{"title":"The Potential of Blood Speckle Imaging and <sup>18</sup>F-Sodium Fluoride Positron Emission Tomography/Computed Tomography in Evaluating the Progression and Inflammation in Aortic Stenosis.","authors":"Ji-Won Hwang","doi":"10.4250/jcvi.2023.0037","DOIUrl":"https://doi.org/10.4250/jcvi.2023.0037","url":null,"abstract":"https://e-jcvi.org Aortic stenosis disease progression occurs through serial inflammatory reactions, calcification, and fibrosis, which are associated with various physiological pathways.1)2) There are no active disease biomarkers available for its detection or personalized treatments that can delay inflammation progression.1)3) Currently, cardiovascular calcification is visualized using noninvasive conventional imaging modalities such as echocardiography, computed tomography (CT), and cardiac magnetic resonance imaging (CMR).4)","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 3","pages":"150-151"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/c8/jcvi-31-150.PMC10374392.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji Soo Oh, Sang Hyun Lee, Jeongsu Kim, Yong Hyun Park, Kook Jin Chun
{"title":"Successful Patent Ductus Arteriosus Closure in Patients With Severe Pulmonary Arterial Hypertension.","authors":"Ji Soo Oh, Sang Hyun Lee, Jeongsu Kim, Yong Hyun Park, Kook Jin Chun","doi":"10.4250/jcvi.2022.0089","DOIUrl":"https://doi.org/10.4250/jcvi.2022.0089","url":null,"abstract":"https://e-jcvi.org A 48-year-old female was referred to our department due to severe dyspnea for several years in conditions of non-ischemic heart failure and uncontrolled type 2 diabetes. Physical examination revealed rales in both lungs, regular heart sounds without murmurs, clubbing of the toes (Figure 1A), and no pitting edema. Chest X-ray showed cardiomegaly and prominent pulmonary vasculature (Figure 1B). Laboratory findings reported elevated brain natriuretic peptide. Transthoracic echocardiography demonstrated patent ductus arteriosus (PDA) with bidirectional shunting (Figure 2, Supplementary Table 1, Movie 1). Right cardiac catheterization revealed severe pulmonary arterial hypertension (PAH) with right ventricle dysfunction (mean pulmonary artery pressure [PAP]: 78 mmHg, pulmonary capillary wedge pressure: 12 mmHg, pulmonary vascular resistance [PVR]: 27.8 Wood units [WU], Qp/Qs: 1.18, and cardiac output: 4.1 L/min by Fick method). We diagnosed PAH associated with PDA1) and started treatment with oral sildenafil (20 mg) 3 times a day in addition to ambrisentan (5 mg) once a day. We conducted a 15-minute closure test on the PDA by measuring the pressure gradient between the central aorta and PA. A decrease of mean PAP by 15 mmHg was observed without any change in cardiac output (Figure 3, Supplementary Table 1). Finally, we performed PDA closure with an Amplatzer septal occluder (8/6 mm). The patient has been in a stable condition with advanced medical treatment for three years (Figure 4, Supplementary Table 1, Movie 2). Although current guidelines recommend PDA closure in patients with high PVR (>5 WU) and Qp/Qs >1.52)3) (class IIb), shunt closure may also be J Cardiovasc Imaging. 2023 Jul;31(3):152-154 https://doi.org/10.4250/jcvi.2022.0089 pISSN 2586-7210·eISSN 2586-7296","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 3","pages":"152-154"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/1c/jcvi-31-152.PMC10374387.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey Yim, Michael Y C Tsang, Anand Venkataraman, Shane Balthazaar, Ken Gin, John Jue, Parvathy Nair, Christina Luong, Darwin F Yeung, Robb Moss, Sean A Virani, Jane McKay, Margot Williams, Eric C Sayre, Purang Abolmaesumi, Teresa S M Tsang
{"title":"Cardiac Phenotyping of SARS-CoV-2 in British Columbia: A Prospective Echo Study With Strain Imaging.","authors":"Jeffrey Yim, Michael Y C Tsang, Anand Venkataraman, Shane Balthazaar, Ken Gin, John Jue, Parvathy Nair, Christina Luong, Darwin F Yeung, Robb Moss, Sean A Virani, Jane McKay, Margot Williams, Eric C Sayre, Purang Abolmaesumi, Teresa S M Tsang","doi":"10.4250/jcvi.2022.0120","DOIUrl":"https://doi.org/10.4250/jcvi.2022.0120","url":null,"abstract":"<p><strong>Background: </strong>There is limited data on the residual echocardiographic findings including strain analysis among post-coronavirus disease (COVID) patients. The aim of our study is to prospectively phenotype post-COVID patients.</p><p><strong>Methods: </strong>All patients discharged following acute COVID infection were systematically followed in the post-COVID-19 Recovery Clinic at Vancouver General Hospital and St. Paul's Hospital. At 4-18 weeks post diagnosis, patients underwent comprehensive echocardiographic assessment. Left ventricular ejection fraction (LVEF) was assessed by 3D, 2D Biplane Simpson's, or visual estimate. LV global longitudinal strain (GLS) was measured using a vendor-independent 2D speckle-tracking software (TomTec).