Journal of Applied Pharmaceutical Research最新文献_第10页

An overview on FDA-approved natural super disintegrants efficacy in a fast dissolving drug delivery system fda批准的天然超级崩解剂在快速溶解给药系统中的功效综述

Journal of Applied Pharmaceutical Research Pub Date : 2021-09-30 DOI: 10.18231/j.joapr.2021.v9.i3.1-7

D. Pradhan, Prodipta Chakraborty, Sudip Halder, A. Bagchi

引用次数: 2

Validation process of EDTA for infusion/ injection with ceftriaxone and sulbactam 头孢曲松舒巴坦输注/注射用EDTA的验证过程

Journal of Applied Pharmaceutical Research Pub Date : 2021-09-30 DOI: 10.18231/j.joapr.2021.v9.i3.39-47

Md. Semimul Akhtar, Akash Babu, Sudip Kumar Mandal

引用次数: 0

Microemulgel: a novel approach for topical drug delivery 微凝胶:一种局部给药的新方法

Journal of Applied Pharmaceutical Research Pub Date : 2021-09-30 DOI: 10.18231/j.joapr.2021.v9.i3.14-20

Priya Kushwah, Pravin Kumar Sharma, Sweta S Koka, A. Gupta, Ravi Sharma, G. Darwhekar

引用次数: 2

Plants as pharmaceutical excipients in oral sustained drug delivery systems: A review 植物在口服持续给药系统中的药用赋形剂研究进展

Journal of Applied Pharmaceutical Research Pub Date : 2021-09-30 DOI: 10.18231/j.joapr.2021.v9.i3.26-38

T. Uwah, E. I. Akpabio, D. Effiong

引用次数: 1

Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate 头孢替尼眼原位凝胶的研制及评价

Journal of Applied Pharmaceutical Research Pub Date : 2021-09-15 DOI: 10.18231/j.joapr.2021.25.29

Shoaeba Shaikh, S. Desai, H. Jain, A. Sahu, D. Meshram

引用次数: 2

Evaluation of analgesic, antioxidant and cytotoxic activities of ethanol extract of Clerodendrum viscosum Vent 粘胶藤乙醇提取物的镇痛、抗氧化和细胞毒活性评价

Journal of Applied Pharmaceutical Research Pub Date : 2021-06-30 DOI: 10.18231/j.joapr.2021.10.14

S. Das, M. Kuddus, N. Qais, C. M. Hasan

{"title":"Evaluation of analgesic, antioxidant and cytotoxic activities of ethanol extract of Clerodendrum viscosum Vent","authors":"S. Das, M. Kuddus, N. Qais, C. M. Hasan","doi":"10.18231/j.joapr.2021.10.14","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.10.14","url":null,"abstract":"Clerodendrum viscosum Vent. is a very common plant in Bangladesh which is locally familiar as “Bhat” or “Ghetu”. Here, the ethanol extract of whole plant part of C. viscosum and its various solvent (petroleum-ether, chloroform and ethyl acetate) fractions were subjected for the appraisal of analgesic, antioxidant and cytotoxic activities. Analgesic activity was tested by acetic acid-induced writhing model in Swiss albino mice. All the plant samples at the oral doses of 100- and 200 mg/kg body weight were found to exhibit significant (p<0.05) pain reducing activity in test animals. Highest inhibition of writhing was 62.38% by the ethyl acetate soluble fraction at dose of 200 mg/kg body weight while the standard drug diclofenac sodium (50 mg/kg) produces 76.14% reduction of abdominal writhing. DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical quenching assay was employed to determine the antioxidant potential of the plant samples while cytotoxic activity was checked by brine shrimp lethality bioassay. In DPPH radical scavenging assay, the plant samples showed prominent antioxidant activity. Among all, the ethyl acetate fraction showed maximum antioxidant potential with IC50 value of 28.02±0.53 μg/ml. In cytotoxic assay, the petroleum-ether fraction demonstrated strong cytotoxicity with LC50 value of 1.42±1.12 μg/ml. In summary, C. viscosum extracts possess significant analgesic, antioxidant and cytotoxic activities which rationalize its traditional use in folk medicine.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80958302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In India, diabetes mellitus is on the rise at an alarming rate: A review 在印度，糖尿病正以惊人的速度上升:综述

