Journal of Biomimetics, Biomaterials and Tissue Engineering最新文献

{"title":"Damping Micromechanisms for Bones above Room Temperature","authors":"O. Lambri, J. Pérez-Landazábal, F. G. Bonifacich, V. Recarte, M. L. Lambri, G. Zelada, F. Tarditti, D. Gargicevich","doi":"10.4028/www.scientific.net/JBBTE.19.87","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.19.87","url":null,"abstract":"The wide damping maximum which is reported to appear in bones, involving both cortical and cancellous parts, between around 280 K and 420 K; has been determined to be a composition of different processes taking place at different temperatures in cancellous and cortical parts. In fact, in the present work the mechanical response of cow ribs bones has been analysed by coupling mechanical spectroscopy, differential scanning calorimetry, thermogravimetry and scanning electron microscopy studies. Cancellous part develops two damping maxima at around 320 K and 350 K. Cortical part exhibits a wide maximum in damping between around 310 K and 410 K and another damping relaxation between 390 K and 410 K. The physical-chemical driving force giving rise to the above relaxation processes are discussed.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"10 1","pages":"87 - 98"},"PeriodicalIF":0.0,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89408255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative In Vivo Study of Biocompatibility of Apatites Incorporated with 1% Zinc or Lead Ions versus Stoichiometric Hydroxyapatite","authors":"Bruno Giorno, Igor Iuco Castro‐Silva, A. Malta Rossi, J. Granjeiro","doi":"10.4028/www.scientific.net/JBBTE.19.109","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.19.109","url":null,"abstract":"Hydroxyapatite is the main ceramic material that has being used in bone repair, although its physico-chemical and in vivo behavior should be better understood. A method to improve the biocompatibility of HA is the substitution of calcium with divalent cations which enhance mechanic resistance and can modulate inflammatory response against implanted material. In this study we analyzed the biocompatibility of HA doped with one per cent of Zn2+ or Pb2+. The first one has being described as an inflammation modulator and the second would be a model for chronic toxicity assay. Biocompatibility of the both materials was studied in vivo following the ISO 10993-6 standard. HA cylinders (ZnHA, PbHA and stoichiometric HA as positive control) were implanted into subcutaneous tissue of 45 Balb-c mice and after 1, 3 and 9 weeks the animals were euthanized (5 for each experimental condition). Necropsies of the skin containing reactional tissue were removed, fixed in 10% formaldehyde and followed the histological processing for paraffin embedding and staining with Hematoxylin-Eosine and Picrosirius red. Microscopic analysis showed for all groups moderate inflammatory response, decreasing throughout the experimental periods, with ZnHA group showing more intense response. Similar presence of macrophages, fibrosis and angiogenesis were observed among the groups. Thereby, we can conclude that ZnHA and PbHA are biocompatible and not bioresorbable, being the ZnHA potentially indicated as bone graft. Detailed studies are required to better understand the role of PbHA as chronic model for lead toxicity.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"24 1","pages":"109 - 120"},"PeriodicalIF":0.0,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82990058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graft Materials in Oral Surgery: Revision","authors":"Xavier Rosello Labres, A. Camps, E. J. Salas, R. Albuquerque, E. V. Ortega, J. López‐López","doi":"10.4172/1662-100X.1000124","DOIUrl":"https://doi.org/10.4172/1662-100X.1000124","url":null,"abstract":"Oral implantology is a common procedure in dentistry, especially for fully or partially edentulous patients. The implants must be placed in the best location from both the aesthetic and functional point of view. Because of this it is increasingly more frequent to resort to regeneration techniques that use substitutes of the bone itself, in order to be able to insert the implants in the most appropriate location. \u0000Material and Methodology: A review was performed on the literature from the last ten years based on the following search limitations: “graft materials\", \"allograft\", \"xenograft\", \"autologous graft” and \"dentistry”. \u0000Results: 241 works were obtained that after reading their respective summaries, they were reduced to 38, and 9 previous works were included in order to summarize the concepts. \u0000Discussion: Autologous grafts are the \"gold standard\" of the bone regeneration. They have obvious advantages, but they also have drawbacks. This is why allogeneic and xenogeneic