Journal of Cancer Prevention & Current Research最新文献_第2页

Identifying necrolytic migratory erythema in glucagonoma syndrome 胰高血糖素瘤综合征坏死性迁移性红斑的鉴别

Journal of Cancer Prevention & Current Research Pub Date : 2021-08-12 DOI: 10.15406/jcpcr.2021.12.00465

R. Vasanwala, Joseph R. Malhis, Vivek Malhotra, Ethan Anderson, Kerry J Williams-Wuch

{"title":"Identifying necrolytic migratory erythema in glucagonoma syndrome ","authors":"R. Vasanwala, Joseph R. Malhis, Vivek Malhotra, Ethan Anderson, Kerry J Williams-Wuch","doi":"10.15406/jcpcr.2021.12.00465","DOIUrl":"https://doi.org/10.15406/jcpcr.2021.12.00465","url":null,"abstract":"The glucagon secreted by a glucagonoma causes the combination of symptoms known as glucagonoma syndrome. 1 A common presenting feature of glucagonoma syndrome is necrolytic migratory erythema (NME) occurring in about 70 to 80 percent of patients. 2,3 Although this rash is can be found in a handful of other disorders, NME should raise an alarm for glucagonoma syndrome especially if present with systemic symptoms. We present a 51 year old male with a past medical history of type 2 diabetes who presented to oncology after seeing several dermatologists regarding a progressive painful pruritic papular rash along his lower extremities and groin. Previous punch biopsies did not reveal the characteristic findings of necrolytic migratory erythema and the rash was thought to be pustular psoriasis. It was only after over a year as the patient continued to worsen that a malignancy work up was done. Eventually glucagonoma syndrome was confirmed. Necrolytic migratory erythema can disguise itself as several different types of rashes. An unusual or unresponsive psoriasiform rash should prompt an investigation for an alternative diagnosis.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74527307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between innovative and biosimilar trastuzumab used in the treatment of breast cancer: cross-sectional study of financial impact 用于乳腺癌治疗的创新曲妥珠单抗与生物仿制药之间的关系:财务影响的横断面研究

Journal of Cancer Prevention & Current Research Pub Date : 2021-07-29 DOI: 10.15406/jcpcr.2021.12.00464

Tamara Marques Previ, Andre Fellipe Freitas Rodrigues

{"title":"Relationship between innovative and biosimilar trastuzumab used in the treatment of breast cancer: cross-sectional study of financial impact","authors":"Tamara Marques Previ, Andre Fellipe Freitas Rodrigues","doi":"10.15406/jcpcr.2021.12.00464","DOIUrl":"https://doi.org/10.15406/jcpcr.2021.12.00464","url":null,"abstract":"The irrational use of drugs today is relevant, so pharmacoeconomics is an analytical tool that links economic factors related to drug use and clinical outcomes. Biological medicines are products derived from genetically modified living cell sources. In this context, the biosimilar drug presents similarity in structure, function, efficacy and safety when compared to the original product. Currently several biosimilars are being developed for the treatment of breast cancer, a fact that directly impacts patient survival. Breast cancer is one of the most common types of cancer, being HER2 positive one of the most aggressive forms of the disease, and its treatment is based on the use of cytotoxic drugs associated with targeted therapy using the monoclonal antibody transtuzumab. There are positive future prospects related to biosimilars with impacts on survival and potential increase of patients with access to innovative treatments. The research aimed to analyze the financial impact of the use of the biosimilar trastuzumab and the increase in the number of patients with access to therapies, through a retrospective documentary cross-sectional study, developed on a representative sample of cost values of the drugs Herceptin and Zedora, for the reference protocol trastuzumab. The results obtained in the descriptive statistics through the analysis of variance were not significant; however, a percentage of savings of 27.89% was obtained for the biosimilar Zedora when compared to Herceptin. Monoclonal antibodies are responsible for 35% of the expenses in oncology. The introduction of biosimilars can contribute to the financial and budgetary sustainability of the health system. Based on the results obtained, it is possible to affirm that for every three patients treated with Herceptin, it is possible to treat four patients using Zedora.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75323722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies for the dentist management of cancer patients: narrative literature review 牙科医师治疗癌症病人的策略:叙述性文献回顾