Journal of Applied Pharmaceutical Research Pub Date : 2021-06-30 DOI: 10.18231/j.joapr.2021.01.05

A. Bagchi, Prosanta Pal

引用次数: 0

Recent advancement in the method of transdermal drug delivery system: A review 经皮给药系统方法的研究进展

Journal of Applied Pharmaceutical Research Pub Date : 2021-06-30 DOI: 10.18231/j.joapr.2021.06.09

Sudip Halder, Prodipta Chakraborty, D. Pradhan, A. Bagchi

{"title":"Recent advancement in the method of transdermal drug delivery system: A review","authors":"Sudip Halder, Prodipta Chakraborty, D. Pradhan, A. Bagchi","doi":"10.18231/j.joapr.2021.06.09","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.06.09","url":null,"abstract":"A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The transdermal drug delivery system (TDDS) provides an alternative safe means of drug delivery to previous intrusive techniques. In the past, topically applied lotions and ointments were the most commonly utilised systems for dermatological issues. The fact that some of these formulations cause systemic side effects indicates that they are absorbed through the skin. All topically applied medication formulations intended to transport the active ingredient into the general circulation are included in the transdermal delivery system. To overcome the skin's formidable barrier to topical medication administration, several substances have been utilised. Because of their unique qualities, such as improved bioavailability, regulated pharmaceutical release, and improved patient compliance, TDDS have recently gained increased attention. The current review focuses on the various advancements in transdermal drug delivery, as well as the various available methods for preparing transdermal patches, characterization and assessment tools for transdermal patch preparation, patents, transdermal compound clinical trials, and drug approved and future applications of transdermal drug delivery systems. As a result, in recent years, the Transdermal Drug Delivery System has received a lot of attention.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90256320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats 菠萝蛋白酶与姜黄联合抗醋酸致溃疡性结肠炎的实验研究

Journal of Applied Pharmaceutical Research Pub Date : 2021-06-30 DOI: 10.18231/j.joapr.2021.15.24

R. Padmavathi, K. Keerthana, A. Shanmuga Sundaram Devi, Y. Hari, A. Samad

{"title":"Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats","authors":"R. Padmavathi, K. Keerthana, A. Shanmuga Sundaram Devi, Y. Hari, A. Samad","doi":"10.18231/j.joapr.2021.15.24","DOIUrl":"https://doi.org/10.18231/j.joapr.2021.15.24","url":null,"abstract":"Objective: The present study planned to study the combined effect of Bromelain and Turmeric in acetic acid induced ulcerative colitis in Wistar rats. \u0000Methodology: Wistar rats of either sex (n = 30) were divided into 5 groups. Group – I, Sham control, administered single dose of vehicle rectally; Group –II, colitis control, colitis was induced by rectal administration of single dose of 2 ml of 3%, v/v of acetic acid in 0.9% saline; Group–III, treated with Turmeric (50 mg/kg/p.o); Group–IV, treated with Bromelain (100 mg/kg/p.o) and Group –V, treated with both Turmeric (50 mg/kg/p.o) and Bromelain (100 mg /kg/p.o). Colitis was induced in all the treatment groups on first day and drug treatment was continued for 7 days. During the treatment period, Disease Activity Index (DAI) was assessed daily and on 8th day White Blood Cell (WBC) Count and Differential Leucocyte Count (DLC) was performed and on 9th day all the rats were sacrificed for the assessment of intestinal inflammation, colon myeloperoxidase (MPO) levels and Histopathology. Results obtained were analysed by one-way analysis of variance followed by Tukey’s multiple comparison test. \u0000Results: Overall changes in DAI, Inflammatory scores, WBC, DLC and MPO has shown significant improvement with Turmeric and Bromelain compared to Colitis control. However, the combined therapy has shown to be more effective in alleviating ulcerative colitis compared to individual therapies. \u0000Conclusion: The present study recommends that the combination of Turmeric and Bromelain has synergistic effect in treating ulcerative colitis.","PeriodicalId":15232,"journal":{"name":"Journal of Applied Pharmaceutical Research","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74472686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quercitin as an antiviral weapon-A review 槲皮素作为抗病毒武器的研究进展

Journal of Applied Pharmaceutical Research Pub Date : 2021-03-28 DOI: 10.18231/joapr.2021.9.1.25.29

Ramen Kalita, K. Bhattacharya, Amir Ali, S. Sandilya

引用次数: 1