Journal of cardiology最新文献

{"title":"Prognostic values of proteinuria in patients with acute heart failure.","authors":"Yuka Akama, Yuya Matsue, Daichi Maeda, Taishi Dotare, Tsutomu Sunayama, Takashi Iso, Yudai Fujimoto, Taisuke Nakade, Shoichiro Yatsu, Sayaki Ishiwata, Yutaka Nakamura, Shoko Suda, Takao Kato, Masaru Hiki, Takatoshi Kasai, Tohru Minamino","doi":"10.1016/j.jjcc.2025.01.010","DOIUrl":"10.1016/j.jjcc.2025.01.010","url":null,"abstract":"<p><strong>Background: </strong>Renal dysfunction is significantly associated with poor prognosis in patients with heart failure. However, the prognostic significance of proteinuria as a potential marker of an impaired glomerular filtration barrier in acute heart failure (AHF) remains unclear. We aimed to investigate the prognostic value of urinary protein/creatinine ratio (PCR) in patients with AHF.</p><p><strong>Methods: </strong>Urinary protein levels measured at admission were adjusted for urinary creatinine concentrations in 346 patients (75 ± 13 years; 61 % men) with AHF. Patients were categorized based on urinary PCR, adhering to the Japanese chronic kidney disease (CKD) guideline cut-offs for CKD staging: A1 (<0.15 g/gCr), A2 (0.15-0.49 g/gCr), and A3 (≥0.5 g/gCr). The primary endpoint was all-cause mortality.</p><p><strong>Results: </strong>Overall, there were 85, 126, and 135 patients in the A1, A2, and A3 groups, respectively. Groups A2 and A3 were associated with lower hemoglobin levels, higher blood urea nitrogen and N-terminal pro-B-type natriuretic peptide levels, and poor renal function. Moreover, groups A2 and A3 had high cystatin C, alpha 1 microglobulin, and urinary liver-type fatty acid-binding protein (L-FABP) levels. Urinary PCR correlated more with tubular markers, alpha 1-microglobulin, and L-FABP than with the glomerular marker cystatin C. Over a median follow-up period of 434 (interquartile range: 89-753) days, 72 deaths occurred. Elevated urinary PCR was associated with higher mortality rates (log-rank test, p < 0.001), even after adjusting for other variables [A2 vs. A1: hazard ratio (HR) 2.59, 95 % confidence interval (CI) 0.71-9,55, p = 0.15; A3 vs. A1: HR 4.40, 95 % CI 1.17-16.6, p = 0.029].</p><p><strong>Conclusions: </strong>Elevated urinary PCR is more prevalent in patients with AHF and is associated with a higher risk of all-cause mortality, independent of covariates, including glomerular function. Thus, urinary PCR at admission should provide prognostic information independent of glomerular function.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal ablation pattern on intraprocedural echocardiography is associated with favorable clinical outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy.","authors":"Junya Matsuda, Yukichi Tokita, Lisa Hoshika, Kentaro Koyama, Kakeru Ishihara, Serina Kobayashi, Saori Uchiyama, Yoichi Imori, Yoshiaki Kubota, Jun Nakata, Hideki Miyachi, Shuhei Tara, Takeshi Yamamoto, Hitoshi Takano, Mitsunobu Kitamura, Morimasa Takayama, Kuniya Asai","doi":"10.1016/j.jjcc.2025.01.007","DOIUrl":"10.1016/j.jjcc.2025.01.007","url":null,"abstract":"<p><strong>Background: </strong>Alcohol septal ablation (ASA) is used to treat drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Intraprocedural echocardiography is essential for identifying the septal area perfused by each septal branch; however, its role in determining the procedural endpoint of ASA remains unclear. This retrospective study aimed to evaluate the impact of intraprocedural echocardiographic findings on clinical outcomes and left ventricular pressure gradient (LVPG) after ASA.</p><p><strong>Methods: </strong>Overall, 120 patients with HOCM who underwent ASA at a single center were divided into two groups based on the presence of optimal ablation. Optimal ablation was defined as the ablated area fully covering the targeted septal myocardium from the point of contact with the onset of the accelerated flow to the basal septum and dense acoustic shadowing accompanying the ablated area. Clinical outcomes and LVPG changes were evaluated using inverse probability of treatment weighting.</p><p><strong>Results: </strong>Significantly more patients showed a New York Heart Association (NYHA) functional class improvement of ≥2 stages or achievement of class I in the optimal ablation group (n = 74) than in the non-optimal ablation group (94 % vs. 62 %; p < 0.001). The optimal ablation group had a significantly greater percentage reduction in LVPG at 1-year after ASA (82 ± 18 % vs. 64 ± 18 %; p = 0.001). Multivariate analyses revealed that optimal ablation was an independent predictor of a NYHA functional class improvement of ≥2 stages or achievement of class I (odds ratio, 11.3; 95 % confidence interval, 3.43-39.1; p < 0.001) and a percentage reduction in LVPG (p = 0.001).</p><p><strong>Conclusions: </strong>Intraprocedural echocardiographic findings of optimal ablation were associated with favorable clinical outcomes and a significant reduction in LVPG.