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"Dark matter of genome” in cancer 癌症中的“基因组暗物质”
Journal of Cancer Prevention & Current Research Pub Date : 2019-02-14 DOI: 10.15406/jcpcr.2019.10.00385
T. Lushnikova
{"title":"\"Dark matter of genome” in cancer","authors":"T. Lushnikova","doi":"10.15406/jcpcr.2019.10.00385","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00385","url":null,"abstract":"Since late 60-th it is known that the most of genomic DNA of eukaryotic organisms consists from non-coding proteins sequences, various repetitive sequences. Later among repetitive and non-coding “junk” DNA or “dark matter of genome” retrotransposons were found, short interspersed nuclear elements SINEs or long short interspersed nuclear elements and LINE,9 gene controlling elements. For many years the scientists were focused on DNA sequences of genes, a small portion of genome coding proteins. Carcinogen aflatoxin B1 covalently binding to DNA showed that DNA repair was deficient in repetitive satellite DNA compare in bulk DNA despite of the initial level of modification was the same in both DNAs.10 Microsatellite mutations associate with cancers and aging.11 Tumor suppressor p53 is multifunctional transcription factor, “the guardian of the genome”, the most frequently mutated gene in tumors contributes in silencing of repeats and noncoding RNAs. The p53 protein mediates expression ~1000 genes and transcription of the repeats and ncRNAs.12 Many p53 binding sites reside in transposable repeats.13 Mouse oncogene Mdm2 is a negative regulator of p53 and DNA repair genes, is overexpressed in tumors and contributes to chromosomal breaks (double-strand breaks, DSBs) and CIN at higher rate in transgenic Mdm2 mice with aging than in wild-type mice.14 The DNA sequences associated with chromosomal breaks and rearrangements are not well understood. The DNA breaks are formed as mistakes in DNA replication, transposition of mobile elements or by environmental agents. DSBs are random but some of them occurred on fragile sites what are near telomere or centromere. The precise genome-mapping of DSBs in human chromosomes revealed non-random fragmentation and DSB hot spots.15","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91138650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late distant metastasis from papillary carcinoma of thyroid gland 甲状腺乳头状癌晚期远处转移
Journal of Cancer Prevention & Current Research Pub Date : 2019-02-14 DOI: 10.15406/jcpcr.2019.10.00384
K. Aryana, R. Zakavi, N. Majdi
{"title":"Late distant metastasis from papillary carcinoma of thyroid gland","authors":"K. Aryana, R. Zakavi, N. Majdi","doi":"10.15406/jcpcr.2019.10.00384","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00384","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77373816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic impact of tumor location in all stages of colorectal cancer 结直肠癌各阶段肿瘤位置的临床病理影响
Journal of Cancer Prevention & Current Research Pub Date : 2019-02-11 DOI: 10.15406/jcpcr.2019.10.00383
E. Oktay
{"title":"Clinicopathologic impact of tumor location in all stages of colorectal cancer","authors":"E. Oktay","doi":"10.15406/jcpcr.2019.10.00383","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00383","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91484428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Irradiation augmentation of genistein-induced apoptosis in androgen-independent DU-145 prostate cancer cells in vitro 辐照增强雄激素非依赖性DU-145前列腺癌细胞凋亡的研究
Journal of Cancer Prevention & Current Research Pub Date : 2019-01-09 DOI: 10.15406/jcpcr.2018.09.00381
Rida Altaf, J. Kumi-Diaka, R. Branly
{"title":"Irradiation augmentation of genistein-induced apoptosis in androgen-independent DU-145 prostate cancer cells in vitro","authors":"Rida Altaf, J. Kumi-Diaka, R. Branly","doi":"10.15406/jcpcr.2018.09.00381","DOIUrl":"https://doi.org/10.15406/jcpcr.2018.09.00381","url":null,"abstract":"Cancer is a complex disease that occurs as a result of accumulated mutations, genetic instability, and altered cellular metabolism, contributing to malignant transformation and to the initiation, growth, and maintenance/proliferation of tumors.1 Prostate cancer (PCa) is still the most common non-skin cancer among men in the United States.2 The American Cancer Society has estimated 164,690 new cases and 29,430 deaths from prostate cancer for 2018.3 The standard treatment modalities (surgery, radio-chemotherapy, hormonal therapy) have been effective in improving the lifestyle of patients. Although the locally confined disease is treatable, treatment of the metastasized prostate cancer is still incurable with mostly guarded prognosis.4,5 The development of resistance to both radiation and chemotherapy has limited the efficacy of current therapeutic interventions for PCa. This has necessitated the search for novel and safer alternative therapeutic regimens. One way to circumvent potential treatment-induced resistance is combination treatment, using two or more therapies that may be mutually inclusive or exclusive in terms of their mechanism of actions.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"180 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89066765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Gene therapy in the era of nanotechnology/a review of current data 纳米技术时代的基因治疗/当前资料综述
Journal of Cancer Prevention & Current Research Pub Date : 2019-01-08 DOI: 10.15406/jcpcr.2018.09.00380
H. Anis
{"title":"Gene therapy in the era of nanotechnology/a review of current data","authors":"H. Anis","doi":"10.15406/jcpcr.2018.09.00380","DOIUrl":"https://doi.org/10.15406/jcpcr.2018.09.00380","url":null,"abstract":"including drugs which can either be dissolved or encapsulated within them forming a nanoparticle and a Nano capsule respectively. The delivered therapeutic proteins or drugs act by altering defective proteins or genes in the patient’s cells. The size of the polymer nanoparticle could be tuned to enable these drugs and therapeutic protein to fit in. PNPs, like all nanoparticles are capable of regaining their size once inside the cell through the physiological change in pH. They are also great candidates for gene delivery, because they are highly stable and they offer controlled release of active ingredients.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77226866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pigmented eccrine poroma mimicking a pigmented basal cell carcinoma 与色素型基底细胞癌相似的色素型内分泌囊肿
