Baolei Xu, Yunfa Fu, G. Shi, Xuxian Yin, Zhidong Wang, Hongyi Li
{"title":"Improving Classification by Feature Discretization and Optimization for fNIRS-based BCI","authors":"Baolei Xu, Yunfa Fu, G. Shi, Xuxian Yin, Zhidong Wang, Hongyi Li","doi":"10.4172/1662-100X.1000119","DOIUrl":"https://doi.org/10.4172/1662-100X.1000119","url":null,"abstract":"In this paper, we present a signal discretization and feature selection method to improve classification accuracy for fNIRS based brain computer interface (BCI) system, which can classifiy right hand clench force motor imagery and clench speed motor imagery at an accuracy of 69%-81% through 5 fold cross validation in 6 subjects. Difference between oxyhemoglobin and deoxyhemoglobin (we abbreviate this difference as HbD) is proposed as a new feature type and shows outstanding performance in some subjects. Linear kernal support vector machine (SVM) classification between clench force motor imagery and clench speed motor imagery using four concentration feature types (oxyhemoglobin, deoxyhemoglobin, totalhemoglobin, and HbD) is implemented. Our results demonstrate that feature discretization using Chi2 algorighm and feature optimization using ‘MIFS’ (Mutual Information Feature Selection) criterion can improve the classification accuracy by more than 35%. Except total hemoglobin, all the other three feature types can be used as the optimum feature for different subjects. The results of this paper can also be used in online BCI applications.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79337486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of Biomimetic Scaffolds for Tissue Engineering","authors":"Xing Zhang","doi":"10.4172/1662-100X.1000E103","DOIUrl":"https://doi.org/10.4172/1662-100X.1000E103","url":null,"abstract":"Volume 18 • Issue 2 • 1000e103 J Biomim Biomater Tissue Eng ISSN: 1662-100X Biochem, an open access journal Tissue engineering is crucially important to help restore or enhance tissue and organ functions by employing a combination of cells, biological scaffolds and growth factors. A proper microenvironment is critical to guiding cells to assemble de novo functional tissues following their in vivo developmental processes. A biomimetic scaffold is key to construction of such a microenvironment, which should not only provide the temporary support for cells, but also elucidate proper cellmatrix interactions.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90425635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Advances in Application of Tissue Engineering to Cancer Biology","authors":"S. Lal","doi":"10.4172/1662-100X.1000E102","DOIUrl":"https://doi.org/10.4172/1662-100X.1000E102","url":null,"abstract":"","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74660995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomimetic Scaffold Materials Used in Tissue Engineering","authors":"E. Kolos, A. Ruys","doi":"10.4172/1662-100X.1000E101","DOIUrl":"https://doi.org/10.4172/1662-100X.1000E101","url":null,"abstract":"Tissue engineering offers a novel route for repairing damaged or diseased tissue by incorporating the patient’s own healthy cells or donated cells into temporary scaffolds that act as a matrix for cell cultivation. The structure and properties of these scaffolds must be selected to ensure normal cell behaviour and performance of the cultivated tissue. The tissue scaffolds support cellular growth and activity both before implantation and during remodelling of surrounding tissue after implantation.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75410030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandro Bittencourt Sousa, Igor Iuco Castro‐Silva, Lawrence Andrade Costa da Rocha Coutinho, Ariel Lenharo, J. Granjeiro
{"title":"Osteoconduction and Bioresorption of Bone Allograft versus Anorganic Bovine Bone Xenograft: A Histomorphometric Study in Humans","authors":"Sandro Bittencourt Sousa, Igor Iuco Castro‐Silva, Lawrence Andrade Costa da Rocha Coutinho, Ariel Lenharo, J. Granjeiro","doi":"10.4028/www.scientific.net/JBBTE.18.85","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.18.85","url":null,"abstract":"This clinical study evaluated the tissue repair process using different bone grafts. Nine dental patients with indication for posterior implantodontic treatment were submitted to maxillary sinus lifting procedures associated to grafting. After 6 months, bone biopsies (6 sites with allogenous bone grafting and 13 sites with bovine xenogenous bone grafting/OsseusTM) were removed and processed for histopathological and histomorphometric analyses (ANOVA and Tukey's test). Both groups had tissue biocompatibility without significant inflammatory response, only punctual presence of multinucleated giant cells in xenograft group. Osteoconductive potential was evidenced by new bone tissue surrounding and in direct contact with the granules of both grafts. Volume density of connective tissue was similar between groups, although there were significant differences in allograft group in comparison to xenograft as the presence of new bone formation (48.50%±13.93 versus 29.83±9.56, respectively, p<0.05) and remnant biomaterial (1.57±2.39 versus 22.23±12.41, respectively, p<0.001), suggesting a greater osteoconductivity and faster bioresorption in the allograft group. These results demonstrate that allogenous bone and OsseusTM can be satisfactorily used as grafts in minor oral surgeries for bone augmentation in humans.