纳米技术时代的基因治疗/当前资料综述

H. Anis
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引用次数: 2

摘要

包括可以溶解或封装在其中的药物,分别形成纳米颗粒和纳米胶囊。输送的治疗蛋白质或药物通过改变患者细胞中有缺陷的蛋白质或基因起作用。聚合物纳米颗粒的大小可以调整,使这些药物和治疗蛋白质能够适应。PNPs,像所有的纳米颗粒一样,一旦进入细胞,就能通过ph的生理变化恢复其大小。它们也是基因传递的绝佳候选者,因为它们高度稳定,并能控制有效成分的释放。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gene therapy in the era of nanotechnology/a review of current data
including drugs which can either be dissolved or encapsulated within them forming a nanoparticle and a Nano capsule respectively. The delivered therapeutic proteins or drugs act by altering defective proteins or genes in the patient’s cells. The size of the polymer nanoparticle could be tuned to enable these drugs and therapeutic protein to fit in. PNPs, like all nanoparticles are capable of regaining their size once inside the cell through the physiological change in pH. They are also great candidates for gene delivery, because they are highly stable and they offer controlled release of active ingredients.
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