Journal of Biomedical and Pharmaceutical Research最新文献

{"title":"Inflammatory Bowel Disease and Gut Microbiota Dysbiosis: Current understanding and Future Direction","authors":"Ritu Verma, Km. Shiva, Ranveer Singh, Kajal Sherawat, Simran, Poonam Bhardwaj","doi":"10.32553/jbpr.v13i1.1043","DOIUrl":"https://doi.org/10.32553/jbpr.v13i1.1043","url":null,"abstract":"Inflammatory Bowel Disease (IBD) represents a group of chronic, relapsing inflammatory disorders primarily affecting the gastrointestinal tract. The pathogenesis of IBD is multifaceted, involving genetic predisposition, environmental triggers, and dysregulation of the immune response. Recent research has illuminated the pivotal role of gut microbiota dysbiosis in the development and perpetuation of IBD. The human gut harbors a complex and dynamic ecosystem of microorganisms that profoundly influences host health and disease. Alterations in the composition, diversity, and function of the gut microbiota, termed dysbiosis, have been consistently linked to IBD. Shifts in microbial composition, reduction in microbial diversity, and imbalances in beneficial versus pathogenic microorganisms characterize the dysbiotic state associated with IBD.The intricate interplay between the host immune system and the gut microbiota is a key determinant in IBD pathogenesis. Dysbiosis triggers aberrant immune responses, leading to chronic mucosal inflammation and tissue damage. Furthermore, dysbiotic alterations disrupt essential microbial-derived metabolites and signaling molecules crucial for gut homeostasis, further exacerbating the disease. Advancements in high-throughput sequencing technologies and metagenomic analysis have enabled comprehensive characterization of microbial communities in IBD, uncovering microbial signatures and functional pathways associated with disease phenotypes and treatment responses. Therapeutic interventions targeting the gut microbiota, such as probiotics, prebiotics, fecal microbiota transplantation, and microbial-based therapies, have shown promise in preclinical and clinical studies for modulating dysbiosis and ameliorating IBD symptoms. \u0000Keywords: Inflammatory Bowel Disease, Dysbiosis, Fecal microbiota, Probiotics","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"67 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel, Economical RP-HPLC Method for Quantification of Cefixime in Bulk and Pharmaceutical Solid Dosage form","authors":"Neha Sharma","doi":"10.32553/jbpr.v12i5.1028","DOIUrl":"https://doi.org/10.32553/jbpr.v12i5.1028","url":null,"abstract":"A new, precise, economical, and linear gradient reverse phase high-performance liquid chromatography (RP-HPLC) method has been developed and validated for assay determination in Cefixime. The chromatographic separation was achieved with Hypersil C18(250*4.6)mmand 3 µm particle size column. The flow rate was 1.0 mL/min and eluents were detected at 220 nm using PDA detector. The retention time was found to be 7.3 min.The percentage recoveries for molecules were found to be in the range of 99–101%. The calibration curve demonstrated good linearity in the range of 20–100 gm/ml. for Cefixime. The approach has been validated in accordance with the International Conference on Harmonization's regulatory criteria. The evaluated parameters are precision, linearity, detection limit, quantification limit, specificity, accuracy, and robustness.The technique may be applied to stability investigations as well as routine analysis to identify and quantify Cefixime in pharmaceutical dosage form .
 Keywords: Cefixim. Reversed Phase High Performance Liquid Chromatography. Assay substances. Methanol","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"138 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135479809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RP-HPLC Method Development and Validation for Determination of Abemaciclib in Bulk Drug Substance and Pharmaceutical Dosage Forms","authors":"M. Maithani, D.K. Dwivedi","doi":"10.32553/jbpr.v12i5.1027","DOIUrl":"https://doi.org/10.32553/jbpr.v12i5.1027","url":null,"abstract":"A simple, economic, rapid and precise method for the quantification of Abemaciclib in bulk drug substance and pharmaceutical dosage forms was developed and validated using RP-HPLC. The chromatographic separation was achieved using Ascentis® C-18 HPLC column (250mm x 4.6mm i.d., particle size 5µ) with mobile phase containing 0.5% TFA: methanol: acetonitrile (35:45:20 v/v/v) with flow rate of 1.2mL/ min was used and effluents were monitored at 295nm. The retention time of Abemaciclib were found to be 3.72 min. The linearity was in the range of 6-42μg/mL. The limit of detection and limit of quantification were found to be 0.6 and 1.8 µg/mL, respectively. The % recoveries were found to be in the range of 99.65±0.77.
