Journal of cardiology最新文献

{"title":"Temporal and geographical trends in anticoagulant therapy and catheter ablation for atrial fibrillation in Japan, 2014-2022.","authors":"Hiroki Sato, Naohiko Takahashi","doi":"10.1016/j.jjcc.2025.07.008","DOIUrl":"10.1016/j.jjcc.2025.07.008","url":null,"abstract":"<p><strong>Background: </strong>In the past decade, treatment of atrial fibrillation (AF) has dramatically changed. Geographical variations and associated factors influencing implementation of anticoagulant therapy and catheter ablation for AF have not been completely elucidated. This study aimed to investigate the temporal and geographical trends in AF treatment and factors associated with the changes in AF treatment in Japan.</p><p><strong>Methods: </strong>In this retrospective observational study, the number of outpatients prescribed direct oral anticoagulants (DOACs), the daily warfarin dosage for outpatient care, and the number of patients who underwent catheter ablation procedures with transseptal puncture (CA-TSP) per 100,000 population across Japanese prefectures from 2014 to 2022 were analyzed using open data from the national database of universal healthcare insurance claims of Japan. The factors influencing the changes in AF treatment from 2014 to 2022 were further assessed.</p><p><strong>Results: </strong>An increase in DOAC prescription and CA-TSP and a decrease in warfarin dosages were observed. It was estimated that over 1.2 % of the Japanese population was prescribed DOACs in 2022. The implementation of anticoagulant therapy and CA-TSP varies geographically. In prefectures with younger populations, the increase in DOAC prescriptions was smaller, the reduction in warfarin dosages was less, and the number of patients who underwent CA-TSP procedures was higher between 2014 and 2022. A higher number of arrhythmia specialists was significantly associated with higher rates of CA-TSP. However, population density and the gross domestic product per capita were not significantly associated with anticoagulant therapy or CA-TSP.</p><p><strong>Conclusions: </strong>A consistent increase in DOAC prescriptions and CA-TSP procedures, along with a decrease in warfarin prescriptions, was observed in Japan between 2014 and 2022. Geographic variations in anticoagulant therapy and CA-TSP in Japan were linked to age distribution. The prevalence of AF in Japan might be increasing more rapidly than anticipated.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and speckle tracking echocardiographic predictors of left ventricular thrombus following primary percutaneous coronary intervention for anterior ST-elevation myocardial infarction.","authors":"Heba M El-Naggar, Alaa A Abdel-Gaber, Yehia T Kishk, Tarek A N Ahmed","doi":"10.1016/j.jjcc.2025.07.007","DOIUrl":"10.1016/j.jjcc.2025.07.007","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular thrombus (LVT) remains a serious complication of acute ST-elevation myocardial infarction (STEMI), mandating timely detection and proper antithrombotic therapy. This study aimed to assess the incidence and possible clinical and echocardiographic predictors of LVT development.</p><p><strong>Methods: </strong>This study prospectively included 300 patients with acute anterior STEMI who underwent primary percutaneous coronary intervention (PPCI). Serial echocardiographic examinations were performed at three time-points post-PPCI: in-hospital, 2-weeks, and 3-months to assess LVT development. LV global (GLS) and regional longitudinal strain (LS) and radial strain were determined. The occurrence of major adverse cardiovascular events (MACE) at three months post-PPCI was reported.