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Journal of Bioterrorism and Biodefense最新文献

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Microbiological and Clinical Aspects of Tularemia Disease 土拉菌病的微生物学和临床方面
Journal of Bioterrorism and Biodefense Pub Date : 2012-07-26 DOI: 10.4172/SCIENTIFICREPORTS.168
Pavlis Oto
{"title":"Microbiological and Clinical Aspects of Tularemia Disease","authors":"Pavlis Oto","doi":"10.4172/SCIENTIFICREPORTS.168","DOIUrl":"https://doi.org/10.4172/SCIENTIFICREPORTS.168","url":null,"abstract":"","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"225 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78468453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Novel LC/MS/MS Extraction Assay for Galanthamine in Guinea Pig Plasma and its Application to Nerve Agent Countermeasures 豚鼠血浆中加兰他敏的LC/MS/MS提取方法的建立及其在神经毒剂防治中的应用
Journal of Bioterrorism and Biodefense Pub Date : 2012-07-25 DOI: 10.4172/SCIENTIFICREPORTS.149
E. Wes
{"title":"Development of a Novel LC/MS/MS Extraction Assay for Galanthamine in Guinea Pig Plasma and its Application to Nerve Agent Countermeasures","authors":"E. Wes","doi":"10.4172/SCIENTIFICREPORTS.149","DOIUrl":"https://doi.org/10.4172/SCIENTIFICREPORTS.149","url":null,"abstract":"Galanthamine Hydrobromide (GAL HBr), approved material for treatment of mild to moderate Alzheimer’s disease, is a centrally-acting reversible Acetylcholinesterase Inhibitor (AChEI) that is currently under evaluation as a therapeutic countermeasure against organophosphorus G- and V-Series nerve agents, which can induce rapid lethality in guinea pigs and humans. It has been shown that upon combination with Atropine (ATR) and pyridine-2Aldoxime Methochloride (2-PAM), a single dose of GAL administered before or soon after the acute exposure to a lethal dose of organophosphorus compounds can safely counteract toxicity in guinea pigs. To that end a new sample preparation extraction method analysis assay has been developed to enable future high-throughput, reproducible, and sensitive assays to quantitate galanthamine in guinea pig plasma. Samples were prepared with Diphenhydramine Hydrochloride (DPH HCl) internal standard and recovered with a 10 min liquid-liquid trichloromethane extraction. Samples were analyzed with a reversed phase liquid chromatographic column interfaced to a triple quadrupole mass spectrometer (LC/MS/MS) operating in the positive ion Multiple Reaction Monitoring (MRM) Turbo Ionspray mode. Precursor to product ion (M+H)+ transitions of 288-to-213 m/z and 256-to-167 m/z for GAL and DPH were observed, respectively. Sample run times of 1.50 min were achieved. Overall extraction method development proved to be acceptable and rugged.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75987999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Strategies in Fighting Bioterrorism 打击生物恐怖主义的战略
Journal of Bioterrorism and Biodefense Pub Date : 2012-07-24 DOI: 10.4172/2157-2526.1000E102
V. Radosavljevic
{"title":"Strategies in Fighting Bioterrorism","authors":"V. Radosavljevic","doi":"10.4172/2157-2526.1000E102","DOIUrl":"https://doi.org/10.4172/2157-2526.1000E102","url":null,"abstract":"","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79863166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Bioterrorism Agents and Hospital Infection Control: No Time to Drop the Guard 生物恐怖制剂和医院感染控制:没有时间放松警惕
Journal of Bioterrorism and Biodefense Pub Date : 2012-07-24 DOI: 10.4172/2157-2526.1000E103
N. Petrosillo
{"title":"Bioterrorism Agents and Hospital Infection Control: No Time to Drop the Guard","authors":"N. Petrosillo","doi":"10.4172/2157-2526.1000E103","DOIUrl":"https://doi.org/10.4172/2157-2526.1000E103","url":null,"abstract":"The hospital setting represents the sounding board for several infections, both from the community and from healthcare facilities, including highly communicable and emerging agents that cause severe and lethal infections. The US cases of anthrax in 2001 and the recent outbreaks (severe acute respiratory syndrome, H1N1 flu, avian flu, Shiga toxin producing E. coli, etc.) have heightened the need for preparedness and response to naturally emerging and re-emerging infections or deliberately released biological agents. However, there are some critical points to be discussed.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75116815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Bioterrorist Attacks on America 对美国的生物恐怖袭击
Journal of Bioterrorism and Biodefense Pub Date : 2012-07-20 DOI: 10.4172/2157-2526.1000115
Y. Ezepchuk
{"title":"The Bioterrorist Attacks on America","authors":"Y. Ezepchuk","doi":"10.4172/2157-2526.1000115","DOIUrl":"https://doi.org/10.4172/2157-2526.1000115","url":null,"abstract":"This article discusses the events surrounding the 9/11 bioterrorist attacks upon US citizens in which anthrax spores were utilized. The arguments presented in this article substantiate the shortcomings regarding the search of “domestic” terrorists, indicating that agents from the Arab world were involved in the organized attacks of sending letters with anthrax spores. Since the attacks employed the use of the weaponized aerosol form of anthrax, there is evidence which demonstrates that the manufacturing of the spores was carried out in a country with capabilities of developing bacteriological weapons. Ultimately, this article presents legitimate arguments in which further investigation is warranted.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74355157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Bioterrorism, Concern on Some Important Tropical Diseases 生物恐怖主义，对一些重要热带病的关注
Journal of Bioterrorism and Biodefense Pub Date : 2012-07-19 DOI: 10.4172/2157-2526.1000E101
V. Wiwanitkit
