{"title":"Conotoxins: Potential Weapons from the Sea","authors":"P. Anderson, Gyula Bokor","doi":"10.4172/2157-2526.1000120","DOIUrl":"https://doi.org/10.4172/2157-2526.1000120","url":null,"abstract":"Cone snails are predatory marine animals that kill their prey with powerful venom. Conotoxins are a pharmacologically and chemically diverse group of toxins found in the venom. A number of species of cone snails, such as Conus geographus, are deadly to humans. Conotoxins affect numerous neurotransmitter receptors and ion channels in the body. The receptors impacted include nicotinic, adrenergic, NMDA, and serotonergic. Ion channels altered include sodium, potassium and calcium. The most lethal effect of conotoxins to humans is muscle paralysis of the diaphragm causing respiratory arrest. Numerous conotoxins are being used as research tools or being explored as therapeutic drugs. Concerns in the homeland security field exist that certain conotoxins could be weaponized and used an aerosol. Conotoxins at risk of terrorist use include α-conotoxins, κ-conotoxins and δ-conotoxins. Most conotoxins are not a bioterrorism threat.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"697 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81191640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthias Geissler, S. Isabel, Benoît Voisin, Chantal M. Fauvel, M. Boissinot, M. Bergeron, T. Veres
{"title":"Modular ultrasonic lysis system for rapid nucleic acid extraction and sample transfer of Bacillus spores.","authors":"Matthias Geissler, S. Isabel, Benoît Voisin, Chantal M. Fauvel, M. Boissinot, M. Bergeron, T. Veres","doi":"10.4172/2157-2526.1000119","DOIUrl":"https://doi.org/10.4172/2157-2526.1000119","url":null,"abstract":"This paper describes the design, functioning and use of an ultrasonic modular system intended for rapid extraction and fragmentation of DNA from microbial organisms following sample collection in the field. PCR assessment of the DNA extracts revealed that the system can disrupt Bacillus atrophaeus spores, a simulant for Bacillus anthracis, in less than 1 min, providing a DNA yield equivalent to that of a commercial nucleic acid extraction method. Simulation of the transfer from a contaminated to a secure area confirmed that the sample remained confined within the module while the exterior surface can be decontaminated through immersion in a disinfectant solution.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84674151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Syndromic Surveillance: Early Warning Systems for Monitoring Emerging Outbreaks of Health Events from Either Natural Causes or from Bioterrorists","authors":"E. Melnick","doi":"10.4172/2157-2526.1000E107","DOIUrl":"https://doi.org/10.4172/2157-2526.1000E107","url":null,"abstract":"Biodefense, as defined in Wikipedia, refers to short term local measures designed to restore biosecurity to a collection of people in a given area, who are subjected to biological warfare. While the US Department of Defense had originally focused on applications of vaccines to fight pathogens in the environment, its scope has expanded to include protection of water and food supplies.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"06 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2012-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80091763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Smallpox: New Perspectives Regarding Risk Assessment & Management","authors":"Jan-Cédric Hansen","doi":"10.4172/2157-2526.S4-002","DOIUrl":"https://doi.org/10.4172/2157-2526.S4-002","url":null,"abstract":"Although official stockpile of smallpox are limited to two sites, everlasting rumors of bioterrorism use of this virus make its risk assessment controversial. After a quick overview of the history of smallpox and its current situational analysis, the author presents his own vision regarding likelihood of smallpox weaponization and new trends regarding its risk management. In particular, four scenarios on how to get hold of smallpox samples are discussed as well as the following steps of potential deliberate release in light of feasibility from the terrorist standpoint. Following, early detection strategies are overviewed with a special focus on their respective limitations. Then up to date therapeutic armamentarium, including drugs under development is detailed. In conclusion, the author exposes a surprising paradox regarding the potential use of smallpox as an agent of bioterrorism by Al-Qaeda terrorists and alike.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85166025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Ceccarelli, Adriano Purgato, Ugo G. Pacifici Noja, L. Pacifici
{"title":"Biodefense Strategies to Reduce the Impact of Communicable Diseases in Developed Countries: The Need of New Policies Designed for Mobile and Vulnerable Populations","authors":"G. Ceccarelli, Adriano Purgato, Ugo G. Pacifici Noja, L. Pacifici","doi":"10.4172/2157-2526.1000E106","DOIUrl":"https://doi.org/10.4172/2157-2526.1000E106","url":null,"abstract":"Migration is a major global phenomenon which influences the health of individuals and populations; currently, estimates suggest that there are more than one billion migrants world-wide. Conditions surrounding modern migration may expose migrants to increased health risks and negative health outcomes: in fact increased movement of people across borders has a great influence on the incidence of communicable diseases, relevant to public health, in developed countries. In addition, migration is continually emphasizing public health responses to the threat of communicable diseases at the international level.