Journal of Biomedical and Pharmaceutical Research最新文献

Polypharmacy: Remedy Leads to Illness 多药疗法：药到病除

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-07-06 DOI: 10.32553/jbpr.v13i4.1096

Archana Mishra, Surbhi Jangir, Divya Singh

{"title":"Polypharmacy: Remedy Leads to Illness","authors":"Archana Mishra, Surbhi Jangir, Divya Singh","doi":"10.32553/jbpr.v13i4.1096","DOIUrl":"https://doi.org/10.32553/jbpr.v13i4.1096","url":null,"abstract":"Background: People often engage in polypharmacy, which is outlined as taking more drugs than is clinically required or using many prescriptions at one time. \u0000Objective: The goal of this research was to provide a descriptive analysis of polypharmacy and to perform the clinical assessment of the patients as well as assess their behavioural changes. \u0000Methods: A cross-sectional study was performed in tertiary care hospital over five months. A total 100 patients are included. The study population include cardiovascular and diabetic patients. Medicine card containing more than 5 medicines are included. Data collection was done by personal communication with the patients which prevents the manipulation of the information. The collected data are determined through graphical methods. \u0000Results: Polypharmacy patients were experiencing excessive behavioural changes such as anxiety and frustration. Statins and Biguanides group of medicine are prescribed more. The blood pressure and heart rate of the patients were also changing continuously due to medicines and hospital restrictions. It was found that diet and oxygen saturation level is not affected by Polypharmacy as these are continuously monitored by the hospital staffs. \u0000Conclusion: Polypharmacy frequently leads to an increased risk of medical related issues. Throughout this study, it was found that patients have major effect on their blood pressure and heart rate simultaneously which could be due to number of medicines prescribed or the hospital environment and restriction. Changes in the patient behaviour is also one of the major concerns which needs to be focused sincerely. \u0000Keywords: Polypharmacy, Blood Pressure, Heart Rate, Behaviour, Cardiovascular","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Drug Management of Essential Hypertension in Patients in the Sikar District (Rajasthan) 对锡卡尔地区（拉贾斯坦邦）高血压患者药物治疗的评估

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-06-14 DOI: 10.32553/jbpr.v13i3.1090

Neha Deora, Surbhi Jangir

引用次数: 0

Formulation and Evaluation of Nanosuspension Containing Carbamazepine 含卡马西平的纳米悬浮剂的制备与评估

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-06-12 DOI: 10.32553/jbpr.v13i3.1089

Shivam Prajapati, Mayank Bansal, Vikas H, Rakesh Kumar Gupta

引用次数: 0

Design, Development and Evaluation of Oral Dissolving film of Montelukast Sodium 设计、开发和评估孟鲁司特钠口腔溶解膜

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-06-07 DOI: 10.32553/jbpr.v13i3.1088

Manhi Chauhan, Ashutosh Sharma, Priya Sharma, Sunil Sain

引用次数: 0

Preliminary Pharmacognostical & Pharmacological Studies on The Pisonia Grandis R. Br. on Rats 对大鼠进行的 Pisonia Grandis R. Br. 初步药理药效研究

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-06-02 DOI: 10.32553/jbpr.v13i3.1086

Surjit Kumar, Shilpi Mishra, Ashish Mishra, Vishnu Kant

{"title":"Preliminary Pharmacognostical & Pharmacological Studies on The Pisonia Grandis R. Br. on Rats","authors":"Surjit Kumar, Shilpi Mishra, Ashish Mishra, Vishnu Kant","doi":"10.32553/jbpr.v13i3.1086","DOIUrl":"https://doi.org/10.32553/jbpr.v13i3.1086","url":null,"abstract":"The plant Pisonia Grandis R.Br. belongs to the family Nyctaginaceae was taken up for the study by me to screening and gave a report on the possible Pharmacognostical and Pharmacological studies. The various ash values and extract values are determined. In Phytochemical screening showed the nature of the chemical constituents such as Alkaloids, Carbohydrates, Phenolic compounds, Protein and Amino acids, Saponins, Sterols, Flavonoids and Tanins present in the leaf extract of Pisonia Grandis R.Br. The LD50 of the aqueous and alcoholic extracts of Pisonia Grandis R.Br. leaves was found to be 2500 mg/kg. Therefore ED50 was calculated as 250 mg/kg. The Hepatoprotective activity was carried out by the Paracetamol induced model in rats. Administration of the aqueous and alcoholic extracts of Pisonia grandis R.Br. leaves showed significant hepatoprotective activity which was compared with the standared drug silymarin. The effect was more pronounced with the aqueous extracts Pisonia grandis R.Br., this may be probably due to the high contents of flavonoids. \u0000Keywords: Pisonia grandis R.Br , Hepatoprotective, Histopathology, Paracetamol. \u0000 ","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"26 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141273288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Anti-acne Niosomal Gel Using Isotretinoin and Lincomycin Combination 使用异维A酸和林可霉素复方制剂配制抗痤疮鼻腔凝胶并对其进行评估