{"title":"Bioterrorism, Concern on Some Important Tropical Diseases","authors":"V. Wiwanitkit","doi":"10.4172/2157-2526.1000E101","DOIUrl":"https://doi.org/10.4172/2157-2526.1000E101","url":null,"abstract":"Bioterrorism is an actual threat to the world population. There are many kinds of possible infectious diseases that can be used as tools for bioterrorism. Here, the author briefly discusses on some specific important tropical diseases which can be used by bioterrorists. This is another important new issue in tropical medicine.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85905964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Mathematical Model of Bioterrorist Attack Risk Assessment 生物恐怖袭击风险评估的数学模型
Journal of Bioterrorism and Biodefense Pub Date : 2012-07-16 DOI: 10.4172/2157-2526.1000114
Radosavljevic Vladan, Belojevic Goran, Jovanovic Larisa
{"title":"A Mathematical Model of Bioterrorist Attack Risk Assessment","authors":"Radosavljevic Vladan, Belojevic Goran, Jovanovic Larisa","doi":"10.4172/2157-2526.1000114","DOIUrl":"https://doi.org/10.4172/2157-2526.1000114","url":null,"abstract":"The authors propose a bioterrorism risk assessment model comprising 22 qualitative and 10 quantitative parameters. Scores 0 and 1 refer to low and high probability of a bioterrorist attack, respectively. Vulnerability analysis is related to targets, while feasibility analysis refers to perpetrators, agents and means/media of delivery. The model is applied on the US anthrax attack in 2001. Mathematical modeling is also proposed to express the risk of human losses in a bioterrorist attack. The model may be helpful in predicting and preventing bioterrorist attacks.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85078922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Psychological Process and Pathways to Radicalization 激进化的心理过程和途径
Journal of Bioterrorism and Biodefense Pub Date : 2012-05-25 DOI: 10.4172/2157-2526.S5-003
K. Bhui, S. Dinos, E. Jones
{"title":"Psychological Process and Pathways to Radicalization","authors":"K. Bhui, S. Dinos, E. Jones","doi":"10.4172/2157-2526.S5-003","DOIUrl":"https://doi.org/10.4172/2157-2526.S5-003","url":null,"abstract":"The recent emphasis on ‘home-grown’ terrorism has resulted in a vigorous discourse on radicalization as a process that might explain how seemingly ordinary people become terrorists. This paper explores the psychological influences, group and individual identity in young people during maturation, when transitions of identity may make them vulnerable to recruitment to violent radicalization. This paper specifically focuses on the recent phenomena of home grown terrorism in Western democracies. This requires investigation without assumptions of similarity with other global and historical acts of terrorism. Studies of terrorism have focused on those identified as engaged with terrorist organizations or convicted of terrorist crimes, with little attention given to populations that are vulnerable to recruitment to terrorist action. Therefore, this paper focuses on home grown terrorism and the psychological processes and pathways to radicalization as a pre-cursor of terrorist acts.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"02 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80087327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Applications of Rat Brain Synaptic Vesicle Proteins for Sensitive and Specific Detection of Botulinum Neurotoxins 大鼠脑突触囊泡蛋白在肉毒杆菌神经毒素敏感和特异性检测中的应用
Journal of Bioterrorism and Biodefense Pub Date : 2012-05-23 DOI: 10.4172/2157-2526.S2-008
M. Singh, V. Chauhan, R. Dhaked
{"title":"Applications of Rat Brain Synaptic Vesicle Proteins for Sensitive and Specific Detection of Botulinum Neurotoxins","authors":"M. Singh, V. Chauhan, R. Dhaked","doi":"10.4172/2157-2526.S2-008","DOIUrl":"https://doi.org/10.4172/2157-2526.S2-008","url":null,"abstract":"We propose here the application of synaptic vesicle proteins isolated from rat brain as a sole substrate for the specific endoproteinase activities of all seven serotypes of Botulinum Neurotoxin (BoNT/A to G). In this study, we used these proteins for evaluating endopeptidase and receptor binding activity for detecting BoNT/A by western blot and surface plasmon resonance with 6.25 pM and 0.22 fM limit of detection, respectively. Substrate and receptor present in the synaptic vesicle proteins are very robust and stable for more than 6 months to use in BoNT detection.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"19 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2012-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86634192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Food Safety in the Czech Republic 捷克共和国的食品安全
Journal of Bioterrorism and Biodefense Pub Date : 2012-05-08 DOI: 10.4172/2157-2526.S2-006
H. Střítecká, P. Hlúbik, L. Dohnalová
{"title":"Food Safety in the Czech Republic","authors":"H. Střítecká, P. Hlúbik, L. Dohnalová","doi":"10.4172/2157-2526.S2-006","DOIUrl":"https://doi.org/10.4172/2157-2526.S2-006","url":null,"abstract":"Food Safety can be understood from many points of views: from the State's obligation to create a legal environment for the production, import and inspection of health safety food to the contents of the individual, even exceeding the legally laid limits or added substances in food. While the first aspect is given by law and therefore is easily controllable, the second is more subjective, poorly clearly verifiable and is part of continuing discussions, both professional and lay public.If the all requirements for the production, distribution and sale are fulfil in accordance to legislative, food in market can be considered such as health and safety food. From 1st May 2004 The Czech Republic became an equal member of the European Union which has led to the adoption of all rules of this Community. One of the basic obligations enshrined in the Treaty establishing the European Community is to guarantee a high level of health protection and strengthen consumer protection.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"3 9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78410557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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