</p><p><strong>Results: </strong>A total of 127 patients (53% female, mean age 58 years) were included in our analyses. At baseline, cardiac conditions were present in 58% of the patients (15% coronary artery disease, 4% heart failure, 44% hypertension, 10% atrial fibrillation) while the remainder were free of cardiac conditions. COVID-19 serious complications were present in 79% of the patients (76% pneumonia, 37% intensive care unit admission, 21% intubation, 1% myocarditis). Normal LVEF was seen in 96% of the cohort and 97% had normal right ventricular systolic function. A high proportion (53%) had abnormal LV GLS defined as < 18%. Average LV GLS of septal and inferior segments were lower compared to that of other segments. Among patients without pre-existing cardiac conditions, LVEF was abnormal in only 1.9%, but LV GLS was abnormal in 46% of the patients.</p><p><strong>Conclusions: </strong>Most post-COVID patients had normal LVEF at 4-18 weeks post diagnosis, but over half had abnormal LV GLS.</p>","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 3","pages":"125-132"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/c4/jcvi-31-125.PMC10374389.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soyoon Park, Woo-Baek Chung, Joo Hyun O, Kwan Yong Lee, Mi-Hyang Jung, Hae-Ok Jung, Kiyuk Chang, Ho-Joong Youn
{"title":"Trans-Aortic Flow Turbulence and Aortic Valve Inflammation: A Pilot Study Using Blood Speckle Imaging and <sup>18</sup>F-Sodium Fluoride Positron Emission Tomography/Computed Tomography in Patients With Moderate Aortic Stenosis.","authors":"Soyoon Park, Woo-Baek Chung, Joo Hyun O, Kwan Yong Lee, Mi-Hyang Jung, Hae-Ok Jung, Kiyuk Chang, Ho-Joong Youn","doi":"10.4250/jcvi.2022.0118","DOIUrl":"https://doi.org/10.4250/jcvi.2022.0118","url":null,"abstract":"<p><strong>Background: </strong><sup>18</sup>F-sodium fluoride positron emission tomography/computed tomography (<sup>18</sup>F-NaF PET/CT) has been proven to be useful in identification of microcalcifications, which are stimulated by inflammation. Blood speckle imaging (BSI) is a new imaging technology used for tracking the flow of blood cells using transesophageal echocardiography (TEE). We evaluated the relationship between turbulent flow identified by BSI and inflammatory activity of the aortic valve (AV) as indicated by the <sup>18</sup>F-NaF uptake index in moderate aortic stenosis (AS) patients.</p><p><strong>Methods: </strong>This study enrolled 18 moderate AS patients diagnosed within the past 6 months. BSI within the aortic root was acquired using long-axis view TEE. The duration of laminar flow and the turbulent flow area ratio were calculated by BSI to demonstrate the degree of turbulence. The maximum and mean standardized uptake values (SUVmax, SUVmean) and the total microcalcification burden (TMB) as measured by <sup>18</sup>F-NaF PET/CT were used to demonstrate the degree of inflammatory activity in the AV region.</p><p><strong>Results: </strong>The mean SUVmean, SUVmax, and TMB were 1.90 ± 0.79, 2.60 ± 0.98, and 4.20 ± 2.18 mL, respectively. The mean laminar flow period and the turbulent area ratio were 116.1 ± 61.5 msec and 0.48 ± 0.32. The correlation between SUVmax and turbulent flow area ratio showed the most positive and statistically significant correlation, with a Pearson's correlation coefficient (R²) of 0.658 and a p-value of 0.014.</p><p><strong>Conclusions: </strong>The high degree of trans-aortic turbulence measured by BSI was correlated with severe AV inflammation.</p>","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 3","pages":"145-149"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/96/jcvi-31-145.PMC10374388.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Ribeiro Silva, Nuno Dias Ferreira, Daniel Martins, Alberto Rodrigues, Ricardo Fontes-Carvalho
{"title":"\"UFO: Unidentified Flying Object in the Heart\": An Unusual Sighting of a Cardiac Calcified Amorphous Tumour.","authors":"Mariana Ribeiro Silva, Nuno Dias Ferreira, Daniel Martins, Alberto Rodrigues, Ricardo Fontes-Carvalho","doi":"10.4250/jcvi.2022.0139","DOIUrl":"https://doi.org/10.4250/jcvi.2022.0139","url":null,"abstract":"","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 3","pages":"155-157"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/17/jcvi-31-155.PMC10374386.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Path to Accurate and Universal Strain Measurement: Insights From a Validation Study.","authors":"Goo-Yeong Cho","doi":"10.4250/jcvi.2023.0029","DOIUrl":"https://doi.org/10.4250/jcvi.2023.0029","url":null,"abstract":"https://e-jcvi.org While myocardial strain measurement is not currently considered a mandatory assessment in the guidelines of various cardiac disease, unlike left ventricular ejection fraction, it is a topic of active research among many investigators due to its potential clinical utility.1) The results of these studies have been promising, suggesting that myocardial strain measurement could become a necessary assessment in the near future. However, there are several challenges that need to be addressed before myocardial strain can be widely used in routine clinical practice. One of the main issues is that strain values can vary depending on the software used for measurement, and there is currently no standardization method for correcting these differences. As a result, it can be difficult to compare strain values obtained using different software programs, which can limit the utility of strain measurements in clinical decision-making. As such, the validation of strain measurement software is a critical step in establishing the reliability and accuracy of this tool. As these developments continue, it is likely that myocardial strain measurement will become an increasingly important tool for the diagnosis, treatment, and management of cardiac disease.","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 3","pages":"142-144"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/95/jcvi-31-142.PMC10374385.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luuk H G A Hopman, Elizabeth Hillier, Yuchi Liu, Jesse Hamilton, Kady Fischer, Nicole Seiberlich, Matthias G Friedrich