Journal of Cancer Prevention & Current Research Pub Date : 2019-01-01 DOI: 10.15406/jcpcr.2019.10.00410
K. Elboukhari
{"title":"Pigmented eccrine poroma mimicking a pigmented basal cell carcinoma","authors":"K. Elboukhari","doi":"10.15406/jcpcr.2019.10.00410","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00410","url":null,"abstract":"A 38 years old man presented a Black nodule on the face, which appears since childhood and was growing up 02 months before the consultation. It was painless and without pruritus. The dermatological examination showed a sessile-based nodule flesh-colored in places and black in others it was localized under the lower left eyelid. Dermoscopy showed typical ovoid nests and thick arborizing vessels. In front of this clinico dermoscopic panel, pigmented basal cell carcinoma was evoked. Histologic examination showed a proliferation of tumors connected to the epidermis, arranged in masse and made of regular cuboid cells presenting monomorphic nuclei with fine finely nucleated chromatin and an abundant basophilic cytoplasm. Massifs and spans are sometimes centered on cavities filled with eosinophilic material. The tumor cells are pigmented and the mitoses were rare (Figure 1–3).","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87713115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin-C: properties, function and application in cancer therapy 维生素c的性质、功能及其在癌症治疗中的应用
Journal of Cancer Prevention & Current Research Pub Date : 2018-12-11 DOI: 10.15406/jcpcr.2018.09.00378
S. Shilpi, Roshni Shivvedi, Amrita Singh, Anil Kumar, G. Saraogi, V. Jain, K. Khatri
{"title":"Vitamin-C: properties, function and application in cancer therapy","authors":"S. Shilpi, Roshni Shivvedi, Amrita Singh, Anil Kumar, G. Saraogi, V. Jain, K. Khatri","doi":"10.15406/jcpcr.2018.09.00378","DOIUrl":"https://doi.org/10.15406/jcpcr.2018.09.00378","url":null,"abstract":"Vitamin-C also known as ascorbic acid and it is a water-soluble antioxidant and enzyme cofactor present in plants and some animals. Unlike most mammals, humans do not have the ability to synthesize this nutrient endogenously and, therefore, obtain it through diet. Ascorbic acid (AA) is a primary antioxidant remains in human plasma.1 While numerous animal and cell studies have shown beneficial anti-oxidant effects of AA. It is a chain breaking antioxidant and it give their effect by reacting with oxygen, hydroxyl, and superoxide radicals of the substances. It react with radicals of tocopheroxy to re-generate vitamin E.2 There are 2 chemical forms of Vitamin-C: the reduced form (ascorbic acid; AA) and the oxidized form (dehydroascorbic acid; DHA) (Figure 1).1,2","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83568286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Topographical study of albino nasal cancer in a developing community 发展中社区白化鼻癌的地形研究
Journal of Cancer Prevention & Current Research Pub Date : 2018-12-11 DOI: 10.15406/jcpcr.2018.09.00376
W. Onuigbo
{"title":"Topographical study of albino nasal cancer in a developing community","authors":"W. Onuigbo","doi":"10.15406/jcpcr.2018.09.00376","DOIUrl":"https://doi.org/10.15406/jcpcr.2018.09.00376","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76447956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The artificial intelligence could help in prevency and treatments carcinoms 人工智能可以帮助预防和治疗癌症
Journal of Cancer Prevention & Current Research Pub Date : 2018-12-10 DOI: 10.15406/JCPCR.2018.09.00374
A. Cuc
{"title":"The artificial intelligence could help in prevency and treatments carcinoms","authors":"A. Cuc","doi":"10.15406/JCPCR.2018.09.00374","DOIUrl":"https://doi.org/10.15406/JCPCR.2018.09.00374","url":null,"abstract":"I am just furious, when my girl-friend with Age 65+ she ist suddenly needless dying on the pneumologic Carcinom – when she was smoking and with sometimes pneumologic insufficiency – but thatfor she regularly was going to the Pneumologic Ambulance to control. But the Pneumolog was regularly controlling only Lungs – Volume Capacity and rustling of her Lungs, but he was never sent her to pneumologic RTG imaging each 2years, despite it must be logically and periodically, but he never did nor at once RTG in duration for last 5years! When Patient has dramatic pains – freguently the carcinom was out of possibilities of surgeon Treatments, because in duration growing about 1,5years there are los of cca half the Lung functional tissue....and after next 5months of beginning dramatic Treatments with combined radiation and chemotherapy without regularly intermediately timing controls after scanning result each 6 weeks at least – the Pneumologic Clinic evidenced to late and frequent despairing fatal Results. In just time the oncologic Patients is with more worse todays rest Health status in probable with comparison to absence a like hood type of the used unapt prolonged Treatments!","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"22 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83743346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the cure for cancer was discovered 癌症的治疗方法是如何发现的
Journal of Cancer Prevention & Current Research Pub Date : 2018-12-03 DOI: 10.26717/BJSTR.2018.11.002131
A. Hague
{"title":"How the cure for cancer was discovered","authors":"A. Hague","doi":"10.26717/BJSTR.2018.11.002131","DOIUrl":"https://doi.org/10.26717/BJSTR.2018.11.002131","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88474439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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