Journal of Cardiology & Current Research最新文献

{"title":"New proposals for diagnosis and treatment of the chronic period without demonstrable pathology of Chagas disease","authors":"L. Giménez, J. Mitelman","doi":"10.15406/JCCR.2018.11.00409","DOIUrl":"https://doi.org/10.15406/JCCR.2018.11.00409","url":null,"abstract":"Introduction Pathophysiology Intervening factors in the development of cardiomyopathy 1. Intrensic myocardial damage during the acute and chronic phase because of: a) Direct parasitic action. b) Immunological disturbances. c) Neurological damage. 2. Induced disorders due to the host immune response. 3. Alterations in the automatic nervous system. 4. Microvascular lesions with alterations in the microcirculation and subsequent myocytolysis.1 Our research group proposes a score of clinical outcomes, with validated studies and proposed treatment for subclinical lesions (autonomic, endothelial anatomical) early to prevent the development of Chagas cardiomyopathy. Integrated Score is to detect early alterations that would lead to the development of cardiac complications in chronic patients without proven pathology. Risk analysis With the approach of the disease using tools and diagnostic tests sufficiently validated and according to the association between them, it is determined to follow up the most committed patients and use different therapies according to the damage found. It is important to note that other studies may be used to detect subclinical lesions that have the same kind of recommendation and the same level of evidence used in this score. We believe that the persistence of the parasite in the infected organism would not be the only mechanism that would have a determinate role in the development of the pathogenesis of the illness and consequently even a successful etiological treatment would not be able to avoid the development of the terminal lesions characterized by the disease (Table 1).2,3","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"11 1","pages":"243-244"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88200879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk and BDNF concentration in vegetarians in the city of Sao Paulo – SP","authors":"Carolina Vieira de Mello Barros Pimentel, E. Teodorov, Viviane Lazari Simomura Viviane Lazari Simomura, M. Rogero, S. Philippi","doi":"10.15406/jccr.2019.12.00457","DOIUrl":"https://doi.org/10.15406/jccr.2019.12.00457","url":null,"abstract":"","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86355052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial hypercholesterolemia: clinical pearls","authors":"Y. M. Hydoub","doi":"10.15406/jccr.2019.12.00454","DOIUrl":"https://doi.org/10.15406/jccr.2019.12.00454","url":null,"abstract":"FH, in its commonest type, is due to an autosomal dominant defect in the genes encoding for proteins involved in LDL metabolism. There are autosomal recessive variants, but these are much less common.3 Patients can have a homozygous or a heterozygous defect, which will determine the severity of the disease and the age of onset of CV disease manifestations. The three main genetic defects that lead to FH are defects in the LDL receptor gene (most common), apolipoprotein B-100 (ApoB-100) gene4, and proprotein convertase subtilisin/Kexin type 9 (PCSK9) gene.5 These three mutations account for 60 to 80 percent of patients with definite FH.6 Other mutations, like the signaltransducing adaptor family member 1 (STAP1) gene mutation, have been reported to be associated with FH.7","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79786396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood transfusion in major non-emergency surgery: The urgent necessity to significantly decrease its indication","authors":"O. Centurión,  Juan Diosnel Cáceres","doi":"10.15406/jccr.2019.12.00452","DOIUrl":"https://doi.org/10.15406/jccr.2019.12.00452","url":null,"abstract":"Lammi JP et al.14 studied the use of blood transfusions in 1404 patients undergoing pancreatic resections in Finland. The authors tried to improve and unify blood transfusion (BT) policies in order to decrease and optimize the use of blood products. They found no differences among high, medium and, low-volume centers in BT utilization, trigger points or the use of reserved blood units after pancreatoduodenectomy or total pancreatectomy. Although, only minor changes in BT trends were found, the lowering of the transfusion trigger point and the best use of reserved blood units occurred only in high-volume centers.14 This is already a plausible finding