Journal of Cancer Prevention & Current Research Pub Date : 2021-07-19 DOI: 10.15406/jcpcr.2021.12.00463

H. Antunes, L. D. B. Alves, Ana C S Menezes, A. Costa, F. Heimlich, D. Goldemberg

{"title":"Strategies for the dentist management of cancer patients: narrative literature review ","authors":"H. Antunes, L. D. B. Alves, Ana C S Menezes, A. Costa, F. Heimlich, D. Goldemberg","doi":"10.15406/jcpcr.2021.12.00463","DOIUrl":"https://doi.org/10.15406/jcpcr.2021.12.00463","url":null,"abstract":"Aim: To present the dental procedures necessary for the prevention, diagnosis, and treatment of oral toxicities related to cancer treatment. Material and methods: A narrative literature review was carried out regarding the topics of interest. Articles in Portuguese and English, without the restriction of the year of publication and full text available in the databases Pubmed, Scielo, Cochrane, and Google Scholar were investigated. Results: Through this search, 100 articles were selected, consisting of 9 systematic reviews, 3 systematic reviews with meta-analysis, 48 literature reviews, 3 randomized clinical trials, 4 prospective cohorts, 12 retrospective cohorts, 5 cross-sectional studies, 2 case-control studies, 5 case reports, 7 expert consensus panels, 1 letter to the editor and 1 qualitative study, published between 1976 and 2020. Dental procedures were classified according to the therapeutic modality (surgery and radiotherapy for head and neck cancer, chemotherapy, hematopoietic stem cell transplantation, and use of antiresorptive medications) and the time of treatment (prior, during, or after each one). Conclusions: The consulted articles were unanimous regarding the need for dental care for cancer patients in the pre, trans, and post-treatment, highlighting the importance of inserting specialized dental surgeons in the oncology patient care team; thus, this professional should act in the prevention, early diagnosis, and treatment of oral toxicities, to minimize their consequences and improve patients’ quality of life.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77847721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of metastatic proximal-type epithelioid sarcoma of the ischioanal fossa: case report and literature review 一罕见的转移性坐骨肛管窝近端上皮样肉瘤病例报告及文献复习

Journal of Cancer Prevention & Current Research Pub Date : 2021-07-01 DOI: 10.15406/JCPCR.2021.12.00462

Harrak Soukaina, Lemsanes Siham, Razine Sawsan, Benchekroun Khadija, Lkhouyaali Siham, Abahsaine Halima, Boutayeb Saber, Errihani Hassan

{"title":"A rare case of metastatic proximal-type epithelioid sarcoma of the ischioanal fossa: case report and literature review","authors":"Harrak Soukaina, Lemsanes Siham, Razine Sawsan, Benchekroun Khadija, Lkhouyaali Siham, Abahsaine Halima, Boutayeb Saber, Errihani Hassan","doi":"10.15406/JCPCR.2021.12.00462","DOIUrl":"https://doi.org/10.15406/JCPCR.2021.12.00462","url":null,"abstract":"Epithelioid sarcoma (ES) is a rare high-grade sarcoma subtype that constitutes less than 1% of soft tissue sarcomas (STS).There are two types: distal-type epithelioid sarcoma and proximal-type epithelioid sarcoma, based on anatomic location and the histopathological features. The clinical presentation of ES is varied and can lead to a delay in diagnosis. histopathology examination followed by immunohistochemistry will help to establish the diagnosis. The treatment of choice of Localized ES is a radical excision with microscopically radical margins and perioperative radiotherapy. systemic therapies are used in cases of locally advanced or metastatic ES. We describe a case of reoccurring proximal-type epithelioid sarcoma of the ischioanal fossa. A 56-year-old man operated two years ago for a epithelioid sarcoma of the ischioanal fossa. The patient presented with reoccurring mass at the same location, Magnetic resonance imaging (MRI) of the pelvis showed a mass of the ischioanal fossa. computed tomography (CT) of the chest, abdomen, and pelvis showed multiple pulmonary and liver metastasis. Histopathological features and immunohistochemistry were those of proximal type epithelioid sarcoma. He received intravenous doxorubicin with a partial response after 3 cycles of treatment.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72907051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biliary mucinous cystic neoplasm with invasive carcinoma and recurrent cholangitis due to hepatolithiasis 胆道黏液性囊性肿瘤合并浸润性癌及肝内胆管炎复发