tissues are used. The former because of their clear similarity with the recipient's tissue and the latter due to their wide availability. Given that these grafts also have drawbacks, the industry has developed synthetic materials that have properties similar to those of human bone tissue. However, as of today, the ideal material to substitute human bone has not yet been found. In recent years the tendency has been to combine these synthetic materials with the patient's own bone, which is extracted during drilling in implant placement, with bone marrow aspiration, or with bone morphogenetic proteins. Thus the intention is to equip these substances with the osteogenic capacity. \u0000Conclusions: There is currently no ideal graft material, with the exception of those materials that come directly from the patient. We hope that in the coming years we will have products that will allow us to perform rehabilitations with better results and provide a better quality of life for our patients, especially those who have more complex situations to resolve, like the patients that are operated on for head and neck cancer.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74556340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Vague Set Based Model for Regional Blood Supply and Demand Balance Adjustment","authors":"M. Zhu, Hussain Hy, J. Wang, Zheng Zw","doi":"10.4172/1662-100X.1000122","DOIUrl":"https://doi.org/10.4172/1662-100X.1000122","url":null,"abstract":"For the collection and clinical usage quantities of regional blood changing randomly, it is hard to efficiently adjust regional blood supply and demand balance extent with quantitative way. To solve this problem to some extent, a vague set based adjustment model is proposed. Blood stock level of regional blood center being chosen as expressing indicator and the ideal blood stock level interval as criteria, and considering the fuzzy characters of the indicator being subject to its criteria interval, vague set similarity measure function is applied to found a vague set based measure function for regional blood supply and demand balance extent. With the introduction of adjustment factor, derived from the measure \u0000function, an adjustment model for regional blood supply and demand balance is established. With the application of the model, and referring to the literature published blood stock operation data of several regional blood centers in China, a determination method of the aimed lower and upper limit of blood center stock control level is obtained. The aimed lower and upper limit of blood center stock control level can be an operable reference to blood center stock operation, which is helpful for regional blood center to effectively manage its blood stock level according to different regional blood supply and demand balance goal.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"355 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84880836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the Skeletal System of Bound Foot: A Case Study","authors":"Y. Zhang, Liebolt Fl, W. Shen, J. S. Li, X. Ren, Yaodong Gu","doi":"10.4172/1662-100X.1000120","DOIUrl":"https://doi.org/10.4172/1662-100X.1000120","url":null,"abstract":"The purpose of this study was to establish the character of skeletal system of bound foot with binding deformity. Medical images were taken with a slice distance of 1mm from CT equipment. 3D models of bound foot were developed using density segmentation techniques through Mimics software. The talocalcaneal angle, calcaneal-first metatarsal angle, talo-first metatarsal angle, hallux valgus angle, I-II inter-metatarsal angle, I-V inter-metatarsal angle, first cuneiform-metatarsal angle, the horizontal metatarsal angle and the length of five metatarsals were evaluated on the lateral and antero posterior view. The results showed that bound foot have great deformation on the second to fifth toe, forming the abnormal higher foot longitudinal arch. The potential formation process of foot deformity associated with the binding process and its influence on the daily life of the foot binding subjects is discussed.