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to demonstrate the causal relationship between sodium-glucose cotransporter 2 receptor and prevention of ventricular arrhythmia in heart failure cohorts.","authors":"Naoya Kataoka, Teruhiko Imamura","doi":"10.1016/j.jjcc.2025.01.006","DOIUrl":"10.1016/j.jjcc.2025.01.006","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cardiac rehabilitation on progression to long-term care: A clinical and economic longitudinal study in Japan.","authors":"Tomoyuki Takura, Arihiro Kiyosue, Teruyuki Koyama, Mitsuo Takei, Asao Honda","doi":"10.1016/j.jjcc.2025.01.005","DOIUrl":"10.1016/j.jjcc.2025.01.005","url":null,"abstract":"<p><strong>Background: </strong>The social burden of nursing care is increasing with age, particularly for patients with heart failure who often require intensive care. This study aimed to clarify the relationship between nursing care needs and the clinical status of patients with a history of cardiovascular disease, focusing on the benefits of cardiac rehabilitation (CR) in reducing these needs.</p><p><strong>Methods: </strong>This single-gate, multicenter, retrospective observational study included patients of all ages with a history of hospitalization for cardiovascular diseases using government-administered insurance claims and health examination data. Data spanning a four-year period (April 2014 to March 2018) were analyzed, and the effects of CR on nursing care needs and associated factors were examined. Multivariate analysis and propensity score matching were used to adjust for confounding factors, ensuring a robust comparison between CR and non-CR groups.</p><p><strong>Results: </strong>A total of 48,456 patients were enrolled, with an average follow-up of 36.1 months. After propensity score matching, patients who participated in CR demonstrated significantly lower mortality rates and reduced nursing care needs compared to those who did not (0.02 ± 0.13 vs. 0.04 ± 0.20, p < 0.01, 0.94 ± 0.27 vs. base: 1, p = 0.05). CR was associated with improved adherence to medications and increased generic drug prescriptions, contributing to better long-term health outcomes. The adjusted odds ratio for CR in reducing nursing care needs was 0.574 (95 % CI, 0.347-0.948, p < 0.05).</p><p><strong>Conclusions: </strong>This study confirms the potential critical role of CR in reducing mortality and nursing care needs in patients with cardiovascular disease. Although CR did not directly reduce nursing care costs, it contributed to improved health outcomes and reduced dependency on long-term care services. These findings highlight the benefits of CR as a preventive intervention, especially in aging populations. Further research is needed regarding its long-term economic benefits.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excimer LASER coronary atherectomy for ST-segment elevation myocardial infarction: Insights from a multicenter registry.","authors":"Yuji Matsuda, Taishi Yonetsu, Ken Kurihara, Shigeo Shimizu, Daisuke Ueshima, Hiroshi Inagaki, Yuko Onishi, Kaoru Sakurai, Takaaki Tsuchiyama, Takashi Ashikaga, Hiroyuki Fujii, Kazuo Kobayashi, Ikhtiyorjon Khamdamov, Yoshinori Kanno, Takayuki Niida, Yosuke Yamakami, Tomoyo Sugiyama, Tomoyuki Umemoto, Tsunekazu Kakuta, Tetsuo Sasano","doi":"10.1016/j.jjcc.2025.01.008","DOIUrl":"10.1016/j.jjcc.2025.01.008","url":null,"abstract":"<p><strong>Background: </strong>Excimer laser coronary atherectomy (ELCA) is used for thrombotic culprit lesions in ST-segment elevation myocardial infarction (STEMI), but its effectiveness is still unclear.</p><p><strong>Methods: </strong>Consecutive patients undergoing primary percutaneous coronary intervention within 24 h of onset were retrospectively investigated. Patients were divided into ELCA and non-ELCA groups. The primary endpoint was target vessel-related major adverse cardiac events (TV-MACE). Cox regression analysis and propensity score matching were performed to compare clinical outcomes between the two groups.</p><p><strong>Results: </strong>A total of 2593 patients were included in the analysis, with a median follow-up of 815 (390-1385) days. In the total cohort, there was no significant difference between the two groups in terms of TV-MACE-free survival rate. ELCA use was not a significant determinant of TV-MACE (hazard ratio 1.265, 95 % confidence interval, 0.910-1.757; p = 0.161). Nevertheless, when the ELCA group was stratified by the ELCA catheter size, the large catheter (1.4 mm-1.7 mm) group showed a lower event rate compared to the others in univariate analysis, although this difference was not significant in multivariate analysis. In the propensity score-matched cohort of 736 patients (368 pairs), the TV-MACE-free survival did not differ between the two groups.</p><p><strong>Conclusions: </strong>ELCA use was not associated with a reduced rate of adverse cardiac events in patients with STEMI. However, the use of large-sized ELCA catheters showed a potential association with better clinical outcomes, warranting further prospective studies.