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-05-01 DOI: 10.32553/jbpr.v13i1.1062

Arushi Sharma, Rajesh Kumar, A. Singh, A. Singh

{"title":"Formulation and Evaluation of Anti-acne Niosomal Gel Using Isotretinoin and Lincomycin Combination","authors":"Arushi Sharma, Rajesh Kumar, A. Singh, A. Singh","doi":"10.32553/jbpr.v13i1.1062","DOIUrl":"https://doi.org/10.32553/jbpr.v13i1.1062","url":null,"abstract":"Acne vulgaris is a prevalent dermatological concern affecting adolescents and young adults, often causing psychological distress and potential scarring. This multifactorial disorder involves hormonal changes, increased sebum production, bacterial colonization, and inflammation. To address these diverse factors, a combination of drugs with different mechanisms of action in topical formulations has been explored. \u0000This study focuses on the formulation and evaluation of an anti-acne niosomal gel incorporating isotretinoin, a retinoid with anti-inflammatory properties, and lincomycin, an antibiotic targeting Propionibacterium acne. The objective is to develop a stable and efficacious topical formulation that comprehensively addresses the various aspects of acne pathogenesis. Niosomes are chosen as the carrier system for their ability to enhance drug penetration, reduce side effects, and improve drug stability. \u0000Several studies have highlighted the synergistic action of isotretinoin and lincomycin, providing a comprehensive approach to managing acne lesions by addressing both inflammatory and bacterial components. Moreover, their combination has shown a reduced risk of antibiotic resistance compared to monotherapy with antibiotics. \u0000The research involves a systematic evaluation of the formulated niosomal gel, including physicochemical characteristics, in vitro release, and stability studies. By adopting a topical approach, the study aims to minimize systemic side effects and enhance drug delivery to the target site, ensuring localized and effective treatment. The outcomes of this study are anticipated to contribute valuable insights into the potential of an isotretinoin and lincomycin combination in a topical niosomal gel for the advanced and effective treatment of acne vulgaris. \u0000Keywords: Acne vulgaris, Isotretinoin, Lincomycin, Topical formulation, Niosomes, Multifactorial acne treatment.","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"71 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141035303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H Hepatoprotective Activity of Piper crocatum (Ruiz &Pav.) Leaves Against Monosodium Glutamate -Induced Hepatotoxicity in Rats H Piper crocatum（Ruiz &Pav.）

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-04-13 DOI: 10.32553/jbpr.v13i2.1070