</p><p><strong>Results: </strong>The incidence of LVT development was 16.3 %, most of which (51 %) were detected early at the post-PPCI in-hospital echocardiography examination, whereas 22.4 % were detected at 2 weeks and 26.5 % after 3 months post-PPCI. Prior infarction, longer total ischemic time, no or partial ST-segment resolution, and high coronary thrombus grade were significant independent predictors of LVT development. On receiver operating characteristic analysis, baseline GLS ≥ -11.08 % [area under the curve (AUC) = 0.73, 95 % confidence interval (CI) = 0.65-0.81, p < 0.001] and apical LS ≥ -4.9 % (AUC = 0.75, 95 % CI = 0.69-0.82, p < 0.001) showed significant discrimination for LVT. Adjusted for other covariates, impaired baseline apical LS was the only echocardiographic independent predictor of later LVT development at 2 weeks and 3 months post-PPCI. MACE were significantly higher among patients who developed LVT. LVT resolution was achieved in 93.3 % after three months of anticoagulation.</p><p><strong>Conclusion: </strong>Serial echocardiographic studies after acute anterior STEMI improved LVT detection. The occurrence of LVT within three months following PPCI was associated with impaired GLS and apical LS obtained after PPCI.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degree of mitral regurgitation in children with ventricular septal defect after surgical closure: A comparative study with and without mitral valve repair - A retrospective research.","authors":"Wenfeng Li, Mengjie Zhou, Taoyue Yao, Jinqiao Liu, Xicheng Deng","doi":"10.1016/j.jjcc.2025.07.006","DOIUrl":"10.1016/j.jjcc.2025.07.006","url":null,"abstract":"<p><p>In cases of ventricular septal defect (VSD) accompanied by mitral regurgitation (MR), there is a lack of clear guidelines regarding the necessity of concomitant mitral valve repair (MVR) during VSD surgical closure. This study aimed to evaluate the degree of MR in children with VSD after surgical closure, comparing outcomes with and without MVR, to assess the necessity of simultaneous MVR. Between January 2010 and January 2023, pediatric patients with VSD and moderate or severe MR who underwent surgical treatment at Hunan Children's Hospital were enrolled. They were categorized into two groups: Group I (VSD repair only) and Group II (VSD repair with MVR). Clinical and surgical data were collected and analyzed. Follow-up commenced from the date of surgery. The primary endpoint was defined as the resolution of MR to a trivial or none level. Survival curves were plotted using the Kaplan-Meier method, and patient outcomes were monitored to determine the necessity of MVR. In pediatric patients with VSD accompanied by MR, MR often resolves with VSD closure alone in the absence of structural MV defects. However, simultaneous MVR offers significant advantages for patients exhibiting overt mitral valve prolapse, cleft, and mitral annular dilatation.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteome-wide Mendelian randomization and colocalization analyses identify novel protein targets for cardiac conduction disorders.","authors":"Zheng-Qi Song, Yu-Peng Xu, Yi-Qi Chen, Han Zeng, Xiao-Shu Lin, Xin-Yu Lu, Yu-Tao, Si Shi, Yi-He Chen","doi":"10.1016/j.jjcc.2025.07.005","DOIUrl":"10.1016/j.jjcc.2025.07.005","url":null,"abstract":"<p><strong>Background: </strong>The occurrence and progression of cardiac conduction disorder (CCD) pose a significant threat to people's health. However, current pharmacological treatments for CCD are relatively limited, with few mechanistic studies and intervention strategies.</p><p><strong>Methods: </strong>We derived protein quantitative trait loci from two comprehensive databases: UKBPPP and deCODE Health study. Genetic associations with CCD and its subsets were obtained from the FinnGen R11 database. Summary-data-based Mendelian randomization and colocalization analyses were conducted to identify potential protein targets. Phenome-wide association study (PheWAS), multivariable Mendelian randomization (MVMR), and multi-omic analyses were further performed to elucidate the underlying biological mechanisms of the identified protein targets.</p><p><strong>Results: </strong>Genetically predicted CASP9 (OR: 2.65, 95 % CI: 1.65 to 4.26, p_FDR = 0.007) and ASPH (OR: 2.03, 95 % CI: 1.32 to 3.11, p_FDR = 0.024) were significantly associated with a higher risk of atrioventricular block, while genetically predicted SRA1 (OR: 0.54, 95 % CI: 0.39 to 0.75, p_FDR = 0.009) was markedly associated with a lower risk of atrioventricular block. Additionally, the protein CFHR5 (OR: 0.82, 95 % CI: 0.70 to 0.96, p_FDR = 0.157) was linked to a decreased incidence of left bundle branch block with suggestive significance. PheWAS and MVMR analyses suggested that hyperkalemia may serve as a potential mediating pathway between CASP9 and atrioventricular block. Multi-omics analysis revealed several methylation sites of CASP9 linked with atrioventricular block.