Smallpox: New Perspectives Regarding Risk Assessment & Management

Although official stockpile of smallpox are limited to two sites, everlasting rumors of bioterrorism use of this virus make its risk assessment controversial. After a quick overview of the history of smallpox and its current situational analysis, the author presents his own vision regarding likelihood of smallpox weaponization and new trends regarding its risk management. In particular, four scenarios on how to get hold of smallpox samples are discussed as well as the following steps of potential deliberate release in light of feasibility from the terrorist standpoint. Following, early detection strategies are overviewed with a special focus on their respective limitations. Then up to date therapeutic armamentarium, including drugs under development is detailed. In conclusion, the author exposes a surprising paradox regarding the potential use of smallpox as an agent of bioterrorism by Al-Qaeda terrorists and alike.