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"732 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91269761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Marrow Derived Connective Tissue Progenitor Cell Responses on Microtextured Substrates with Controlled Mechanical Cues","authors":"E. J. Kim, A. Mata, A. Fleischman, G. Muschler, Shuvo Roy","doi":"10.4172/1662-100X.1000121","DOIUrl":"https://doi.org/10.4172/1662-100X.1000121","url":null,"abstract":"The relationship between mechanical and topographical features of tissue engineering scaffolds and the likely response of human adult stem cells was investigated by a simple, yet powerful in vitro model, based on varying substrate stiffness with the precise and reproducible patterning capabilities of micro fabrication techniques. Polydimethylsiloxane (PDMS) pre-polymer and cross-linker were combined at various weight ratios designated as PDMS-a to PDMS-e, corresponding to 5.7, 10.0, 14.3, 21.4, and 42.9 wt. % cross-linker, respectively. PDMS microtextures with 10 μm diameter and 6 μm height microposts were produced using soft lithography and correlated to preferential human bone marrow derived connective tissue progenitor cells (CTPs) behavior as a function of varying stiffness. To investigate cell proliferation and osteogenic differentiation, CTPs were cultured for 30 days on a topographical map of substrates that combines 3 different types of PDMS microtextures and smooth PDMS. Elastic modulus, which is directly related to stiffness, increased from 0.78 ± 0.25 MPa (PDMS-a) to 2.83 ± 0.26 MPa (PDMS-c), and decreased down to 1.66 ± 0.18 MPa (PDMS-e). The cell number and gene expression levels were proportional to the PDMS stiffness, and PDMS microtextures exhibited greater numbers of CTPs compared to smooth PDMS. Alkaline phosphatase expressed greater on post microtextures than smooth surfaces on early days. Regardless of surface topographies, however, cells on PDMS-b consistently expressed more osteocalcin compared on other substrates on day 30. These results indicate that CTP proliferation and early osteogenic differentiation are more likely to be affected by surface microtextures, while substrate stiffness is more likely to influence the late osteogenic differentiation.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73045873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Classification by Feature Discretization and Optimization for fNIRS-based BCI","authors":"Baolei Xu, Yunfa Fu, G. Shi, Xuxian Yin, Zhidong Wang, Hongyi Li","doi":"10.4172/1662-100X.1000119","DOIUrl":"https://doi.org/10.4172/1662-100X.1000119","url":null,"abstract":"In this paper, we present a signal discretization and feature selection method to improve classification accuracy for fNIRS based brain computer interface (BCI) system, which can classifiy right hand clench force motor imagery and clench speed motor imagery at an accuracy of 69%-81% through 5 fold cross validation in 6 subjects. Difference between oxyhemoglobin and deoxyhemoglobin (we abbreviate this difference as HbD) is proposed as a new feature type and shows outstanding performance in some subjects. Linear kernal support vector machine (SVM) classification between clench force motor imagery and clench speed motor imagery using four concentration feature types (oxyhemoglobin, deoxyhemoglobin, totalhemoglobin, and HbD) is implemented. Our results demonstrate that feature discretization using Chi2 algorighm and feature optimization using ‘MIFS’ (Mutual Information Feature Selection) criterion can improve the classification accuracy by more than 35%. Except total hemoglobin, all the other three feature types can be used as the optimum feature for different subjects. The results of this paper can also be used in online BCI applications.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79337486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogels as Biomaterials – How Long More is the Road Ahead?","authors":"Loh Xian Jun","doi":"10.4172/1662-100X.1000E104","DOIUrl":"https://doi.org/10.4172/1662-100X.1000E104","url":null,"abstract":"","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"137 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86475685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Biomimetic Scaffolds for Tissue Engineering","authors":"Xing Zhang","doi":"10.4172/1662-100X.1000E103","DOIUrl":"https://doi.org/10.4172/1662-100X.1000E103","url":null,"abstract":"Volume 18 • Issue 2 • 1000e103 J Biomim Biomater Tissue Eng ISSN: 1662-100X Biochem, an open access journal Tissue engineering is crucially important to help restore or enhance tissue and organ functions by employing a combination of cells, biological scaffolds and growth factors. A proper microenvironment is critical to guiding cells to assemble de novo functional tissues following their in vivo developmental processes. A biomimetic scaffold is key to construction of such a microenvironment, which should not only provide the temporary support for cells, but also elucidate proper cellmatrix interactions.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90425635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Application of Tissue Engineering to Cancer Biology","authors":"S. Lal","doi":"10.4172/1662-100X.1000E102","DOIUrl":"https://doi.org/10.4172/1662-100X.1000E102","url":null,"abstract":"","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74660995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}