since there is compelling evidence indicating that BT is excessive and sometimes unnecessary worldwide. Nearly 14million units of blood are donated annually in the USA, and about 4million people receive BT every year.15,16 Blood transfusion administration in surgical and critical care settings varies between 30-100% of patients. Lammi JP et al.14 observed that 65.9% of their study patients received BT. The mean number of red BT units was 5.22/patient (1.9–8.76). The mean trigger point for BT was an Hb level of 8.6g/dL. The mean percentage of blood units used out of the reserved red blood was 63.4%. We can see that the percentage of BT is still elevated, the trigger Hb level and the utilization of reserved blood units is also high. Although, the authors did not mention BT related complications in their study, the utilization of reserved blood is strongly associated to ischemic complications. Stored red blood cells are known to have decreased 2,3 DPG in the cell membrane, hence, they are less deformable, less likely to deliver oxygen to the tissues, and with greater tendency to produce capillary obstruction.16 On the other hand, the mechanisms responsible for the increased incidence of infectious complications are due to the immunosuppressive effects of BT. Administration of blood products causes profound negative effects on the human immune system, a condition termed transfusion-related immune modulation.17 Another reason to decrease BT is the fact that blood donations have significantly diminished mainly because of decreasing number of qualified donors.18 This fact has resulted in a shortage of blood supply in blood banks worldwide which makes it necessary to seek out new treatment options.19 Although, alternatives to BT and other treatment options exist, they are seldom utilized.","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74424570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homocysteine can induce calcific aorta valve stenosis with or without coronary artery disease in the elderly surgical and medical measures","authors":"F. Cacciapuoti","doi":"10.15406/jccr.2019.12.00453","DOIUrl":"https://doi.org/10.15406/jccr.2019.12.00453","url":null,"abstract":"","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90549173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct and Interactive Associations of Self-Efficacy and Social Support with Anxiety and Depression in Cardiovascular Patients","authors":"","doi":"10.36879/jcr.19.000123","DOIUrl":"https://doi.org/10.36879/jcr.19.000123","url":null,"abstract":"The objectives of the study were twofold: i) perceived social support and self-efficacy would negatively predict depression and anxiety in\u0000Cardiovascular Diseases (CVD) patients; and ii) self-efficacy would moderate the association of perceived social support with anxiety and\u0000depression in CVD patients. There were 174 CVD patients (ages 19- 60 years) selected from cardiac units of government sector hospitals. They\u0000were assessed from self-report scales of self-efficacy, social support, anxiety and, depression. The results from correlation and regression analyses\u0000showed that only friend’s social support was a negative predictors of anxiety, and friend’s and significant other’s support were negative predictors of\u0000depression. Additionally, self-efficacy was a stronger negative predictor of both the anxiety and depression after controlling the effects due to social\u0000support. Finally, self-efficacy moderated the associations of friend’s and significant other’s support with anxiety and depression. It was concluded\u0000that self-efficacy and social support are significant positive resources for better mental health of CVD patients.","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77299950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of left ventricular systolic dysfunction after 6 months of aortic valve replacement in patients with chronic severe aortic regurge ","authors":"M. Gouda, A. Ammar, Mohammad Hassan, MF Abdel-Alwahab","doi":"10.15406/jccr.2019.12.00451","DOIUrl":"https://doi.org/10.15406/jccr.2019.12.00451","url":null,"abstract":"","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81634051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Risk Scores for the Prediction of Outcomes after Surgery for Acute Type A Aortic Dissection","authors":"","doi":"10.36879/jcr.19.000122","DOIUrl":"https://doi.org/10.36879/jcr.19.000122","url":null,"abstract":"We compared the performance of four existing risk models and a newly developed risk score for type A acute aortic dissection surgery. In 327\u0000consecutives with type A aortic dissection surgery patients during 2003/03-2017/03 at our centre, operative mortality occurred in 65 (19.9%).