 Keywords: Abemaciclib, Estimation, Bulk drug substance, Pharmaceutical dosage forms","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"13 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136158654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Potential of Ferns from Uttarakhand Region","authors":"Akhil Gupta, Rakesh Sharma, Neeraj Kumar, Mayank Bansal, Rupesh Dudhe, Shiv Kumar Gupta","doi":"10.32553/jbpr.v12i5.1026","DOIUrl":"https://doi.org/10.32553/jbpr.v12i5.1026","url":null,"abstract":"The current study deals with the anticancer potential of ferns in Uttarakhand region. The ferns are widely used by the local people of the Uttarakhand Himalaya. The present study documents anticancer and antioxidant activity of some fern plants, which are prevalent in study area along with botanical name, family, chemical constituents and their activity for medicinal use. Among all the pteridophytes examined taxa from the Pteridaceae, Polypodiaceae, and Adiantaceae exhibited significant medicinal activity. Based on our review, many pteridophytes have properties that could be used in alternative medicine for treatment of cancer.
 Keywords: Anti-cancer, Anti-oxidants, Ferns, Uttarakhand.","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Cancer – Risk Factors, Staging and Treatment: A Review","authors":"Ramya N, Girish Gowda A","doi":"10.32553/jbpr.v12i5.1025","DOIUrl":"https://doi.org/10.32553/jbpr.v12i5.1025","url":null,"abstract":"The sixth-most common malignancy in the world was oral cancer. The most common risk factors for developing oral cancer are tobacco, smoking, alcohol, and HPV infection. Most malignant oral tumours are detected at an advanced stage. AJCC staging of tumours gives better treatment for malignancies. Surgery is the first-line treatment, followed by radiotherapy and chemotherapy for patients who are not able to tolerate surgery. In this paper overview the various risk factors, staging, and treatment of oral cancer have been reviewed.
 Key words: Malignancy, AJCC staging, Radiotherapy, Chemotherapy","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136013142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacognostical and Pharmacological Evaluation of leaves of Citrullus lanatus L.","authors":"None Divya Sharma, None Mughisa Nagori, None S.C. Mahajan, None Prachi Maheshwari, None Saurabh Sharma","doi":"10.32553/jbpr.v12i4.1023","DOIUrl":"https://doi.org/10.32553/jbpr.v12i4.1023","url":null,"abstract":"Citrullus lanatus (Watermelon) is commonly available throughout India and traditionally used in treatment of various ailments. This plant is well-explored for its fruit but the potential of its leaves is still unexplored. Thus, the present study focuses on pharmacognostical and pharmacological evaluation of leaves of Citrullus lanatus. In pharmacognostical evaluation, all macroscopic, microscopic, qualitative, quantitative and microbiological analysis were performed. In pharmacological evaluation, the study mainly focuses on the potential of leaves for antioxidant and antidiabetic activities. The antioxidant activity has been performed by various methods such as DPPH and phospho-molybdenum method. The antidiabetic activity has been performed by non-enzymatic glycosylation of hemoglobin assay method, glucose uptake in yeast cells method, alpha amylase inhibition assay method and alpha glucosidase inhibition assay method. The results of antioxidant activity shows that the plant extract possess good free radical scavenging properties due to the presence of vitamin C, polyphenol and flavonoid content. The results of antidiabetic activity by non-enzymatic glycosylation method shows that the plant extract of C. lanatus exhibit significant inhibition of glycosylation as compared with standard drug alpha tocopherol. In glucose uptake by yeast cells method, the extract showed greater efficiency in increasing the glucose uptake by yeast cells as compared to standard drug acarbose. In alpha amylase inhibition method, Alpha amylase inhibitors bind to alpha bond of polysaccharide and prevent breakdown of polysaccharide in mono and disaccharide which shows significant activity of plant extract as compared to an acarbose standard drug. Thus from the above findings, it can be concluded that C. lanatus leaves possess a great potential for antioxidant and antidiabetic activity and this plant should be more researched and formulation should be marketed in the recent future.