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86499313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structure and Implementation of United States Biological Export Control Policy","authors":"Michael A. Bailey, G. W. Christopher, J. David","doi":"10.4172/2157-2526.1000118","DOIUrl":"https://doi.org/10.4172/2157-2526.1000118","url":null,"abstract":"Treaties governing the proliferation of weapons of mass destruction in general, and biological weapons specifically, derive their value from the norms set forth in their articles. They provide a common starting point for signatory nations as they traverse the complex world of dual-use technologies and transfer of potentially dangerous materials. Treaties, however, are not enforceable regulations. Such regulations are developed separately, and are codified into law by the controlling authorities within national governments. This review will analyze the structure, implementation and administration of the United States’ export controls related to biological weapons; it will evaluate the U.S. government’s work with like-minded governments to harmonize regulations to achieve a common goal of stopping the proliferation of biological weapons. Further, the shortcomings of current policy in this area will be examined and recommendations for improvement will be offered. A review of the literature revealed surprisingly little academic research in the area of Biological Export Control regimes, and their effectiveness from a policy standpoint. This review seeks to add to and broaden the policy discussion in this important area.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79659834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biodefense by Protecting Mitochondria","authors":"Amanda Claire Milstein, R. Vartak, Yidong Bai","doi":"10.4172/2157-2526.1000E104","DOIUrl":"https://doi.org/10.4172/2157-2526.1000E104","url":null,"abstract":"Nuclear weaponry was and remains the most significant threat to public health during war. However, during these times of covert terrorist attacks, a new and potentially deadly form of warfare is coming to light. As modern science has progressed, the affordability of producing chemical and biological agents on mass scale has made them an attractive mode of attack and it is now of paramount importance to devise ways that can limit the dangers posed by these agents.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73387199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical Countermeasures for Biothreat Agents: in vivo Studies and Animal Models","authors":"S. I. Alam","doi":"10.4172/2157-2526.1000E105","DOIUrl":"https://doi.org/10.4172/2157-2526.1000E105","url":null,"abstract":"Biothreat agents are prioritized in terms of their threat potentials by taking several factors into account, such as inhalation route of infection / intoxication, infectious dose or toxicity, stability in the environment, and availability of therapeutics / prophylaxis. Most of these factors are intrinsic features of the given pathogen or toxin and are not under our control to modulate. However, pre-exposure prophylaxis and post exposure therapeutics are the criteria that intensive research can handle and dislodge a particular organism from the Select Agent and Toxin List (SATL). Our ability, to impart immunity to human population against an infectious agent and/or treat the disease, substantially mitigates a potential threat and renders the agent obnoxious from bioterrorism or warfare viewpoint. For instance, Clostridium tetani and its neurotoxin are equivalent to Clostridium botulinum at least in terms of the lethality of the neurotoxins but the former is not considered a potential select agent for the availability of prophylactic measures and immunization regimen. The problems associated with pre-exposure prophylaxis for threat agents is confounded by several factors including the long list of select agents and the uncertainty of use for a particular agent. For the agents of public health importance, we are aware of the endemecity of natural disease outbreaks, but it is difficult to predict which agent will be used in a bioterror or BW attack. Theoretically, a pre-exposure prophylaxis in biothreat scenario requires immunization against all the agents or least against those posing potential threat. Assuming that we have developed vaccines for each of the threat agents, the vaccination of even a vulnerable population for this wide array of pathogens is a magnanimous task.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89188112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of an algorithm for calculating the 'risk' of terrorist - CBRN.","authors":"Bolduc Dl, J. Marr, J. King, R. Dudley","doi":"10.4172/2157-2526.1000117","DOIUrl":"https://doi.org/10.4172/2157-2526.1000117","url":null,"abstract":"In order to avert a disaster from a terrorist chemical, biological, radiological or nuclear (CBRN) attack, it is important to study the likelihood of terrorists using CBRN weapons. This study reports on the development of an algorithm for calculating the ‘risk’ of a terrorist seeking CBRN weaponry with 67.3 percent prediction accuracy. The algorithm was developed through four phases, Phase I proposed independent variables likely associated with Terrorist-CBRN (T-CBRN) derived from our interpretation of the literature; Phase II involved constructing a ‘Random Nations Matrix’ from 74 countries or locations of the world selected at random, for correlating the proposed independent variables; Phase III entailed the construction of a multivariate model from the independent variables which met our correlation criteria with T-CBRN; and finally in Phase IV, an algorithm was derived from the model design for calculating the risk of a terrorist seeking, acquiring and or using a CB","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73437531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Human Factors and Bioagent Transmission following an Indoor Bioterror Attack","authors":"Jonathon Taylor, K. Lai, Z. Nasir","doi":"10.4172/2157-2526.1000116","DOIUrl":"https://doi.org/10.4172/2157-2526.1000116","url":null,"abstract":"The spread of bioagent through the population in a building following a bioattack is dependent on the built environment, the characteristics of the agent and the medium in which it is introduced, and the actions of individuals inside the building. While there has been a great deal of research on the spread of contaminants in indoor environments, many studies do not take into account the impact of human factors on bioagent spread and transmission. This paper discusses how bioagents may be spread through an indoor environment following an attack due to the behaviours and characteristics of the building population, in terms of their typical behaviour, as well as any emergency response measures they implement. Modelling methodologies are proposed which can be used to supplement existing air transport and Markovian models in order to take into account the actions and decisions of the building population.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88319694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}