\u0000Independent predictors of operative mortality were critical pre-operative state and malperfusion syndrome, and a novel additive “CritMal” Score\u0000was constructed from this. C-statistics (95% confidence interval) for operative mortality were EuroSCORE 0.60 (0.52-0.67), EuroSCORE II 0.64\u0000(0.57-0.72), Rampoldi 0.68 (0.59-0.76), Leontyev 0.56 (0.48-0.64), and CritMal 0.72 (0.64-0.80) respectively. This is the first study externally\u0000assessing surgical scores for aortic dissection surgery, with modest accuracy for all and moderate for CritMal. There is room for improvement of\u0000these risk models, and further refinements and external validation are warranted for clinical application.","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83031767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of H11 Kinase in the Failing Left Ventricular Myocardium","authors":"","doi":"10.36879/jcr.19.000121","DOIUrl":"https://doi.org/10.36879/jcr.19.000121","url":null,"abstract":"Background: Increased expression of H11 kinase (H11K) has been observed in Left Ventricular (LV) myocardium of failed human hearts. Its\u0000potential role as a contributor to the progression of Heart Failure (HF) remains uncertain. In the present study we examined the expression of H11K\u0000in cytosolic and mitochondrial fractions of failing human and dog LV myocardium and assessed its interaction with Akt (cell-survival enzyme) and\u0000p38MAPK (programmed cell death enzyme).\u0000Methods: Total RNA and Sodium-Dodecyl Sulfate (SDS) extracts were prepared from homogenate of LV specimens of 6 dogs with intracoronary\u0000microembolization-induced HF, 6 normal (NL) dogs, 7 explanted failed human hearts due to Idiopathic Dilated Cardiomyopathy (IDC), 7 failed\u0000human hearts due to Ischemic Cardiomyopathy (ICM) and 7 non-failing human donor hearts (DNR). SDS extracts were also prepared from\u0000cytosolic and mitochondrial fractions isolated from LV specimens.\u0000Results: H11K mRNA and protein levels normalized to GAPDH increased significantly in LV tissue from ICM and IDC hearts compared to DNR\u0000hearts and in HF dogs compared with NL dogs. H11K protein levels increased in cytosolic fractions but decreased in mitochondrial fractions of\u0000both failed human and dog hearts compared to DNR hearts and NL dog hearts. Immunoprecipitation studies in specimens from HF dogs showed\u0000that H11K cytosolic fractions interacted predominantly with p38MAPK and least with Akt when compared with NL dogs.\u0000Conclusions: Enhanced interaction of H11K with p38MAPK in HF can promote cell death thus contributing to progressive LV dysfunction.\u0000Therapeutic modalities that restore interaction of H11K with Akt and augment H11K translocation to mitochondria can potentially and partially\u0000reverse the progression of LV dysfunction by promoting cell survival.","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89171576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There any Relation between Blood Groups and Flu Treatment with or without Medication?","authors":"","doi":"10.36879/jcr.19.000120","DOIUrl":"https://doi.org/10.36879/jcr.19.000120","url":null,"abstract":"Influenza virus is an RNA enveloped virus and consists neuraminidase, hemagglutinin and matrix protein. Each component has own role to lead\u0000infection. Different methods especially reverse transcription PCR is more appropriate to diagnose influenza. ABO blood group system is most\u0000common methods among 33 blood group system. It helps to check compatibility between donor and recipients especially in blood transfusion and\u0000transplantation. By using blood group determining kit we checked which type of blood group is in all blood samples. Antibody serum A, B and\u0000D helped to determine blood group via displaying agglutination in respective portions. B+ is observed commonly 42% males and 21% females\u0000shown B+ blood while they did not prefer medication for flu treatment. AB- is not observed in collected sample and moreover B- and A- is also least\u0000common. There is not any prominent relationship between type of blood group and treatment of flu with or without medication.","PeriodicalId":15200,"journal":{"name":"Journal of Cardiology & Current Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74839587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}