 Keywords: Citrullus lanatus (Cucurbitaceous), Watermelon, Anti-oxidant Activity, Anti-diabetic Activity","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136071644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Diabetes Mellitus in Myocardial Infarction Patients -An Observational Study","authors":"Nikita Chauhan, Paras Chauhan","doi":"10.32553/jbpr.v12i4.1020","DOIUrl":"https://doi.org/10.32553/jbpr.v12i4.1020","url":null,"abstract":"Abstract: \u0000Background: According to studies, having diabetes is a risk factor in and of itself for developing cardiovascular disease. The World Health Organization (WHO) reports that the worldwide burden of death and morbidity attributable to cardiovascular disease is increasing. \u0000Material & Methods: The present observational research was conducted at our tertiary care institution and lasted six months, from June to November 2022. We recruited 100 AMI patients upon receipt of written informed permission. \u0000Results: 60% of research participants had normal blood sugar levels, 25% previously knew they had diabetes mellitus, 11% had the diagnosis identified while they were hospitalized, and 4% experienced stress-related blood sugar elevations. \u0000Conclusion:    In addition to being a predictor of prognosis and recurrences, elevated blood sugar was connected to acute cardiovascular problems, especially in those with acute myocardial infarction. \u0000Keywords: Risk factors, prevalence of diabetes mellitus, and acute myocardial infarction.","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80483655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Demonetization on Small and Medium-Sized Businesses","authors":"Saidulukelothu, Dinesh Chandra","doi":"10.32553/jbpr.v12i4.1018","DOIUrl":"https://doi.org/10.32553/jbpr.v12i4.1018","url":null,"abstract":"ResearchGate, SSRN, Google Scholar, and Academia were used to conduct a systematic literature review on digital payment systems used by bank customers. Key words included digital banking, internet banking, digital payment, customer adoption, perception, and conceptual framework. In order to conceptualize the research, we scanned and read all of the relevant literature. The adoption of a digital payment system was researched using ABCD analysis, which was also utilized to build a search proposal. The evaluation method uncovered both individual and societal elements that play a role in the rising popularity of digital payments among banking clients. Various research gaps were identified in the area of digital payment strategy adoption, and various suggestions were made to increase the rate at which consumers adopted digital payment methods. Systematic investigation has shown a distinct image of the digital system adoption by banking consumers. The research also found that there is a connection between customers and individual and demographic aspects, as well as between consumers and different strategies to improve use patterns. Increasing the number of consumers is one of the goals of Digital India, and its implementation will help the country get there. Systematic reviews are a kind of academic paper. \u0000Keywords: Cashless transactions, digital currency, and the Indian economy","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87724248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Absorption on Non- Newtonian Fluid over A Vertical Plate with Radiation Heat Flux","authors":"Pallapatisaidulu, Rajeev Kumar","doi":"10.32553/jbpr.v12i4.1017","DOIUrl":"https://doi.org/10.32553/jbpr.v12i4.1017","url":null,"abstract":"The study of radiation absorption in non-Newtonian fluids flowing over a vertical plate subjected to radiation heat flux is a complex yet critical area of research that finds wide applications in engineering, physics, and environmental sciences. In this investigation, we explore the intricate interplay between radiation heat transfer, the unique rheological properties of non-Newtonian fluids, and the resulting fluid dynamics and heat transfer phenomena. Non-Newtonian fluids, characterized by their nonlinear relationship between shear stress and shear rate, exhibit behavior that deviates from traditional Newtonian fluids. This departure introduces complexity into the heat transfer process when subjected to radiation heat flux. The vertical plate, a common boundary encountered in practical engineering scenarios, serves as a platform for examining these interactions. Research in this field employs a multidisciplinary approach, encompassing experimental investigations, mathematical modeling, and computational simulations. These methodologies are instrumental in unraveling the complexities of radiation absorption in non-Newtonian fluids over vertical plates and provide a foundation for advancements in various engineering and scientific domains. \u0000Keywords: Radiation, Absorption, Transfer, Modeling, non-Newtonian","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"266 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79786047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation on The Local Flora of WANAPARTHY For Its Therapeutic Properties","authors":"K. Sunitha Bai, Gulab Singh","doi":"10.32553/jbpr.v12i4.1019","DOIUrl":"https://doi.org/10.32553/jbpr.v12i4.1019","url":null,"abstract":"There are 355 plant species total in the Government Degree and PG College campus in Wanaparthy; 15 of them are unique to the area. There were also a significant variety of medicinal plants, wild relatives, fodder plants, and edible plants found in the area. The findings showed that the college campus has an abundance of plant species, which is great for the academic pursuits of the student body. \u0000Keyword: Conservation, Endangered, Economic Importance, Related Species, Wild.","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90189360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}