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"45 1","pages":"85 - 95"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77440691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2","authors":"F. Y. Zhou, A. Wei, A. Diwan","doi":"10.4028/www.scientific.net/JBBTE.18.97","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.18.97","url":null,"abstract":"Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"53 1","pages":"118 - 97"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77011008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Venation-Inspired Growth Technique for Stiffener Layout Design of Plate and Shell Structures","authors":"Kai Xue, Lei Li, Q. Li","doi":"10.4028/www.scientific.net/JBBTE.18.1","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.18.1","url":null,"abstract":"A novel design method for stiffener layout of plate and shell structures is proposed in this paper. The method is inspired by the morphogenesis mechanism of dicotyledonous venation which is featured by hierarchy and functional adaptivity. It is expected that a optimal stiffener layout can be gradually achieved if the stiffeners extend by obeying a similar growth rule as the venation. Starting from the so called “seeds”, the stiffeners grow and branch off towards the direction that optimizes the structural performance. And the stiffeners with the minimum effectiveness to the structural performance are degenerated simultaneously. During the design process, the relative density of each element is treated as the design variable. The growth and degeneration of the stiffeners are determined by the nodal and elemental sensitivity numbers respectively. The design algorithm is programmed in Python and integrated with Abaqus software which is used as the FEA preprocessor and solver. To validate the effectiveness of the proposed method, it is applied to design the stiffener layouts of some typical structures with the objective of maximizing the overall stiffness with a volume constraint.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"38 1","pages":"1 - 12"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81006452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zou Feng, Zhang Shangkun, Li Yan, Chen Ying, Li Lijiang
{"title":"miR-143 is Associated with ER-α36 Expression Gastric Carcinoma of Xenografted Model","authors":"Zou Feng, Zhang Shangkun, Li Yan, Chen Ying, Li Lijiang","doi":"10.4172/1662-100X.1000117","DOIUrl":"https://doi.org/10.4172/1662-100X.1000117","url":null,"abstract":"We investigated the expression profile of microRNA (miRNA) in ER-α36-mediated transplantable tumours. SGC7901 cell lines of higher or lower ER-α36 expression were constructed with a lentivirus vector. Five million SGC7901 cells were injected into nude mice to form a gastric xenografted carcinoma in the subcutaneous tissue of nude mice. Observation was performed for 30 days. The weight and propagation of the tumours were determined. miRNA expression profiles of the three SGC7901 cell lines were analysed by miRNA microarray. miR-143 expression in transplantable tumours was determined by real-time PCR using TaqMan assay. The expression level of ER-α36 was proportional to the size and propagation of gastric xenografted carcinomas in nude mice. The expression level of miR-143 significantly decreased in highly expressing ER-α36 SGC7901 cells and significantly increased in lowly expressing ER-α36 SGC7901 cells. miR-143 expression results in transplantable tumours amongst nude mice were consistent with the miRNA microarray findings. The expression of miR-143 was suppressed by high ER-α36 expression. These findings suggest that deregulation of miR-143 plays an important role in the progression of ER-α36-mediated gastric xenografted carcinoma.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79584940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on Catalytic Ozone Oxidation with Nano-TiO2 Modified Membrane for Treatment of Municipal Wastewater","authors":"Yueqi Zhu, Hongwei Zhang, Xuehua Zhang","doi":"10.4172/1662-100X.1000113","DOIUrl":"https://doi.org/10.4172/1662-100X.1000113","url":null,"abstract":"In this paper, we studied the application of Nano-TiO2 Modified membrane technology in municipal wastewater treatment, which has not been previously reported to exhibit in this area. Ozone (O3) aeration can produce a large number of high oxidizing free radicals (hydroxyl radical HO•) to degrade organic matters when ozone contacts with nano- TiO2 Modified membrane, which process is called catalytic ozone oxidation process. This approach is a new frontier of municipal wastewater treatment, which has excellent reactive activity and degradation of organic compounds without the need of catalyst recycling. Our purpose is to remove organic matters by ozone aeration pre-treatment and nano-TiO2 modified membrane. This method is more efficient since it combines both chemical oxidation and physical filtration. In this study, municipal sewage is called raw water. Polyvinylidene fluoride (PVDF) and the nano-TiO2 modified PVDF ultrafiltration membranes are selected as experimental materials. Results suggest that the removal rate of organic matters with this new method (TiO2+O3) is 66.4%, which is 13.3% higher than original membrane with O3 (PVDF+O3) under the same condition. Therefore we can extract that, this part of contribution belongs to catalytic ozone oxidation process on TiO2 modified membrane. Compared with traditional PVDF membrane filtration, whose removal rate is 38.7%, this novel approach has a removal rate 27.7% higher.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89735808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guibao Cao, Shuangling Wang, B. Wei, Yilong Yin, Gongping Yang
{"title":"A Hybrid Cnn-Rf Method for Electron Microscopy Images Segmentation","authors":"Guibao Cao, Shuangling Wang, B. Wei, Yilong Yin, Gongping Yang","doi":"10.4172/1662-100X.1000114","DOIUrl":"https://doi.org/10.4172/1662-100X.1000114","url":null,"abstract":"To get new insights into the function and structure of the brain,neuroanatomists need to build 3D reconstructions of brain tissue from electron microscopy (EM) images. One key step towards this is to get automatic segmentation of neuronal structures depicted in stacks of electron microscopy images. However, due to the visual complex appearance of neuronal structures, it is challenging to automatically segment membranes in the EM images. Based on Convolutional Neural Network (CNN) and Random Forest classifier (RF), a hybrid CNN-RF method for EM neuron segmentation is presented. CNN as a feature extractor is trained firstly, and then well behaved features are learned with the trained feature extractor automatically. Finally, Random Forest classifier is trained on the learned features to perform neuron segmentation. Experiments have been conducted on the benchmarks for the ISBI2012 EM Segmentation Challenge, and the proposed method achieves the effectiveness results: The Rand error, Warping error and Pixel error attains to 0.109388991, 0.001455688 and 0.072129307, respectively.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89951562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}