of the formulations were reproducible. Healthy and alloxan induced hyperglycaemic male albino mice were used for in-vivo experimentation by evaluating plasma glucose level reduction and % reduction in the blood glucose level after administration of pure drug and formulations. The results indicate significant sustained fall in the blood glucose level for about 10 hrs following formulation administration as compared to the pure drug.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140412487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kumar B., Kouser Banu Khaleeluddin, Saikarthick Jayakumar, Ezhil Vendhan K
{"title":"Prevalence and awareness of text neck syndrome and text thumb syndrome in young adult population","authors":"S. Kumar B., Kouser Banu Khaleeluddin, Saikarthick Jayakumar, Ezhil Vendhan K","doi":"10.18231/j.joapr.2024.12.1.22.28","DOIUrl":"https://doi.org/10.18231/j.joapr.2024.12.1.22.28","url":null,"abstract":"Background: The term \"text neck\" can be defined as repetitive strain injury and pain due to excessive viewing and texting on a smartphone for a prolonged duration. Long-term untreated text neck results in inflammation of ligaments and muscles, which can lead to permanent arthritic changes. Many smart phone users experience thumb/wrist pain, but some people who develop pain are smart phone addicts. The present study checks the prevalence and awareness of text neck and thumb text syndrome in young adults. Methods: A cross-sectional study was conducted with 200 volunteers between 18-25 years age who have been using mobile phone in the last 5 years. A structured questionnaire was created, validated, and used for the study. Descriptive statistics was used to assess responses received from participants. The prevalence of text neck syndrome and thumb text syndrome has been established. Results: About 50.3% of the participants were unaware of text neck syndrome and 57.1% of text thumb syndrome. Maximum mobile phone usage included texting and calls. About 45.2% of the participants use their right thumb and index finger to text. 33% of people have a head forward posture when using mobile phones. An analysis of pain, discomfort, and duration during mobile phone use was done and will be presented at a forum. Conclusion: The prevalence of text neck and thumb text syndrome in the young adult population indicates the need to plan future pain management strategies and increase user awareness","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}