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface steel ball calibration - A novel method for facilitating fluoroscopic measurement during implantation of WATCHMAN.","authors":"Feng Mao, Yijun Sun, Xianfeng Du, Guohua Fu, Fei Yu, Libin Chen, Yibo Yu, Mingjun Feng, Shengmin Zhang, Huimin Chu","doi":"10.1016/j.jjcc.2025.01.002","DOIUrl":"10.1016/j.jjcc.2025.01.002","url":null,"abstract":"<p><strong>Background: </strong>Although the method of autocalibration or calibration based on catheter diameters was proposed for fluoroscopic measurement during percutaneous left atrial appendage occlusion (LAAO), it may be imprecise and lead to mismeasurement. We sought to investigate whether the utilization of the surface steel ball calibration (SSBC) method under fluoroscopy could facilitate the fluoroscopic measurement of the post-implanted WATCHMAN device (Boston Scientific Corporation, Natick, MA, USA) in LAAO.</p><p><strong>Methods: </strong>This retrospective study included 97 consecutive patients who underwent percutaneous LAAO with the WATCHMAN device. The SSBC method and sheath calibration method under fluoroscopy, and transesophageal echocardiography (TEE) were employed to measure the diameter of the post-implanted device during the LAAO procedure. The results of the three methods were then compared.</p><p><strong>Results: </strong>The success rate for procedural WATCHMAN implantation was 100 %. The mean maximal diameter of the post-implanted devices was 24.7 ± 3.1 mm, 23.5 ± 3.2 mm, and 24.2 ± 3.0 mm, as measured by the SSBC method, sheath calibration method, and TEE, respectively (all p < 0.001). The relevant coefficient of correlation between the SSBC method/TEE, SSBC method/sheath calibration method, and TEE/sheath calibration method, was 0.94, 0.93, and 0.89, respectively (all p < 0.001).</p><p><strong>Conclusion: </strong>The SSBC method, when employed under fluoroscopy, demonstrated a high correlation with the sheath calibration method and TEE for measurements. It may be applied to facilitate fluoroscopic measurements during percutaneous LAAO procedures.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between delirium severity and prognosis following Transcatheter aortic valve implantation.","authors":"Tomohiro Suenaga, Kenichi Ishizu, Shinichi Shirai, Satoru Yoshida, Hayashi Wakugawa, Katsunori Miyahara, Ko Yamamoto, Akira Otani, Norihisa Miyawaki, Kenji Nakano, Euihong Ko, Yu Yoshino, Yasuo Tsuru, Miho Nakamura, Toru Morofuji, Masaomi Hayashi, Akihiro Isotani, Nobuhisa Ohno, Shinichi Kakumoto, Kenji Ando","doi":"10.1016/j.jjcc.2025.01.004","DOIUrl":"10.1016/j.jjcc.2025.01.004","url":null,"abstract":"<p><strong>Background: </strong>Delirium is associated with patient prognosis after transcatheter aortic valve implantation (TAVI). However, the prognostic impact of subsyndromal delirium, described as an intermediate stage between delirium and normal cognition, is uncertain. The present study aimed to investigate the prognostic impact of delirium severity in patients undergoing TAVI.</p><p><strong>Methods and results: </strong>We prospectively assessed the delirium status of 1617 consecutive patients who underwent TAVI at Kokura Memorial Hospital using the Intensive Care Delirium Screening Checklist (ICDSC). The patients were divided into the following three groups: no-delirium [ICDSC score 0, n = 1035 (64.0 %)], subsyndromal delirium [ICDSC 1-3, n = 348 (21.5 %)], and delirium [ICDSC 4-8, n = 234 (14.5 %)] groups. A worse delirium status was associated with older age, higher degree of frailty, and higher prevalence of comorbidities, including atrial fibrillation, dementia, and peripheral arterial disease. At 2 years post-procedure with a clinical follow-up rate of 92.6 %, the cumulative all-cause mortality rate was significantly higher in the subsyndromal delirium (21.8 %) (p < 0.001) and delirium (29.1 %) (p < 0.001) groups than in the no-delirium group (11.9 %). After adjusting for pre- and post-procedural confounders, subsyndromal delirium and delirium were associated with an increased mortality risk [adjusted hazard ratio (HR) for subsyndromal delirium, 1.38; 95 % CI, 1.00-1.90; p = 0.049; adjusted HR for delirium, 1.61; 95 % CI, 1.15-2.17; p = 0.006].</p><p><strong>Conclusions: </strong>Delirium conditions, including delirium and subsyndromal delirium, occurred in more than one-third of patients who had undergone TAVI and were associated with increased mortality.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collaboration between dyspnea clinic and primary care physicians to identify heart failure with preserved ejection fraction in the community: Results from the Maebashi City HF project.","authors":"Naoki Yuasa, Satoshi Ubukata, Ryo Takayanagi, Eiji Yamashita, Keiji Hoshino, Yuta Tani, Takashi Kawashima, Hideki Ishii, Masaru Obokata","doi":"10.1016/j.jjcc.