</p><p><strong>Conclusion: </strong>We identified several novel protein targets for CCD and uncovered their underlying biological processes.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply.","authors":"Toshiaki Isogai, Kojiro Morita, Akira Okada, Hideo Yasunaga","doi":"10.1016/j.jjcc.2025.07.004","DOIUrl":"10.1016/j.jjcc.2025.07.004","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between left ventricular hypertrophy and hemoglobin A1c levels.","authors":"Mayu Sakuma, Yuko Kato, Naomi Hirota, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroto Kano, Shunsuke Matsuno, Shinya Suzuki, Takayuki Otsuka, Junji Yajima, Takeshi Yamashita, Yasuchika Takeishi, Tokuhisa Uejima, Yuji Oikawa","doi":"10.1016/j.jjcc.2025.07.003","DOIUrl":"10.1016/j.jjcc.2025.07.003","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hospitalization-associated disability and all-cause mortality or hospitalizations for heart failure in elderly patients undergoing transcatheter aortic valve replacement.","authors":"Yoshito Arasaki, Yuichiro Toma, Akira Minei, Terumi Hirata, Shuichiro Ikemiya, Morikuni Wakugawa, Nagomi Koyama, Yuya Tamaki, Haruno Nagata, Naoki Yamada, Kojiro Furukawa, Kenya Kusunose","doi":"10.1016/j.jjcc.2025.07.002","DOIUrl":"10.1016/j.jjcc.2025.07.002","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of congestive heart failure on early fluid administration and mortality in patients with sepsis.","authors":"Zhiyuan Ma, Mahesh Krishnamurthy, Vikas Yellapu, Eluwana Amaratunga, Peter Puleo, David Allen, Jamshid Shirani","doi":"10.1016/j.jjcc.2025.07.001","DOIUrl":"10.1016/j.jjcc.2025.07.001","url":null,"abstract":"<p><strong>Background: </strong>Congestive heart failure (CHF) may increase the risk of volume overload and mortality in patients with sepsis, potentially complicating fluid resuscitation-a cornerstone of sepsis management. We aimed to assess whether pre-existing CHF is associated with excess mortality and different fluid administration patterns in intensive care unit patients with sepsis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the MIMIC-IV database of critically ill adults with sepsis. Multivariable logistic regression and propensity score matching were used to compare in-hospital mortality and fluid resuscitation between patients with and without CHF. Generalized additive models assessed the relationship between fluid volume and mortality.</p><p><strong>Results: </strong>Among 24,376 patients with sepsis, 6838 (28.1 %) had CHF. CHF was associated with higher in-hospital mortality (14.3 % vs. 9.8 %, p < 0.001) and lower 24-hour fluid volume (median 1936 mL vs. 3037 mL, p < 0.001). Adjusted odds of mortality were higher in CHF patients (OR 1.25, 95 % CI 1.14-1.37; p < 0.001). A U-shaped association between fluid volume and mortality was observed in non-CHF patients, with the lowest mortality at ~60 mL/kg. In CHF patients, high fluid administration did not improve survival, while restrictive strategies increased mortality.</p><p><strong>Conclusions: </strong>Pre-existing CHF is linked to higher mortality in sepsis. Adequate fluid administration improved mortality in those without CHF, while in CHF patients, neither liberal nor restrictive fluid administration showed a clear mortality benefit.