Journal of Cancer Prevention & Current Research Pub Date : 2021-06-15 DOI: 10.15406/jcpcr.2021.12.00460

F. Kulalı

引用次数: 0

Three-in-one: case of multiple primary malignancies concurrently in a 70 year-old female 三合一:70岁女性多发性原发恶性肿瘤合并病例

Journal of Cancer Prevention & Current Research Pub Date : 2021-05-12 DOI: 10.15406/JCPCR.2021.12.00458

Joseph R. Malhis, Chintav Shah, S. O’Brien, R. Vasanwala, S. Jaggernauth

引用次数: 0

Curious case of acute encephalopathy in a 64-yearold male 一例64岁男性急性脑病的奇怪病例

Journal of Cancer Prevention & Current Research Pub Date : 2021-05-11 DOI: 10.15406/JCPCR.2021.12.00457

Joseph R. Malhis, S. O’Brien, Alex Belote, B. Brander

{"title":"Curious case of acute encephalopathy in a 64-yearold male","authors":"Joseph R. Malhis, S. O’Brien, Alex Belote, B. Brander","doi":"10.15406/JCPCR.2021.12.00457","DOIUrl":"https://doi.org/10.15406/JCPCR.2021.12.00457","url":null,"abstract":"A 64-year-old male presents with acute encephalopathy and upon further evaluation, he was found to have lymphadenopathy in the neck and parotid region. Subsequent lumbar puncture (LP) revealed the presence of blast cells in the CSF concerning for leukemic meningitis. A lymph node biopsy was consistent with CD5 positive DLBCL. He was started on chemotherapy with Hyper-CVAD and intrathecal methotrexate, improving his clinical condition but he was lost to follow up. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Diagnosis is based on symptoms and excisional lymph node biopsy with immunotyping. It is extremely important to have a lymph node biopsy if suspicious for lymphoma because of its aggressive nature. Indicators for such include CD5 positivity and extranodal involvement. The risk factors for CNS involvement in DLBCL include high International Prognostic Index (IPI) score, bone marrow involvement, and extranodal involvement such as bone, lung and testis. The purpose of the report is to emphasize the importance of ruling out lymphoma when diffuse lymphadenopathy is present in the setting of encephalopathy; the potential of aggressive behavior of this disease including involvement of the CNS; and discussing the overall social determinants of health for this patient resulting in delayed diagnosis and lack of an optimal treatment plan to be carried out.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76853670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral breast carcinoma with three different histological types-case report 三种不同组织学类型的单侧乳腺癌1例报告

Journal of Cancer Prevention & Current Research Pub Date : 2021-04-23 DOI: 10.15406/JCPCR.2021.12.00454

Aditi Agrawal, Rajshri Kelkar, Tuhina Mishra

引用次数: 0

Physiotherapeutic performance in mastectomy after breast cancer: a literature review 物理治疗在乳腺癌乳房切除术后的表现:文献综述

Journal of Cancer Prevention & Current Research Pub Date : 2021-04-21 DOI: 10.15406/JCPCR.2021.12.00453

Adrianne Moura Carvalho, G. Salerno

引用次数: 0

A study on disease dynamics of covid-19 in different states of India: A data driven analysis of the available evidence 关于印度不同邦covid-19疾病动态的研究:对现有证据的数据驱动分析

Journal of Cancer Prevention & Current Research Pub Date : 2021-03-23 DOI: 10.15406/JCPCR.2021.12.00451

J. Prasad, Pradyuman Verma, N. Tyagi

引用次数: 0