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.01.001","url":null,"abstract":"<p><strong>Background: </strong>Despite increasing awareness in general practice, heart failure with preserved ejection fraction (HFpEF) remains under-diagnosed in the community due to diagnostic difficulties. Dedicated dyspnea clinics are responsible for diagnosing HFpEF and efficient referral from primary care physicians is the key to enhance its role.</p><p><strong>Methods: </strong>This retrospective analysis was performed to assess the effectiveness of a one-year collaborative project between our dyspnea clinic and the Maebashi Medical Association. Primary care physicians were encouraged to screen patients at risk for HFpEF and refer them to the dyspnea clinic, where exercise stress echocardiography was utilized to enhance the identification of HFpEF. To evaluate the clinical value of the project, the data obtained were compared with data from the previous year without collaboration.</p><p><strong>Results: </strong>The collaborative project was conducted between May 2023 and May 2024. The rate of patients referred from the city increased from 47 % during the previous year to 87 % during the collaborative period (p < 0.0001). Most of the patients were referred by non-cardiologists (77 %). The prevalence of HFpEF diagnosis tended to increase from 32 % to 39 % after the collaborative project, while pulmonary causes of dyspnea tended to decrease from 21 % to 12 %. After a thorough evaluation at the dyspnea clinic, 98 % of referred patients were referred back to their referring physicians for further treatment and follow-up.</p><p><strong>Conclusions: </strong>These data suggest the effectiveness of our approach to identify HFpEF in the community through collaboration between the dedicated dyspnea clinic and primary care physicians.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital mortality and risk factors in critically ill patients with hypertrophic cardiomyopathy.","authors":"Zhiyuan Ma, Jamshid Shirani","doi":"10.1016/j.jjcc.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.01.003","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy (HCM) is a common genetic disease with estimated prevalence of 0.2-0.5 %. Contemporary management has substantially improved HCM outcomes. However, the impact of HCM on critically ill patients admitted to intensive care units (ICU) has not been well studied.</p><p><strong>Methods: </strong>Unmatched and propensity score matched patients with or without HCM were examined in the MIMIC-IV database and compared for mortality, morbidity, and length of stay. Multivariable logistic regression was used to identify risk factors associated with in-hospital mortality in patients with HCM.</p><p><strong>Results: </strong>Of 51,926 critically ill patients, 165 (0.32 %) were also diagnosed with HCM. Compared with those without HCM, patients with HCM had higher body mass index, higher rates of heart failure, atrial fibrillation, and chronic renal disease, and more often had implantable cardioverter defibrillators. There were no significant differences in in-hospital mortality (10.3 % vs 10.2 %) or length of stay (9.3 ± 9.6 vs 9.3 ± 1 0.6 days) between the two groups. Similar results were obtained in propensity score matched patients with or without HCM. Univariable analyses identified respiratory failure, sepsis, use of vasopressors, and circulatory support devices as predictors of in-hospital mortality in adults with HCM. In multivariable logistic regression analysis, respiratory failure and use of vasopressors and circulatory support devices were the predictors of in-hospital mortality in HCM patients.</p><p><strong>Conclusions: </strong>Presence of HCM did not affect in-hospital mortality in critically ill patients, but the need for vasopressors and circulatory support devices predicted worse in-hospital mortality among critically ill patients with HCM.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary artery calcification as an incremental predictive risk: Research perspectives in primary prevention.","authors":"Alberto Cereda, Antonio G Franchina, Lorenzo Tua, Matteo Rocchetti, Davide Garattini, Emilia D'Elia, Stefano Lucreziotti","doi":"10.1016/j.jjcc.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.jjcc.2024.12.005","url":null,"abstract":"<p><p>Coronary artery calcium (CAC) score is a neglected biomarker that can be derived from non-cardiac chest computed tomography scan and represents a surrogate for atherosclerosis. We created a simulation model using different CAC score values in the MESA coronary artery risk score in a population derived from the Fourier Trial. CAC score could modulate the sample sizes of cardiovascular trials in primary and secondary prevention and offer new primary prevention treatments to high-risk subjects with reasonable numbers needed to treat comparable to secondary prevention trials.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}