Sri Endarti Rahayu, Bayu Kharisma, S. Suprihatin

{"title":"H Hepatoprotective Activity of Piper crocatum (Ruiz &Pav.) Leaves Against Monosodium Glutamate -Induced Hepatotoxicity in Rats","authors":"Sri Endarti Rahayu, Bayu Kharisma, S. Suprihatin","doi":"10.32553/jbpr.v13i2.1070","DOIUrl":"https://doi.org/10.32553/jbpr.v13i2.1070","url":null,"abstract":"Monosodium glutamate (MSG) is widely used as additive in food. Excess consumption of MSG was reported to cause oxidative stress on liver resulted increased production of reactive oxygen species (ROS). Without proper treatment, it can induce liver injury and fatal hepatic diseases, including cirrhosis. Red betel (Piper crocatum Ruis and Pav.) is one of Indonesia’s medicinal plants that has been known to exhibit antioxidant activity. The current study evaluated hepatoprotective effect of red betel leaves extract (RBLE) towards liver injury. Animals (n=5 per group) were randomly divided into five groups as follows: Group 1, control (distilled water); group 2, negative control, receive 7 mg/kg bw of MSG; group 3, receive oral 7g/kg b.w of MSG plus 200 mg/kg bw RBLE; group 4, receive oral 7g/kg b.w of MSG plus 400 mg/kg b.w RBLE and group 5, receive oral 7g/kg b.w of MSG plus 600 mg/kg b.w RBLE. The rats were sacrificed on twenty-ninth day of the experiment. Measuring serum levels of aspartate aminotransferase (AST) and alanin aminotransferase (ALT) was done. Histopathological examination of liver was performed by calculated necrosis cell percentage. RBLE treatment (200 mg/kg b.w) decrease alanin aminotransferase and aspartate aminotransferase demonstrated increased compare to negative control. The histological findings revealed RBLE treatment were also able to decrease necrosis cells percentage. The study was able to demonstrate that RBLE treatment could decrease necrotic cell percentage. Low concentration of RBLE (200 mg/kg b.w) exhibit best anti-inflammatory properties and had the lowest ALT enzyme and increased live cell percentage by shifting cell death pathway from necrosis to apoptosis, and these indicating its antioxidant properties. These results could be used as a baseline in the purification of red betel bioactive components to be used for liver injury medication. \u0000Key words: Antioxidant, hepatoprotective, histopathology, liver enzymes, MSG, red betel.","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"107 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Approach on Nanosphere Based Colon Targeted Drug Delivery System 基于纳米圈的结肠靶向给药系统的新方法

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-04-08 DOI: 10.32553/jbpr.v13i2.1073

Vaishali Pardhe, Ashish Jain, A. Singhai

引用次数: 0

Efficacy of Percutaneous Tenotomy in Chronic Lateral Epicondylitis Over Time 慢性外上髁炎经皮腱鞘切开术的疗效随时间变化

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-04-08 DOI: 10.32553/jbpr.v13i2.1078

Anu Kumar Changkum, Akshay Sharma, Ashish Meena, Vipin Sharma

引用次数: 0

Efficacy and Outcomes of Gamma Nail Versus Proximal Femoral Nail in the Treatment of Stable Extracapsular Fractures of the Proximal Femur: A Comparative Study 伽马钉与股骨近端钉治疗稳定型股骨近端囊外骨折的疗效和结果：比较研究

Journal of Biomedical and Pharmaceutical Research Pub Date : 2024-04-08 DOI: 10.32553/jbpr.v13i2.1080

Akshay Sharma, Anu Kumar Changkum, Ashish Meena, Vipin Sharma

{"title":"Efficacy and Outcomes of Gamma Nail Versus Proximal Femoral Nail in the Treatment of Stable Extracapsular Fractures of the Proximal Femur: A Comparative Study","authors":"Akshay Sharma, Anu Kumar Changkum, Ashish Meena, Vipin Sharma","doi":"10.32553/jbpr.v13i2.1080","DOIUrl":"https://doi.org/10.32553/jbpr.v13i2.1080","url":null,"abstract":"Background: Stable extracapsular fractures of the proximal femur are a common and challenging injury in the elderly, with Gamma Nail and Proximal Femoral Nail (PFN) being the primary surgical options. This study aims to compare the efficacy and outcomes of these two methods. \u0000Methods: A prospective study was conducted on 50 patients with stable extracapsular fractures, randomly assigned to undergo CRIF with either Gamma Nail or PFN. Parameters such as operation time, blood loss, radiological outcomes, and postoperative recovery were analyzed. \u0000Results: The Gamma Nail group experienced shorter operation times (33±6.5 min) and less blood loss (28.08±32.80 ml) compared to the PFN group. Radiological outcomes showed no significant difference between the groups, with high success rates in achieving stable fixation. Both methods demonstrated effectiveness in managing these fractures, but Gamma Nail offered some technical advantages. \u0000Conclusion: Gamma Nail and PFN are both effective for treating stable extracapsular fractures of the proximal femur, with the choice of technique depending on various patient-specific factors. \u0000Keywords: Extracapsular fractures, proximal femur, Gamma Nail, Proximal Femoral Nail, orthopedic surgery, elderly. \u0000 ","PeriodicalId":15193,"journal":{"name":"Journal of Biomedical and Pharmaceutical Research","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0