Formulation and Evaluation of Anti-acne Niosomal Gel Using Isotretinoin and Lincomycin Combination

Abstract

Acne vulgaris is a prevalent dermatological concern affecting adolescents and young adults, often causing psychological distress and potential scarring. This multifactorial disorder involves hormonal changes, increased sebum production, bacterial colonization, and inflammation. To address these diverse factors, a combination of drugs with different mechanisms of action in topical formulations has been explored. This study focuses on the formulation and evaluation of an anti-acne niosomal gel incorporating isotretinoin, a retinoid with anti-inflammatory properties, and lincomycin, an antibiotic targeting Propionibacterium acne. The objective is to develop a stable and efficacious topical formulation that comprehensively addresses the various aspects of acne pathogenesis. Niosomes are chosen as the carrier system for their ability to enhance drug penetration, reduce side effects, and improve drug stability. Several studies have highlighted the synergistic action of isotretinoin and lincomycin, providing a comprehensive approach to managing acne lesions by addressing both inflammatory and bacterial components. Moreover, their combination has shown a reduced risk of antibiotic resistance compared to monotherapy with antibiotics. The research involves a systematic evaluation of the formulated niosomal gel, including physicochemical characteristics, in vitro release, and stability studies. By adopting a topical approach, the study aims to minimize systemic side effects and enhance drug delivery to the target site, ensuring localized and effective treatment. The outcomes of this study are anticipated to contribute valuable insights into the potential of an isotretinoin and lincomycin combination in a topical niosomal gel for the advanced and effective treatment of acne vulgaris. Keywords: Acne vulgaris, Isotretinoin, Lincomycin, Topical formulation, Niosomes, Multifactorial acne treatment.