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valve in valve transcatheter versus redo surgical replacement of a failing surgical bioprosthetic aortic valve: An updated systematic review and meta-analysis.","authors":"Kyriakos Dimitriadis, Nikolaos Pyrpyris, Konstantinos Aznaouridis, Stergios Soulaidopoulos, Georgios Koutsopoulos, Eirini Beneki, Fotis Tatakis, Eleni Adamopoulou, Panagiotis Tsioufis, Chiara DeBiase, Dejan Milasinovic, Ole De Backer, Maarten Vanhaverbeke, Konstantina Aggeli, Konstantinos Tsioufis","doi":"10.1016/j.jjcc.2025.06.022","DOIUrl":"10.1016/j.jjcc.2025.06.022","url":null,"abstract":"<p><strong>Background: </strong>With the aging population, degeneration of surgical aortic valves is an important clinical scenario. Currently, in most European countries, both redo surgery [redo-surgical aortic valve replacement (SAVR)] and valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) are established alternatives for treating such patients. This meta-analysis aims to compare redo-SAVR and ViV-TAVI for treating a failing bioprosthetic aortic valve.</p><p><strong>Methods: </strong>A systematic search was performed from inception to June 2023. After selecting all appropriate trials according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a random effect meta-analysis was performed. Clinical and echocardiographic outcomes were compared among the groups.</p><p><strong>Results: </strong>Twenty-six studies with a total of population of 17,581 patients were included [ViV-TAVI (n = 9163) or redo-SAVR (n = 8418]. ViV-TAVI was associated with lower 30-day mortality (RR: 0.55; 95%CI: 0,47 to 0,66) and 1-year mortality (RR: 0.85; 95%CI: 0.75 to 0.96), major bleeding events (RR: 0.58; 95%CI: 0.42-0.79), and a trend towards lower new pacemaker implantations (RR: 0.70; 95%CI: 0.49-1.01) at 30 days. On the other hand, ViV-TAVI resulted in a higher mean transprosthetic gradient and higher rates of severe patient-prosthesis mismatch (RR: 1.64; 95%CI: 1.01 to 2.65) and paravalvular leak (RR: 2.44; 95%CI: 1.73-3.45) as compared to redo-SAVR. No significant difference was observed in 30-day myocardial infarction (RR: 0.90; 95%CI: 0.56 to 1.46) or stroke (RR: 0.77; 95%CI:0.55 to 1.06).</p><p><strong>Conclusion: </strong>ViV-TAVI has a satisfying safety profile with better short-term survival outcomes as compared to redo-SAVR. However, adequate pre-procedural planning of VIV-TAVI cases is needed, in order to minimize the risk of a suboptimal hemodynamic outcomes following ViV-TAVI.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis and risk of aortic stenosis in Japanese elderly: A population-based nested case-control study.","authors":"Takuya Uematsu, Yusuke Hirabuki, Shuko Nojiri, Yuji Nishizaki","doi":"10.1016/j.jjcc.2025.06.019","DOIUrl":"10.1016/j.jjcc.2025.06.019","url":null,"abstract":"<p><strong>Background: </strong>Aortic stenosis (AS), a common condition among older adults, is caused by aging and calcium metabolism, and its association with osteoporosis has garnered attention. However, the relationship between AS and osteoporosis has not been consistent across studies in Japan and globally. This study aimed to investigate the association between osteoporosis and AS in the older adult population in Japan.</p><p><strong>Methods: </strong>We conducted a nested case-control study using an administrative database in Japan comprising 1.16 million individuals. Cases and controls were matched 1:1 based on age and sex. A conditional logistic regression model was employed for estimating the adjusted odds ratio of osteoporosis for AS, along with its 95 % confidence interval (CI), after adjusting for covariates.</p><p><strong>Results: </strong>Overall, 8136 cases of AS and 8136 controls aged 65 years were identified. After adjusting for covariates, the odd of exposure to osteoporosis for AS was 0.887 (95 % CI, 0.778-1.01), indicating no significant association between the two conditions. However, significant associations were observed for diabetes mellitus, chronic kidney disease, hypertension, and dyslipidemia. Additionally, the use of diuretics, particularly in the late elderly, was significantly associated with AS.</p><p><strong>Conclusions: </strong>The findings of this study, based on real-world data involving over one million individuals, revealed no association between AS and osteoporosis. Future research should further clarify the impact of diuretics on AS and perform a comprehensive analysis considering other factors related to the relationship between AS and osteoporosis.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}