{"title":"Dynamic Cardiac Magnetic Resonance Fingerprinting During Vasoactive Breathing Maneuvers: First Results.","authors":"Luuk H G A Hopman, Elizabeth Hillier, Yuchi Liu, Jesse Hamilton, Kady Fischer, Nicole Seiberlich, Matthias G Friedrich","doi":"10.4250/jcvi.2022.0080","DOIUrl":"https://doi.org/10.4250/jcvi.2022.0080","url":null,"abstract":"BACKGROUND Cardiac magnetic resonance fingerprinting (cMRF) enables simultaneous mapping of myocardial T1 and T2 with very short acquisition times. Breathing maneuvers have been utilized as a vasoactive stress test to dynamically characterize myocardial tissue in vivo. We tested the feasibility of sequential, rapid cMRF acquisitions during breathing maneuvers to quantify myocardial T1 and T2 changes. METHODS We measured T1 and T2 values using conventional T1 and T2-mapping techniques (modified look locker inversion [MOLLI] and T2-prepared balanced-steady state free precession), and a 15 heartbeat (15-hb) and rapid 5-hb cMRF sequence in a phantom and in 9 healthy volunteers. The cMRF5-hb sequence was also used to dynamically assess T1 and T2 changes over the course of a vasoactive combined breathing maneuver. RESULTS In healthy volunteers, the mean myocardial T1 of the different mapping methodologies were: MOLLI 1,224 ± 81 ms, cMRF15-hb 1,359 ± 97 ms, and cMRF5-hb 1,357 ± 76 ms. The mean myocardial T2 measured with the conventional mapping technique was 41.7 ± 6.7 ms, while for cMRF15-hb 29.6 ± 5.8 ms and cMRF5-hb 30.5 ± 5.8 ms. T2 was reduced with vasoconstriction (post-hyperventilation compared to a baseline resting state) (30.15 ± 1.53 ms vs. 27.99 ± 2.07 ms, p = 0.02), while T1 did not change with hyperventilation. During the vasodilatory breath-hold, no significant change of myocardial T1 and T2 was observed. CONCLUSIONS cMRF5-hb enables simultaneous mapping of myocardial T1 and T2, and may be used to track dynamic changes of myocardial T1 and T2 during vasoactive combined breathing maneuvers.","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 2","pages":"71-82"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/13/jcvi-31-71.PMC10133810.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9395787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Longitudinal Changes of Left Atrial Volume Index as a Prognosticator in Hypertrophic Cardiomyopathy.","authors":"Sungseek Kim, Wook-Jin Chung","doi":"10.4250/jcvi.2022.0143","DOIUrl":"https://doi.org/10.4250/jcvi.2022.0143","url":null,"abstract":"outflow tract obstruction, LAVI, E/e ′ , tricuspid regurgitation velocity","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 2","pages":"96-97"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/76/jcvi-31-96.PMC10133809.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9395790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is a Low Dose Computed Tomography Angiography Protocol Feasible in Terms of Maintaining Adequate Diagnostic Image Quality for TAVR Candidates?","authors":"Sung Min Ko","doi":"10.4250/jcvi.2023.0022","DOIUrl":"https://doi.org/10.4250/jcvi.2023.0022","url":null,"abstract":"https://e-jcvi.org Transcatheter aortic valve replacement (TAVR) has been initiated first for inoperable patients with severe aortic stenosis (AS) and prohibitive comorbidities, then in high-, intermediateand, more recently, low-risk patients. Nowadays, TAVR has been established as the firstline treatment method for symptomatic patients of any age with severe AS and a high or prohibitive surgical risk.1) Computed tomography angiography (CTA) allows pre-procedural comprehensive evaluation for TAVR including coronary artery, aortic valve, aortic root, entire aorta, and vascular access site suitability at the same time.2) Accordingly, large amount of contrast medium is mandatory for obtaining good quality of images from the subclavian arteries to the femoral arteries. Chronic kidney disease is a common underlying disease in patients with severe AS and is significantly associated with aggravation of renal function in case of excessive use of iodinated contrast medium during both the pre-TAVR planning and TAVR procedure.3)4) Therefore, reducing the use of contrast medium for pre-procedural CTA imaging in TAVR is required for prevention of deteriorating renal function and worsening clinical outcomes in patients with renal dysfunction.","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"31 2","pages":"116-117"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/b7/jcvi-31-116.PMC10133808.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9390404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}